| Interacting proteins: P52564 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| MTK 1 overexpression also activated the MKK 3 , MKK 6 and SEK 1 MAPKKs , but not the MEK 1 MAPKK . ^^^ Furthermore , MTK 1 phosphorylated and activated MKK 6 and SEK 1 in vitro . ^^^ |
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| Interacting proteins: P52564 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| In the autoinhibited conformation , the MTK 1 kinase domain can not interact with its substrate , MKK 6 . ^^^ Mutants of full length MTK 1 were isolated that can interact with MKK 6 in the absence of the activator GADD 45 proteins . ^^^ |
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| Interacting proteins: P52564 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| Although it is known that MEKK 4 regulates MKK 6 , and p 38 MAP kinase , extracellular stimuli that activate the serine / threonine kinase , MEKK 4 , are unknown . ^^^ Pyk 2 phosphorylates MEKK 4 in vitro and Pyk 2 dependent phosphorylation further regulates MEKK 4 dependent phosphorylation of MKK 6 . ^^^ |
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| Interacting proteins: P52564 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| By disrupting this interaction we demonstrated that CIN 85 binding to MEKK 4 enhances the activation of MKK 6 and of the downstream p 38 MAP kinase following oxidative stress and growth factor stimulation . ^^^ |
|
| Interacting proteins: P52564 and Q9Y6R4 |
Pubmed |
SVM Score :0.0 |
| NA |
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