| Interacting proteins: P51825 and Q8IUQ4 |
Pubmed |
SVM Score :0.0 |
| Siah 1a and Af 4 are expressed in Purkinje cells and colocalize in the nucleus of human embryonic kidney 293T and P 19 cells . ^^^ In vitro binding assays and coimmunoprecipitation reveal a significant reduction in affinity between Siah 1a and robotic mutant Af 4 compared with wild type , which correlates with the almost complete abolition of mutant Af 4 degradation by Siah 1a . ^^^ |
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| Interacting proteins: P51825 and Q8IUQ4 |
Pubmed |
SVM Score :0.0 |
| The mutation , which lies in a highly conserved region among the ALF family members , significantly reduces the binding affinity of Af 4 to the E 3 ubiquitin ligase Siah 1a , isolated with Siah 2 as interacting proteins in the brain . ^^^ |
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| Interacting proteins: P51825 and Q8IUQ4 |
Pubmed |
SVM Score :0.0 |
| The underlying oncogenic mechanism involves the two E 3 ubiquitin ligases SIAH 1 and SIAH 2 , the N terminal portion of AF 4 and the protection of the AF4 . ^^^ |
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