| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.57002847 |
| In an effort to further characterize the binding properties of MCP 2 on leukocytes , we observed that MCP 2 , but not MCP 1 , effectively competed with MIP 1beta for binding to monocytes , suggesting that MCP 2 may interact with CCR 5 . 0.57002847^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 is most closely related to CCR2b , another chemokine receptor that responds to monocyte chemoattractant protein ( MCP ) 1 , MCP 2 , MCP 3 , and MCP 4 . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 has an expanded ligand binding repertoire and is the primary receptor used by MCP 2 on activated T cells . ^^^ We found that MCP 2 could bind to CCR 5 transfectants with high affinity and cross compete effectively with RANTES , MIP 1alpha , and MIP 1beta . ^^^ MCP 2 is a true agonist for CCR 5 , eliciting a robust chemotactic response in CCR 5 transfectants similar to that of the three known CCR 5 ligands and exhibiting cross desensitization with RANTES in the Ca2+ flux response . ^^^ Furthermore , MCP 2 inhibited the binding of the M tropic HIV 1 gp 120 envelope glycoprotein to CCR 5 and HIV 1 infection of peripheral blood mononuclear cells . ^^^ More importantly , we found that MCP 2 could bind and elicit chemotaxis in CD 3 activated and IL 2 maintained T cells , and most of these functions could be specifically inhibited by the anti CCR 5 mAb 2D7 , whereas the responses mediated by MIP 1alpha or MCP 4 were only partially inhibited by 2D7 . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 , a receptor for chemokines MIP 1alpha ( LD78alpha ) , MIP 1beta , RANTES , and MCP 2 , is of particular importance in vivo as polymorphisms in this gene affect HIV infection and rate of progression to AIDS . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| We now show that islet allograft rejection is associated with a steady increase in intragraft expression of the chemokines CCL 8 ( monocyte chemoattractant protein 2 ) , CCL 9 ( monocyte chemoattractant protein 5 ) , CCL 5 ( RANTES ) , CXCL 10 ( IFN gamma inducible protein 10 ) , and CXCL 9 ( monokine induced by IFN gamma ) and their corresponding chemokine receptors CCR 2 , CCR 5 , CCR 1 , and CXCR 3 . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| The roles of CCR 5 in excitotoxic injury in CCR 5 deficient mice are compensated by increased CCR 2 and CCR 3 expression , which share the common MCP 2 ligand with CCR5 . . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 is a G protein coupled receptor for RANTES , MIP 1alpha , MIP 1beta , and MCP 2 that functions as the front line coreceptor for human immunodeficiency virus type 1 infection . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 binds multiple CC chemokines : MCP 3 acts as a natural antagonist . ^^^ Among these ligands , MCP 3 had the remarkable property of binding CCR 5 with high affinity without eliciting a functional response , MCP 3 could also inhibit the activation of CCR 5 by MIP 1beta and may therefore be considered as a natural antagonist for CCR 5 . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 is a functional receptor for MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed ) , MCP 2 , and MCP 4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| The chemokines Mig ( CXCR 3 ligand ) , TARC ( CCR 4 ligand ) , and MCP 2 ( CCR 5 ligand ) were detected in intratumoral blood vessels and histiocytes . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| MCP 2 is a potent inhibitor of HIV 1 by virtue of its high affinity binding to the receptor CCR 5 , one of the major coreceptors for HIV 1 . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| In this study we extended our previous observations and examined various lympho hematopoietic CD 34 ( + ) cells isolated from thymus ( Th ) , cord blood ( CB ) , mobilized peripheral blood ( mPB ) , and BM for the expression of beta chemokines binding to CCR 5 , i . e . , MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , and MCP 4 , and the alpha chemokine SDF 1 ( binding to CXCR 4 ) as these chemokines may compete with the R 5 and X 4 HIV strains , respectively , for entry into cells . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of a number of naturally occurring chemokines ( MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , MCP 4 ) on different processes linked to the chemokine receptor CCR 5 in recombinant CHO cells expressing the receptor at different levels . 2 . ^^^ MIP 1alpha , MIP 1beta , RANTES , MCP 2 and MCP 4 were able to stimulate increases in intracellular calcium ions via activation of CCR 5 whereas MCP 3 was without effect . 6 . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| Furthermore , MCP 2 induces a robust , pertussis toxin sensitive calcium flux in primary lymphocytes , and cross desensitization studies indicate that MCP 2 acts via CCR 5 . ^^^ These data confirm that MCP 2 is a ligand for CCR 5 on CD 4 ( + ) lymphocytes and can specifically block R 5 HIV 1 . . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| A number of inflammatory CC chemokines , including MIP 1 alpha , MIP 1 beta , RANTES , MCP 2 , and HCC 1 [ 9 74 ] act as CCR 5 agonists , while MCP 3 is a natural antagonist of the receptor . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| Association of genetic variants of the chemokine receptor CCR 5 and its ligands , RANTES and MCP 2 , with outcome of HCV infection . ^^^ The chemokine receptors CCR 5 , CCR 2 , and CCR 3 and their ligands , RANTES , MCP 1 , MCP 2 , and MIP 1alpha , are involved in the immune responses and the selective recruitment of lymphocytes to the liver in HCV infection . ^^^ In conclusion , our study suggests a possible role of the polymorphisms CCR 5 delta32 , RANTES 403 , and MCP 2 Q46K in the outcome of HCV infection . . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| Both WT B 6 and IRF 1 / profiles showed 13 genes upregulated ( IFN gamma , MCP 2 , MIP 1alpha , MIP 1beta , CCR 5 , MIG , IP 10 and others ) and one gene downregulated ( SDF 2 ) among the 76 genes detectable on the array . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| METHODS : We conducted a nested case control study of African Americans ( 266 HIV 1 seroconverter cases and 532 seronegative controls from the AIDS Link to Intravenous Experience cohort ) , to examine the association between 50 single nucleotide polymorphisms ( SNPs ) in 9 candidate genes ( CCR 5 , CCR 2 , RANTES , MIP1A , MCP 2 , IL 10 , IFNG , MCSF , and IL 2 ) and susceptibility to HIV 1 infection . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| CCR 5 is a G protein coupled receptor activated by the chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha and 1beta , and monocyte chemotactic protein 2 and is the main co receptor for the macrophage tropic human immunodeficiency virus strains . ^^^ |
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| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P80075 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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