| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| Activation of stress activated protein kinase 3 ( SAPK 3 ) by cytokines and cellular stresses is mediated via SAPKK 3 ( MKK 6 ) ; comparison of the specificities of SAPK 3 and SAPK 2 ( RK / p38 ) . ^^^ SAPK 3 and SAPK 2 were activated at similar rates in vitro by SAPKK 3 ( also termed MKK 6 ) , and SAPKK 3 was the only activator of SAPK 3 that was induced when KB or 293 cells were exposed to cellular stresses or stimulated with IL 1 or TNF . ^^^ Co transfection with SAPKK 3 induced SAPK 3 activity and greatly enhanced activation in response to osmotic shock . ^^^ These experiments indicate that SAPKK 3 mediates the activation of SAPK 3 in several mammalian cells . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| Additionally , we demonstrated that these GPCRs can elevate the activity of novel members of the MAPK family , including ERK 5 , p38alpha , p38gamma , and p38delta , and that the activation of certain kinases acting downstream from MEK 5 ( ERK 5 ) and MKK 6 ( p38alpha and p38gamma ) is necessary to fully activate the c jun promoter . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| Involvement of the MKK 6 p38gamma cascade in gamma radiation induced cell cycle arrest . ^^^ Activation of the MKK 6 p38gamma cascade is sufficient to induce G ( 2 ) arrest in cells , and expression of dominant negative alleles of MKK 6 or p38gamma allows cells to escape the DNA damage induce G ( 2 ) delay . ^^^ These data suggest a model in which activation of ATM by gamma irradiation leads to the activation of MKK 6 , p38gamma , and Cds 1 and that activation of both MKK 6 and p38gamma is essential for the proper regulation of the G ( 2 ) checkpoint in mammalian cells . . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| MKK 4 and MKK 6 phosphorylation increased and decreased in a trend similar to that observed with JNK activity and p38gamma phosphorylation . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| We have investigated the ability of the mitogen activated protein kinase ( MAPK ) kinase MKK 6 to activate different members of the p 38 subfamily of MAPKs and found that some MKK 6 mutants can efficiently activate p38alpha but not p38gamma . ^^^ We also found that the preferential activation of p38alpha by MKK 6 correlated with more efficient binding of MKK 6 to p38alpha than to p38gamma . ^^^ Furthermore , increasing concentrations of constitutively active MKK 6 differentially activated either p38alpha alone ( low MKK 6 activity ) or both p38alpha and p38gamma ( high MKK 6 activity ) , both in vitro and in injected oocytes . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| The p38beta isoform increases the activation of AP 1 transcriptional activities by MKK 6 and / or arsenite , whereas p38gamma / p38delta inhibits or has no effect on the stimulation . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PKNalpha associates with each member of the p38gamma MAPK signaling pathway ( p38gamma , MKK 6 , and MLTKalpha ) . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| L 6 myotubes were transfected with empty vector ( pCAGGS ) , activating MKK 6 ( MKK6CA ) , or p38gamma specific siRNA . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipit ation experiments indicate that p38gamma / SAPK3 is the major p 38 activated by MKK 6 in the oocytes . ^^^ We have cloned Xenopus p38gamma ( Xp38gamma ) and show that co expression of active MKK 6 with Xp38gamma induces oocyte maturation in the absence of progesterone . ^^^ |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and P53778 |
Pubmed |
SVM Score :0.0 |
| NA |
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