| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| Using the reverse transcription polymerase chain reaction ( RT PCR ) technique and sequencing of the amplified products we detected messenger ribonucleic acid ( mRNA ) for the cystic fibrosis transmembrane conductance regulator ( CFTR ) , the putative Cl channel or Cl channel regulator pICln , and the Cl channels ClC 2 , ClC 3 , ClC 5 and ClC 6 in HT 29 cells . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| The most likely candidates for the genes that encode the cAMP and swelling activated chloride conductances in the heart are an alternatively spliced variant of CFTR and ClC 3 , respectively . ^^^ In this study we have 1 ) measured the density of CFTR and ClC 3 mRNA levels across the left ventricular free wall ( LVFW ) of the rabbit heart using in situ hybridization and 2 ) measured the corresponding current density of cAMP and swelling activated chloride channels in myocytes isolated from subepicardial , midmyocardial , and subendocardial regions of the LVFW . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| RT PCR studies performed with primers for ClC 2 , ClC 3 , ClC 4 , ClC 5 , ClC 6 , and the cystic fibrosis transmembrane conductance regulator showed only the expression of ClC 3 . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| ClC 3B , a novel ClC 3 splicing variant that interacts with EBP 50 and facilitates expression of CFTR regulated ORCC . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| ClC 5 , ClC 3 , ClC 2 , and CFTR mRNA expression was confirmed with RT PCR analysis , and protein expression was detected with Western blot analysis and immunofluorescence microscopy . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| However , ClC 3 and CFTR were not expressed . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| All cardiac Cl channels described to date may be encoded by five different Cl channel genes : the PKA and PKC activated cystic fibrosis tansmembrane conductance regulator ( CFTR ) , the volume regulated ClC 2 and ClC 3 , and the Ca2+ activated CLCA or Bestrophin . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| Taken together , our data suggest that ( 1 ) astrocytic volume dependent EAA release is largely mediated by the VRAC , and ( 2 ) the ClC 2 , ClC 3 , ClC 4 , ClC 5 , VDAC , CaCC , MDR 1 and CFTR gene products do not contribute to EAA permeability . . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| This analysis confirmed translation of the genes of interest and showed that NKCC 1 , Na+ , K+ ATPase and the M 3 cholinergic receptor are expressed on the basolateral membrane of duct cells , whereas KCC 1 , IK ( Ca ) 1 , CFTR , and ClC 3 are apically localized . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| Moreover , the 1 ( ATPCl ) magnitude from wild type animals was comparable to that from mice with null mutations in the Cftr , Clcn 3 and Clcn 2 Cl channel genes . ^^^ |
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| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51790 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|