| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Coexpression of downstream kinases , MAP kinase kinase 4 , MAP kinase kinase 6 , and c Jun NH ( 2 ) terminal kinase 1 , but not MAP kinase kinase 3 and p 38 , augmented ARE activation by MEKK 1 , TAK 1 , and ASK 1 . ^^^ |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| A MAP kinase kinase kinase ( MAPKKK ) , termed ASK 1 , was identified that activated two different subgroups of MAP kinase kinases ( MAPKK ) , SEK 1 ( or MKK 4 ) and MKK3 / MAPKK6 ( or MKK 6 ) , which in turn activated stress activated protein kinase ( SAPK , also known as JNK ; c Jun amino terminal kinase ) and p 38 subgroups of MAP kinases , respectively . ^^^ |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Dominant negative ASK 1 , MKK 6 , MKK 4 and JNK 1 potently inhibited EGCG induced cell death . ^^^ |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation data showed that NO production inhibited a binding of ASK 1 , but not ASK 1 ( C869S ) , to MKK 3 or MKK 6 . ^^^ |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Expression of hD53L1 enhances autophosphorylation and kinase activity of ASK 1 but has no effect on ASK 1 oligomerization that is necessary for kinase activity and on binding of ASK 1 to MKK 6 , a downstream factor of ASK 1 . ^^^ |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Here we present evidence that the tau phosphorylation characteristic of neurofibrillary tangles may be mediated by a physical association of MKK 6 ( mitogen associated protein kinase kinase 6 ) with tau and subsequent phosphorylation of tau by the MKK 6 substrate , p 38 MAPK ; and that APP ( beta amyloid precursor protein ) may be co immunoprecipitated both with MKK 6 and its upstream MAPKKK , ASK 1 . ^^^ Taken together with recent data demonstrating APP dimerization by beta amyloid peptide ( Abeta ) ( Lu et al . , 2003 ) , and the possible activation of ASK 1 via APP dimerization ( Hashimoto et al . , 2003 ) , these results suggest a model of AD in which Abeta peptide dimerizes APP directly , leading to the activation of ASK 1 , MKK 6 , and p 38 , with subsequent phosphorylation of tau at sites characteristic of AD . . ^^^ |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and Q99683 |
Pubmed |
SVM Score :0.0 |
| NA |
|