| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| Up regulation of CC chemokine , CCL3L1 , and receptors , CCR 3 , CCR 5 in human glioblastoma that promotes cell growth . ^^^ To examine gene expression of chemokine , CCL3L1 , and its receptors , CCR 1 , CCR 3 and CCR 5 , we analyzed tumor tissues from 21 patients with several types of primary gliomas . ^^^ CCL3L1 , CCR 3 and CCR 5 gene exhibited over expression in 70 % ( 7 / 10 ) , 60 % ( 6 / 10 ) , and 60 % ( 6 / 10 ) of glioblastoma , in comparison with lower frequencies seen in lower grade gliomas . ^^^ These data suggest that increased expression of the CCL3L1 , CCR 3 and CCR 5 chemokine receptors system is involved in brain tumorigenesis , especially in the progression of glioblastoma . . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 ( MIP 1alphaP ) , a potent human immunodeficiency virus 1 ( HIV 1 ) suppressive chemokine and ligand for the HIV coreceptor CCR 5 . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| The MIP 1 alpha isoform LD 78 beta , that was purified form natural sources , inhibited HIV infection completely in CCR 5 transfected cells , mononuclear leukocytes and purified monocytes at low ( ng / ml ) concentrations . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| Here we show that a non allelic isoform of human MIP 1alpha ( LD78alpha ) , termed LD78beta or MIP 1alphaP , has enhanced receptor binding affinities to CCR 5 ( approximately 6 fold ) and the promiscuous beta chemokine receptor , D 6 ( approximately 15 20 fold ) . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| The LD78beta isoform of MIP 1alpha is the most potent CCR 5 agonist and HIV 1 inhibiting chemokine . ^^^ Using CC chemokine receptor transfected cells , both molecular forms of LD78beta proved to be much more potent than LD78alpha in inducing an intracellular calcium rise through CCR 5 . ^^^ Compared with LD78alpha and RANTES , this preferential binding of LD78beta to CCR 5 resulted in a 10 to 50 fold higher potency in inhibiting infection of peripheral blood mononuclear cells by CCR 5 using ( R 5 ) HIV 1 strains . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| However , CD26 / DPP 4 cleaved LD78beta , a most potent CCR 5 binding chemokine and inhibitor of macrophage tropic human immunodeficiency virus 1 ( HIV 1 ) infection , into LD78beta ( 3 70 ) . ^^^ LD78beta ( 3 70 ) retained its high capacity to induce an intracellular calcium increase in CCR 5 transfected cells . ^^^ CD26 / DPP 4 cleaved LD78beta ( 3 70 ) is the most potent CCR 1 and CCR 5 agonist that retains strong anti HIV 1 activity , indicating the importance of the chemokine protease interaction in normal and pathologic conditions . ( Blood . 2000 ; 96 : 1674 1680 ) . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| The LD78beta isoform of MIP 1alpha is the most potent CC chemokine in inhibiting CCR 5 dependent human immunodeficiency virus type 1 replication in human macrophages . ^^^ LD78beta was recently reported to be a much more potent CCR 5 agonist than LD78alpha and RANTES in inducing intracellular Ca2+ signaling and chemotaxis . ^^^ LD78beta strongly downregulated CCR 5 expression in M / M , thereby explaining its potent antiviral activity . . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| Genetic variations in the receptor ligand pair CCR 5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease . ^^^ However , the magnitude of the reduced risk of KD associated with the CCR 5 Delta 32 allele and certain CCR 5 haplotypes was significantly greater in individuals who also possessed a high copy number of the gene encoding CCL3L1 , the most potent CCR 5 ligand . ^^^ These findings , derived from the largest genetic study of any systemic vasculitis , suggest a central role of CCR 5 CCL3L1 gene gene interactions in KD susceptibility and the importance of gene modifiers in infectious diseases . . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| On the other hand , non MHC encoded genes are CCR 5 , CCR 2 , RANTES , CXCL 12 , CXCR 6 , CCL3L1 , Interleukin 10 ( IL 10 ) , and interferon gamma . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| LD78beta ( 3 70 ) competed tenfold more efficiently than LD78beta ( 1 70 ) with [ 125I ] RANTES for binding to the CC chemokine receptors CCR 5 and CCR 1 . ^^^ Taken together , both LD78beta isoforms are potent HIV 1 inhibitors ( CCR 5 ) and activators for neutrophils ( CCR 1 ) and eosinophils ( CCR 1 , CCR 3 ) , affecting infection and inflammation . . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| Identification of amino acid residues critical for LD78beta , a variant of human macrophage inflammatory protein 1alpha , binding to CCR 5 and inhibition of R 5 human immunodeficiency virus type 1 replication . ^^^ In an attempt to determine which amino acid ( s ) of LD78beta , a variant of human macrophage inflammatory protein 1alpha , plays a critical role in the interaction with CCR 5 , we generated six LD78beta variants with an amino acid substituted to Ala at the NH ( 2 ) terminus of LD78beta . ^^^ The present data suggest that Pro 2 , Asp 6 , Pro 8 , and Thr 9 are critical for LD78beta binding to CCR 5 and HIV 1 replication inhibition , and that LD78beta binding to CCR 5 , regardless of affinity , is sufficient for the initial signal transduction of LD78beta , whereas the greater anti HIV 1 activity requires the greater magnitude of binding . ^^^ The data also suggest that LD78beta variants with appropriate amino acid substitution ( s ) such as LD78beta ( D6A ) and LD78beta ( P8A ) may represent effective chemokine based anti HIV 1 therapeutics while preserving LD78beta CCR 5 interactions . . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| Since both human MIP 1alpha subtypes ( LD78alpha and LD78beta ) and MIP 1beta signal through CCR 5 , the major co receptor for M tropic HIV 1 strains , these chemokines are capable of inhibiting HIV 1 infection in susceptible cells . ^^^ |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16619 and P51681 |
Pubmed |
SVM Score :0.0 |
| NA |
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