Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.64026893
Compared with persons with a wild type genotype for CCR 2 and CCR 5 , subjects with a CCR 2 64I / + or 64I / 64I ( but CCR 5 wild type homozygous genotype ) had significantly delayed disease progression ( relative hazard , 0 . 66 ; 95 % confidence interval , 0 . 44 0 . 99 ) with a 1 . 5 fold slower CD 4 T lymphocyte decline and a 1 . 2 fold lower RNA virus load . 0.64026893^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.64004509
We investigated the immune responses in mice lacking CCR 2 , CCR 5 , or macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , a ligand for CCR 5 , in two situations : following T cell stimulation or after challenge with Leishmania donovani , an intracellular microbe whose control is dependent on a Th 1 immune response . 0.64004509^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.65328151
We confirm that CCR 2 64I is in strong linkage disequilibrium with CCR 5 59653T ( 96 . 92 % of individuals had the same genotype for both CCR 2 64I and CCR 5 59653T polymorphisms ) . 0.65328151^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.7185807
CCR 5 was previously shown to homodimerize and heterodimerize with CCR2b , a closely related receptor . 0.7185807^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.6353209
Because the gene encoding CCR 5 , the major coreceptor for HIV type 1 primary isolates , lies 15 kb 3 ' to CCR 2 , linked mutations in the CCR 5 promoter or other regulatory sequences could explain the association of CCR 2 64I with slowed AIDS pathogenesis . 0.6353209^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In this study , we demonstrate that the CC chemokine receptors CCR 2 and CCR 5 , but not cytokine receptors such as interleukin ( IL ) 2Ralpha , IL 2Rbeta , tumor necrosis factor receptor 1 , or transforming growth factor betaR , are redistributed to a pole in T cells that are migrating in response to chemokines . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Contrasting genetic influence of CCR 2 and CCR 5 variants on HIV 1 infection and disease progression . ^^^ Because CCR 2 64I occurs invariably on a CCR 5 + bearing chromosomal haplotype , the independent effects of CCR 5 Delta32 ( which also delays AIDS onset ) and CCR 2 64I were determined . ^^^ An estimated 38 to 45 percent of AIDS patients whose disease progresses rapidly ( less than 3 years until onset of AIDS symptoms after HIV 1 exposure ) can be attributed to their CCR 2 + / + or CCR 5 + / + genotype , whereas the survival of 28 to 29 percent of long term survivors , who avoid AIDS for 16 years or more , can be explained by a mutant genotype for CCR 2 or CCR5 . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Using a set of overlapping lambda clones , the genomic organisation of the locus was investigated , demonstrating that the ChemR 13 gene is physically linked , and in the same orientation , as the CC CKR 2 gene that encodes a receptor for the monocyte chemoattractant protein 1 ( MCP 1 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The genes encoding CC CKR 1 , CC CKR 2 , CC CKR 3 , and CC CKR 5 ( designated respectively CMKBR 1 , CMKBR 2 , CMKBR 3 , and CMKBR 5 in the Genome Data Bank ) were found to be clustered in the 3p21 . 3 region of chromosome 3 , between the AFM362WB9 and the WI 6983 markers . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Conversely , a chimeric receptor with the N terminus of CCR 2 replacing that of CCR 5 responded to macrophage inflammatory protein 1beta and MCP 1 but did not efficiently support viral entry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Effect of CCR 2 and CCR 5 variants on HIV disease : abstract and commentary . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The recessive protective effect of SDF 1 3 ' A was increasingly pronounced in individuals infected with HIV 1 for longer periods , was twice as strong as the dominant genetic restriction of AIDS conferred by CCR 5 and CCR 2 chemokine receptor variants in these populations , and was complementary with these mutations in delaying the onset of AIDS . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
DC expressed appreciable levels of the CCR 1 , CCR 2 , and CCR 5 receptors for the CC chemokines and the chemokine receptors CXCR 1 , CXCR 2 , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Purified blood DC contained CCR 1 , CCR 2 , CCR 3 , and CCR 5 as well as the CXCR 4 chemokine receptor RNA transcripts and high levels of fusin on the cell surface . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We report the cloning of a novel rat CC chemokine receptor , the rat CCR 10 related receptor ( rCCR10rR ) , with 72 % amino acid identity to the human CC chemokine receptor CCR 10 and 30 % 35 % amino acid identity to the known human CC chemokine receptors CCR 1 , CCR 2 , CCR 3 , CCR 4 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Using a combination of 3 ' rapid amplification of cDNA ends and nested polymerase chain reaction , we detected mRNA for CC chemokine receptor ( CCR ) 1 , CCR 2 , CCR 3 and low level of CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The CC chemokine receptors CCR 5 , CCR 2 , and CCR 3 and the CXC chemokine receptor CXCR 4 have been implicated as CD 4 associated cofactors in the entry of primary and cell line adapted human immunodeficiency virus type 1 ( HIV 1 ) strains . ^^^ These include CCR 1 , CCR 2 , CCR 3 , CCR 4 , CCR 5 , CXCR 2 , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
It shows no ability to compete with ligand for binding to the two interleukin ( IL ) 8 receptors ( CXC chemokine receptors 1 and 2 ) or to CCR 2 , CCR 4 or CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Instead , direct cell cell contact between macrophages and cells engineered to express CD40L ( also known as CD 154 ) resulted in the production of large amounts of macrophage inflammatory protein 1alpha and 1beta , and RANTES ( all ligands for CCR 5 ) , and monocyte chemoattractant protein 1 ( a ligand for CCR 2 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The role of CCR 5 and CCR 2 polymorphisms in HIV 1 transmission and disease progression . ^^^ A chemokine receptor CCR 2 allele delays HIV 1 disease progression and is associated with a CCR 5 promoter mutation . ^^^ We show that CCR 2 V64I is indeed protective against disease progression and go on to show that the CCR 2 V64I allele is in complete linkage disequilibrium with a point mutation in the CCR 5 regulatory region . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To begin to address the role of chemokine receptors in CNS physiology , we identified , by molecular cloning techniques , the rat orthologs of the chemokine receptors , CCR 2 , CCR 3 , CCR 5 , and CXCR 4 . ^^^ CCR 2 and CCR 5 expression was detected in rat spleen , lung , kidney , thymus and macrophages ; CCR 5 mRNA was also detected in rat brain . ^^^ Induction of experimental allergic encephalomyelitis ( EAE ) in the rat was accompanied by increased levels of CCR 2 , CCR 5 , CXCR 4 , and CX3CR1 mRNAs in the lumbar spinal cords of animals displaying clinical signs of the disease . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Allelic variants for the HIV 1 co receptors chemokine receptor 5 ( CCR 5 ) and CCR 2 , as well as the ligand for the co receptor CXCR 4 , stromal derived factor ( SDF 1 ) , have been associated with a delay in disease progression . ^^^ Here we describe the evolutionary relationships between the phenotypically important CCR 5 alleles , define precisely the CCR 5 regulatory sequences that are linked to the CCR 5 delta32 and CCR 2 641 polymorphisms , and identify genotypes associated with altered rates of HIV 1 disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokines monocyte chemotactic protein ( MCP ) 3 , MCP 4 , and eotaxin acted like RANTES , whereas macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MCP 1 , and stromal cell derived factor 1 were inactive , suggesting a role for the eotaxin receptor , CCR 3 , and ruling out the involvement of CCR 1 , CCR 2 , CCR 5 , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Influence of the CCR 2 V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b , CCR 3 , CCR 5 , and CXCR 4 . ^^^ Peripheral blood mononuclear cells ( PBMCs ) from CCR 2 V64I heterozygotes had normal levels of CCR2b and CCR 5 but slightly reduced levels of CXCR 4 . ^^^ The MCP 1 induced calcium mobilization mediated by CCR2b signaling was unaffected by the polymorphism , but MCP 1 signaling mediated by either CCR2b or CCR 2 V64I encoded receptors resulted in heterologous desensitization ( i . e . , limiting the signal response of other receptors ) of both CCR 5 and CXCR 4 . ^^^ The heterologous desensitization of CCR 5 and CXCR 4 signaling by both CCR 2 allele receptor types provides a mechanistic link that might help explain the in vivo effects of CCR 2 gene variants on progression to AIDS as well as the reported antiviral activity of natural CCR 2 ligands . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Exchanges of the amino terminal segment of CCR 5 with the equivalent domains of CCR 1 , CCR 2 , and CXCR 4 did not significantly affect infection with virus pseudotyped with envelope glycoproteins ( Envs ) from HIV 2 and SIV , but substitution with the CXCR 4 sequence abrogated entry mediated by Env from HIV 1 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Immature DC expressed CCR 1 , CCR 2 , CCR 5 and CXCR 1 and responded to their respective ligands , which are chemokines produced at inflammatory sites . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Thus , although MCP 2 can bind to and signal through CCR 1 , CCR2b , and CCR 5 , among which both CCR 2 and CCR 5 are expressed at high levels on activated T cells , it appears to preferably utilize CCR 5 on these cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Distinctive effects of CCR 5 , CCR 2 , and SDF 1 genetic polymorphisms in AIDS progression . ^^^ Using this unique assembly , we performed genetic studies on three recently discovered polymorphisms of CCR 5 , CCR 2 , and SDF 1 , which have been shown to slow the rate of disease progression . ^^^ The increased prevalence of mutant alleles among Slowprogs from the GRIV cohort was significant for CCR 5 ( p < . 0001 ) but not for CCR 2 ( p = . 09 ) or SDF 1 ( p = . 12 ) , emphasizing the predominant role of CCR 5 as the major HIV 1 coreceptor . ^^^ However , the prevalence of the CCR 2 mutant allele ( 64I ) was significantly increased among Slowprogs homozygous for wild type CCR 5 compared with Fastprogs ( p = . 04 ) . ^^^ The effects of the CCR 2 and SDF 1 mutations are overshadowed by the protective effects of the CCR 5 deletion . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The expression of CCR 2 , CCR 5 , and CXCR 1 4 was not augmented . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Combined genotypes of CCR 5 , CCR 2 , SDF 1 , and HLA genes can predict the long term nonprogressor status in human immunodeficiency virus 1 infected individuals . ^^^ In this work , we tried to understand whether combined genotypes of CCR 5 triangle up 32 , CCR 2 64I , SDF 1 3 ' A and HLA alleles can predict the LT NP status . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Here we report that superantigen stimulation of human peripheral blood monocytes results in a rapid , dose dependent , and specific down regulation of chemokine ( macrophage inflammatory protein 1alpha ( MIP 1alpha ) , monocyte chemotactic protein 1 and MIP 1beta ) binding sites ( e . g . , CCR 1 , CCR 2 , and CCR 5 ) , which correlates with a concomitant hyporesponsiveness of human monocytes to these CC chemokine ligands . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Therefore , 746 HIV 1 infected persons were examined for associations of previously described stromal cell derived factor 1 ( SDF 1 ) chemokine and CCR 5 and CCR 2 chemokine receptor gene variants with the risk of B cell non Hodgkin ' s lymphoma ( NHL ) . ^^^ The acquired immunodeficiency syndrome ( AIDS ) protective chemokine receptor variant CCR 5 triangle up 32 was highly protective against NHL , whereas the AIDS protective variant CCR 2 64I had no significant effect . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Chemokines induce the formation of two specialized regions in the NK cell : the advancing front or leading edge , where chemokine receptors CCR 2 and CCR 5 cluster , which might guide the cells toward the chemotactic source , and the uropod , where adhesion molecules ICAM 1 and 3 are redistributed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Tat was able to displace binding of beta chemokines from the beta chemokine receptors CCR 2 and CCR 3 , but not CCR 1 , CCR 4 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
MDC binds to CC chemokine receptor 4 ( CCR 4 ) but not to CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 6 , or CCR 7 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To address the issues of redundancy and specificity of chemokines and their receptors in lymphocyte biology , we investigated the expression of CC chemokine receptors CCR 1 , CCR 2 , CCR 3 , CCR 5 , CXCR 3 , and CXCR 4 and responses to their ligands on memory and naive , CD 4 and CD 8 human T cells , both freshly isolated and after short term activation in vitro . ^^^ In contrast , the effects of short term activation on expression of other chemokine receptors was modest , and expression of CCR 2 , CCR 3 , and CCR 5 on CD 4 cells was restricted to memory subsets . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Among three , two are genes encoding receptors for chemokines , namely CCR 5 and CCR 2 , which act as entry coreceptors for HIV 1 virus . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Frequencies of SDF 1 chemokine , CCR 5 , and CCR 2 chemokine receptor gene alleles conferring resistance to human immunodeficiency virus type 1 and AIDS in Kuwaitis . ^^^ The CCR 2 641 , SDF 1 3 ' A , and CCR 5 m303 mutations were detected by polymerase chain reaction restriction fragment length polymorphism ( PCR RFLP ) tests using restriction endonucleases Bsa BI , Msp 1 , and Hinc 2 , respectively . ^^^ The frequency of the mutant alleles were : for CCR 2 641 , 0 . 1195 ( 95 % CI 0 . 0801 0 . 1694 ) ; for SDF 1 3 ' A , 0 . 2593 ( 95 % CI 0 . 2024 0 . 3231 ) , and for CCR 5 m303 , less than 0 . 0025 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Levels of surface expression of CCR 5 , CXCR 4 , and CD 4 were low compared to those of blood monocytes , but CCR 3 was not detectable . mRNA for CCR 5 , CXCR 4 , CCR 2 , and CCR 3 were all detectable , but to varying degrees and with variability among donors . ^^^ Expression of CCR 5 , CXCR 4 , and CCR 2 mRNA was downregulated following stimulation with lipopolysaccharide ( LPS ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 6 and CXCR 3 are down regulated within 6 h , while CCR 7 , CCR 4 , CCR 8 and CXCR 5 are up regulated for 2 to 3 days . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Chemokine receptor CCR 2 and CCR 5 polymorphisms in children with insulin dependent diabetes mellitus . ^^^ CC chemokine receptors CCR 2 and CCR 5 bind chemokines that are involved in the trafficking of leukocytes in both basal and inflammatory states . ^^^ A common 32 bp deletion mutation in the CCR 5 gene ( CCR5delta32 ) and a G to A nucleotide substitution in the CCR 2 at position 190 ( CCR 2 64I ) have recently been described . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Culturing of monocytes for 7 days resulted in a progressive decrease of the mRNA that encodes for CCR 2 and CCR 3 , whereas the expression of mRNA for other chemokine receptors ( CCR 1 , CCR 4 , CCR 5 , and CXCR 4 ) was not substantially affected . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RT PCR analysis revealed constitutive expression of CCR 1 , CCR 2 and CCR 5 mRNA . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The effects of the CCR 5 and CCR 2 mutations were genetically independent and similar in the magnitude of their protective effect on progression to a CD 4 count < 200 cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Other chemokine receptor messages ( CCR 1 , CCR 4 , CCR 5 , CCR 2 , and CXCR 2 ) were found in E12 . 5 tissues concordant temporally and spatially with definitive ( adult like ) hematopoiesis . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
TNF alpha down regulated CC chemokine receptor ( CCR ) 1 , CCR 2 , and CCR 5 and up regulated CCR 7 mRNA levels , in agreement with functional data . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Similarly , the CCR2b ligands MCP 1 and MCP 3 inhibit productive infection of PBMCs by both CCR 5 and CXCR 4 dependent strains of HIV 1 , suggesting that expression of the MCP 1 chemokine may affect HIV infection via signaling through the CCR 2 receptor and subsequent desensitization of the CCR 5 and / or CXCR 4 signaling pathway . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Under these conditions , no mRNA for CCR 2 , CCR 3 , CCR 4 , CCR 5 , or CCR 8 was detected . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Monocytes have detectable mRNA for CCR 1 , CCR 2 , CCR 3 , CCR 4 , and CCR 5 , and they respond to the ligands for these receptors in chemotaxis but not always in calcium mobilization . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 ( HIV 1 ) CC chemokine coreceptor 5 ( CCR 5 ) and in the related CCR 2 protein ( the CCR 2 64I mutation ) . ^^^ We genotyped 1 , 442 infants ( 1 , 235 uninfected and 207 HIV 1 infected ) for five CCR 5 and CCR 2 polymorphisms : CCR 5 59353 T / C , CCR 5 59356 C / T CCR 5 59402 A / G , CCR 5 Delta32 , and CCR 2 64I . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
During the development of nephrotoxic nephritis ( NTN ) in the mouse , we find that a variety of chemokines and chemokine receptors are induced : CCR 1 ( RANTES , MIP 1alpha ) , CCR 2 ( MCP 1 ) , CCR 5 ( RANTES , MIP 1alpha , MIP 1beta ) , CXCR 2 ( MIP 2 ) , and CXCR 3 ( IP 10 ) . ^^^ Their timing of expression indicated that CXCR 2 and CCR 1 are probably important in the neutrophil dependent heterologous phase of the disease , whereas CCR 1 , CCR 2 , CCR 5 , and CXCR 3 accompany the subsequent mononuclear cell infiltration characteristic of autologous disease . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To assess the effect of mutations at the CCR 2 and CCR 5 loci on heterosexual human immunodeficiency virus ( HIV ) transmission , 144 persons heterosexually exposed to HIV ( infected and uninfected [ EU ] ) and 57 HIV positive index partners were genotyped . ^^^ Thus heterozygosity for 64I at CCR 2 acts as a risk factor for HIV infection of women after heterosexual contact but heterozygosity for Delta 32 at CCR 5 has no detectable effect . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Five chemokine receptor genes ( CCR 1 , CCR 3 , CCR 2 , CCR 5 , and CCR 6 ) were localized in CER 1 in a 225 kb cluster . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : To study the role of the chemokine receptors CCR 5 and CCR 2 in patients with arthritis . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The defect was selective for CCR 2 in that CCR 1 and CCR 5 were expressed normally in TAM . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In normal CNS mRNAs for CCR 1 , CCR 3 , and CCR 5 were observed , and these were elevated in EAE animals . mRNAs for CCR 2 were also detected in the CNS of affected mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Allelic distribution of CCR 5 and CCR 2 genes in an Italian population sample . ^^^ Genetic polymorphisms of CCR 5 and CCR 2 human chemokine receptors have been associated with resistance during HIV 1 infection and disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
A main cluster of six genes ( CCR 1 , CCR 3 , CCRL 2 , CCR 5 , CCR 2 and CCXCR 1 ) , covered by four BACs , was mapped to the 3p21 . 3 region of the human genome . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 64I , CCR 5 59029A / G and CCR 5 59353C / T genotypes were determined by PCR followed by restriction fragment length polymorphism analysis . ^^^ CCR 5 59029A and CCR 5 59353C homozygotes were found to be significantly under represented in the long term non progressor group as compared with the other HIV 1 positive groups , with the effect being more marked in the absence of the CCR 5 delta32 and CCR 2 64I mutations . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In human monocytes , the antioxidant pyrrolidine dithiocarbamate ( PDTC ) rapidly inhibited CCR 2 ( 95 100 % of inhibition ) and CCR 5 ( 77 100 % of inhibition ) mRNA expression by strongly decreasing transcript stability . ^^^ CCR 2 half life was decreased from 1 . 5 h to 45 min ; CCR 5 half life was decreased from 2 h to 70 min . ^^^ Accordingly , H ( 2 ) O ( 2 ) and the glutathione depleting drug buthionine sulfoximine increased to different extents CCR 2 , CCR 5 , and CXCR 4 mRNA expression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Host factors that may contribute to disease progression include HLA and allelic variants of the chemokine receptors CCR 5 and CCR 2 , which have been shown to influence both long term survival and rapid progression . ^^^ In this study , we have examined the contribution of HLA and polymorphisms in CCR 5 and CCR 2 to long term survival in transfusion acquired HIV 1 infected individuals . ^^^ However , there was no apparent contribution by allelic variants of CCR 5 and CCR 2 to long term survival and the combined influence of HLA and CCR polymorphisms could not be evaluated in this relatively small ( n = 20 ) group of study subjects . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In paralyzed control mice , the SC had increased cellular infiltration and strong expression of the chemokines RANTES , IFN inducible 10 kDa protein , and monocyte chemoattractant protein 1 and the cognate chemokine receptors CCR 1 , CCR 2 , and CCR 5 , with lower expression of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and MIP 2 ; whereas brain had less infiltration and a lower expression of a different pattern of chemokines and receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
These results support the view that CXCR 3 , CCR 5 and CCR 2 may play an important role in lymphocyte localization within the intestinal mucosa . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
HIV 1 co receptor CCR 5 and CCR 2 mutations among Greeks . ^^^ The frequency of CCR 5 and CCR 2 alleles in human immunodeficiency virus ( HIV ) positive and HIV negative populations of Northern Greece was investigated . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Multicolor flow cytometric analysis of whole peripheral blood revealed that , as opposed to CD14++ monocytes , the CD14+CD16+ subset lacked surface expression of monocyte chemotactic protein 1 ( MCP 1 ) receptor CCR 2 , however , it showed significantly higher surface expression of the macrophage inflammatory protein 1alpha ( MIP 1alpha ) / RANTES receptor CCR 5 . ^^^ In comparison to CD14++ monocytes , CD14+CD16+ cells expressed lower CCR 2 but higher CCR 5 transcript levels , whereas CCR 1 levels were equivalent . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Homing in this in vivo assay was independent of the CC chemokine receptors , CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genotyping for chemokine receptor gene polymorphisms ( CCR 5 delta32 , CCR 5 59029A / G , CCR 2 641 ) was performed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptors CCR 2 and CCR 5 and their respective ligands regulate leukocyte chemotaxis and activation . ^^^ To determine the role of these chemokine receptors in the regulation of the intestinal immune response , we induced colitis in CCR 2 and CCR 5 deficient mice by continuous oral administration of dextran sodium sulfate ( DSS ) . ^^^ Both CCR 2 and CCR 5 deficient mice were susceptible to DSS induced intestinal inflammation . ^^^ The lack of CCR 2 or CCR 5 did not reduce the DSS induced migration of macrophages into the colonic lamina propria . ^^^ However , both CCR 5 deficient mice and , to a lesser degree , CCR 2 deficient mice were protected from DSS induced intestinal adhesions and mucosal ulcerations . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Furthermore , the expression of CCR 6 mRNA is 100 to 1000 fold higher on sorted CLA+ memory T cells than other chemokine receptors , including CXCR 1 , CXCR 2 , CXCR 3 , CCR 2 , CCR 3 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Contrasting effects of CCR 5 and CCR 2 deficiency in the pulmonary inflammatory response to influenza A virus . ^^^ CC chemokine receptors CCR 5 and CCR 2 are both expressed on activated macrophages and T cells . ^^^ We examined how the absence of these chemokine receptors would affect pulmonary chemokine expression and induced leukocyte recruitment by infecting CCR 5 deficient mice and CCR 2 deficient mice with a mouse adapted strain of influenza A virus . ^^^ CCR 5 ( / ) mice displayed increased mortality rates associated with acute , severe pneumonitis , whereas CCR 2 ( / ) mice were protected from the early pathological manifestations of influenza because of defective macrophage recruitment . ^^^ Infected CCR 5 ( / ) mice and CCR 2 ( / ) mice both exhibited increased expression of the gene for MCP 1 , the major ligand for CCR 2 ( / ) and a key regulator of induced macrophage migration . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Our data reveals an immunosuppressive potential of chemokines engaging the CXCR 3 and CCR 7 receptors , but not the CXCR 4 , CCR 2 , CCR 4 , or CCR 5 receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In isolated glomeruli we found by RT PCR an increase of CCR 1 , CCR 2 and CCR 5 of between 3 and 12 fold . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Prevalence of CCR 5 and CCR 2 HIV coreceptor gene polymorphisms in Belgium . ^^^ Polymorphisms of the chemokine receptor genes CCR 5 and CCR 2 are associated with resistance to HIV 1 infection or delayed progression to AIDS . ^^^ Few data are available on their combined prevalence in healthy subjects ; we therefore examined the occurrence of CCR 5 Delta32 and CCR 2 64I polymorphisms in a sample of 310 healthy Belgians . ^^^ Allele frequencies were 0 . 119 and 0 . 074 for CCR 5 Delta32 and CCR 2 64I , respectively . ^^^ Genotype distributions for both polymorphisms were found to be in accordance with Hardy Weinberg equilibrium , but a significant ( p = 0 . 002 ) linkage disequilibrium between CCR 5 Delta32 and CCR 2 64I was observed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The inhibitors are TAK 779 , which is specific for CCR 5 and CCR 2 , aminooxypentane RANTES , which blocks entry via CCR 5 and CCR 3 , and AMD 3100 , which targets CXCR 4 . ^^^ The replication in human PBMC of SIV ( rcm ) ( from a red capped mangabey ) , a virus which uses CCR 2 but not CCR 5 for entry , was blocked by TAK 779 , suggesting that CCR 2 is indeed the paramount coreceptor for this virus in primary cells . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We found that deficiency of CCR 2 but not CCR 5 or MIP 1alpha led to distinct defects in DC biology . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of the beta chemokine receptors CCR 2 , CCR 3 and CCR 5 in multiple sclerosis central nervous system tissue . ^^^ We have examined the expression of the beta chemokine receptors CCR 2 , CCR 3 and CCR 5 in post mortem MS CNS tissue using single and double labelling immunocytochemistry techniques . ^^^ Low levels of CCR 2 , CCR 3 and CCR 5 were expressed by microglial cells throughout control CNS tissue . ^^^ In chronic active MS lesions CCR 2 , CCR 3 and CCR 5 were associated with foamy macrophages and activated microglia . ^^^ CCR 2 and CCR 5 were also present on large numbers of infiltrating lymphocytes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To investigate the genetic susceptibility of different ethnic populations to human immunodeficiency virus 1 ( HIV 1 ) infection by comparing the characteristics of gene mutation frequency and polymorphism of CCR 5 , CCR 2 and SDF 1 alleles among different nationalities in the world . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In contrast to other chemokines , such as monocyte chemotactic protein 1 ( CC chemokine receptor 2 [ CCR 2 ] ) , macrophage inflammatory protein 1beta ( CCR 5 ) , liver and activation regulated chemokine ( LARC [ CCR 6 ] ) , Epstein Barr virus induced molecule 1 ligand chemokine ( ELC [ CCR 7 ] ) , and IP 10 ( CXCR 3 ) , SDF 1 stimulates the prolonged activation of protein kinase B and extracellular signal regulated kinase ( ERK ) 2 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Cerebral CCR gene expression was dominated by CCR 1 , CCR 2 and CCR 5 . ^^^ Virus activated CD8+ T cells were found to express CCR 2 and CCR 5 , whereas activated monocytes / macrophages expressed CCR 1 in addition to CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Several mutant genes in HIV co receptors ( e . g . , CCR 5 , CCR 2 and CXCR 4 ) have been correlated with susceptibility to HIV or / and rate of progression to AIDS . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : A wide variety of chemokine receptors ( CCR 1 , CCR 2 , CCR 3 , CCR 5 , CXCR 1 , and CXCR 2 ) was detected on human chondrocytes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Furthermore , this review explains and discusses allelic variations for some of the components of the chemokine receptors family , particularly the genes which codify for CCR 5 and CCR 2 and other genetic factors such as the SDF 1 3 ' . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In addition , studies in CC chemokine receptor knockout mice have demonstrated that CCR 2 and CCR 5 are required not only for leukocyte recruitment but also for other aspects of immune response development and innate imunity to C . neoformans . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Influence of nucleotide polymorphisms in the CCR 2 gene and the CCR 5 promoter on the expression of cell surface CCR 5 and CXCR 4 . ^^^ Polymorphisms in the CCR 2 gene ( CCR 2 64I ) and the CCR 5 promoter ( pCCR 5 59029G ) have been correlated with slower HIV 1 disease progression . ^^^ For this , a cohort of Chinese volunteers in Taiwan was subjected to the determination of CCR 2 and pCCR 5 genotypes followed by analysis of the surface CCR 5 and CXCR 4 expression on five cell types derived from peripheral blood mononuclear cells by flow cytometry . ^^^ The most important finding was that an increased number of CD 4 ( + ) cells expressing CCR 5 correlated with pCCR 5 59029A homozygosity without the interference of both the CCR 2 64 and the CCR 5 delta 32 ( deleted 32 bp ) mutations ( P : = 0 . 0453 ) , which is consistent with the previous data on the association of the genotype to AIDS progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genes for the chemokine receptors CCR 5 and CCR 2 are characterized by polymorphisms resulting in a nonfunctional receptor expression . ^^^ Ligands for CCR 2 and CCR 5 ( chemokines monocyte chemotactic protein 1 [ MCP 1 ] and RANTES ) are implicated in the pathogenesis of sarcoidosis . ^^^ We have , therefore , analyzed polymorphisms of CCR 5 ( 32 bp deletion in CCR 5 gene [ Delta 32 ] ) and of CCR 2 ( replacement of valine by isoleucine in CCR 2 gene [ 64I ] ) in 66 Czech patients with sarcoidosis in comparison with a representative sample of Czech normal population . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 ( / ) mice immunized with MOGp 35 55 failed to develop mononuclear cell inflammatory infiltrates in the CNS and failed to increase CNS levels of the chemokines RANTES ( regulated on activation , normal T cell expressed and secreted ) , MCP 1 , and interferon ( IFN ) inducible protein 10 ( IP 10 ) as well the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We extend these findings in this report to reveal that such sites exemplify characteristics of the recognized major receptors for MCP 1 and MIP 1alpha : CCR 2 , and CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
These genotypes were used to determine linkage and haplotypes for CCR 2 and CCR 5 alleles . ^^^ Survival analysis was used to assess the effect of CCR 2 , CCR 5 , and CCR 5 promoter haplotypes on progression to AIDS in seroincident African Americans . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Inflammatory signals , which cause dendritic cell ( DC ) maturation and migration to lymphoid organs , induce a chemokine receptor switch , with down regulation of inflammatory receptors ( such as CCR 1 , CCR 2 , CCR 5 ) and induction of CCR 7 . ^^^ LPS + IL 10 treated DCs showed low expression of CCR 7 and high expression of CCR 1 , CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Immunohistochemical analysis of CCR 2 , CCR 3 , CCR 5 , and CXCR 4 in the human brain : potential mechanisms for HIV dementia . ^^^ These include CCR 5 , CCR 3 , CCR 2 , CCR 1 , CCR 8 , CX3CR1 , STRL 33 ( BONZO ) , GPR 15 ( BOB ) , GPR 1 , US 28 , and APJ . ^^^ Neuronal expression of CCR 2 , CCR 3 , and CCR 5 has been less consistent . ^^^ We performed a semiquantitative immunohistochemical analysis of the expression of CCR 2 , CCR 3 , CCR 5 , and CXCR 4 in 23 regions of the brain and in two sections of the spinal cord . ^^^ Hippocampal neurons were positive for CCR 2 , CCR 3 , and CXCR 4 , but not for CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically ablated for CCR 2 , CCR 5 and the CCR 5 receptor ligand , MIP 1 alpha . ^^^ Peripheral NK cells express the CC chemokine receptor CCR 2 , for MCP 1 and CCR 5 , for MIP 1 alpha and RANTES . ^^^ To assess the roles of CCR 2 , CCR 5 and MIP 1 alpha in NK cell migration to the uterus and localization within implantation sites , histological analysis was conducted on implantation sites from mice genetically ablated for CCR 2 , CCR 5 , MIP 1 alpha or CCR 2 and MIP 1 alpha . ^^^ Thus , migration , distribution and activation of NK cells within the pregnant uterus are independent of CCR 2 , CCR 5 and MIP 1 alpha . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The present study investigates the course of Wallerian degeneration after transection of the sciatic nerve in mice deficient in two chemokine receptors : CCR 2 , the main receptor for MCP 1 , and CCR 5 , a marker for Th 1 T lymphocytes but also present on macrophages . ^^^ Macrophage invasion was significantly impaired in CCR 2 knockout mice when compared with wildtype controls and CCR 5 deficient mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Moreover , expression of CCR 2 and CCR 5 , the receptors for these chemokines , was also detected in the tumor infiltrating cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Distribution of three HIV 1 resistance conferring polymorphisms ( SDF 1 3 ' A , CCR 2 641 , and CCR 5 delta32 ) in global populations . ^^^ Chemokine receptors ( CCR 5 , CXCR 4 and CCR 2 ) have been shown to be important co receptors for HIV infection . ^^^ Mutations at CCR 5 ( CCR 5 delta2 ) , CCR 2 ( CCR 2 641 ) , and stromal derived factor SDF 1 ( SDF 1 3 ' A ) , a primary ligand for CXCR 4 , are known to have protective effects against HIV 1 infection and the onset of AIDS symptoms . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Blocking Gi protein coupled receptor signaling by pertussis toxin as well as deficiencies in G alpha 12 , chemokine receptor 2 ( CCR 2 ) , CCR 5 , chemokine ligand 2 ( CCL 2 , also known as monocyte chemoattractant protein 1 , or MCP 1 ) , CCL 3 ( macrophage inflammatory protein 1 alpha , or MIP 1 alpha ) and CCL 5 ( RANTES ) have all been found to have effects on the magnitude and cytokine polarity of the T cell response . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : A mutation detection assay for the entire coding region of CCR 5 was designed ; this included amplification of part of the coding region of CCR 2 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Upregulation of mRNAs for the chemokines , interferon inducible protein 10 ( IP 10 ) ; regulated on activation normal T cell expressed and secreted ; macrophage inflammatory protein 1alpha ( MIP 1alpha ) ; MIP 1beta ; and lymphotactin , as well as the chemokine receptors , CCR 2 and CCR 5 , were documented during allograft rejection . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The most active chemokines for resting Th ( IL 10 ) , in terms of calcium mobilization and in vitro migration , were in order of potency : CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , CCL 17 ( thymus and activation regulated chemokine , CCR 4 ligand ) , CCL 1 ( 1 309 , CCR 8 ligand ) , CXCL 12 ( stromal derived factor 1 , CXCR 4 ) , and CCL 11 ( eotaxin , CCR 3 ligand ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In contrast , no significant induction of CCR 2 , CCR 3 , CCR 4 , or CCR 5 mRNA was observed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
For examples , Langerhans cells migrate selectively to MIP 3 alpha ( via CCR 6 ) , blood CD11c+ DC to MCP chemokines ( via CCR 2 ) , monocytes derived DC respond to MIP 1 alpha / beta ( via CCR 1 and CCR 5 ) , while blood CD11c DC precursors do not respond to any of these chemokines . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Designated as `` PCR+ ' ' tumors , they were examined by reverse transcription ( RT ) PCR , together with four of six previously studied tumors derived from MCH910 . 7 , which carried a del ( 3 ) ( pter p21 . 1 ) , for the expression of 14 human genes : 5 genes within CER 1 ( LIMD 1 , CCR 1 , CCR 2 , CCR 3 , CCR 5 ) , 5 genes located within regions that were homozygously deleted in a variety of carcinomas ( ITGA4L , LUCA 1 , PTPRG , FHIT , DUTT 1 ) , and 4 other genes in chr3p ( VHL , MLH 1 , TGM 4 , UBE1L ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression and characterization of the chemokine receptors CCR 2 and CCR 5 in mice . ^^^ The chemokine receptors CCR 2 and CCR 5 play important roles in the recruitment of monocytes / macrophages and T cells . ^^^ To better understand the role of both receptors in murine models of inflammatory diseases and to recognize potential problems when correlating these data to humans , we have generated mAbs against murine CCR 2 and CCR 5 . ^^^ Using a model of immune complex nephritis , we examined the effects of inflammation on chemokine receptor expression and found a 10 fold enrichment of CCR 5 ( + ) and CCR 2 ( + ) T cells in the inflamed kidneys . ^^^ The activity of various chemokines and the antagonistic properties of the mAbs were measured by ligand induced internalization of CCR 2 and CCR 5 on primary leukocytes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Eotaxin is a natural antagonist for CCR 2 and an agonist for CCR 5 . ^^^ This study shows that eotaxin also interacts with CCR 2 and CCR 5 and can , thus , affect the responses of monocytes , which express both receptors . ^^^ In human monocytes pretreatment with eotaxin decreased responsiveness to MCP 1 , a selective ligand for CCR 2 , as well as to RANTES and MIP 1 beta , which bind to CCR 5 . ^^^ Similar effects were obtained with transfected cells expressing CCR 2 or CCR 5 , but here a difference became apparent : Eotaxin triggered CCR 5 at a concentration of 100 nM but not CCR 2 even at 1 microM , suggesting an antagonistic effect on this receptor . ^^^ In agreement with this observation , eotaxin induced internalization of CCR 5 but not of CCR 2 in human monocytes and transfected cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We observed a time dependent change of expression and functional responsiveness of CCR 1 , CCR 2 , and CCR 5 within 48 h . ^^^ Whereas freshly harvested monocytes were strongly attracted by monocyte chemotactic protein 1 ( MCP 1 ) , a specific ligand for CCR 2 , only a weak response was observed to macrophage inflammatory protein 1alpha ( MIP 1alpha ) , which binds to CCR 1 and CCR 5 . ^^^ During the time course of monocyte to macrophage differentiation , mRNA levels and surface expression of CCR 2 decreased , whereas that of CCR 1 and CCR 5 increased . ^^^ The time dependent switch from CCR 2 on monocytes to CCR 1 and CCR 5 on mature macrophages reflects a functional change belonging to the differentiation process of monocytes to macrophages and may form the basis for a differential responsiveness of monocytes and macrophages to distinct sets of chemokines . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The mRNA of CCR 1 , CCR 2 , and CCR 5 but not CCR 3 or CCR 4 were upregulated at week 1 and decreased at weeks 2 and 4 . ^^^ In summary , in a model of transient IC GN , MCP 1 and RANTES and their receptors CCR 1 , CCR 2 , and CCR 5 are expressed early and are already downregulated at the peak of proteinuria and leukocyte infiltration . ^^^ Therefore , it is concluded that glomerular MCP 1 and RANTES production directs circulating leukocytes that express CCR 1 , CCR 2 , and CCR 5 into the glomerulus . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The CCR 5 Delta32 , CCR 2 64I , SDF 1 3 ' A , and CCR 5 promoter 59029 polymorphisms have been suggested to influence HIV 1 disease progression . ^^^ Furthermore , the CCR 5 Delta32 and the CCR 2 64I polymorphisms have been associated with various other diseases . ^^^ The multiplex assay offers a quick tool for the determination of the CCR 5 Delta32 , CCR 2 64I , SDF 1 3 ' A , and CCR 5 promoter 59029 A / G polymorphisms . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Increased mRNA expression of CCR 1 , CCR 2 , CCR 3 , and CCR 5 was detected in SCF and IgE stimulated BMMCs . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We show that , in the chemokine response , heterodimerization is also permitted between given receptor pairs , specifically between CCR 2 and CCR 5 . ^^^ This has functional consequences , as the CCR 2 and CCR 5 ligands monocyte chemotactic protein 1 ( MCP 1 ) and RANTES ( regulated upon activation , normal T cell expressed and secreted ) cooperate to trigger calcium responses at concentrations 10 to 100 fold lower than the threshold for either chemokine alone . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RA PB monocytes expressed CCR 1 ( 56 % ) and CCR 2 ( 76 % ) , with significantly more expressing CCR 3 ( 18 % ) , CCR 4 ( 38 % ) , and CCR 5 ( 17 % ) compared with normal PB monocytes . ^^^ Significantly fewer SF monocytes from RA patients expressed CCR 1 ( 17 % ) , CCR 2 ( 24 % ) , and CCR 4 ( 6 % ) while significantly more expressed CCR 3 ( 35 % ) and CCR 5 ( 47 % ) compared with RA and normal PB monocytes ; CCR 6 and CXCR 3 were rarely detected . ^^^ CCR 1 , CCR 2 , and CCR 5 immunoreactive cells were found in RA synovial tissue and colocalized with CD68+ macrophages . ^^^ CONCLUSION : Monocytes mainly express CCR 1 and CCR 2 in normal and RA PB , CCR 3 and CCR 5 in RA PB and RA SF , and CCR 4 in RA PB . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 and CCR 5 receptor binding properties of herpesvirus 8 vMIP 2 based on sequence analysis and its solution structure . ^^^ The analysis of the sequence and three dimensional structure of vMIP 2 indicates the presence of epitopes involved in binding two receptors CCR 2 and CCR 5 . ^^^ We propose that vMIP 2 was initially specific for CCR 5 and acquired receptor binding properties to CCR 2 and other chemokine receptors . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The mRNA expression of CC chemokines ( predominantly monocyte chemoattractant protein 1 [ MCP 1 ] / CCL2 , RANTES / CCL5 ) and their receptors CCR 1 , CCR 2 , CCR 5 increased progressively from days 2 to 10 . ^^^ By in situ hybridization , a prominent interstitial mRNA expression of MCP 1 and RANTES and their receptors CCR 2 and CCR 5 localized to interstitial mononuclear cell infiltrates . ^^^ Fluorescence activated cell sorter analysis of single cell suspensions from obstructed kidneys revealed a prominent expression of CCR 2 and CCR 5 by infiltrating macrophages , whereas most lymphocytes expressed CCR 5 only . ^^^ These data demonstrate an increased expression of MCP 1 / CCL2 and RANTES / CCL5 at sites of tubulointerstitial damage and progressive fibrosis during unilateral ureteral obstruction that correlates with simultaneous accumulation of interstitial macrophages and T lymphocytes expressing the respective surface receptors CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Polymorphism of CC chemokine receptors CCR 2 and CCR 5 in Crohn ' s disease . ^^^ We tested the hypothesis that CC chemokine receptors CCR 2 and CCR 5 might be important in the regulation of the intestinal immune response in this disease , and we speculated that carriers of a defective 32 base pair deletion mutant of CCR 5 , CCR5Delta32 , which results in a non functional receptor , might be protected from CD . ^^^ No significant differences in the CD phenotype classification for the different CCR 5 and CCR 2 alleles were observed , except for a trend to disease sparing of the upper gastrointestinal tract ( carrier frequency 0 versus 19 . 6 % , Delta=1 9 . 6 % , P=0 . 079 ) as well as a more stricturing disease behaviour ( 23 . 5 versus 16 . 2 % , Delta=7 . 3 % , P=0 . 136 ) in carriers of the mutant CCR5Delta32 allele . ^^^ These results indicate that the different CCR 5 but not CCR 2 alleles may influence disease behaviour and thereby contribute to the observed heterogeneity of CD . ^^^ CCR 2 and CCR 5 polymorphisms are unlikely to be important determinants of overall disease susceptibility . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Mutant alleles of the chemokine receptors CCR 5 and CCR 2 affect the susceptibility to HIV infection as well as the rate of disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 and CCR 5 gene polymorphisms in children with recurrent respiratory infections . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
At week 12 , the renal expression of chemokine receptor 1 ( CCR 1 ) , CCR 2 , and CCR 5 was increased , mice became proteinuric , and renal damage was histologically evident . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Human CC chemokine liver expressed chemokine / CCL16 is a functional ligand for CCR 1 , CCR 2 and CCR 5 , and constitutively expressed by hepatocytes . ^^^ Consistently , LEC was found to bind to CCR 1 , CCR 2 and CCR 5 with relatively low affinities . ^^^ Taken together , LEC is a new low affinity functional ligand for CCR 1 , CCR 2 and CCR 5 , and is constitutively expressed by liver parenchymal cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Our objective was to examine the association between myocardial infarction ( MI ) and two DNA polymorphisms at the proinflammatory chemokine receptors CCR 2 ( I64V ) and CCR 5 ( 32 bp deletion , ( Delta ) ccr 5 ) , defining if these polymorphisms influence the age for the onset of MI . ^^^ A total of 214 patients with an age at the first MI episode < 55 years , 96 patients that suffered the first MI episode when older than 60 years , and 360 population controls were polymerase chain reaction genotyped for the CCR 2 V64I and CCR 5 Delta32 / wt polymorphisms . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Our data showed that phagocytosis of apoptotic / necrotic tumor cells resulted in maturation of DCs with up regulated expression of proinflammatory cytokines [ interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha , interferon gamma and granulocyte macrophage colony stimulating factor ] , chemokines ( MIP 1alpha , MIP 1beta and MIP 2 ) , the CC chemokine receptor CCR 7 and the cell surface molecules ( MHC class 2 , CD11b , CD 40 and CD 86 ) , and down regulated expression of the CC chemokine receptors CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Among several factors associated with HIV 1 disease progression , genetic polymorphism of CCR 2 , CCR 5 , and CXCR 4 in HIV 1 infection has been found . ^^^ Single nucleotide polymorphisms ( SNPs ) in the CCR 2 , CCR 5 , and CXCR 4 genes as well as a 32 base pair deletion in the open reading frame of the CCR 5 gene are associated with HIV disease progression among Caucasians and African Americans in North America and Europe . ^^^ In our study SNPs in CCR 2 coding and CCR 5 regulatory regions have been examined in 98 Japanese HIV positive individuals . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We found that while human megakaryoblasts express several chemokine receptors ( CXCR 4 , CCR 6 , CCR 8 , CCR 5 , CCR 2 and CXCR 3 ) , CXCR 4 was the only receptor detectable by FACS on human platelets . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In EAE protected mice , 17 beta estradiol strongly inhibited mRNA expression of the chemokines RANTES , MIP 1 alpha , MIP 2 , IP 10 , and MCP 1 , and of the chemokine receptors CCR 1 , CCR 2 and CCR 5 at both time points . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Two known polymorphisms in the CCR 2 and CCR 5 genes were analysed , neither of which showed significant association with IBD . ^^^ CONCLUSIONS : This study provides confirmatory linkage evidence for an IBD susceptibility locus on chromosome 3p and suggests that CCR 2 and CCR 5 are unlikely to be major susceptibility loci for IBD . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : De novo expression of CCR 2 , CCR 4 , and CCR 5 was not detected at either the protein or the mRNA level . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The protection is specific for the absence of CCR 2 , as CCR 5 ( / ) mice are not protected . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Other human polymorphisms , such as the CCR 2 64I and the CCR 5 promoter 2459 A / G transition that has been discovered recently , have also been shown to influence HIV progression . ^^^ When including the concurrent effects of the CCR 5 Delta32 and CCR 2 64I mutations , homozygous carriers of the CCR 5 promoter 2459A allele had a significantly faster progression towards death than heterozygous A / G individuals ( P = 0 . 03 ) , whereas this adverse effect was not significant when comparing A / A and G / G individuals . ^^^ Homozygous carriers of the 2459A allele that lack the protective effects of the CCR 5 Delta32 and CCR 2 64I mutations were found to have a median survival of 6 . 0 years , whereas carriers of the 2459G allele had a median survival of 9 . 4 years ( P < 0 . 01 ) . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In addition , intrathyroidal lymphocytes from AITD patients showed higher expression of CXCR 3 , CCR 2 , and CCR 5 chemokine receptors than autologous peripheral blood lymphocytes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In this study we show that CCL2 / monocyte chemotactic protein 1 , CCL5 / RANTES , and CXCL12 / stromal cell derived factor 1 enhanced IL 6 and IL 8 production by fibroblast like synoviocytes ( FLS ) from patients with RA , and their corresponding receptors , CCR 2 , CCR 5 , and CXCR 4 , respectively , were expressed by RA FLS . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The expression of CC chemokine receptor 1 ( CCR 1 ) , CCR 2 , CCR 3 , CCR 5 , and CXC chemokine receptor 3 ( CXCR 3 ) was studied on leukocyte subsets using flow cytometry , and the cytokine profile of T cells expressing CCR 2 and CCR 5 was determined . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The expression of chemokine receptors associated with T helper ( Th ) 1 type response , CCR 1 and CCR 5 , correlated with their appropriate ligands and was the highest at the peak of AU , whereas CCR 2 , the receptor for CCL2 / MCP 1 , was present before the onset of the disease . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Role of CCR 5 , CCR 2 and SDF 1 gene polymorphisms in a population of HIV 1 infected individuals . ^^^ In this study we analyzed the prevalence of CCR 5 delta32 , CCR 2 641 and SDF 1 3 ' A alleles in a highly selected group of 42 Long Term Nonprogressors ( LTNPs ) compared to 112 subjects with a typical course of HIV 1 infection ( TPs ) and 117 healthy controls ( HCs ) . ^^^ In addition , we correlated CCR 5 , CCR 2 and SDF 1 genotypes with molecular indexes of HIV 1 replication , cell free RNA and both unspliced ( US ) and multiply spliced ( MS ) intracellular transcripts , to investigate the role of the mutant alleles in determining a long term nonprogressive course of HIV 1 disease . ^^^ Our results indicate a significantly higher prevalence of CCR 5 delta32 allele in LTNPs compared to TPs ( p=0 . 0434 ) , while the proportions of CCR 2 64I and SDF 1 3 ' A alleles were comparable between the two groups . ^^^ However , SDF 1 wild type LTNP subjects showed significantly lower levels of HIV 1 genomic RNA , US and MS transcripts than SDF 1 3 ' A heterozygous ones ( p=0 . 0021 , 0 . 016 , 0 . 0031 , respectively ) , whereas both CCR 5 and CCR 2 wild type individuals had similar rates of viral replication compared to CCR 5 delta32 and CCR 2 64I heterozygous ones . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Associations of CCR 5 , CCR 2 , and stromal cell derived factor 1 genotypes with human immunodeficiency virus disease progression in patients receiving nucleoside therapy . ^^^ Genotype data for CCR 5 , CCR 2 , and stromal cell derived factor 1 ( SDF 1 ) were obtained from 354 human immunodeficiency virus type 1 ( HIV 1 ) positive subjects who were being treated with nucleosides . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In the SF the majority T cells stained positive for CCR 5 ( 93 % ) and CCR 2 ( 57 % ) , compared to the peripheral blood ( 36 % and 25 % ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 6 , CCR 7 , and CCR 8 mRNA is expressed by normal CD 4 ( + ) T cells . ^^^ In vitro activated T cells expressed CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 6 , CCR 7 , and CCR 8 mRNA as well as CCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Cells from secondary lymphoid tissues of pregnant donors gave high level uNK cell reconstitution , which was independent of chemokine receptors CCR 2 or CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Distribution of chemokine receptor CCR 2 and CCR 5 genotypes and their relative contribution to human immunodeficiency virus type 1 ( HIV 1 ) seroconversion , early HIV 1 RNA concentration in plasma , and later disease progression . ^^^ At the CC ( beta ) chemokine receptor 2 ( CCR 2 ) and CCR 5 loci , combinations of common single nucleotide polymorphisms ( SNPs ) and a 32 bp deletion ( Delta 32 ) form nine stable haplotypes ( designated A through G * 2 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 V64I and CCR 5 59029 ( G / A ) were detected by polymerase chain reaction restriction fragment length polymorphism in 401 patients with type 2 diabetes who had a serum creatinine < 2 . 0 mg / dl . ^^^ Although the CCR 2 V64I genotype showed no association with nephropathy , the frequency of the CCR 5 59029 A positive genotype ( G / A or A / A ) was significantly higher in patients with microalbuminuria ( urinary albumin to creatinine ratio [ ACR ] > or = 30 and < 300 mg / gCre , 86 % ) and patients with macroalbuminuria ( ACR > or = 300 mg / gCre , 87 % ) than in patients with normoalbuminuria ( ACR < 30 mg / gCre , 75 % ; P = 0 . 0095 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
After day 7 , a gradual increase in CCR 2 and CCR 5 mRNA , monocyte chemoattractant protein ( MCP ) 1 mRNA and protein expression was measured . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
This study was undertaken to characterize the expression of chemokine receptors CCR 1 , CCR 2 , CCR 3 , CCR 4 , CCR 5 , CCR 6 , CXCR 3 , and CX3CR1 in normal ( NL ) peripheral blood ( PB ) , RA PB , and RA synovial fluid ( SF ) . ^^^ RESULTS : The percentage of CD3+ lymphocytes expressing CCR 2 , CCR 4 , CCR 5 , and CX3CR1 was significantly elevated in RA PB compared with that in NL PB , while the percentage of CD3+ lymphocytes expressing CCR 5 was significantly enhanced in RA SF compared with that in NL and RA PB . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Reciprocally , maturation dependent down regulation occurred with one cytokine ( IGF 1 ) , two chemokine receptor ( CCR 2 and CCR 5 ) , and three other ( RP 105 , Ax 1 , and UCP 2 ) genes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
At 26 weeks postirradiation , messages encoding the chemokines BLC ( now known as Scyb 13 ) , C 10 ( now known as Scya 6 ) , IP 10 ( now known as Scyb 10 ) , MCP 1 ( now known as Scya 2 ) , MCP 3 ( now known as Scya 7 ) , MIP 1gamma ( now known as Scya 9 ) , and RANTES ( now known as Scya 5 ) and the chemokine receptors Ccr 1 , Ccr 2 , Ccr 5 and Ccr 6 were elevated in fibrosis sensitive ( C57BL / 6 ) mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Upregulated expression of the corresponding receptors for the chemokines , including CCR 1 , CCR 2 , CCR 3 , CCR 5 , and CXCR 3 , coincided with the development of the inflammatory infiltrate . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The association of human chemokine receptor genetic variants , CCR 5 Delta32 , CCR 5 59029 A / G , CCR 2 V64I , CX3CR1 V249I , and CX3CR1 T280M , with outcome in 163 renal transplant recipients was examined here . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Here , we report the expression pattern of the chemokine receptors CCR 1 , CCR 2 , CCR 4 , CCR 5 and CXCR 3 in sural nerve biopsies obtained from patients with classical Guillain Barr syndrome ( acute inflammatory demyelinating polyradiculoneuropathy ) , chronic inflammatory demyelinating polyradiculoneuropathy and various non inflammatory neuropathies . ^^^ CCR 1 and CCR 5 were primarily expressed by endoneurial macrophages , whereas CCR 2 , CCR 4 and CXCR 3 could be localized to invading T lymphocytes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of CCR 1 , CCR 2 , CCR 5 , CCR 6 , CCR 7 , CXCR 3 and CXCR 4 were analysed by FACS , and attracting chemokines were identified by blocking studies . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 and CCR 5 genotypes in HIV type 1 infected adolescents : limited contributions to variability in plasma HIV type 1 RNA concentration in the absence of antiretroviral therapy . ^^^ Our PCR based haplotyping of genetic variants at the loci encoding CC ( beta ) chemokine receptor 2 ( CCR 2 ) and CCR 5 revealed nine haplotypes ( designated A through G * 2 ) in 179 seronegative and 228 seropositive adolescent participants from the Reaching for Excellence in Adolescent Care and Health ( REACH ) Study of the Adolescent Medicine and HIV / AIDS Research Network . ^^^ The CCR 2 64I coding haplotype F * 2 and the infrequent CCR 5 Delta32 bearing haplotype G * 2 had negligible impact on HIV 1 RNA level ( p > 0 . 83 ) and CD4+ T cell counts ( p > 0 . 30 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We have analysed the expression of CXCR 3 and CCR 5 as Th 1 specific chemokine receptors , CCR 3 as a marker for Th 2 cells , CXCR 4 ( expressed on unprimed , naive T cells ) and CCR 2 ( known to be involved in autoimmunity ) on peripheral blood ( PBL ) and thyroid derived lymphocytes ( TL ) using flow cytometry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Human chemokine receptor ( HCR ) is a putative chemokine receptor sharing high similarity with CCR 1 , CCR 2 , CCR 3 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Distribution of HIV 1 resistance conferring polymorphic alleles SDF 1 3 ' A , CCR 2 64I and CCR 5 Delta32 in diverse populations of Andhra Pradesh , South India . ^^^ Polymorphic allelic variants of chemokine receptors CCR 2 and CCR 5 , as well as of stromal derived factor 1 SDF 1 , the ligand for the chemokine receptor CXCR 4 , are known to have protective effects against HIV 1 infection and to be involved with delay in disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Also , increased expression of IFN gamma was associated with a significant increase in expression of RANTES and monocyte chemotactic protein ( MCP ) 1 , chemokines that may inhibit HIV 1 infection by blocking viral attachment to CCR 2 and CCR 5 co receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Mouse eosinophils isolated from IL 5 transgenic mice expressed transcripts encoding the chemokine receptors CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 8 , CXCR 2 , and CXCR 4 , but not CCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Unlike other conventional T cell populations , we show that most NKT cells express receptors for extralymphoid tissue or inflammation related chemokines ( CCR 2 , CCR 5 , and CXCR 3 ) , while few NKT cells express lymphoid tissue homing chemokine receptors ( CCR 7 and CXCR 5 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The CCR 2 deficient mice also exhibited reduced expression of mRNA for chemokine receptors CCR 1 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We find that the chemotactic activities of both mu and delta opioid receptors are desensitized following activation of the chemokine receptors CCR 5 , CCR 2 , CCR 7 , and CXCR 4 but not of the CXCR 1 or CXCR 2 receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genes such as CCR 5 , CCR 2 , SDF 1 , and more recently CX3CR1 received great attention from several laboratories including ours , since they play a role as HIV coreceptor and , as such , on the infectivity of the host . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genes for the chemokine stromal derived factor 1 ( SDF 1 ) and CC chemokine receptors CCR 2 and CCR 5 are characterized by polymorphisms which alter their function . ^^^ The CCR 2 and CCR 5 polymorphisms were not associated with significant differences in mortality rate . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Several receptors expressed on macrophages and associated with inflammatory responses , including CCR 2 and CCR 5 , were down regulated by RANKL . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : Among the 13 receptor genes examined , the CXCR 3 , CCR 5 , and CCR 2 genes and those of their corresponding ligands were selectively and strongly induced in grafts that develop transplant vasculopathy . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Depending on the MIP 1 subtype and its NH ( 2 ) terminal processing , one or more of the CC chemokine receptors CCR 1 , CCR 2 , CCR 3 and CCR 5 are recognized . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In addition , we determined the expression of several chemokine receptors on cultured human T cells including CCR 1 , CCR 2 , CCR 4 , CCR 5 , CXCR 3 , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The prevalence of the CCR 5 delta32 polymorphism was 21 % ( 27 of 130 subjects ) , and the prevalence of the CCR 2 64I polymorphism was 15 % ( 19 of 130 subjects ) . ^^^ There were no major differences between subjects with and without polymorphisms in the CCR 5 and / or CCR 2 genes with respect to the rate of initial viral clearance , proportion of subjects with plasma HIV 1 RNA levels below the lower limit of quantification , rate of virologic treatment failure , immunologic responses , and disease progression during 96 weeks of follow up . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Analysis of chemokine receptor mRNA expression by M 133 147 expanded CCR 5 ( / ) derived CD 4 ( + ) T cells revealed reduced expression of CCR 1 , CCR 2 , and CXCR 3 , indicating that CCR 5 signaling is important in increased expression of these receptors , which aid in trafficking of CD 4 ( + ) T cells into the CNS . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 5 , CXCR 3 and CXCR 6 were expressed on a large fraction of activated cells , while moderate to low expression of CCR 2 , CCR 6 and CX ( 3 ) CR 1 was observed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The contribution of these residues to ligand binding and selectivity is tested by molecular docking simulations of TAK 779 to CCR 1 , CCR 2 , and CCR 5 . ^^^ The results are consistent with current site directed mutagenesis data and with the observed selectivity of TAK 779 for CCR 5 over CCR 1 and CCR 2 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Only CpG ODN exacerbated HAF GN with an increase of glomerular macrophages , which was associated with massive albuminuria and increased renal MCP 1 / CCL2 , RANTES / CCL5 , CCR 1 , CCR 2 , and CCR 5 mRNA expression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We demonstrated that , in the absence of any stimulation , human fetal and simian adult astrocytes express mRNA for receptors APJ , BOB / GPR15 , Bonzo / CXCR6 , CCR 2 , CCR 3 , CCR 5 , CCR 8 , ChemR 23 , CXCR3 / GPR9 , CXCR 4 , GPR 1 , and V28 / CX3CR1 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : Six chemokine system polymorphisms ( CCR5Delta32 , CCR 5 promoter 59029 G / A , CCR 2 64I , RANTES [ regulated upon activation , normal T cells expressed and secreted ] 403 G / A , and 28 C / G and stromal derived factor 1 3 ' A ) were studied in 417 patients with liver diseases ( 339 with hepatitis C ) and 2380 blood donors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of the chemokine receptors CCR 1 , CCR 2 , CCR 3 , CCR 4 , CCR 5 , CCR 6 , CCR 7 , CCR 8 , CXCR 3 and CXCR 4 were analysed by flow cytometry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The expression of chemokine receptors ( CCR 2 and CCR 5 ) associated with Th 1 type T cells correlated with their appropriate ligands . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCL receptors , CCR 2 , CCR 1 , and CCR 5 , also showed increased expression in mdx muscle . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The expression and the functional activities of different chemokine receptors ( CC motif : CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 6 ; CXC motif : CXCR 1 , CXCR 2 , CXCR 3 , CXCR 4 , CXCR 5 ) were investigated in 12 patients with lymphoproliferative disease of granular lymphocytes ( LDGL ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We recently applied this technique to determine the differential expression of murine chemokine receptors CCR 2 and CCR 5 on infiltrating renal leukocyte subsets . ^^^ Flow cytometry analysis revealed an accumulation of CCR 5 , but not CCR 2 positive lymphocytes in inflamed kidneys , compared to the peripheral blood . ^^^ In both models , infiltrating renal macrophages were positive for CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Several other receptors ( CCR 2 , CCR 3 , CCR 4 , CCR 5 , CXCR 6 and CRTh 2 ) were acquired progressively as a function of cell division and in a fashion that was influenced by polarizing cytokines . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Other chemokines acting on CCR 2 , CCR 4 and CCR 5 failed to protect against apoptosis and to induce BW 5147 chemotaxis , suggesting that these receptors were not functionally expressed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 5 and CCR 2 gene polymorphisms in hypertensive patients . ^^^ Variant alleles are derived from a deletion in the CCR 5 gene ( CCR5delta32 ) and a substitution mutation at the CCR 2 locus ( CCR264I ) . ^^^ Here , we evaluate the allelic distribution of CCR 5 and CCR 2 genes in essential hypertension in a case control study . ^^^ A statistically significant difference was observed for CCR 5 and CCR 2 mutant alleles in essential hypertensive patients , compared with the controls ( P=0 . 004 and P=0 . 003 , respectively ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Cross sectional studies have reported significantly different expression of chemokine receptors CXCR 3 , CCR 5 and CCR 2 on peripheral blood lymphocytes in multiple sclerosis ( MS ) compared with controls . ^^^ The aims of this study were to detect any changes in the serial expression of chemokine receptors CCR 2 , CCR 3 , CCR 5 and CXCR 3 on peripheral blood CD4+ lymphocytes from patients with MS and to correlate the changes with relapses . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of CCR 2 , CCR 5 , and CXCR 3 by CD4+ T cells is stable during a 2 year longitudinal study but varies widely between individuals . ^^^ In the present report , the expression of CCR 2 , CCR 5 , and CXCR 3 , associated with migration of mononuclear cells to inflamed tissue , was determined on CD4+ T cells in a 2 year longitudinal study of healthy volunteers using flow cytometry . ^^^ The expression of CCR 2 , CCR 5 , and CXCR 3 on CD4+ T cells was directly proportional to percentages of CD45RO ( hi ) / CD4+ T cells . ^^^ In addition , highly significant associations between levels of CCR 2 , CCR 5 , and CXCR 3 on CD4+ T cells were demonstrated in individual subjects , implying a common mechanism for regulating the expression of these CKRs on circulating T cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In this regard , CXCR 3 appears to play a more important role in cardiac allograft rejection than CCR 2 and CCR 5 . ^^^ We have found that CCR 2 , CCR 5 , and CXCR 3 and their ligands , as well as Th 1 cytokines are induced to high levels in rejecting islet allografts . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor CCR 5 is not a necessary inflammatory mediator in kainic acid induced hippocampal injury : evidence for a compensatory effect by increased CCR 2 and CCR 3 . ^^^ In contrast , CCR 5 KO mice showed CCR 2 mRNA expression that was remarkably increased after KA treatment . ^^^ The roles of CCR 5 in excitotoxic injury in CCR 5 deficient mice are compensated by increased CCR 2 and CCR 3 expression , which share the common MCP 2 ligand with CCR5 . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
As to their receptors , the levels of CCR 1 , CCR 2 , and CXCR 3 mRNAs showed significant and prominent elevations , CCR 5 mRNA also increased moderately , and their receptor protein expressing cells also increased . ^^^ The present findings suggest that MCP 1 , RANTES , and IP 10 may participate in the pathogenesis of mercuric chloride induced tubulointerstitial fibrosis with mononuclear cell infiltration , via CCR 2 , CCR 1 or CCR 5 , and CXCR 3 , respectively . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Constitutive activation of CCR 5 and CCR 2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2 . ^^^ The CCR 5 CAM , but not the CCR 2 CAM had a reduction in ligand binding affinity . ^^^ Whereas the amplitude of calcium mobilization induced by RANTES stimulation was lower in the CCR 5 CAM than the wild type ( WT ) receptor , MCP 1 induced a higher signal in the CCR 2 CAM than in CCR 2 WT . ^^^ CCR 2 , the receptor most closely genetically related to CCR 5 , shared a similar signaling mechanism , but other receptors containing the TXP motif did not . ^^^ The expression of CCR 5 and CCR 2 in yeast and the availability of variants with autonomous signaling represent critical tools for characterizing receptor antagonists and developing approaches to block their role in human diseases . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The majority of T cells infiltrating the infected corneas were 4 1BB ( + ) activated effector cells that expressed cell surface markers CD 44 , CD 25 , and / or CD62L , as well as chemokine receptors CCR 1 , CCR 2 , and CCR 5 , and a limited number of TCR Vbeta chains ( Vbeta8 . 1 / 8 . 2 , Vbeta8 . 3 , Vbeta10b , and Vbeta5 . 1 / 5 . 2 , in order of abundance ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Effects of CCR 5 delta32 and CCR 2 64I alleles on disease progression of perinatally HIV 1 infected children : an international meta analysis . ^^^ OBJECTIVE : Among perinatally infected children , the effects of certain alleles of the CCR 5 and CCR 2 genes on the rate of disease progression remain unclear . ^^^ We addressed the effects of CCR 5 delta32 and CCR 2 64I in an international meta analysis . ^^^ For progression to clinical AIDS , both CCR 5 delta32 and CCR 2 64I showed overall non significant trends for protection [ hazard ratios 0 . 84 , 95 % confidence interval ( CI ) 0 . 58 1 . 23 ; and 0 . 87 , 95 % CI 0 . 67 1 . 14 , respectively ] . ^^^ CCR 5 delta32 and CCR 2 64I offered no clear protection after clinical AIDS had developed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
These results suggest that RGS 16 may regulate T lymphocyte activation in response to inflammatory stimuli and migration induced by CXCR 4 , CCR 3 , and CCR 5 , but not CCR 2 or CCR7 . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
It has been reported that different polymorphisms in the regulatory regions of CCR 5 and in the CCR 2 gene of the chemokine receptors are associated with AIDS . ^^^ We decided to determine the congruence between CCR 5 59653T and CCR 2 64I alleles in a group of 281 persons . ^^^ Frequencies of combined CCR 5 59653T and CCR 2 64I haplotypes were examined in a group of 281 persons . ^^^ Among 281 individuals 26 ( 9 . 3 % ) and 24 ( 8 . 5 % ) respectively were carriers of the CCR 5 59653T and the CCR 2 64I alleles . ^^^ The calculation of the congruence revealed that 92 . 0 % of individuals exhibited the same genotype for both CCR 2 64I and CCR 5 59653T polymorphisms . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
They expressed high levels of CD 40 and CD 86 , were exclusively positive for the chemokine receptor ( CCR ) 7 but negative for CCR 5 and CCR 2 , and were able to enter the paracortex of draining lymph nodes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : We observed increased expression of several chemokine receptors ( CCR 1 , CCR 2 , CCR 5 , CXCR 3 ) in the infected ileum . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Celecoxib also significantly decreased C C family chemokine ( Rantes and MCP 1 ) mRNA expression in irradiated skin tissues , but not in tumor tissues , which was accompanied by a decrease in skin mRNA expression of both C C ( CCR 2 and CCR 5 ) and C 10 C ( CXCR 2 and CXCR 4 ) chemokine receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the possible association of CCR 2 and CCR 5 chemokine receptor gene polymorphisms with the susceptibility , clinical features , and the outcome of systemic lupus erythematosus ( SLE ) . ^^^ CONCLUSION : Polymorphisms of CCR 2 and CCR 5 do not seem to be involved in susceptibility to SLE , although a slight contribution of the CCR 5 polymorphism in the production of anti dsDNA autoantibodies , in the development of lupus nephritis , and in the outcome of the disease could be postulated . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD1d restricted T cells in the peripheral blood and CD1d restricted T cell clones expressed high levels of CXCR 3 , CCR 5 , and CCR 6 ; intermediate levels of CXCR 4 and CXCR 6 ; and low levels of CXCR 1 , CCR 1 , CCR 2 , and CX ( 3 ) CR 1 , a receptor pattern often associated with tissue infiltrating effector Th 1 cells and CD8+ T cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
After 2 to 4 weeks , L . amazonensis infected mice had significantly delayed and depressed expression of inflammatory cytokines ( interleukin 12 [ IL 12 ] , gamma interferon , IL 1 alpha , IL 1 beta ) , CC chemokines ( CC chemokine ligand 3 [ CCL 3 ] / macrophage inflammatory protein 1 alpha [ MIP 1 alpha ] , CCL4 / MIP 1 beta , CCL5 / RANTES , MIP 2 ) , and chemokine receptors ( CCR 1 , CCR 2 , CCR 5 ) in foot tissues and draining lymph nodes compared to the expression in L . major infected controls . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
However , T cell receptor ( TCR ) triggering resulted in the rapid but transient induction of a lymph node ( LN ) homing program , as evidenced by functional CCR 7 expression and concomitant reduction in expression and function of CCR 5 and , to a lesser degree , CCR 2 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In both strains , we detected similarly increased expression of chemokines RANTES / CCL5 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) / CCL3 , MIP 1beta / CCL4 , and MIP 2 , as well as chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In contrast , the expression of CCR 1 , CCR 2 , CCR 5 , CCR 6 , CCR 7 , CXCR 1 , and CXCR 2 remained undetectable on either blood or BAL eosinophils . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genotypes of CCR 2 and CCR 5 chemokine receptors in human myasthenia gravis . ^^^ The aim of this study was to examine the association of human autoimmune myasthenia gravis ( MG ) with two DNA polymorphisms of the chemokine receptors CCR 5 Delta 32 and CCR 2 64I . ^^^ CCR 2 and CCR 5 interact primarily with the human CC family ligands CCL 2 ( formerly called monocyte chemoattractant protein ; MCP 1 ) , CCL 3 and CCL 4 ( macrophage inflammatory protein 1 alpha and 1 beta ; MIP 1 alpha / beta ) , and their main function is to recruit leukocytes from circulation into the tissues , thus playing an important role in human inflammatory disorders . ^^^ A PCR based genotyping method was used to determine the genetic variation at the CCR 5 gene and an automated real time Pyrosequencing technology was employed for the analysis of G right curved arrow A point mutation at the CCR 2 gene . ^^^ Results obtained from 158 patients and 272 healthy controls demonstrate no evidence of association between genetic variants of CCR 2 and CCR 5 with MG and its clinical manifestations . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Frequency of polymorphisms of genes coding for HIV 1 co receptors CCR 5 and CCR 2 in a Brazilian population . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
For the treatment of MS in particular , the chemokine receptors CCR 1 , CCR 2 , CCR 5 , and CXCR 3 are possible targets in a chemokine based therapeutic approach . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
When using monocytes as antigen presenting cells , mAb specific for CCR 1 , CCR 2 , CCR 5 , and CXCR 4 were 100 10 , 000 fold more efficient at inducing T cell proliferation when compared to isotype matched control mAb on a per molecule basis . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Shikonin down regulated surface expression of CCR 5 , a primary HIV 1 coreceptor , on macrophages to a greater degree than the other receptors ( CCR 1 , CCR 2 , CXCR 4 , and the formyl peptide receptor ) did . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In the present study , venous blood was obtained from MS patients concurrent with MRI examination of the brain , and expression of chemokine receptors CCR 1 , CCR 2 , CCR 5 , CXCR 3 and CXCR 4 by CD 4 T cells and monocytes , proportions of Tr cells , as well as expression of CD45RO , CD 95 , CTLA 4 , HLA DR and interleukin ( IL ) 10 by Tr cells and non Tr ( CD 25 ) CD 4 T cells was analyzed by flow cytometry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Surprisingly , there was no significant difference in the expression of CC ( CCR 2 and CCR 5 ) and CXC ( CXCR 2 ) chemokine receptors across the leprosy spectrum . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We have tested lentiviral vectors expressing shRNAs targetting CCR 5 in primary CD 4 T cells from donors representing various CCR 5 and CCR 2 genetic backgrounds covering the full spectrum of CCR 5 expression levels and permissiveness for HIV 1 infection . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptors CCR 5 , CCR 2 , and CCR 3 and their ligands , RANTES , MCP 1 , MCP 2 , and MIP 1alpha , are involved in the immune responses and the selective recruitment of lymphocytes to the liver in HCV infection . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of chemokine receptors CCR 1 , CCR 2 , CCR 5 , CXCR 3 , CXCR 4 , and CX3CR1 was assessed on whole blood samples by immunofluorescence analysis . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : We showed significant up regulation of CCR 1 , CCR 2 , CCR 5 , and macrophage inflammatory protein 1beta / CCL4 mRNA in AIA on post adjuvant injection day 18 , coincident with peak inflammation . ^^^ Additionally , increases in tyrosine phosphorylation of CCR 1 ( days 14 , 18 , 21 , and 24 ) , CCR 2 ( days 14 and 18 ) , and CCR 5 ( days 14 , 18 , and 21 ) were detected in AIA rats compared with control ( nonarthritic ) rats . ^^^ CONCLUSION : CCR 1 , CCR 2 , and CCR 5 mRNA expression and tyrosine phosphorylation increased with peak inflammation in the AIA model . ^^^ CCR 1 , CCR 2 , and CCR 5 tyrosine phosphorylation are associated with the JAK / STAT 1 / STAT 3 pathway at different stages of rat AIA , as well as with macrophage and endothelial cell infiltration . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Blocking HIV 1 infection via CCR 5 and CXCR 4 receptors by acting in trans on the CCR 2 chemokine receptor . ^^^ This effect is explained by the ability of CCR 2 01 to induce oligomerization of CCR 2 with the CCR 5 or CXCR 4 viral coreceptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genetic influence of CCR 5 , CCR 2 , and SDF 1 variants on human immunodeficiency virus 1 ( HIV 1 ) related disease progression and neurological impairment , in children with symptomatic HIV 1 infection . ^^^ Variants including CCR 2 V64I , CCR 5 wt / Delta32 , CCR 5 59029 G / A , CCR 5 59353 T / C , CCR 5 59356 C / T , and SDF 1 3 ' G / A were identified by polymerase chain reaction genotyping . ^^^ Modest or little impact was associated with the CCR 5 59353 , CCR 5 59356 , or CCR 2 genotypes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Our study identifies eight genes ( IL 1beta , IL 1RA , macrophage inflammatory protein 1beta , monocyte chemoattractant protein 1 , CC chemokine receptor ( CCR ) 1 , CCR 2 , CCR 5 , and F4 / 80 ) that are highly expressed in all of our experimental groups . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We evaluated the expression of chemokine receptors ( CCR 1 , CCR 2 , CCR 5 , and CXCR 4 ) on the surface of peripheral blood mononuclear cells obtained from patients with chronic chagasic cardiomyopathy ( CCC ) and noninfected individuals . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of chemokine receptors CXCR 4 , CCR 2 , CCR 5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain . ^^^ We have studied the expression of chemokine receptors CXCR 4 , CCR 2 , CCR 5 , and CX3CR1 at the mRNA and protein levels in adult neural progenitor cells ( NPCs ) in neurosphere cultures using RT PCR and immunocytochemistry methods . ^^^ Using cultured cortical microglial cells as positive control , we demonstrated the mRNA expression of CXCR 4 , CCR 2 , CCR 5 , and CX3CR1 in neurospheres by RT PCR . ^^^ Double immunofluorescent staining further confirmed the co localization of nestin with either CXCR 4 , CCR 2 , CCR 5 , or CX3CR1 on neurospheres . ^^^ These results suggest that adult NPCs in the neurosphere cultures express chemokine receptors CXCR 4 , CCR 2 , CCR 5 , and CX3CR1 . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Differential expression of beta chemokines MCP 1 and RANTES and their receptors CCR 1 , CCR 2 , CCR 5 in acute rejection and chronic allograft nephropathy of human renal allografts . ^^^ The potential relationship of expression of these chemokines , their chemokine receptors CCR 1 , CCR 2 , CCR 5 , and the cell populations of inflammatory infiltrate , histological and clinical diagnoses were investigated in biopsies at the time of AR and compared with biopsies of CAN . ^^^ METHODS : In 24 renal transplant biopsies with AR ( n = 15 ) and CAN ( n = 9 ) , the expression of MCP 1 and RANTES , their receptors CCR 1 , CCR 2 , and CCR 5 and the infiltration with monocytes / macrophages and T cells were studied . ^^^ Biopsies with CAN revealed a lower expression of MCP 1 , RANTES , CCR 1 , CCR 2 and CCR 5 in tubulointerstitial cells , and a significantly lower infiltration with MRP 14 positive monocytes / macrophages than biopsies with AR . ^^^ In AR , MCP 1 and CCR 1 showed a lower expression compared to RANTES , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We now show that islet allograft rejection is associated with a steady increase in intragraft expression of the chemokines CCL 8 ( monocyte chemoattractant protein 2 ) , CCL 9 ( monocyte chemoattractant protein 5 ) , CCL 5 ( RANTES ) , CXCL 10 ( IFN gamma inducible protein 10 ) , and CXCL 9 ( monokine induced by IFN gamma ) and their corresponding chemokine receptors CCR 2 , CCR 5 , CCR 1 , and CXCR 3 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The receptors CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 6 , CXCR 1 , CXCR 2 , CXCR 5 , and CX3CR1 were rarely and inconsistently detected in lesional skin and thus their participation in mycosis fungoides could largely be ruled out . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In addition , evaluation of chemokine and cytokine mRNA and protein expression revealed that sHZ induces the expression of chemokines , macrophage inflammatory protein ( MIP ) 1alpha / CCL3 , MIP 1beta / CCL4 , MIP 2 / CXCL2 , and monocyte chemoattractant protein 1 / CCL2 ; chemokine receptors , CCR 1 , CCR 2 , CCR 5 , CXCR 2 , and CXCR 4 ; cytokines , IL 1beta and IL 6 ; and myeloid related proteins , S100A8 , S100A9 , and S100A8 / A9 , in the air pouch exudates . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Analysis of the involvement of CCR 5 Delta32 and CCR 2 V64I variants in the development of endometriosis . ^^^ Thus we postulated that the genes encoding CCR 5 and CCR 2 , which are the receptors for RANTES and MCP 1 respectively , could be good candidate genes for the disease . ^^^ We have used real time PCR and FRET technologies to genotype and evaluate the variants CCR 5 Delta32 and CCR 2 V64I , as susceptibility factors in a cohort of Spanish women with endometriosis . ^^^ These data would suggest the lack of association between these polymorphisms and endometriosis in our population , although they do not permit us to discard completely a possible role of other variants within CCR 5 and CCR 2 genes in this pathology . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the production of dynamic alpha and beta chemokines represented by interleukin 8 ( IL 8 ) as alpha chemokine and CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , ( CCL 5 , regulated upon activation , normal T cell expressed and secreted ( RANTES , CCR 5 ligand ) as beta chemokines by the human intestinal cell line INT 407 stimulated with factors produced by living Campylobacter jejuni ( C . jejuni ) and those present within sonicated and filtrated bacteria . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Mononuclear cells were stained by a 2 color ( fluorescein isothiocyanate / phycoerythrin ) flow cytometric assay using antibodies to the chemokine receptors ( CXCR 1 , CXCR 2 , CXCR 3 , CXCR 4 , CXCR 5 , CCR 2 , CCR 4 , CCR 5 , CCR 6 , and CCR 7 ) and also to CD 19 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : The expression of chemokine receptors CCR 1 , CCR 2 , CCR 3 , CCR 5 and CXCR 3 , and activation markers CD 25 ( IL2R alpha chain ) , CD 122 ( IL2R beta chain ) and CD 69 were studied on peripheral blood mononuclear cells using flow cytometry in 10 patients with acute anterior uveitis and in 10 healthy controls . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The prevailing paradigm is that in human rheumatoid arthritis ( RA ) , the accumulation of monocytes and T cells in the joint , mediated in part by such CC chemokine receptors ( CCRs ) as CCR 2 and CCR 5 , respectively , plays a central role in disease pathogenesis . ^^^ To further validate this paradigm , we conducted proof of principle studies and tested the hypothesis that gene inactivation of Ccr 2 or Ccr 5 will ameliorate experimental RA . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In wild type control mice , mRNA transcripts of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and monocyte chemoattractant protein ( MCP ) 1 as well as their major receptors , CCR 5 and CCR 2 , increased after freeze injury and gradually returned to control ( uninjured ) levels by 14 days . ^^^ To dissect the role of these chemokines , additional studies were conducted in CCR 5 and CCR 2 deficient mice . ^^^ Strength recovery was also impaired in mice deficient for the receptor of MCP 1 , CCR 2 , but not in CCR 5 / mice that were not injected with MCP 1 antiserum . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We studied the prevalence of genetic variations in CCR 2 , SDF 1 , and the CCR 5 gene and its promoter region at positions 59029 , 59353 , and 59356 in a seroprevalent cohort of 1057 children with symptomatic HIV 1 infection in the United States . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Lack of association of human chemokine receptor gene polymorphisms CCR 2 64I and CCR 5 Delta32 with autoimmune Addison ' s disease . ^^^ We investigated whether human chemokine receptor gene polymorphisms , namely CCR 5 Delta32 and CCR 2 64I , are associated with susceptibility to autoimmune Addison ' s disease . ^^^ Genotyping was performed in 56 patients and 127 healthy controls by a new method using pyrosequencing for CCR 2 64I and by polymerase chain reaction and detecting gel for CCR 5 Delta32 . ^^^ None of the CCR 2 or CCR 5 alleles was found to be associated , either positively or negatively , with disease risk . ^^^ Our results indicate that the CCR 2 64I and CCR 5 Delta32 gene polymorphisms do not play a major role in conferring genetic risk for , and / or protection against , autoimmune Addison ' s disease . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Six single nucleotide polymorphisms and a 32 bp deletion in the genes coding for CCR 3 , CCR 2 and CCR 5 ( which are all located in a cluster on chromosome 3 ) were investigated in 465 consecutively recruited patients infected with HCV and 370 matched controls . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
At defined time points , CC chemokines ( monocyte chemoattractant protein 1 , macrophage inflammatory protein 1 , and regulated upon activation normal T cell expressed and secreted ) , CXC chemokines ( interferon gamma inducible protein 10 , stromal derived factor 1 , and interleukin 8 ) , and receptor ( CCR 2 , CCR 3 , CCR 5 , CXCR 1 , CXCR 2 , CXCR 3 , and CXCR 4 ) mRNA expression were semiquantified by using a reverse transcriptase reaction followed by polymerase chain reaction . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Recently , genetic variants of monocyte chemotactic protein 1 ( MCP 1 ) , CC chemokine receptor 2 ( CCR 2 ) , CC chemokine receptor 5 ( CCR 5 ) genes have been identified . ^^^ These results suggest that polymorphisms of the MCP 1 , CCR 2 and CCR 5 genes may be associated with T1DM and its complications . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
This was associated with reduced renal expression of CC chemokines CCL 2 , CCL 3 , CCL 4 , and CCL 5 and the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
It has been found that rMSCs express CXCR 4 and CX3CR1 , the respective receptors for SDF 1 and fractalkine , and other chemokine receptors , CCR 2 and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The expression of chemokine receptors ( CCR ) associated with both Th 1 and Th 2 lymphocytes , such as CCR 2 , CCR 3 , CCR 4 , CCR 5 , and CCR 8 , was increased . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To investigate these possibilities , we studied a neurovirulent retrovirus , Fr 98 , that induces severe non lymphocyte mediated neurological disease and causes the upregulation of several chemokines that bind to chemokine receptors CCR 2 and CCR 5 . ^^^ Thus , signaling through CCR 2 , but not CCR 5 , plays an important role in Fr 98 mediated pathogenesis . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Here , we explore the influence of genetic polymorphisms of chemokine and chemokine receptors such as regulated upon activation and T cell secreted ( RANTES ) , CC chemokine receptor 5 ( CCR 5 ) and CCR 2 on the outcome of interferon ( IFN ) monotherapy . ^^^ METHODS : In a cohort of 105 patients with chronic hepatitis C as well as in 50 sustained responders and 55 nonresponders the presence of polymorphisms such as CCR 5 Delta32 , CCR 5 59029G / A , CCR 2 V64I and RANTES 403G / C was determined . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Differential expression of chemokines and chemokine receptors in murine islet allografts : the role of CCR 2 and CCR 5 signaling pathways . ^^^ During the 7 d after transplantation , the chemokines MCP 1 , MCP 2 , RANTES , MIG , IP 10 , 1 TAC , and two CC chemokine receptors CCR 2 and CCR 5 were highly expressed in allografts when compared with isografts . ^^^ Disrupting the CCR 2 and CCR 5 pathways individually resulted in prolongation of the survival time 16 . 1 + / 0 . 4 and 15 . 8 + / 0 . 9 d , respectively , of fully major histocompatibility complex mismatched islet grafts compared with wild type controls ( 11 . 2 + / 1 . 0 d ) . ^^^ The disruption of the CCR 2 and CCR 5 signaling , alone or in combination , moderately prolong islet allograft survival . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genetic polymorphisms of CCR 5 , CCR 2 , and SDF 1 genes have been associated with resistance during human immunodeficiency virus type 1 ( HIV 1 ) infection and disease progression . ^^^ In the present report , we studied the frequency and co occurrence of CCR5Delta32 , CCR 5 59029A / G , CCR 2 64I , and SDF 1 3 ' A allelic variants among HIV 1 seronegative individuals ( n = 171 ) in Moscow . ^^^ Observed allelic frequencies were 0 . 0906 [ 95 % confidence interval ( CI ) , 0 . 06 0 . 1212 ] for CCR5Delta32 , 0 . 4072 ( 95 % CI , 0 . 3542 0 . 4602 ) for CCR 5 59029G , 0 . 1061 ( 95 % CI , 0 . 0728 0 . 1394 ) for CCR 2 64I , and 0 . 2218 ( 95 % CI 0 . 1715 0 . 2721 ) for SDF 1 3 ' A . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : A total of 256 HIV infected patients receiving HAART and 221 healthy controls were analysed for the chemokine receptor 5 ( CCR 5 ) Delta 32 bp , stromal derived factor 1 ( SDF 1 ) 3 ' A and chemokine receptor 2 ( CCR 2 ) 64I polymorphisms . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We show that fresh tumor cells are able to migrate in response to CXCR 4 , CCR 2 , CCR 5 , CCR 6 , and CCR 7 ligands , and the ability of CXCR 3 ligands to increase the responsiveness to CXCL 12 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Animal studies have suggested potential roles for CCR 2 and CCR 5 in inflammatory bowel disease ( IBD ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Analysis of genetic polymorphisms in CCR 5 , CCR 2 , stromal cell derived factor 1 , RANTES , and dendritic cell specific intercellular adhesion molecule 3 grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV 1 . ^^^ However , the CCR 5 59029A , CCR 2 64I , stromal cell derived factor ( SDF ) 1 3 ' A , RANTES ( regulated on activation , normally T cell expressed and secreted ) 403A , and RANTES 28G polymorphisms were not associated with resistance to HIV 1 infection . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The transfer of CD4+CD45RBhigh T cells into severe combined immunodeficiency mice induced the infiltration of T cells and macrophages , and the gene expression of CC chemokine receptor ( CCR ) 1 , CCR 2 , CCR 5 , CXC chemokine receptor 3 , their ligands , tumor necrosis factor alpha , interferon gamma , and IL 6 was progressively augmented as colitis developed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : Donor genomic DNA restriction fragment length polymorphisms were assayed for evidence of common cytokine [ interleukin ( IL ) 2 , IL 6 , IL 10 , tumor necrosis factor ( TNF ) alpha , TGF beta , interferon ( IFN ) gamma ] and chemokine ( CCR 2 , CCR 5 ) polymorphisms . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genes for their related receptors , CCR 2 and CCR 5 , respectively , are characterized by the presence of two polymorphisms : a conservative change of a valine with an isoleucine at codon 64 of CCR 2 ( CCR 2 64I ) and a 32 bp deletion in the coding region of CCR 5 ( CCR5Delta32 ) , which leads to the expression of a nonfunctional receptor . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To determine the role of chemokines in DC mobilization , we applied this analysis to CCR 1 , CCR 2 , CCR 5 , and CCR 6 chemokine receptor knockout mice . ^^^ Both Mycobacteria bovis protein Ags and helminthic , Schistosoma mansoni egg Ags elicited multiple chemokines , including CCR 1 , CCR 2 , CCR 5 , and to a lesser extent CCR 6 ligands . ^^^ DCs from wild type lungs expressed transcripts for chemokine receptors , CCR 1 , CCR 2 , CCR 5 , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of CCR 5 on monocytes was significantly reduced , whereas CCR 2 and CXCR 4 expression were not affected by PGE ( 2 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Chemokines ( RANTES and MCP 1 ) and chemokine receptors ( CCR 2 and CCR 5 ) gene polymorphisms in Alzheimer ' s and Parkinson ' s disease . ^^^ We examined whether DNA polymorphisms at the genes encoding chemokines MCP 1 ( 2518 A / G ) and RANTES ( 403 A / G ) , and chemokine receptors 5 ( CCR 5 , Delta 32 ) and 2 ( CCR 2 , V64I ) , were associated with the risk and / or the clinical outcome of LOAD and PD . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Mobilized blood dendritic cells migrated to CCR 2 and CCR 5 ligands and trafficked to renal intertubular sites following adoptive ( intravenous ) transfer . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Recent data suggest that two important polymorphisms in CCR 2 and CCR 5 chemokine receptors , CCR5Delta32 and CCR 2 64I , prevent HIV transmission and delay disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To do this , they have characterised haplotypes comprising alleles at 11 biallelic loci in four chemokine receptor genes ( CCR 3 , CCR 2 , CCR 5 and CCRL 2 ) , which span 150 kb on chromosome 3p21 , and haplotyes of nine biallelic loci in six chemokine genes [ MCP 1 ( CCL 2 ) , Eotaxin ( CCL 11 ) , RANTES ( CCL 5 ) , MPIF 1 ( CCL 23 ) , PARC ( CCL 18 ) and MIP 1alpha ( CCL 3 ) ] on chromosome 17q11 12 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
SNP haplotypes , estimated from unphased genotypes using the Expectation Maximization algorithm , are described in a cluster of four CC chemokine receptor genes ( CCR 3 , CCR 2 , CCR 5 and CCRL 2 ) on chromosome 3p21 , and a cluster of three CC chemokine genes [ MPIF 1 ( CCL 23 ) , PARC ( CCL 18 ) and MIP 1alpha ( CCL 3 ) ] on chromosome 17q11 12 . ^^^ An analysis of haplotype blocks in this region indicates recombination between CCR 2 and CCR 5 , although long range pairwise linkage disequilibrium across the region appears to remain intact on two common haplotypes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : FLS constitutively expressed the receptors CCR 2 , CCR 5 , CXCR 3 , and CXCR 4 , both at the cell surface and mRNA levels , but failed to express CCR 3 and CCR 6 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The authors report the relative contributions to AIDS progression of CCR 2 64I , CCR 5 Delta32 , and the CCR 5 promoter haplotype + . ^^^ Follow up of SP demonstrated that these polymorphisms have little effect after 8 years , because the subset of SP who had progression after study entry had the same genotype distribution as the global population of SP , suggesting that factors other than CCR 5 or CCR 2 genetic variants must be responsible for the long term maintenance of nonprogression . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULTS : Compared with peripheral blood , alveolar T cells expressed significantly more CCR 2 , CCR 5 , CCR 6 , CXCR 3 and CCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The percentages of blood DC expressing the cell surface marker CD1a , co stimulatory molecules CD 80 and CD 86 , adhesion molecule CD 54 , and chemokine receptors CCR 1 , CCR 2 , CCR 5 , and CXCR 4 were not affected in GBS or CIDP . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Increased expression of mRNA specific for various chemokines ( eotaxin , MIP 1alpha , MIP 2 ) and chemokine receptors ( CCR 1 , CCR 2 and CCR 5 ) was observed in the lungs of nonsensitized mice challenged with the spores . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The intestinal MCp concentration in CXCR 2 ( / ) mice was reduced by 67 % , but was unaltered in CC chemokine receptor 2 ( / ) ( CCR 2 ( / ) ) , CCR 3 ( / ) , or CCR 5 ( / ) mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The combination of unique single nucleotide polymorphisms in the CCR 5 regulatory and in the CCR 2 and CCR 5 coding regions , defined nine CCR 5 human haplogroups ( HH ) : HHA HHE , HHF * 1 , HHF * 2 , HHG * 1 , and HHG * 2 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : To explore genetic polymorphisms CCR 5 of HIV coreceptor and CCR 2 in Chinese Yi Ethnic group in Sichuan . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We identified genes for six CC chemokine receptors ( CCR 1 , CCR 2 , CCR 3 , CCR 5 , CCR 9 , and CCRL 2 ) and two other chemokine receptors ( CXCR 6 and XCR 1 ) in this region . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of the chemokine receptors CCR 2 and CCR 5 by DC and their responsiveness to the respective ligands , CCL 2 and CCL 3 , were downregulated , while the level of CCR 7 and the DC response to its ligand CCL 21 were enhanced . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The following parameters were studied : surface molecules expression ( CD 18 , CD11b , CD 44 , CD 162 , CD15s , CD 80 , CD 86 , CD 16 , CD49d , CD 29 , CD 25 , HLA DR , Toll like receptor 4 [ TLR 4 ] , CXCR 1 , CCR 2 , CCR 5 , CX3CR1 ) , oxidative burst response , monocyte platelet conjugates ( using antibodies against CD 45 , CD 14 , CD41a ) , and platelet activation ( CD62P , PAC 1 ) . ^^^ RESULTS : Coronary reperfusion down modulated monocyte molecules expression , especially for CD 18 ( P = 0 . 048 ) , CD 44 ( P = 0 . 0035 ) , CD49d ( P = 0 . 0029 ) , CD 29 ( P = 0 . 032 ) , HLA DR ( P < 0 . 0001 ) , TLR 4 ( P = 0 . 0109 ) , CCR 2 ( P = 0 . 0184 ) , CCR 5 ( P = 0 . 0396 ) , and CX3CR1 ( P < 0 . 0001 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The recruitment of major histocompatibility complex ( MHC ) class 2 ( + ) LC was significantly suppressed in CCR 5 ( / ) mice and blockade of RANTES and MIP 1beta , but not in CCR 1 ( / ) , CCR 2 ( / ) / MIP 1alpha ( / ) , or MIP 1alpha ( / ) mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
PDTC effectively inhibited NF kappaB activation in the iris and ciliary body , and markedly inhibited the expression of chemokine genes , including monocyte chemoattractant protein ( MCP ) 1 , regulated on activation normal T cell expressed and secreted ( RANTES ) , and interleukin ( IL ) 8 and chemokine receptors genes including CCR 2 , CCR 5 , and CXCR 3 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genetic variants were identified in the chemokine receptors ( CCR 2 , CCR 5 , and CCR 5 promoter ) and the chemokine RANTES using TaqMan and restriction fragment length polymorphism assays . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The gene expression of the chemokine receptors CCR 1 , CCR 2 , CCR 5 , and CXCR 3 was monitored by using quantitative real time polymerase chain reaction . ^^^ It is interesting to note that we saw increasing gene expression levels a few days before acute GVHD was diagnosed clinically at 17 , 15 , 22 , and 19 occasions for CCR 5 , CXCR 3 , CCR 1 , and CCR 2 , respectively . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In this review , we examine the relevant information regarding the role of CCR 2 , and to a lesser extent of the closely related chemokine receptor CCR 5 , in the immunopathogenesis of collagen induced arthritis , an animal model of rheumatoid arthritis . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Spores provoked a loss of tissue retaining chemokine receptors ( CCR 2 , CCR 5 ) with a concurrent increase in lymph node homing receptors ( CCR 7 , CD11c ) on the membrane of DCs . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
RESULT : The chemokines of CCL 11 ( eotaxin 1 ) , CCL 24 ( eotaxin 2 ) , CCL 7 ( MCP 3 ) , CCL 13 ( MCP 4 ) , RANTES ( CCL 5 ) and receptors of CCR 2 , CCR 3 , CCR 4 , CCR 5 were differential expressed on four samples , and most of the chemokines and their receptors has tendency regulation on T help 2 ( Th 2 ) lymphocytes and involved in the prodeeds such as inducement of allergic reaction , accumulation of inflammacytes and degranulation of sensitized cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The aim of this study was to assess the involvement of inherited variations in CCR 2 , CCR 5 , and the ligand RANTES in determining disease outcome in hepatitis C virus ( HCV ) infected individuals . ^^^ METHODS : A total of 283 women , all exposed to HCV genotype 1b from a single donor , and including those who had spontaneously cleared the virus and those chronically infected , were genotyped for CCR 2 , CCR 5 , and RANTES polymorphisms . ^^^ RESULTS : CCR 5 , CCR 2 , and RANTES genotypes were compared with HCV polymerase chain reaction ( PCR ) status , alanine aminotransferase levels , and liver histology . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Susceptibility to HIV 1 infections is , beside other factors , determined by individual host genetic variants like HLA class 1 alleles , CCR 5 and CCR 2 variants and levels of CCR 5 binding chemokines . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The simultaneous blockade of chemokine receptors CCR 2 , CCR 5 and CXCR 3 by a non peptide chemokine receptor antagonist protects mice from dextran sodium sulfate mediated colitis . ^^^ Chemokine receptors CCR 2 , CCR 5 and CXCR 3 are involved in the regulation of macrophage and T cell mediated immune responses and in the migration and activation of these cells . ^^^ The expression of CCR 2 , CCR 5 and CXCR 3 mRNAs was inhibited in the TAK 779 treated mice . ^^^ The blockade of CCR 2 , CCR 5 and CXCR 3 prevents murine experimental colitis by inhibiting the recruitment of inflammatory cells into the mucosa . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Polymorphisms in the CC chemokine receptor 2 ( CCR 2 ) and 5 ( CCR 5 ) genes and risk of coronary heart disease among US women . ^^^ OBJECTIVE : Genetic variation in CC chemokine receptor 2 ( CCR 2 ) and 5 ( CCR 5 ) , and their common haplotypes , acting through inflammatory responses , may affect atherosclerosis and risk of coronary heart disease ( CHD ) . ^^^ METHOD AND RESULTS : We examined seven common variants in the CCR 2 and CCR 5 loci and risk of CHD among women in the Nurses ' Health Study . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The analysis of mRNA expression revealed increased levels of CCR 1 , CCR 2 , CCR 3 , CCR 5 , CXCR 1 , and CXCR 3 in both types of lesion compared with controls . ^^^ CONCLUSIONS : The increase in Th 1 type ( CCR 1 , CCR 5 , and CXCR 3 ) and Th 2 type ( CCR 2 and CCR 3 ) receptors in both periapical lesions suggests the concomitant occurrence of Th 1 and Th 2 responses . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Chemokine receptors Ccr 1 , Ccr 2 , and Ccr 5 mediate neutrophil migration to postischemic tissue . ^^^ However , the role of chemokine receptors Ccr 1 , Ccr 2 , and Ccr 5 for each single step of the postischemic recruitment process of leukocytes has not yet been characterized . ^^^ Prior to 30 min of ischemia as well as at 5 , 30 , 60 , 90 , and 120 min after onset of reperfusion , migration parameters were determined in wild type , Ccr 1 / , Ccr 2 / , and Ccr 5 / mice . ^^^ Already after 5 min of reperfusion , this increase was reduced significantly in Ccr 1 / and Ccr 5 / mice , whereas only in Ccr 2 / mice , was adherence attenuated significantly at 120 min after onset of reperfusion . ^^^ This elevation was significantly lower in Ccr 1 / , Ccr 2 / , and Ccr 5 / mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Distribution of HIV / AIDS protective SDF 1 , CCR 5 and CCR 2 gene variants within Cretan population . ^^^ The mutations most frequently studied are the CCR 5 delta32 , CCR 2 64I and SDF 1 3 ' A . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The coexpression of CKRs ( CCR 2 , CCR 3 , CCR 5 , CXCR 3 , and CXCR 4 ) and intracellular cytokines ( interleukin 10 [ IL 10 ] , IL 4 , tumor necrosis factor alpha [ TNF alpha ] , and gamma interferon [ IFN gamma ] ) on T CD4+ and CD8+ peripheral cells from individuals with indeterminate ( IND ) or cardiac ( CARD ) clinical forms of Chagas ' disease after in vitro stimulation with Trypanosoma cruzi antigens , were evaluated in this study . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In order to contribute to the identification of the genetic differences underlying this phenotypic diversity in SCD , we proposed to study the distribution of polymorphic variants of the genes encoding the chemokine receptors CCR 2 and CCR 5 , as well as three polymorphisms in the NOS 3 gene , in Brazilian SCD patients . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To test the hypothesis that chemokines exhibit previously undiscovered pleiotropic effects important for the behavioral actions of ethanol , we studied mutant mice with deletion of the Ccr 2 , Ccr 5 , Ccl 2 or Ccl 3 genes . ^^^ Ccr 2 and Ccr 5 null mutant mice did not differ from wild type mice in ethanol induced loss of righting reflex ( LORR ) , but mice lacking Ccl 2 or Ccl 3 showed longer LORR than wild type mice . ^^^ On the contrary , known QTLs on Chr 9 are outside of 129 / SvJ region in Ccr 2 and Ccr 5 ( 71 . 9 and 72 . 0 cM , respectively ) null mutant mice . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Exposed seronegative individuals ( ES ) with persistent high risk sexual behavior may be less susceptible to human immunodeficiency virus type 1 ( HIV 1 ) infection because they carry the chemokine receptor ( CR ) gene alleles CCR 5 open reading frame ( ORF ) Delta 32 , CCR 5 promoter 2459G , or CCR 2 ORF 64I ( CCR 2 64I ) , all of which have been found to diminish HIV 1 infectivity and / or disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The therapeutic impact of the blockade of CCR 1 , CCR 2 , CCR 4 , CCR 5 , or the corresponding ligands has been further studied in various renal disease models . ^^^ Recent studies on the role of the chemokine receptors in human diseases have demonstrated the expression of CXCR 1 , CXCR 3 , CCR 2 , and CCR 5 on different subsets of inflammatory cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
YM 355179 did not , however , affect any CC chemokine receptor ( CCR 1 , CCR 2 , CCR 4 , or CCR 5 ) mediated Ca ( 2+ ) influx signals . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : Macrophages were isolated from rejecting CCR 2 , CCR 5 , CD 40 and control C57BL / 6 mice that were recipients of neonatal porcine pancreatic cell cluster ( NPCC ) xenografts and were transferred to NPCC recipient NOD SCID mice . ^^^ RESULTS : Macrophages isolated from rejecting NPCC xenografts in CD 40 and wildtype C57BL / 6 mice demonstrated upregulated expression of macrophage activation markers as well as CCR 5 and CCR 2 genes , and caused pig islet xenograft destruction 8 days after transfer to NOD SCID recipients . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : In a retrospective analysis of a cohort of heart transplanted patients ( n=158 ) , we examined eight polymorphisms in four genes implicated in this inflammatory process : RANTES , CCR 5 , CCR 2 and CX3CR1 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Similar results were obtained when CCR 2 / and CCR 5 / mice were used . ^^^ CONCLUSIONS : Overall , these findings suggest that the chemokines MCP 1 and MIP 1alpha , acting through their receptors CCR 2 and CCR 5 , are important in the induction of EAM and that inhibition of MCP 1 with 7ND gene transfection significantly reduced disease severity . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 5 , binding MIP 1alpha / CCL3 and RANTES / CCL5 , was up regulated on ST macrophages during the course of AIA , correlating with macrophage expression of CCR 2 , a receptor for monocyte chemoattractant protein 1 / CCL2 . ^^^ CONCLUSION : These findings show that 1 ) constitutive expression of CCR 1 on macrophages remains high during AIA ; 2 ) CCR 2 and CCR 3 may play a role in initial recruitment of leukocytes to ST in AIA ; 3 ) macrophage expression of CCR 2 and CCR 5 may be important for sustaining inflammatory changes ; and 4 ) EC CXCR 4 may be a harbinger of inflammatory changes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
METHODS : We conducted a nested case control study of African Americans ( 266 HIV 1 seroconverter cases and 532 seronegative controls from the AIDS Link to Intravenous Experience cohort ) , to examine the association between 50 single nucleotide polymorphisms ( SNPs ) in 9 candidate genes ( CCR 5 , CCR 2 , RANTES , MIP1A , MCP 2 , IL 10 , IFNG , MCSF , and IL 2 ) and susceptibility to HIV 1 infection . ^^^ RESULTS : Four SNPs ( CCR 2 V64I , CCR 5 2459 , MIP1A+954 , and IL2+3896 ) and specific haplotypes in the IL 2 and CCR2 / CCR5 regions were significantly associated with HIV 1 infection susceptibility in different genetic models . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Skin NK cells expressed high levels of the chemokines receptors CXCR 3 and CCR 5 , intermediate amounts of CXCR 1 , CCR 6 and CCR 8 , and low levels of CCR 1 , CCR 2 , CCR 4 , CCR 7 and CX3CR1 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Moreover , we demonstrate a chemokine dependent mechanism of EPC homing into tumor , whereby neovessels of late stage tumors release a battery of CC chemokines , which direct CCR 2 ( + ) and CCR 5 ( + ) progenitors into the vasculature . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Analysis of CCR 5 , CCR 2 , CX3CR1 , and SDF 1 polymorphisms in HIV positive treated patients : impact on response to HAART and on peripheral T lymphocyte counts . ^^^ Although polymorphisms of chemokine genes ( SDF 1 , stromal cell derived factor 1 and RANTES , regulated on activation , normal T cell expressed and secreted ) and chemokine receptor genes ( CCR 5 , CCR 2 , CX ( 3 ) CR 1 ) were shown to be associated with sensitivity to HIV infection and untreated HIV disease progression , their association with the response to highly active antiretroviral therapy ( HAART ) remains unclear . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Here , we explored the effects of the glucocorticoid , corticosterone ( CORT ) , on the expression of CCL 2 and its receptors , CCR 2 and CCR 5 , in the hippocampal formation using intact , adrenalectomized ( ADX ) and trimethyltin ( TMT ) treated rats . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 9 ( / ) OT 2 cells were disadvantaged in their ability to localize to the intestinal lamina propria ; however , they were readily detected at this site and expressed alpha ( 4 ) beta ( 7 ) , but little CCR 2 , CCR 5 , CCR 6 , CCR 8 , CCR 10 , CXCR 3 , or CXCR 6 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
No significant changes in the frequencies of CCR 2 , CCR 3 , CCR 4 , and CCR 5 were observed in either MG group . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of CX3CL1 ( fractalkine ) , CCL 7 ( MCP 3 ) , and their receptors ( CX3CR1 , CCR 1 , CCR 2 , CCR 3 , and CCR 5 ) mRNA was examined in cellular components of the maternal embryonic interface by RT PCR . ^^^ CX3CR1 , CCR 1 , CCR 2 , and CCR 5 were also expressed by endometrial cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We have demonstrated previously that the chemokine receptors CCR 2 and CCR 5 form homo and heterodimers and that dimers can only bind a single chemokine molecule with high affinity . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Deficiency in CCR 5 significantly reduced neointimal area after arterial wire injury , associated with a decrease in macrophages , CD 3 ( + ) T lymphocytes , and CCR 2 ( + ) cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Associations of polymorphisms in CCL 5 ( G 403A ) and its receptor CCR 5 ( Delta 32 ) , CCL 2 ( A 2578G ) and CCR 2 ( V64I ) , and CX3CR1 V249I and T280M with coal worker ' s pneumoconiosis ( CWP ) were investigated in 209 miners examined in 1990 , 1994 and 1999 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Effects of CCR 5 delta32 , CCR 2 64I and SDF 1 3 ' A polymorphic alleles on human immunodeficiency virus 1 ( HIV 1 ) infection in the Polish population ] . ^^^ Between host genetic factors identified and analyzed for their role in HIV 1 transmission and disease progression are polymorphisms in the genes encoding chemokine receptors and CCR 5 , CCR 2 and SDF 1 a natural ligand for CXCR 4 receptor . ^^^ The aim of present study was to examine the frequencies of polymorphic alleles CCR 5 delta32 , CCR 2 64I and SDF 1 3 ' A and their role in human immunodeficiency virus ( HIV 1 ) transmission in Polish population . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Whole cell RNA was isolated and chemokine ( IL 8 , CCL2 / MCP 1 , CXCL10 / IP 10 and CCL5 / RANTES ) and chemokine receptor ( CCR 2 and CCR 5 ) expression was tested by quantitative PCR . ^^^ RANTES , CCR 2 , and CCR 5 expression did not change in ischemic vs . reperfusion biopsies . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
There were no significant increases in the expression of IL 1beta , IL 8 , IP 10 , SDF 1 , RANTES , Fractalkine , CX3CR 1 , CCR 2 , CCR 5 , CCR 11 , TNF alpha , GM CSF and TGF beta using RT PCR . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genetic variation at chemokine receptor CCR 5 in leporids : alteration at the 2nd extracellular domain by gene conversion with CCR 2 in Oryctolagus , but not in Sylvilagus and Lepus species . ^^^ While absent in Sylvilagus and Lepus species , this CCR 2 imposed CCR 5 ECL2 alteration was observed in all genomes of 25 European rabbits , representing the subspecies O . cuniculus algirus and O . cuniculus cuniculus . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of leukocyte markers ( CD 3 , CD 4 , CD 8 , CD4 / CD8 ratio , CD 16 , CD 19 , and CD 14 ) and chemokine receptors ( CXCR 1 , CXCR 4 , CCR 2 , CCR 5 , and CCR 7 ) was studied in 73 effusions by using flow cytometry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CXCR 3 , CCR 1 , CCR 2 and CCR 5 on CD 4 and CD 8 T cells and CD 14 monocytes were evaluated . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We describe CCR 2 , CCR 5 and CCR 7 expression on human cells from blood , spleen and pulmonary hilar lymph nodes ( PHLN ) stimulated by M . tuberculosis antigens . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Using RT PCR , we show that primary OPC from neonatal rats express CCR 3 , while CCR 1 , CCR 2 , CCR 4 , CCR 5 , and CCR 7 are not expressed . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
At 24 h after infection , while the chemokine receptors CX3CR and CCR 7 were unaffected , CCR 1 , CCR 2 , CCR 5 , and CXCR 4 were downmodulated on the cell surface and retained intracellularly . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We found that infection of alveolar epithelial cells with the mouse adapted influenza A virus strain PR / 8 strongly induced the release of monocyte chemoattractants CCL 2 and CCL 5 followed by a strong monocyte transepithelial migration , and this monocytic response was strictly dependent on monocyte CCR 2 but not CCR 5 chemokine receptor expression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 2 , CCR 5 , CCR 7 , CCL 19 , and interleukin 12a were upregulated in a time and tissue dependent manner . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
GluVII : 06 has been demonstrated to be crucially important for the binding and action of a number of non peptide ligands in for example the CCR 1 , CCR 2 and CCR 5 receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
On the other hand , non MHC encoded genes are CCR 5 , CCR 2 , RANTES , CXCL 12 , CXCR 6 , CCL3L1 , Interleukin 10 ( IL 10 ) , and interferon gamma . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We report that A / J mice immunized with mc TnI developed severe inflammation of the myocardium with increased expression of inflammatory chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , monocyte chemoattractant protein 1 , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MIP 2 , T cell activation gene 3 , and eotaxin and chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The aim of the present study was to evaluate the possible relation between CCR 2 and CCR 5 alleles and blood pressure ( BP ) levels in hypertensive subjects . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Immunocytochemistry of the heart tissues with monoclonal antibodies revealed a high expression of CXCR 4 and CCR2A and a low expression of CCR 3 and CCR 5 on coronary vessel endothelia . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
When co expressed with CCR 5 , CCR2A 64I interfered more severely with cell surface expression of CCR 5 than did wild type CCR2A . ^^^ Furthermore , immunoprecipitation experiments showed that CCR2A co precipitated with an immature form of CCR 5 . ^^^ CONCLUSION : These results suggest that CCR2A binds to CCR 5 in the cytoplasm and down modulates its surface expression . ^^^ We propose that the increased ability of CCR2A 64I to down modulate CCR 5 expression might be a possible cause of a delay in HIV 1 disease progression in patients with this allele . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Subsets of inflammatory cells , identified as macrophages and T cells , in all three types of IIM expressed CCR2A , CCR2B , CCR 3 , CCR 4 , and CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The deduced amino acid sequence of this novel receptor , designated CCR 5 , is most similar to CCR2B , sharing 71 % identical residues . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The amino acid sequence deduced from the TER 1 cDNA shows 43 , 40 , 40 , and 39 % identity to CCR 4 , CCR 5 , CCR 1 , and CCR2B beta chemokine receptors , respectively . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Regions in beta chemokine receptors CCR 5 and CCR2b that determine HIV 1 cofactor specificity . ^^^ Macrophage tropic ( M tropic ) HIV 1 strains use the beta chemokine receptor CCR 5 , but not CCR2b , as a cofactor for membrane fusion and infection , while the dual tropic strain 89 . 6 uses both . ^^^ A CCR2b chimera containing the first 20 N terminal residues of CCR 5 supported M tropic envelope protein fusion . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Analysis of chimeras containing elements from human CCR 5 and human CCR2B suggested that a complex structure rather than single contact sites is responsible for facilitation of viral entry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
However , in patients with disease progression , the virus expanded its coreceptor use to include CCR 5 , CCR 3 , CCR2b , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Primary CD 4 T cells from delta ccr 5 homozygous individuals were highly resistant to infection with prototype M tropic HIV 1 strains , including an isolate ( YU 2 ) that uses CCR 5 and CCR 3 , but were permissive for both a T tropic strain ( 3B ) and a dual tropic variant ( 89 . 6 ) that uses CXCR 4 , CCR 5 , CCR 3 , or CCR2b . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptors CXCR 4 , CCR2B , CCR 3 , and CCR 5 have recently been shown to serve along with CD 4 as coreceptors for HIV 1 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Recent studies using human CCR5 / CCR2B chimeras have suggested that the determinants of CCR 5 co receptor activity are complex and may involve multiple extracellular receptor domains and that viral co receptor activity is dissociable from ligand dependent signaling responses . ^^^ In the present report , using a series of CCR5 / CCR2B chimeras we ascribe an important role for the second and third extracellular loop of CCR 5 in supporting the co receptor activity of CCR 5 . ^^^ The hypothesis that the structural determinants for CC chemokine / CCR5 interactions and CCR 5 HIV 1 fusion co receptor activity may be shared was confirmed by two novel observations : first , the fusion activity supported by two hybrid receptors could be inhibited by both RANTES and monocyte chemoattractant protein 1 , chemokines specific to CCR 5 and CCR2B , respectively ; and second , the chemokine specificity for inhibition of envelope mediated cell fusion matched the agonist profile of these hybrid receptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptors CXCR 4 , CCR2b , CCR 3 , and CCR 5 are cell entry coreceptors for HIV 1 . ^^^ Using an HIV 1 envelope ( Env ) dependent cell cell fusion model of entry , we show that CCR 3 can interact with Envs from certain macrophage ( M ) tropic strains ( which also use CCR 5 ) , T cell line ( TCL ) tropic laboratory adapted strains ( which also use CXCR 4 ) , and a dual tropic primary isolate ( which also uses CCR2b , CCR 5 , and CXCR 4 ) . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD4 glioma cell lines , stably expressing the chemokine receptor CCR 1 , CCR2b , CCR 3 , CCR 5 , or CXCR 4 , we have tested chemokine receptor specificity for a panel of genetically diverse envelope glycoprotein genes cloned from primary HIV 1 isolates and have found that receptor usage was closely associated with the biological phenotype of the virus isolate but not the genetic subtype . ^^^ In addition to the regular use of CXCR 4 , many rapid / high viruses used CCR 5 and some also used CCR 3 and CCR2b . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CCR 5 is most closely related to CCR2b , another chemokine receptor that responds to monocyte chemoattractant protein ( MCP ) 1 , MCP 2 , MCP 3 , and MCP 4 . ^^^ We have investigated by mutagenesis the regions of CCR 5 and CCR2b involved in the specificity of binding and functional response to their respective ligands . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Finally , AMD 3100 had no effect on the Ca2+ flux induced by the CC chemokines MIP 1alpha , regulated on activation normal T cell expressed and secreted ( RANTES ; also a ligand for CCR 5 ) , or monocyte chemoattractant protein 3 ( a ligand for CCR 1 and CCR2b ) , nor was it able to induce Ca2+ fluxes by itself . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor CCR 5 and to a lesser extent CCR 3 and CCR2b have been shown to serve as coreceptors for human immunodeficiency virus type 1 ( HIV 1 ) entry into blood or tissue derived macrophages . ^^^ Therefore , we examined the expression of the chemokine receptors CCR 1 , CCR2b , CCR 3 , CCR 5 , and CXCR 4 as RNAs or as membrane expressed antigens in monocytes maturing into macrophages and correlated these results with the susceptibility of macrophages to HIV 1 infection , as measured by their concentrations of extracellular p 24 antigen and levels of intracellular HIV DNA by quantitative PCR . ^^^ There was little change in levels of CCR 1 , CCR2b , and CCR 5 RNAs . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD4 glioma cells stably expressing chemokine receptor CCR 1 , CCR2b , CCR 3 , CCR 5 , or CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD4 cells expressing CCR 1 , CCR2b , CCR 3 , CCR 4 , CCR 5 , and CXCR 4 but also in HOS . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Here we show that primary HIV 2 isolates can use a broad range of coreceptor molecules , including CCR 1 , CCR2b , CCR 3 , CCR 4 , CCR 5 , and CXCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
A 32 base pair inactivating deletion in the CCR 5 gene and a point mutation within the CCR2b gene resulting in a conservative amino acid substitution have been examined and shown to be independently associated with delayed disease progression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Analysis of GHOST 4 cell lines expressing various chemokine receptors ( CCR 1 , CCR2b , CCR 3 , CCR 4 , CCR 5 , CXCR 4 , BONZO , and BOB ) further defined specific coreceptor usage of primary HIV 2 isolates . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In this report we describe a distamycin analogue , 2 , 2 ' [ 4 , 4 ' [ [ aminocarbonyl ] amino ] bis [ N , 4 ' di [ pryrrole 2 carboxamide 1 , 1 ' dimethyl ] ] 6 , 8 naphthalenedisulfonic acid ] hexasodium salt ( NSC 651016 ) , that selectively inhibited chemokine binding to CCR 5 , CCR 3 , CCR 1 , and CXCR 4 , but not to CXCR 2 or CCR2b , and blocked chemokine induced calcium flux . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We found that rhesus macaque BCECs express chemokine receptors involved in HIV and SIV entry including CCR 5 , CCR 3 , CXCR 4 , and STRL 33 , but not CCR2b , GPR 1 , or GPR 15 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Macrophages from individuals homozygous for an inactivating mutation of CCR 5 are resistant to prototype M tropic strains that depend on CCR 5 but are permissive for a dual tropic isolate , 89 . 6 , that can use both CCR 5 and CXCR 4 , as well as CCR2b , CCR 3 , and CCR 8 . ^^^ Here we show that 89 . 6 entry into CCR 5 deficient macrophages is blocked by an anti CXCR 4 antibody and by the CXCR 4 specific chemokine SDF but not by the ligands to CCR2b or CCR 3 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We have investigated the role of the recently described mutation in CCR2b named 64I in relation to HIV resistance , CD 4 T cell counts , and disease progression in Danish individuals by polymerase chain reaction ( PCR ) based methods as well as sequenced full length CXCR 4 and CCR 5 genes from HIV infected long term nonprogressors for possible mutations . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Quantitative kinetic reverse transcription polymerase chain reaction was developed to determine the in vivo expression levels of CCR 5 , CXCR 4 , CCR 3 , CCR2b , and the cytomegalovirus encoded US 28 in peripheral blood mononuclear cells and cervical biopsies from 12 women with and without sexually transmitted diseases , genital ulcer disease , and progesterone predominant conditions . ^^^ CCR 5 mRNA expression in the ectocervix was 10 fold greater than CXCR 4 , 20 fold greater than CCR2b , and 100 fold greater than CCR 3 . ^^^ In peripheral blood , CXCR 4 expression was 1 . 5 fold greater than CCR 5 , 10 fold greater than CCR2b , and 15 fold greater than CCR 3 . ^^^ In vitro studies demonstrate that progesterone increases CCR 5 , CXCR 4 , and CCR 3 expression and decreases CCR2b expression in lymphocytes and monocytes / macrophages . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Factors responsible include two inherited human alleles , CCR 5 delta32 and CCR 2 641 , which alter the protein coding regions for the HIV 1 coreceptors / chemokine receptors CCR 5 and CCR2b . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD4 transfectants expressing CCR 1 , CCR2b , CCR 3 , CCR 4 or CCR 5 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We tested chemokine receptor subset usage by diverse , well characterized primary viruses isolated from peripheral blood by monitoring viral replication with CCR 1 , CCR2b , CCR 3 , CCR 5 , and CXCR 4 U87MG . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We have tested a panel of pediatric and adult human immunodeficiency virus type 1 ( HIV 1 ) primary isolates for the ability to employ the following proteins as coreceptors during viral entry : CCR 1 , CCR2b , CCR 3 , CCR 4 , CCR 5 , CCR 8 , CXCR 4 , Bonzo , BOB , GPR 1 , V 28 , US 28 , and APJ . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Forty human immunodeficiency virus type 1 ( HIV 1 ) infected women participated in a cross sectional study of possible correlations between chemokine receptor ( CCR 5 and / or CCR2B ) genotype , HIV 1 RNA and DNA load , and beta chemokine levels ( RANTES , MIP 1alpha , MIP 1beta ) in blood and cervix . ^^^ HIV 1 nucleic acid and beta chemokines were found in all patient blood samples and in more than half of the cervical samples regardless of CCR 5 or CCR2B genotype . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
To this end , we sought to ( 1 ) phenotype human hematopoietic cells for CD 4 and the HIV 1 coreceptors CXCR 4 , CCR 5 , CCR 3 , and CCR2b ; ( 2 ) correlate CD 4 and chemokine receptor expression with their susceptibility to HIV 1 infection ; and ( 3 ) examine any potential interplay between inflammatory cytokines released during HIV 1 infection and regulation of chemokine receptor expression . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We tested 11 primary HIV 2 isolates for coreceptor usage in human cell lines : U 87 glioma cells , stably expressing CD 4 and the chemokine receptor CCR 1 , CCR2b , CCR 3 , CCR 5 , or CXCR 4 , and GHOST ( 3 ) osteosarcoma cells , coexpressing CD 4 and CCR 5 , CXCR 4 , or the orphan receptor Bonzo or BOB . ^^^ Unlike HIV 1 , many of the HIV 2 isolates were promiscuous in their coreceptor usage in that they were able to use , apart from CCR 5 , one or more of the CCR 1 , CCR2b , CCR 3 , and BOB coreceptors . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
All isolates could use CCR 5 as coreceptor , whereas no isolates could use CCR2b , CCR 3 , CCR 5 , CXCR 4 , Bonzo / STRL33 , or BOB / GPR15 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Effects of plasma HIV RNA , CD4+ T lymphocytes , and the chemokine receptors CCR 5 and CCR2b on HIV disease progression in hemophiliacs . ^^^ We have investigated the effects of plasma HIV RNA , CD4+ T lymphocytes and chemokine receptors CCR 5 and CCR2b on HIV disease progression in hemophiliacs . ^^^ Genoytpe variants CCR2b 641 and CCR 5 delta32 were detected using standard molecular techniques . ^^^ Those with the mutant allele for CCR2b , and to a lesser extent CCR 5 , had lower plasma HIV RNA , and higher CD4+ T lymphocytes than did those without these genetic variants . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
TCS also significantly augmented chemokine stimulated activation of chemokine receptors CCR 5 and CXCR 4 as well as CCR 1 , CCR2B , CCR 3 , and CCR 4 transiently expressed in HEK 293 cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Although the CD 4 CXCR4 hybrids yielded enhanced SU interactions with the chemokine receptor moiety , this did not overcome the specific coreceptor requirement of different HIV 1 strains : the X 4 virus HIV 1 ( LAI ) and the X4R5 virus HIV 1 ( 89 . 6 ) , unlike the R 5 strain HIV 1 ( SF 162 ) , infected Mv 1 lu cells expressing the CD 4 ( 2D ) CXCR 4 hybrid , but none could use hybrids of CD 4 and the chemokine receptor CCR2b , CCR 5 , or CXCR 2 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
No evidence for an effect of the CCR 5 delta32 / + and CCR2b 64I / + mutations on human immunodeficiency virus ( HIV ) 1 disease progression among HIV 1 infected injecting drug users . ^^^ The relationship between CCR 5 and CCR2b genotypes and human immunodeficiency virus ( HIV ) 1 disease progression was studied among the 108 seroconverters of the Amsterdam cohort of injecting drug users ( IDUs ) . ^^^ In contrast to earlier studies among homosexual men , no effect on disease progression of the CCR 5 Delta32 / + and the CCR2b 64I / + genotypes was found , when progression to AIDS , death , or a CD 4 cell count < 200 / microL was compared by a Cox proportional hazards model . ^^^ Furthermore , CD 4 cell decline ( by a regression model for repeated measurements ) and virus load in the first 3 years after seroconversion did not differ between the CCR 5 and CCR2b wild type and heterozygous genotypes . ^^^ A nested matched case control study also revealed no significant effect of the CCR 5 and CCR2b mutations . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The inhibition of beta chemokine receptors by TAK 779 appeared to be specific to CCR 5 because the compound antagonized CCR2b to a lesser extent but did not affect CCR 1 , CCR 3 , or CCR 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Fluorocytometry and calcium mobilization assay did not provide evidence of expression of any of the major HIV 1 coreceptors , including CXCR 4 , CCR 5 , CCR 3 , and CCR2b , as well as the CD 4 molecule on the cell surface of human fetal astrocytes . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor CCR 5 and to a lesser extent CCR2b and CCR 3 have been shown to serve as coreceptors for HIV 1 entry into macrophages . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The occurrence of protective genotypes in CCR 5 , CCR2b , and SDF 1 ( stromal cell derived factor 1 ) genes and susceptibility to infection by HIV 1 were also studied . ^^^ Genetic analysis of CCR 5 , CCR2b , and SDF 1 showed several polymorphisms associated with resistance in some HIV exposed uninfected hemophiliacs . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Encoded here are two chemokine receptors , CCR 5 and CCR2B . ^^^ We examined the chromosome 3p21 24 region in 125 MS families ( 322 total affecteds and 200 affected sib pairs ) , and performed genetic analyses of CCR 5 and CCR2B loci and two nearby markers ( D3S1289 and D3S1300 ) using both linkage and association based tests . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Human chemokine receptors CCR 5 , CCR 3 and CCR2B share common polarity motif in the first extracellular loop with other human G protein coupled receptors implications for HIV 1 coreceptor function . ^^^ Similar hydrophobicity motifs were found in the first extracellular loops of the CRs CCR 5 , CCR 3 , and CCR2B , and are all used by M tropic HIV 1 for cell entry . ^^^ The potential biological significance of the identified structural motif shared by the human CCR 5 , CCR 3 , CCR2B and other GPCRs is discussed . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Expression of CCR2b , CCR 4 , CCR 5 , and CXCR 4 was unchanged or decreased after IFN alpha treatment . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Biological HIV 1 clones were isolated both early and late in infection from progressors and long term survivors with wild type or mutant CCR 5 or CCR2b genotypes and analyzed for their capacity to use CCR 1 , CCR2b , CCR 3 , CCR 5 , and CXCR 4 on U 87 cells coexpressing CD 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Mutations in CCR 5 and CCR2b have been recently shown to affect disease progression towards AIDS . ^^^ This study demonstrates the successful use of PCR techniques to isolate host CCR 5 and CCR2b , and HIV 1 V 3 sequences from paraffin embedded tissues from patients with and without ADC . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD4 and GHOST ( 3 ) engineered to express stably CD 4 and the chemokine receptors CCR 1 , CCR2b , CCR 3 , CCR 5 , or CXCR 4 , or the orphan receptors BOB / gpr15 or Bonzo / STRL33 / TYMSTR . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Of the eight NSI isolates , three used CCR 5 only , two used CCR 5 and CCR2b , one used CCR 5 and CCR 3 , and one used CCR 5 , CCR 3 , and CCR2b . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Therefore , the expression of monocyte chemoattractant protein 1 ( MCP 1 ) , its receptor chemokine receptor 2B ( CCR2B ) , and CCR 5 in human cGN was studied . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
No transcripts corresponding to CCR2b , CCR 5 , or CCR 8 were detected . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In contrast to the parent recombinant , the rB 15 and rV1V2 pseudotypes retained their infectability in cells expressing low levels of CD 4 independent of the levels of CCR 5 , and they infected cells expressing CD 4 with a chimeric coreceptor containing the third extracellular loop of CCR2b in the context of CCR 5 or a CCR 5 Delta4 amino terminal deletion mutant . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Genetic polymorphism in the CCR 5 , CCR2b , or SDF 1 genes appeared not to be associated with resistance in the Ethiopian CSWs . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We also tested this clone for its ability to use the chemokine receptors CCR 1 , CCR2b , CCR 3 , CXCR 4 , and CCR 5 and found that the clone utilizes only CCR 5 as the coreceptor for cell entry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
In this report , we present the cloning and comparison of 11 rhesus macaque chemokine receptors and receptor like proteins ( CCR 1 , CCR2b , CCR 3 , CCR 5 , CCR 8 , CXCR 4 , STRL 33 , GPR 1 , GPR 15 , APJ , and CRAM A / B ) , the human counterparts of which have been previously shown to be utilized by SIV for entry . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
The CCR 5 24 bp deletion previously described in red capped mangabeys from Gabon was also observed in Nigerian red capped mangabeys , and SIVrcmNG 411 , like SIVrcmGB 1 , used CCR2B and STRL 33 as coreceptors for virus entry . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Of the nine X 4 tropic isolates , seven also used at least one of the following coreceptors : CCR 8 , CCR 1 , CCR2b , or CX3CR1 , and none employed CCR 5 as an additional coreceptor . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Heterozygosity for CCR 5 Delta32 but not CCR2b 64I protects against certain intracellular pathogens . ^^^ OBJECTIVE : To determine the association between CCR 5 and CCR2b genotype and the clinical manifestation of first and subsequent AIDS defining illnesses ( ADIs ) . ^^^ METHODS : The distribution of ADIs was examined by CCR 5 and CCR2b genotype in a subset of homosexual men enrolled in the Sydney AIDS Prospective Study . ^^^ Of these individuals , 17 were heterozygous for the CCR 5 Delta32 mutation and 11 were heterozygous for CCR2b 64I . ^^^ CONCLUSION : Results from this study show that heterozygosity for CCR 5 Delta32 but not CCR2b 64I appears to protect against opportunistic infections . . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Here we demonstrate that , like the CC chemokine receptors CCR 5 and CCR2b , CXCR 4 is posttranslationally modified by sulfation of its amino terminal tyrosines . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Characterization of the chemokine receptor specificity of MIP 1 beta ( 3 69 ) showed that the truncated protein not only shares the ability of intact MIP 1 beta to induce Ca ( 2+ ) signaling through CCR 5 , but unlike the full length protein , it also triggers a Ca ( 2+ ) response via CCR 1 and CCR2b . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Grape seed extract proanthocyanidins downregulate HIV 1 entry coreceptors , CCR2b , CCR 3 and CCR 5 gene expression by normal peripheral blood mononuclear cells . ^^^ Recent studies documented that the beta chemokine receptors , CCR2b , CCR 3 and CCR 5 , and the alpha chemokine receptors , CXCR 1 , CXCR 2 and CXCR 4 serve as entry coreceptors for HIV 1 . ^^^ Our results showed that GSE significantly downregulated the expression of the HIV 1 entry co receptors , CCR2b , CCR 3 and CCR 5 in normal PBMC in a dose dependent manner . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Population survey of CCR 5 delta32 , CCR 5 m303 , CCR2b 64I , and SDF 1 3 ' A allele frequencies in indigenous Chinese healthy individuals , and in HIV 1 infected and HIV 1 uninfected individuals in HIV 1 risk groups . ^^^ The aim of this study is to determine in indigenous Chinese ethnic groups the frequencies of the chemokine ( SDF 1 3 ' A ) and chemokine receptors ( CCR 5 delta32 , CCR 5 m303 , and CCR2b 64I ) HIV 1 / AIDS restriction alleles . ^^^ The variant allele frequencies were determined to be 0 % to 3 . 48 % for CCR 5 delta32 , 0 % for CCR 5 m303 , 16 . 23 % to 28 . 79 % for CCR2b 64I , and 17 . 70 % to 27 . 76 % for SDF 1 3 ' A in Chinese healthy individuals from eight ethnic groups . ^^^ These findings show that allele frequencies differ among the eight Chinese ethnic groups for CCR 5 delta32 , CCR2b 64I , and SDF 1 3 ' A and that the CCR 5 m303 and CCR 5 delta32 mutant alleles were absent or infrequent in Chinese , which may be helpful for studies of specific anti HIV 1 vaccine trials and coreceptor inhibitor drug targets in Chinese populations . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Allelic variation in chemokine receptor genes can markedly affect the course of HIV disease ; consequently , we analyzed CCR 5 and CCR2B genotypes among a cohort of HIV 1 infected individuals that received IL 2 therapy . ^^^ Samples from 47 trial participants ( 25 CIV IL 2 group ; 22 placebo group ) were analyzed for CCR 5 and CCR2B genotype . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Hormonal and embryonic regulation of chemokine receptors CXCR 1 , CXCR 4 , CCR 5 and CCR2B in the human endometrium and the human blastocyst . ^^^ The aim of this study was to investigate mRNA expression and protein levels of chemokine receptors CXCR 1 , CXCR 4 , CCR 5 and CCR2B in human endometrium throughout the menstrual cycle , during HRT and in the human blastocyst . ^^^ We found up regulation of endometrial CXCR 1 mRNA ( 419 fold increase ) , CCR 5 mRNA ( 612 fold increase ) and CCR2B mRNA ( 657 fold increase ) during the luteal phase peaking in the pre menstrual endometrium . ^^^ Immunoreactive CCR 5 and CCR2B receptors were detected in human blastocysts whereas CXCR 4 and CXCR 1 were not present . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Individuals with CTL activity ( HIV 1 env ( IIIB ) or pol or gag ) were then compared to those without CTL activity in relation to plasma HIV 1 RNA , ICD p 24 antigen , beta ( 2 ) microglobulin , CD 4 and CD 8 T cell counts , CCR 5 and CCR2b genotypes , and progression to CD 4 < 500 cells / microl or commencement of antiretroviral treatment . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
CD4 and GHOST ( 3 ) , expressing CD 4 and CCR 1 , CCR2b , CCR 3 , CCR 5 , CXCR 4 , CXCR 6 or BOB . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Given similar post translational modification of other receptors , including CCR 5 , CX3CR1 and CCR2b , tyrosine sulfation may be of universal importance in chemokine signaling . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
AMD 3100 did not inhibit calcium flux against cells expressing CXCR 3 , CCR 1 , CCR2b , CCR 4 , CCR 5 or CCR 7 when stimulated with their cognate ligands , nor did it inhibit receptor binding of LTB 4 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
We observed that curcumin inhibited Abeta 1 40 induced expression of CCR 5 but not of CCR2b in THP 1 cells . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines , MCP 1 , and MIP 1 beta , while reciprocally upregulating the expression of their specific receptors , CCR2b , CCR 3 , and CCR 5 as detected by real time quantitative PCR . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
ST chemokine ( CCL2 / MCP 1 , CCL5 / RANTES , CCL7 / MCP 3 , CCL8 / MCP 2 , CCL14 / HCC 1 , CCL15 / HCC 2 , CCL16 / HCC 4 ) , chemokine receptor ( CCR 1 , CCR2b , CCR 5 , CXCR 4 ) , and CD 13 expression was analysed by immunohistochemistry and two colour immunofluorescence . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Chemokine receptors CCR2b and CCR 4 were potently induced by RANKL ( 12 . 6 and 49 fold , P = 4 . 0 10 10 ( 7 ) and 4 . 0 10 10 ( 8 ) , respectively ) , while CCR 1 and CCR 5 were not regulated . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
Previous work has shown that IL 16 / CD4 induces desensitization of both CCR 5 and CXCR 4 induced migration , with no apparent effect on CCR2b or CCR 3 . ^^^
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P41597 and P51681	Pubmed	SVM Score :0.0
NA