| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| RESULT : The chemokines of CCL 11 ( eotaxin 1 ) , CCL 24 ( eotaxin 2 ) , CCL 7 ( MCP 3 ) , CCL 13 ( MCP 4 ) , RANTES ( CCL 5 ) and receptors of CCR 2 , CCR 3 , CCR 4 , CCR 5 were differential expressed on four samples , and most of the chemokines and their receptors has tendency regulation on T help 2 ( Th 2 ) lymphocytes and involved in the prodeeds such as inducement of allergic reaction , accumulation of inflammacytes and degranulation of sensitized cells . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| MCP 4 induced a calcium flux in HEK 293 cells transfected with the monocyte selective MCP 1 receptor ( CCR 2B ) and the eosinophil selective eotaxin receptor ( CCR 3 ) , but not in the more widely expressed CCR 1 or CCR 5 . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 is most closely related to CCR2b , another chemokine receptor that responds to monocyte chemoattractant protein ( MCP ) 1 , MCP 2 , MCP 3 , and MCP 4 . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| The chemokines monocyte chemotactic protein ( MCP ) 3 , MCP 4 , and eotaxin acted like RANTES , whereas macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MCP 1 , and stromal cell derived factor 1 were inactive , suggesting a role for the eotaxin receptor , CCR 3 , and ruling out the involvement of CCR 1 , CCR 2 , CCR 5 , and CXCR 4 . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| MCP 4 also bound to CCR 5 with high affinity and was efficiently displaced by other CCR 5 ligands . ^^^ More importantly , we found that MCP 2 could bind and elicit chemotaxis in CD 3 activated and IL 2 maintained T cells , and most of these functions could be specifically inhibited by the anti CCR 5 mAb 2D7 , whereas the responses mediated by MIP 1alpha or MCP 4 were only partially inhibited by 2D7 . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 is a functional receptor for MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed ) , MCP 2 , and MCP 4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| In this study we extended our previous observations and examined various lympho hematopoietic CD 34 ( + ) cells isolated from thymus ( Th ) , cord blood ( CB ) , mobilized peripheral blood ( mPB ) , and BM for the expression of beta chemokines binding to CCR 5 , i . e . , MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , and MCP 4 , and the alpha chemokine SDF 1 ( binding to CXCR 4 ) as these chemokines may compete with the R 5 and X 4 HIV strains , respectively , for entry into cells . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of a number of naturally occurring chemokines ( MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , MCP 4 ) on different processes linked to the chemokine receptor CCR 5 in recombinant CHO cells expressing the receptor at different levels . 2 . ^^^ MIP 1alpha , MIP 1beta , RANTES , MCP 2 and MCP 4 were able to stimulate increases in intracellular calcium ions via activation of CCR 5 whereas MCP 3 was without effect . 6 . ^^^ |
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| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99616 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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