| Interacting proteins: P51825 and O43255 |
Pubmed |
SVM Score :0.0 |
| The underlying oncogenic mechanism involves the two E 3 ubiquitin ligases SIAH 1 and SIAH 2 , the N terminal portion of AF 4 and the protection of the AF4 . ^^^ |
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| Interacting proteins: P51825 and O43255 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular basis of this mutation , we carried out a yeast two hybrid screen and show that Af 4 binds the E 3 ubiquitin ligases Drosophila seven in absentia ( sina ) homologues ( Siah ) 1a and Siah 2 in the brain . ^^^ |
|
| Interacting proteins: P51825 and O43255 |
Pubmed |
SVM Score :0.0 |
| The mutation , which lies in a highly conserved region among the ALF family members , significantly reduces the binding affinity of Af 4 to the E 3 ubiquitin ligase Siah 1a , isolated with Siah 2 as interacting proteins in the brain . ^^^ |
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