| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.98848391 |
| In two hybrid studies , ENL interacted with AF 4 and AF5q31 as well as with a fragment of AF 10 . 0.98848391^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| A novel gene , AF 1p , fused to HRX in t ( 1 ; 11 ) ( p 32 ; q 23 ) , is not related to AF 4 , AF 9 nor ENL . ^^^ The predicted wild type AF 1p product is a 98 kDa acidic protein which does not exhibit similarity to the AF 4 , AF 9 and ENL gene products . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| The MLL gene , on human chromosome 11q23 , undergoes chromosomal translocation in acute leukemias , resulting in gene fusion with AF 4 ( chromosome 4 ) and ENL ( chromosome 19 ) . ^^^ The mRNA translocation junction from 22 t ( 4 ; 11 ) patients , including six adult leukemias , and nine t ( 11 ; 19 ) tumors reveals a remarkable conservation of breakpoints within MLL , AF 4 , or ENL genes , irrespective of tumor phenotype . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| AF 4 , AF 9 , and ENL proteins contain nuclear targeting sequences as well as serine rich and proline rich regions . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| Database comparisons with EAF 2 identified a region with a high content of serine , aspartic acid , and glutamic acid residues that is conserved with EAF 1 and exhibited amino acid similarity with several translocation partner proteins of MLL , including AF 4 and ENL . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| The study shows that the device can detect frequent ( AF 4 , AF 6 , AF 10 , ELL or ENL ) as well as rare partner genes ( AF 17 , MSF ) . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| Results from a pilot experiment using Smart 3D FISH on ENL , MLL , and AF 4 genes in two lymphoblastic cell lines were satisfactory and consistent with data published in the literature . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| Analysis of the nuclear 3D position of the gene MLL , frequently involved in chromosomal translocations and five of its translocation partners ( AF 4 , AF 6 , AF 9 , ENL and ELL ) , and two control loci revealed a characteristic radial distribution pattern in all hematopoietic cells studied . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| Simultaneous localization of MLL , AF 4 and ENL genes in interphase nuclei by 3D FISH : MLL translocation revisited . ^^^ Since the MLL gene involved in 11q23 translocation has more than 40 partners , the study of the relative positions of the MLL gene with both the most frequent partner gene ( AF 4 ) and a less frequent partner gene ( ENL ) , should elucidate the MLL translocation mechanism . ^^^ METHODS : Using triple labeling 3D FISH experiments , we have determined the relative positions of MLL , AF 4 and ENL genes , in two lymphoblastic and two myeloid human cell lines . ^^^ RESULTS : In all cell lines , the ENL gene is significantly closer to the MLL gene than the AF 4 gene ( with P value < 0 . 0001 ) . ^^^ |
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| Interacting proteins: P51825 and Q03111 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the four most frequently found TPGs ( AF 4 , AF 9 , ENL and AF 10 ) encode nuclear proteins that are part of a protein network involved in histone H3K79 methylation . ^^^ |
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