| Interacting proteins: P51681 and P42224 |
Pubmed |
SVM Score :0.0 |
| Previously we reported that in T cells , RANTES activation of CCR 5 results in Stat 1 and Stat 3 phosphorylation activation , leading to Stat 1 : 1 and Stat 1 : 3 dimers that exhibit DNA binding activity and the transcriptional induction of a Stat inducible gene , c fos . ^^^ |
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| Interacting proteins: P51681 and P42224 |
Pubmed |
SVM Score :0.0 |
| METHODS : Using TaqMan real time reverse transcription polymerase chain reaction , Western blot analysis , and immunohistochemistry , we defined chemokine and chemokine receptor messenger RNA ( mRNA ) expression , CC chemokine receptor ( CCR ) protein activation during the disease course , CCR associated signaling pathways , and immunopositive CCR 5 , phosphorylated signal transducer and activator of transcription 1 ( p STAT 1 ) , and p STAT 3 cells in rat AIA versus control joints . ^^^ The association of STAT 1 and STAT 3 with CCR 5 on days 18 and 21 correlated with JAK 1 phosphorylation and binding on day 18 . ^^^ Immunohistochemical analysis demonstrated that the expression of CCR 5 , p STAT 1 , and p STAT 3 was detected on synovial lining cells , macrophages , and endothelial cells in arthritic rat ankles on post adjuvant injection day 18 . ^^^ While the majority of the CCR 5 and p STAT 1 immunostaining was on synovial lining cells and macrophages , p STAT 3 was predominantly expressed on endothelial cells . ^^^ CCR 1 , CCR 2 , and CCR 5 tyrosine phosphorylation are associated with the JAK / STAT 1 / STAT 3 pathway at different stages of rat AIA , as well as with macrophage and endothelial cell infiltration . ^^^ |
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| Interacting proteins: P51681 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51681 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
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