| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| Also , in the case of APP , another two closely related proteins exist , named beta amyloid precursor like protein ( APLP ) 1 and APLP 2 : by using the interaction trap procedure we observed that both Fe 65 and Fe65L2 interact with APP , APLP 1 or APLP 2 , although with different efficiencies . . ^^^ |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that similar to APP , APLP 1 and APLP 2 are also cleaved by BACE 1 but not by ADAM 9 , another APP protease , and also transactivate nuclear Tip 60 in a complex with Fe 65 . ^^^ |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| We identified a novel human homologue of the rat FE 65 gene , hFE65L , by screening the cytoplasmic domain of beta amyloid precursor protein ( beta PP ) with the `` interaction trap . ' ' The cytoplasmic domains of the beta PP homologues , APLP 1 and APLP 2 ( amyloid precursor like proteins ) , were also tested for interaction with hFE65L . ^^^ |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| Finally , and probably most interestingly , we show that although the A beta PP family members APLP 1 and APLP 2 ( for amyloid beta precursor like protein ) can cause activation in combination with Fe 65 , APLP 1 and APLP 2 show little or no activation in combination with JIP 1 . ^^^ |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| A similar phenotype is observed in triple mutant mice lacking the APP family members APP , APLP 1 and APLP 2 , all of which interact with FE 65 proteins , suggesting that this phenotype may be caused by decreased transmission of an APP dependent signal through the FE 65 proteins . ^^^ |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51693 and O00213 |
Pubmed |
SVM Score :0.0 |
| NA |
|