| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.99317417 |
| Their pattern also argues for the transdifferentiation of beta cells into progenitor cells , demonstrating neuroepithelial features and overexpressing both PBX 1 , a homeodomain protein that can bind as a heterodimer with PDX 1 and could switch the nature of its transcriptional activity , and neurogenin 3 , a key factor for the generation of endocrine islet cells . 0.99317417^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| Pre B cell leukemia transcription factor 1 ( PBX 1 ) encodes a homeodomain containing protein that is essential for pancreatic development and interacts with insulin promoter factor 1 to regulate insulin secretion . ^^^ Pre B cell leukemia transcription factor 1 ( PBX 1 ) encodes a homeodomain containing protein that is essential for pancreatic development and interacts with insulin promoter factor 1 to regulate insulin secretion . ^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| Pbx 1 inactivation disrupts pancreas development and in Ipf 1 deficient mice promotes diabetes mellitus . ^^^ In vitro studies have shown that Pbx 1 regulates the activity of Ipf 1 ( also known as Pdx 1 ) , a ParaHox homeodomain transcription factor required for the development and function of the pancreas in mice and humans . ^^^ Analysis of trans heterozygous Pbx1+ / Ipf1+ / mice revealed in vivo genetic interactions between Pbx 1 and Ipf 1 that are essential for postnatal pancreatic function ; these mice developed age dependent overt diabetes mellitus , unlike Pbx1+ / or Ipf1+ / mice . ^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| However , transcriptional activity of both mutant IPF 1 proteins , alone or in combination with HNF 3 beta / Foxa2 , Pbx 1 , or the heterodimer E 47 beta 2 was reduced , findings accounted for by decreased IPF 1 steady state levels and not by impaired protein protein interactions . ^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| In contrast , in the context of the intact somatostatin promoter or mini enhancer , Pbx 1 and Prep 1 alone have no effect , but they produce a drastic activation when the pancreatic homeodomain factor PDX 1 is also coexpressed . ^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| We , therefore , studied the expression of the transcription factors Pdx 1 , Pbx 1 , Meis 2 , Nkx2 . 2 and the putative stem cell markers c Kit and nestin in rat pancreata 3 , 5 and 7 days after duct ligation . ^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| We examined , in human obesity , a model for pancreatic endocrine tissue plasticity , the gene and protein expression of PBX 1 a transcription factor expressed in regenerating rat ductules and potentially implicated in the pancreatic development , alone or in association with PDX 1 . ^^^ When comparing gene expression , by quantitative real time RT PCR , in pancreatic exocrine tissue from obese non diabetic subjects with increased islet mass , we found that Pbx 1 and Pdx 1 were up regulated ( 5 . 9+ / 1 . 2 and 2 . 4+ / 0 . 6 versus non obese ) . ^^^ |
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| Interacting proteins: P52945 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
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