| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The effect of the cap on translation is mediated by the initiation factor eIF 4F , whereas the effect on pre mRNA splicing involves a nuclear complex ( CBC ) composed of two cap binding proteins , CBP 80 and CBP 20 . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| Purified CBC consists of two previously identified proteins , CBP 80 and CBP 20 . ^^^ |
|
| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| In vertebrates , a nuclear cap binding complex ( CBC ) formed by two cap binding proteins , CBP 20 and CBP 80 , is involved in several steps of RNA metabolism , including pre mRNA splicing and nuclear export of some RNA polymerase 2 transcribed U snRNAs . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| Interaction between the human nuclear cap binding protein complex and hnRNP F . hnRNP F was identified in a screen for proteins that interact with human CBP 80 and CBP 20 , the components of the nuclear cap binding complex ( CBC ) . ^^^ In vitro interaction studies showed that hnRNP F can bind to both CBP 20 and CBP 80 individually . hnRNP F and CBC bind independently to RNA , but hnRNP F binds preferentially to CBC RNA complexes rather than to naked RNA . ^^^ The hnRNP H protein , which is 78 % identical to hnRNP F and also interacts with both CBP 80 and CBP 20 in vitro , does not discriminate between naked RNA and CBC RNA complexes , showing that this effect is specific . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The CBC represents a 20 and 80 kDa heterodimer ( the subunits independently referred to as CBP 20 and CBP 80 , respectively ) that binds the 7 methylguanosine cap on RNAs transcribed by RNA polymerase 2 . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The cyc 1 512 mutation in Saccharomyces cerevisiae causes a 90 % reduction in the level of iso 1 cytochrome c because of the lack of a proper 3 ' end forming signal , resulting in low levels of eight aberrantly long cyc 1 512 mRNAs which differ in length at their 3 ' termini . cyc 1 512 can be suppressed by deletion of either of the nonessential genes CBC 1 and CBC 2 , which encode the CBP 80 and CBP 20 subunits of the nuclear cap binding complex , respectively , or by deletion of the nonessential gene UPF 1 , which encodes a major component of the mRNA surveillance complex . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| In this report , we define a genetic relationship between NPL 3 and the nonessential genes encoding the subunits of the cap binding complex ( CBP 80 and CBP 20 ) . ^^^ Deletion of CBP 80 or CBP 20 in combination with certain temperature sensitive npl 3 mutant alleles fail to grow and thus display a synthetic lethal relationship . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The nuclear cap binding complex ( CBC ; consisting of CBP 20 and CBP 80 ) mediates the stimulatory functions of the cap in pre mRNA splicing , 3 ' end formation , and U snRNA export . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| Evidence for a pioneer round of mRNA translation : mRNAs subject to nonsense mediated decay in mammalian cells are bound by CBP 80 and CBP 20 . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The cap bound conformation of CBP 20 is stabilized by an intricate network of interactions both to the ligand and within the subunit , as well as new interactions of the CBP 20 N terminal tail with the large subunit CBP 80 . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The latter consists of a CBP 20 subunit , which binds the cap , and a CBP 80 subunit , which ensures high affinity cap binding . ^^^ CBP 80 stabilizes the movement of the N terminal loop of CBP 20 and locks the CBC into a high affinity cap binding state . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The structure of human CBC , which comprises the subunits CBP 20 and CBP 80 , has previously been determined in a mildly trypsinated form which can no longer bind the cap . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| Here we show that the cap binding proteins ( CBPs ) , CBP 20 and CBP 80 , are associated with the lnRNP particles , as well as components of the 3 ( ' ) end processing activity . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| Complex loaded mRNA is thought to undergo a pioneer round of translation when still bound by cap binding proteins CBP 80 and CBP 20 and poly ( A ) binding protein 2 . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| We show that baculovirus produced CBP 80 and CBP 20 independently interact with eIF4GI . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| The structure of CBP 80 , in complex with the nuclear cap binding protein CBP 20 , is used to build a model for the mutual orientation of the domains in eIF4G and their interactions with other factors . ^^^ |
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| Interacting proteins: P52298 and Q09161 |
Pubmed |
SVM Score :0.0 |
| NA |
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