| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Beta chemokine receptor CCR 5 signals via the novel tyrosine kinase RAFTK . ^^^ Macrophage inflammatory protein 1 beta ( MIP 1 beta ) binding to its cognate receptor CCR 5 resulted in activation of the related adhesion focal tyrosine kinase ( RAFTK ) , with subsequent activation of the cytoskeletal protein paxillin and the down stream transcriptional activators , c Jun N terminal kinase ( JNK ) / stress activated protein kinase ( SAPK ) and p 38 mitogen activated protein ( MAP ) kinase . ^^^ Thus , RAFTK appears to provide a functional `` bridge ' ' for the transmission of CCR 5 receptor signaling to the cytoskeleton and nucleus , primary sites of chemotaxis and growth regulation . . ^^^ |
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| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| We and others have shown that CCR 5 activates related adhesion focal tyrosine kinase ( RAFTK ) / Pyk2 / CAK beta . ^^^ Syk was also activated upon MIP1beta stimulation of CCR 5 L1 . 2 transfectants or T cells and associated with RAFTK . ^^^ Overexpression of a dominant negative Src binding mutant of RAFTK ( RAFTK ( m 402 ) ) significantly attenuated Syk activation , whereas overexpression of wild type RAFTK enhanced Syk activity , indicating that RAFTK acts upstream of CCR 5 mediated Syk activation . ^^^ Taken together , these results suggest that MIP1beta stimulation mediated by CCR 5 induces the formation of a signaling complex consisting of RAFTK , Syk , SHP 1 , and Grb2 . . ^^^ |
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| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| This study shows that chemokine receptor engagement by both CCR 5 dependent ( R 5 ) and CXCR 4 dependent ( X 4 ) gp 120 led to rapid phosphorylation of the focal adhesion related tyrosine kinase Pyk 2 in macrophages . ^^^ Pyk 2 phosphorylation was also induced by macrophage inflammatory protein 1beta ( MIP 1beta ) and stromal cell derived factor 1alpha , chemokine ligands for CCR 5 and CXCR 4 . ^^^ |
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| Interacting proteins: P51681 and Q14289 |
Pubmed |
SVM Score :0.0 |
| The authors also showed that both R 5 and X 4 gp120 activate intracellular signals in macrophages through CCR 5 and CXCR 4 , including calcium elevations ; K+ , Cl and nonselective cation channel activation ; phosphorylation of the nonreceptor tyrosine kinase Pyk 2 ; and activation of p 38 and SAPK / JNK mitogen activated protein kinases ( MAPKs ) . ^^^ |
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