| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.53606709 |
| We conclude that PDX 1 in synergy with NeuroD specifies part of the beta cell phenotype including transcriptional activation of insulin and IAPP genes , but that other factors such as Nkx6 . 1 and Pax 6 are required for additional features of the fully mature beta cell phenotype . . 0.53606709^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| These genes encode the enzyme glucokinase and the transcription factors hepatocyte nuclear factor 4alpha , hepatocyte nuclear factor 1alpha , insulin promoter factor 1 , hepatocyte nuclear factor 1beta and neuroD 1 . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| These genes encode the glycolytic enzyme glucokinase ( MODY 2 ) and the other five encode the transcription factors hepatocyte nuclear factor ( HNF ) 4alpha ( MODY 1 ) , HNF 1alpha ( MODY 3 ) , HNF 1beta ( MODY 5 ) , insulin promoter factor 1 ( IPF 1 ) ( MODY 4 ) and neurogenic differentiation factor 1 ( NeuroD 1 ) ( MODY 6 ) . . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| The majority of proteins associated with MODY are transcription factors , such as hepatocyte nuclear factor 4alpha ( HNF 4alpha ) , HNF 1alpha , insulin promoter factor 1 ( IPF 1 ) , HNF 1beta , and NEUROD 1 . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| MODY is both clinically and genetically heterogeneous , with six different genes identified to date ; glucokinase ( GCK ) , hepatocyte nuclear factor 1 alpha ( HNF1A , or TCF 1 ) , hepatocyte nuclear factor 4 alpha ( HNF4A ) , insulin promoter factor 1 ( IPF 1 or PDX 1 ) , hepatocyte nuclear factor 1 beta ( HNF1B or TCF 2 ) , and neurogenic differentiation 1 ( NEUROD 1 ) . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| The diabetes of STZ mice was partially reversed by HDAD mediated transfer of NeuroD ( Neurod ) , a factor downstream of Ipf 1 , and completely reversed by a combination of Neurod and betacellulin ( Btc ) , without producing hepatitis . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| RESULTS : No mutations were detected in the HNF 4alpha , IPF 1 , NEUROD 1 or HNF 1beta genes in any of the families studied . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Six genetic mutations have been described , one of them affecting the glucokinase gene ( MODY 2 ) and the others various transcription factors HNF 1alpha , HNF 4alpha , HNF 1beta , IPF 1 and NeuroD ( MODY 1 , 3 , 4 , 5 , 6 , respectively ) . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| We examined the association of variants in genes encoding several transcription factors ( TCF 1 , TCF 2 , HNF4A , ISL 1 , IPF 1 , NEUROG 3 , PAX 6 , NKX 2 2 , NKX 6 1 , and NEUROD 1 ) and genes encoding the ATP sensitive K ( + ) channel subunits Kir6 . 2 ( KCNJ 11 ) and SUR 1 ( ABCC 8 ) with type 2 diabetes in a Japanese cohort of 2 , 834 subjects . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Recent genetic studies have identified a network of transcription factors , including Pdx 1 , Isl 1 , Pax 4 , Pax 6 , NeuroD , Nkx2 . 2 , and Hlxb 9 , regulating the development of islet cells at different stages , but the molecular mechanisms controlling the specification of pancreatic endocrine precursors remain unknown . neurogenin 3 ( ngn 3 ) is a member of a family of basic helix loop helix transcription factors that is involved in the determination of neural precursor cells in the neuroectoderm . ngn 3 is expressed in discrete regions of the nervous system and in scattered cells in the embryonic pancreas . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| In HeLa and HepG 2 cells c Myc exerted a suppressive effect on the insulin promoter activity only in the presence of NeuroD / BETA2 but not PDX 1 . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Examination of the HUH 7 ins cells as well as the parent cell line for beta cell transcription factors showed the presence of NeuroD but not PDX 1 . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| The glucose induced response is dependent upon ERK1 / 2 phosphorylation of a subset of transcription factors that include Beta 2 ( also known as NeuroD 1 ) and PDX 1 . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Transcription factors Pdx 1 and NeuroD bind to this fragment at A 2 and E 1 sequence motifs . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that MafA overexpression , together with PDX 1 ( pancreatic and duodenal homeobox factor 1 ) and NeuroD , markedly increases insulin gene expression in the liver . ^^^ Furthermore , in streptozotocin induced diabetic mice , MafA overexpression in the liver , together with PDX 1 and NeuroD , dramatically ameliorated glucose tolerance , while combination of PDX 1 and NeuroD was much less effective . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| PDX 1 / VP16 fusion protein , together with NeuroD or Ngn 3 , markedly induces insulin gene transcription and ameliorates glucose tolerance . ^^^ In this study , we showed that a modified form of the pancreatic and duodenal homeobox factor 1 ( PDX 1 ) carrying the VP 16 transcriptional activation domain ( PDX 1 / VP16 ) markedly increases insulin biosynthesis and induces various pancreas related factors in the liver , especially in the presence of NeuroD or neurogenin 3 ( Ngn 3 ) . ^^^ Furthermore , in streptozotocin induced diabetic mice , PDX 1 / VP16 overexpression , together with NeuroD or Ngn 3 , drastically ameliorated glucose tolerance . ^^^ Thus PDX 1 / VP16 expression , together with NeuroD or Ngn 3 , markedly induces insulin gene transcription and ameliorates glucose tolerance . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| A five stage culturing strategy starting with embryoid bodies ( EBs ) was used in this study . mRNA for pancreatic duodenal homeobox gene 1 ( PDX 1 ) and neurogenic differentiation ( NeuroD ) was detected from stage 1 , hepatocyte nuclear factor 3 beta ( HNF3beta ) and insulin 2 from stage 2 , Ngn 3 and glucose transporter 2 ( GLUT 2 ) from stage 3 , and insulin 1 and other beta cell markers , at stages 4 5 . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Analysis of the INGAP promoter suggested that candidate regulators of INGAP expression include the transcription factors PDX 1 , NeuroD , PAN 1 , STAT and AP 1 . ^^^ In contrast , co expression of PDX 1 but not NeuroD inhibits activation of the INGAP promoter driven by PAN 1 , PMA or LIF stimulation . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| Major insulin gene transcription factors , such as PDX 1 or NeuroD 1 , have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells . ^^^ |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52945 and Q13562 |
Pubmed |
SVM Score :0.0 |
| NA |
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