| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| A novel gene , AF 1p , fused to HRX in t ( 1 ; 11 ) ( p 32 ; q 23 ) , is not related to AF 4 , AF 9 nor ENL . ^^^ The predicted wild type AF 1p product is a 98 kDa acidic protein which does not exhibit similarity to the AF 4 , AF 9 and ENL gene products . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| We cloned and sequenced cDNAs derived from transcripts of the AF 4 and AF 9 genes involved in the most common chromosome abnormalities , t ( 4 : 11 ) ( q 21 : q 23 ) and t ( 9 : 11 ) ( p 22 : q 23 ) , respectively . ^^^ AF 4 , AF 9 , and ENL proteins contain nuclear targeting sequences as well as serine rich and proline rich regions . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| To begin studying this , we examined the All 1 , AF 4 , AF 9 , and AF 17 proteins for the presence of potential transcriptional regulatory domains . ^^^ These results suggest that ALL 1 , AF 4 , and probably AF 9 interact with the transcriptional machinery of the cell . . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the four most frequently found TPGs ( AF 4 , AF 9 , ENL and AF 10 ) encode nuclear proteins that are part of a protein network involved in histone H3K79 methylation . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| The 2 most frequent human MLL hematopoietic malignancies involve either AF 4 or AF 9 as fusion partners ; each has distinct biology but the role of the fusion partner is not clear . ^^^ We produced Mll AF 4 knock in ( KI ) mice by homologous recombination in embryonic stem cells and compared them with Mll AF 9 KI mice . ^^^ The early onset of distinct mixed lymphoid / myeloid lineage deregulation in Mll AF 4 mice shows evidence for both `` instructive ' ' and `` noninstructive ' ' roles for AF 4 and AF 9 as partners in MLL fusion genes . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| MLL fusion partners AF 4 and AF 9 interact at subnuclear foci . ^^^ We have identified a protein interaction between the two most common MLL fusion partners AF 4 and AF 9 . ^^^ The AF 4 AF9 interaction is maintained by the MLL AF 4 fusion protein , and expression of the MLL AF 4 fusion can alter the subnuclear localization of AF 9 . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| Analysis of the nuclear 3D position of the gene MLL , frequently involved in chromosomal translocations and five of its translocation partners ( AF 4 , AF 6 , AF 9 , ENL and ELL ) , and two control loci revealed a characteristic radial distribution pattern in all hematopoietic cells studied . ^^^ Analysis of the position of MLL , AF 4 , AF 6 and AF 9 in cell lines carrying chromosomal translocations involving these genes revealed that the position of the normal genes was different from that of the fusion genes , and this was again consistent with the changes in local gene density within a 2 Mbp window . ^^^ |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51825 and P42568 |
Pubmed |
SVM Score :0.0 |
| NA |
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