| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| We also observed that p38delta was strongly activated by MKK 3 and MKK 6 , while p38alpha was preferentially activated by MKK 6 . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| However , unlike the other p 38 isoforms , the kinase activity of p38delta is not blocked by the pyridinyl imidazole , 4 ( 4 fluorophenyl ) 2 2 ( 4 hydroxyphenyl ) 5 ( 4 pyridyl ) imidazole ( identicalto SB 202190 ) . p38delta can be activated by MKK 3 and MKK 6 , known activators of the other isoforms . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| Additionally , we demonstrated that these GPCRs can elevate the activity of novel members of the MAPK family , including ERK 5 , p38alpha , p38gamma , and p38delta , and that the activation of certain kinases acting downstream from MEK 5 ( ERK 5 ) and MKK 6 ( p38alpha and p38gamma ) is necessary to fully activate the c jun promoter . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| MEK 6 regulates human involucrin gene expression via a p38alpha and p38delta dependent mechanism . ^^^ These results suggest that MEK 6 increases hINV gene expression by regulating the balance between activation of p38alpha , which increases gene expression , and p38delta , which decreases gene expression . . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| The p38beta isoform increases the activation of AP 1 transcriptional activities by MKK 6 and / or arsenite , whereas p38gamma / p38delta inhibits or has no effect on the stimulation . ^^^ Consistent with the positive and negative roles of p38beta and p38delta in AP 1 regulation , MKK 6 stimulates AP 1 dependent transcription in NIH 3T3 but not EMT 6 cells . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| A constitutively active form of MEK 6 , an upstream activator of p38delta , can also produce cell death when coupled with p38delta . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| Activation of the novel stress activated protein kinase SAPK 4 by cytokines and cellular stresses is mediated by SKK 3 ( MKK 6 ) ; comparison of its substrate specificity with that of other SAP kinases . ^^^ SAPK 4 was activated in vitro by SKK 3 ( also called MKK 6 ) or when co transfected with SKK 3 into COS cells . ^^^ |
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| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| Activation of the novel MAP kinase homologue SAPK 4 by cytokines and cellular stresses is mediated by SKK 3 ( MKK 6 ) . ^^^ |
|
| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15264 and P52564 |
Pubmed |
SVM Score :0.0 |
| NA |
|