| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| The Cek 7 ligand shows a 48 % sequence identity at the protein level to B 61 , a ligand for the related Eck RPTK , 30 % to the Cek 5 ligand , 59 % to the recently cloned Ehk 1 L , and identity to ELF 1 , a recently described ligand for the Mek 4 and Sek RPTKs . ^^^ |
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| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| Conversely , ephrin A 2 , ephrin A 3 , and ephrin A 5 bind EphA 7 but not EphA 4 . ^^^ |
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| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| Although several patterns of early gene expression are stable ( e . g . , EphA 3 , EphA 4 , and EphA 6 ) , others change as development proceeds ( e . g . , EphA 5 , EphA 7 , ephrin A 2 , ephrin A 3 , and ephrin A 5 ) , perhaps responding to extrinsic cues . ^^^ Thus , at E 95 , after connections between the cortical plate and thalamus have formed , receptor subtypes EphA 3 , EphA 5 , EphA 6 , and EphA 7 and the ligand ephrin A 5 are expressed in posterior regions , whereas EphA 4 and ephrin A 2 and ephrin A 3 are either uniformly distributed or anteriorly biased . ^^^ |
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| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| In neonatal mice , the fraction containing combined organ of Corti and spiral ganglion showed relatively strong expression of EphA 4 , EphB 3 , ephrin A 3 , ephrin B 2 and ephrin B 3 . ^^^ In the lateral wall , EphA 4 , ephrin A 3 and ephrin B 2 were strongly expressed , while ephrin A 3 was particularly strongly expressed in utricular and saccular sensory epithelia . ^^^ |
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| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| Here we describe a repulsive interaction that regulates postsynaptic morphology through the EphA 4 receptor tyrosine kinase and its ligand ephrin A 3 . ^^^ EphA 4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus , and ephrin A 3 is localized on astrocytic processes that envelop spines . ^^^ Activation of EphA 4 by ephrin A 3 was found to induce spine retraction , whereas inhibiting ephrin / EphA4 interactions distorted spine shape and organization in hippocampal slices . ^^^ Thus , our data support a model in which transient interactions between the ephrin A 3 ligand and the EphA 4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross talk . . ^^^ |
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| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P52797 and P54764 |
Pubmed |
SVM Score :0.0 |
| NA |
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