| Interacting proteins: P52945 and P15923 |
Pubmed |
SVM Score :0.0 |
| E2A gene products dimerize with cell specific basic helix loop helix proteins and synergize with the homeodomain transcription factor , PDX 1 , in insulin gene transactivation . ^^^ |
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| Interacting proteins: P52945 and P15923 |
Pubmed |
SVM Score :0.0 |
| Transcription factor BETA 2 acts cooperatively with E2A and PDX 1 to activate the insulin gene promoter . ^^^ Separate expression of BETA 2 , E2A , or PDX 1 led to modest ( < 10 fold ) activation of the insulin promoter , whereas co expression of the three proteins produced synergistic , high level activation ( 160 fold ) . ^^^ |
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| Interacting proteins: P52945 and P15923 |
Pubmed |
SVM Score :0.0 |
| The majority of the islet restricted ( BETA 2 , PDX 1 , RIP3b1 Act / C1 ) and ubiquitous ( E2A , HEB ) insulin binding proteins have been characterized . ^^^ |
|
| Interacting proteins: P52945 and P15923 |
Pubmed |
SVM Score :0.0 |
| HD transgenic mice develop an age dependent reduction of insulin mRNA expression and diminished expression of key regulators of insulin gene transcription , including the pancreatic homeoprotein PDX 1 , E2A proteins , and the coactivators CBP and p 300 . ^^^ |
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