Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.51674656
In this regard , the interaction between CCL 5 and CCR 5 may be critical in regulating T cell functions , by mediating their recruitment and polarization , activation , and differentiation . 0.51674656^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.85613684
RANTES interacts with CCR 5 and SDF 1 with CXCR 4 receptors . 0.85613684^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.69665622
We demonstrate that the key region of CCR 5 involved in its specific interaction with MIP 1alpha , MIP 1beta , and RANTES , and its subsequent activation , lies within the second extracellular loop ( and possibly the adjacent transmembrane segments ) . 0.69665622^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.80144698
RANTES also caused a loss of cell surface CCR 5 , although its effect was less than with AOP RANTES . 0.80144698^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.81035078
RANTES binds CCR 5 and inhibits HIV 1 entry into peripheral blood cells . 0.81035078^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.58691154
These included derivatives of a CCR 5 ligand , RANTES , with modified N termini as well as Kaposi ' s sarcoma associated herpesvirus encoded chemokines that bind a wide range of co receptors , including CCR 5 , CXCR 4 , CCR 3 and CCR 8 , as well as the orphan 7TM receptors GPR 1 and STRL 33 . 0.58691154^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.61817084
Coimmunoprecipitation studies demonstrate that RANTES forms complexes with glycanated syndecan ( SD ) 1 and 4 , in addition to CCR 5 on the CCR 5 positive HeLa cells . 0.61817084^^^ Therefore , RANTES bindings to SD 1 and 4 depend on glycosaminoglycans and facilitate RANTES interaction with CCR 5 . 0.60743978^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.69297683
This suggests that glycosaminoglycans ( GAGs ) are involved in RANTES binding to the PGs and that such bindings facilitate the subsequent interaction of RANTES with CCR 5 , on the MDM , characterized by low membrane expression of CCR 5 . 0.69297683^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.7047178
We recently demonstrated that RANTES forms complexes with CCR 5 , syndecan 1 ( SD 1 ) , SD 4 , and CD 44 expressed by human primary macrophages and that SD 1 and SD 4 but neither CD 44 nor SD 2 coimmunoprecipitate with CCR 5 . 0.7047178^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Blocking Gi protein coupled receptor signaling by pertussis toxin as well as deficiencies in G alpha 12 , chemokine receptor 2 ( CCR 2 ) , CCR 5 , chemokine ligand 2 ( CCL 2 , also known as monocyte chemoattractant protein 1 , or MCP 1 ) , CCL 3 ( macrophage inflammatory protein 1 alpha , or MIP 1 alpha ) and CCL 5 ( RANTES ) have all been found to have effects on the magnitude and cytokine polarity of the T cell response . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This process , triggered by CCL 5 binding to CCR 5 , is not mediated by TNFalpha , Fas , or caspase 8 . ^^^ The effect is not unique to CCL 5 , as other CCR 5 ligands such as CCL 3 ( MIP 1alpha ) and CCL 4 ( MIP 1beta ) also trigger TIL cell death , nor is it limited to melanoma cells , as it also operates in activated primary T lymphocytes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
It was shown that residues in the N ter are necessary for binding of the physiologic ligands , RANTES ( CCL 5 ) and MIP 1 alpha ( CCL 3 ) . vMIP 2 , encoded by the Kaposi ' s sarcoma associated herpesvirus , is a high affinity CCR 5 antagonist , but lacks efficacy as a coreceptor inhibitor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CC chemokine receptor 5 ( CCR 5 ) binds the chemokine ligands RANTES ( CCL 5 ) and MIP 1alpha ( CCL 3 ) , which have been implicated in the development of alveolitis in sarcoidosis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
An abortive ligand induced activation of CCR 1 mediated downstream signaling event and a deficiency of CCR 5 expression are associated with the hyporesponsiveness of human naive CD4+ T cells to CCL 3 and CCL 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We also determined that CCR 5 binding chemokines MIP 1alpha ( CCL 3 ) , CCL 4 , and RANTES ( CCL 5 ) , specifically by signaling through CCR 5 , could affect all progenitor B cell populations through a novel mechanism involving heterologous desensitization of CXCR 4 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We examined the responses of human peripheral blood T cells , present in an ECM like context , to combinatorial signaling transduced by SDF 1alpha ( CXCL 12 ) , and two CCR 5 ligands , RANTES ( CCL 5 ) and MIP 1beta ( CCL 4 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In parallel , CCR 1 and CCR 5 expression is down regulated and CXCL 8 , CCL 2 , CCL 3 and CCL 5 production is up regulated . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
IL 8 activation of CXCR 1 , but not the IL 8 receptor CXCR 2 , cross phosphorylated CCR 5 and CXCR 4 and cross desensitized their responsiveness to RANTES ( regulated on activation normal T cell expressed and secreted ) ( CCL 5 ) and stromal derived factor ( SDF 1 or CXCL 12 ) , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
ATG were shown to bind to CXCR 4 and CCR 7 on lymphocytes , CXCR 4 , and CCR 5 on monocytes ; to down modulate cell surface expression of CCR 7 ; and to decrease monocyte chemotactic response to CCL 5 ( RANTES ) and lymphocyte chemotactic response to CCL 19 ( MIP 3beta ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
To test the in vivo relevance of this , we used a murine melanoma system and knockout mice to investigate the function of the chemokine receptor CCR 5 and its ligands , CCR ligand ( CCL ) 3 and CCL 5 . ^^^ In contrast , the loss of the CCR 5 ligand , CCL 3 , led to an early delay in tumor growth that did not persist , while the absence of the CCR 5 ligand , CCL 5 , had no effect . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , the presence of CCL 5 and CXCL 10 in the cytolytic granules of tissue infiltrating CD 8 ( + ) T cells expressing CCR 5 and CXCR 3 reveals a potential self recruiting mechanism involving activated effector cytotoxic T cells . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In addition , the relative roles of the chemokines that bind CXCR 3 ( CXCL 9 , CXCL 10 , CXCL 11 ) and CCR 5 ( CCL 3 , CCL 4 , CCL 5 ) in this process are unknown . ^^^ Thus , CXCR 3 ligands are more chemotactic than CCR 5 ligands in vitro ; however , in vivo , CXCL 10 and CCL 5 have comparable T cell recruiting activities to cutaneous sites and are more potent than the other CXCR 3 and CCR 5 chemokines . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In situ hybridization histochemistry revealed local production of the CCR 1 ligands CCL 3 ( MIP 1 alpha ) and CCL 5 ( RANTES ) , as well as large numbers of CCR 1 and CCR 5 expressing cells within inflammatory brain lesions . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Pharmacological regulation of CCL 5 and CCR 5 expression was therefore explored in bronchoalveolar cells obtained from patients with DLD . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor , CCR 5 , is a G protein coupled receptor responsible for some of the effects of the chemokines CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The focus of TGFbeta inhibition is observed to be directed in genes involved in chemotaxis ( IL 15 , CXCL 1 , CXCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 9 ) , chemokine receptors ( CCR 5 , CCR 9 ) , LIF receptor , and FPR 2 , and on genes mediating cell migration ( MMP 9 , MMP 13 , MacMARCKS , endothelin receptor B , Ena / VASP , Gas 7 ) , apoptosis ( FAS , TNF , TNF receptor , caspase 1 and 11 ) , and host response to infection ( toll like receptor 6 , Mx 1 , and MARCO ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
One anti CXCR 4 factor is macrophage derived chemokine ( chemokine ligand 22 , CCL 22 ) , and anti CCR 5 factors include macrophage inflammatory protein 1 alpha ( CCL 3 ) , macrophage inflammatory protein 1 beta ( CCL 4 ) , and RANTES ( regulated upon activation of normal T cells expressed and secreted ) ( CCL 5 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We found that CCL 5 ( RANTES ) was produced by the tumor cells , and its receptors , CCR 1 and CCR 5 , were expressed by the leukocyte infiltrate . ^^^ As Met CCL 5 is an antagonist of CCR 1 and CCR 5 with activity in models of inflammatory disease , we tested its activity against 410 . 4 tumors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Our data also suggest a self recruiting mechanism involving CCR 5 and CCL 5 for tissue accumulation of such T cells . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We now show that islet allograft rejection is associated with a steady increase in intragraft expression of the chemokines CCL 8 ( monocyte chemoattractant protein 2 ) , CCL 9 ( monocyte chemoattractant protein 5 ) , CCL 5 ( RANTES ) , CXCL 10 ( IFN gamma inducible protein 10 ) , and CXCL 9 ( monokine induced by IFN gamma ) and their corresponding chemokine receptors CCR 2 , CCR 5 , CCR 1 , and CXCR 3 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
DAMGO pretreatment enhanced phosphorylation of the chemokine CCR 5 receptor and reduced RANTES ( CCL 5 ) promoted [ 35S ] GTP gamma S binding . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In addition , chemotaxis toward the CCR 1 and CCR 5 ligands CCL 3 and CCL 5 was also increased . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In view of these findings and the CCL 5 ( RANTES , the CCR 5 ligand ) expression by pancreatic islets , we treated NOD mice with a neutralizing anti CCR 5 antibody . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the production of dynamic alpha and beta chemokines represented by interleukin 8 ( IL 8 ) as alpha chemokine and CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , ( CCL 5 , regulated upon activation , normal T cell expressed and secreted ( RANTES , CCR 5 ligand ) as beta chemokines by the human intestinal cell line INT 407 stimulated with factors produced by living Campylobacter jejuni ( C . jejuni ) and those present within sonicated and filtrated bacteria . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Three CC chemokines MIP 1alpha ( CCL 3 ) , MIP 1beta ( CCL 4 ) , and RANTES ( CCL 5 ) are natural ligands for the human immunodeficiency virus 1 ( HIV 1 ) coreceptor CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In particular , the interaction between chemokines CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) and CCL 5 ( RANTES ) and their receptor , CC chemokine receptor 5 ( CCR 5 ) , may be critical in regulating T cell functions by mediating recruitment , polarization , activation and differentiation of antiviral type 1 cytokine secreting T helper and cytotoxic T cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This was associated with reduced renal expression of CC chemokines CCL 2 , CCL 3 , CCL 4 , and CCL 5 and the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 bound RANTES ( CCL 5 ) and MIP 1beta ( CCL 4 ) only exhibit pH dependent dissociation at pH < 4 . 0 , below the values normally found in endocytic organelles . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In the present study , we report that two CCR 5 ligands , CCL 4 and CCL 5 , are expressed in gut tissues after Ag feeding . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We then examined whether ligation of CD 4 , CCR 5 and \ or CXCR 4 , the receptor and coreceptors of human immunodeficiency virus envelope gp 120 , respectively , affected DC activation or maturation , neither a monoclonal antibody to the gp 120 binding site on CD 4 nor CCL 5 nor CXCL 12 , the natural ligands of CCR 5 and CXCR 4 , respectively , nor gp 120 altered the DC activation and maturation processes . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
M . tuberculosis infection causes an increase in the expression of beta chemokines CCL 3 , CCL 4 , and CCL 5 , and their receptor CCR 5 , in the lungs . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Higher levels of CCL 7 were present in cultures of IIP fibroblasts compared with non IIP fibroblasts , and CCL 5 , a CCR 5 agonist , significantly increased the synthesis of CCL 7 by UIP fibroblasts . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Differentiated human NT 2 N neurons were shown to express CCR 5 and CXCR 4 chemokine receptor mRNA and protein , and to be responsive to the chemokines CCL 5 and CXCL 12 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
These results indicate that CCR 1 , CCR 5 , and CCL 3 cooperatively contribute to the cutaneous Arthus reaction , and also suggest that enhanced expression of CCL 3 and CCL 5 compensates for the loss of CCR 1 , CCR 5 , and CCL 3 in the reaction . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
AMD 3451 dose dependently inhibited the intracellular Ca ( 2+ ) signaling induced by the CXCR 4 ligand CXCL 12 in T lymphocytic cells and in CXCR 4 transfected cells , as well as the Ca ( 2+ ) flux induced by the CCR 5 ligands CCL 5 , CCL 3 , and CCL 4 in CCR 5 transfected cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
To do this , they have characterised haplotypes comprising alleles at 11 biallelic loci in four chemokine receptor genes ( CCR 3 , CCR 2 , CCR 5 and CCRL 2 ) , which span 150 kb on chromosome 3p21 , and haplotyes of nine biallelic loci in six chemokine genes [ MCP 1 ( CCL 2 ) , Eotaxin ( CCL 11 ) , RANTES ( CCL 5 ) , MPIF 1 ( CCL 23 ) , PARC ( CCL 18 ) and MIP 1alpha ( CCL 3 ) ] on chromosome 17q11 12 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
For CCR 5 , agonists such as the chemokine CCL 5 induce internalization into early endosomes containing the transferrin receptor , a marker for clathrin dependent endocytosis , but it has been suggested that CCR 5 may also follow clathrin independent routes of internalization . ^^^ Using CCR 5 transfected cell lines , immunofluorescence , and electron microscopy , we demonstrate that CCL 5 causes the rapid redistribution of scattered cell surface CCR 5 into large clusters that are associated with flat clathrin lattices . ^^^ Invaginated clathrin coated pits could be seen at the edge of these lattices and , in CCL 5 treated cells , these pits contain CCR 5 . ^^^ Receptors internalized via clathrin coated vesicles follow the clathrin mediated endocytic pathway , and depletion of clathrin with small interfering RNAs inhibits CCL 5 induced CCR 5 internalization . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Four cell lines also expressed CCR 5 , a receptor for CCL 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The expression of CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , CCL 5 ( RANTES ) and their main receptors ( CCR 1 and CCR 5 ) was studied by semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry in a series of 16 IIM and five controls ( four normal muscles and one tonsil ) . ^^^ CCL 5 expression was low , restricted to a few inflammatory cells in all IIM ; CCR 1 expression was mainly restricted to macrophages and s IBM endothelial cells , whereas CCR 5 was localized in inflammatory cells invading non necrotic muscle fibres . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , 873140 blocked the calcium response effects of CCR 5 activation by CCL 5 ( RANTES ) ( as did the other antagonists ) , indicating a unique divergence of blockade of function and binding with this antagonist . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We investigated the role played by chemokine receptor 5 ( CCR 5 ) in the influx of T cells to the cardiac tissue of T . cruzi infected mice . mRNA and protein for the CCR 5 ligands CCL 3 , CCL 4 , and CCL 5 were detected in the hearts of infected mice in association with CD4+ and CD8+ T cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULT : The chemokines of CCL 11 ( eotaxin 1 ) , CCL 24 ( eotaxin 2 ) , CCL 7 ( MCP 3 ) , CCL 13 ( MCP 4 ) , RANTES ( CCL 5 ) and receptors of CCR 2 , CCR 3 , CCR 4 , CCR 5 were differential expressed on four samples , and most of the chemokines and their receptors has tendency regulation on T help 2 ( Th 2 ) lymphocytes and involved in the prodeeds such as inducement of allergic reaction , accumulation of inflammacytes and degranulation of sensitized cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
From each blood sample PBMCs were separated and gene expression levels for chemokines CCL 3 , CCL 4 , CCL 5 , CXCL 10 , and their receptors CCR 1 , CCR 5 , and CXCR 3 , were determined using real time quantitative PCR . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Similar kinetics of expression were found for the chemokines CCL 5 , CCL 4 , CCL 3 and CXCL 10 and for the receptors CCR 5 and CXCR 3 , all of them linked to the Th 1 type pattern . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In vitro and in vivo studies in human cell lines and primary T cells showed that synthetic peptides containing these residues blocked responses induced by the CCR 5 ligand CCL 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Met RANTES , an amino terminal modified methionylated form of RANTES ( CCL 5 ) , antagonizes the binding of the chemokines RANTES and macrophage inflammatory protein 1alpha ( MIP 1alpha ; CCL 3 ) to their receptors CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Through analysis of mononuclear cell infiltration in WT and IL 6 deficient mice during peritoneal inflammation , we now report that IL 6 selectively governs T cell infiltration by regulating chemokine secretion ( CXCL 10 , CCL 4 , CCL 5 , CCL 11 , and CCL 17 ) and chemokine receptor ( CCR 3 , CCR 4 , CCR 5 , and CXCR 3 ) expression on the CD3+ infiltrate . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Variants of CCR 5 , which are permissive for HIV 1 infection , show distinct functional responses to CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULTS : Abundant expression of CCR 1 , CXCR 4 , and CCR 5 was found in all forms of arthritis , with a specific increase of CCL 5 and CCL 15 in RA . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Stimulation with CCL 5 of RBL cells , which co expressed CCR 5 together with an N terminally truncated CCR 5 DeltaNT mutant , resulted in both protein kinase C ( PKC ) and G protein coupled receptor ( GPCR ) kinase ( GRK ) mediated cross phosphorylation of the mutant unligated receptor , as determined by phosphosite specific monoclonal antibody . ^^^ Co expression of CCR 5 DeltaNT together with a phosphorylation deficient CCR 5 mutant that neither binds beta arrestin nor undergoes internalization partially restored the CCL 5 induced association of beta arrestin with the homo oligomeric receptor complex and augmented cellular uptake of ( 125 ) 1 CCL 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Expression of CCL 5 ( RANTES ) and CCR 5 in prostate cancer . ^^^ CCL 5 was shown to induce breast cancer cell migration , mediated by the receptor CCR 5 . ^^^ Recently , CCL 5 and CCR 5 mRNA expression was reported in prostate cancer ( PCa ) tissues . ^^^ Herein , we characterized CCL 5 and CCR 5 expression in cultures of PCa cells and explored possible functions of CCL 5 in PCa progression . ^^^ Proliferation and invasion assays were performed to determine potential functions of CCL 5 and CCR 5 in PCa . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCL 5 CCR 5 interaction provides antiapoptotic signals for macrophage survival during viral infection . ^^^ The protective effect of Ccl 5 requires activation of the Ccr 5 chemokine receptor and consequent bilateral activation of G ( alphai ) PI3K AKT and G ( alphai ) MEK ERK signaling pathways . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Serum ELISAs were performed to detect the CCR 5 ligands CCL 5 , CCL 3 ; the CXCR 3 ligands CXCL 10 , CXCL 9 ; and the CCR 4 ligand , CCL 17 before and after administration of the TNFalpha blocking agent infliximab . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Central nervous system ( CNS ) expression of the chemokine receptor CCR 5 and its ligand CCL 5 was prominently up regulated by WNV , and this was associated with CNS infiltration of CD4+ and CD8+ T cells , NK1 . 1+ cells and macrophages expressing the receptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The majority of genes with higher expression in BA positive mice encoded proinflammatory cytokines involved in the Th 1 pathway , such as CCL 2 , CCL 5 , CCR 5 , CXCL 10 , CCL 2 , IL1F5 and in apoptosis , such as DDR 3 and granzyme A and B . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Such T cells coexpressed the chemokine receptors CCR 7 , CCR 5 , and CXCR 4 and migrated in response to both inflammatory chemokines ( CCL 5 ) and homing chemokines ( CXCL 12 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In contrast , YM 355179 did not affect the binding of CCL 5 to CCR 1 or CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Ocular herpes simplex virus type 1 ( HSV 1 ) infection elicits a strong inflammatory response that is associated with production of the beta chemokines CCL 3 and CCL 5 , which share a common receptor , CCR 5 . ^^^ However , by day 7 post infection , the CCR 5 / mice showed a significant elevation in the chemokines CCL 2 , CCL 5 , CXCL 9 and CXCL 10 in the trigeminal ganglion and brainstem , as well as a significant increase in virus burden . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Associations of polymorphisms in CCL 5 ( G 403A ) and its receptor CCR 5 ( Delta 32 ) , CCL 2 ( A 2578G ) and CCR 2 ( V64I ) , and CX3CR1 V249I and T280M with coal worker ' s pneumoconiosis ( CWP ) were investigated in 209 miners examined in 1990 , 1994 and 1999 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Because the chemokine receptor CCR 5 and its ligands ( CCL 3 , CCL 4 , and CCL 5 ) regulate leukocyte chemotaxis and activation , we investigated the role of CCR 5 during Con A induced liver injury . ^^^ CCR 5 / mice also exhibited increased production of interleukin 4 , tumor necrosis factor alpha , CCL 3 , CCL 4 , and CCL 5 , and a prominent liver mononuclear cell infiltrate , among which many cells were CCR1+ . ^^^ In vivo neutralization of CCR 5 ligands in CCR 5 / mice afforded a protection against hepatitis only when CCL 5 was neutralized . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 usage by CCL 5 induces a selective leukocyte recruitment in human skin xenografts in vivo . ^^^ To address this question , we used a humanized severe combined immunodeficient mouse model grafted with human skin and autologous leukocytes , and evaluated the effect of a blocking antibody against human CCR 5 , on CCL 5 induced cutaneous leukocyte recruitment in vivo . ^^^ In vivo , anti CCR 5 antibody was able to almost completely inhibit the recruitment of monocytes / macrophages and T helper ( Th ) 1 type cells to inhibit partially the attraction of memory T cells , but had no effect on eosinophil infiltration , although all these cell types express other CCL 5 binding chemokine receptors than CCR 5 . ^^^ These results indicate that the in vivo environment regulates target cell specificity of CCL 5 leading to differential cell recruitment , suggesting that antagonizing CCR 5 receptor may be of therapeutic value in diseases such as acquired immuno deficiency syndrome , where CCL5 / CCR5 , monocytes , and Th 1 type cells play a predominant role . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCL 5 CCR 5 mediated apoptosis in T cells : Requirement for glycosaminoglycan binding and CCL 5 aggregation . ^^^ CCL 5 ( RANTES ( regulated on activation normal T cell expressed and secreted ) ) and its cognate receptor , CCR 5 , have been implicated in T cell activation . ^^^ CCL 5 induced apoptosis is CCR 5 dependent , since native PM 1 and MOLT 4 cells lacking CCR 5 expression are resistant to CCL 5 induced cell death . ^^^ Viewed altogether , these data suggest that CCL 5 GAG binding and CCL 5 aggregation are important for CCL 5 activity in T cells , specifically in the context of CCR 5 mediated apoptosis . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We found that infection of alveolar epithelial cells with the mouse adapted influenza A virus strain PR / 8 strongly induced the release of monocyte chemoattractants CCL 2 and CCL 5 followed by a strong monocyte transepithelial migration , and this monocytic response was strictly dependent on monocyte CCR 2 but not CCR 5 chemokine receptor expression . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Functional evidence of an interaction between HSP 70 , CCR 5 and CD 40 was shown by enhanced production of CCL 5 by HEK 293 cells transfected with both CD 40 and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage tropic strains of HIV 1 is CC CKR 5 , a receptor for the beta chemokines RANTES , MIP 1alpha and MIP 1beta . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^ CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Molecular cloning and functional characterization of a novel human CC chemokine receptor ( CCR 5 ) for RANTES , MIP 1beta , and MIP 1alpha . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Cloning and functional expression of CC CKR 5 , a human monocyte CC chemokine receptor selective for MIP 1 ( alpha ) , MIP 1 ( beta ) , and RANTES . ^^^ Macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES were all potent agonists for CC CKR 5 ( EC 50 = 3 30 nM ) when calcium flux was measured in transfected HEK 293 cells , yet the apparent binding affinities of the corresponding iodinated chemokines to intact cells expressing the receptor were low ( IC 50 approximately 100 nM ) . ^^^ These data suggest that CC CKR 5 is a G ( 1 ) coupled receptor that may mediate monocyte responses to MIP 1alpha , MIP 1beta , and RANTES . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Macrophage tropic HIV 1 isolates are generally specific for CCR 5 , a receptor for the CC chemokines RANTES , MIP 1alpha , and MIP 1beta , while T cell line tropic viruses tend to use CXCR 4 ( also known as fusin , LESTR , or HUMSTR ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES and other chemokines that interact with CCR 5 and block infection of peripheral blood mononuclear cell cultures inhibit infection of primary macrophages inefficiently at best . ^^^ A derivative of RANTES that was created by chemical modification of the amino terminus , aminooxypentane ( AOP ) RANTES , did not induce chemotaxis and was a subnanomolar antagonist of CCR 5 function in monocytes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Ligation of CCR 5 by the CC chemokines RANTES , MIP 1alpha or MIP 1beta , and of CXCR 4 by the CXC chemokine SDF 1alpha , profoundly inhibits the replication of HIV strains that use these coreceptors for entry into CD 4 ( + ) T lymphocytes . ^^^ We found a rapid and extensive downregulation of CXCR 4 by SDF 1alpha and of CCR 5 by RANTES or the antagonist RANTES ( 9 68 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
There is a close correspondence between the ability of RANTES and macrophage inflammatory proteins 1alpha and 1beta to activate CC chemokine receptor 5 ( CCR 5 ) and the ability to inhibit CCR 5 dependent membrane fusion mediated by the envelope glycoprotein of human immunodeficiency virus ( HIV ) , type 1 . ^^^ The hypothesis that the structural determinants for CC chemokine / CCR5 interactions and CCR 5 HIV 1 fusion co receptor activity may be shared was confirmed by two novel observations : first , the fusion activity supported by two hybrid receptors could be inhibited by both RANTES and monocyte chemoattractant protein 1 , chemokines specific to CCR 5 and CCR2B , respectively ; and second , the chemokine specificity for inhibition of envelope mediated cell fusion matched the agonist profile of these hybrid receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are HIV 1 suppressive factors secreted by CD8+ cells that inhibit NSI viruses . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Physiological ligands of CCR 5 , namely the beta chemokines MIP 1alpha , MIP 1beta , and RANTES , were found to competitively inhibit the V 3 loop CCR 5 interaction . ^^^ We therefore hypothesized that the V 3 loop of gp 120 of macrophage tropic HIV 1 may share a binding site on CCR 5 with MIP 1alpha , MIP 1beta , and RANTES and that the V 3 loop therefore might have some homology with these beta chemokines . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this study we have used alanine scanning mutagenesis to identify residues on RANTES that specifically interact with its receptors CCR 1 , CCR 3 , and CCR 5 for binding and activation . ^^^ The results of this study show that , within the N loop , the side chain of R 17 is necessary for RANTES binding to CCR 1 , F 12 for binding to CCR 3 , and F 12 and I 15 for binding to CCR 5 , thus forming distinct but overlapping binding epitopes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Genetic deletion of one of the MIP1alpha and RANTES receptors , CCR 5 , is associated with protection from infection with HIV 1 in humans , while deletion of the ligand MIP1alpha protects against Coxsackie virus associated myocarditis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
One mAb termed 2D7 completely blocked the binding and chemotaxis of the three natural chemokine ligands of CCR 5 , RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta , to CCR 5 transfectants . ^^^ This mAb was a genuine antagonist of CCR 5 , since it failed to stimulate an increase in intracellular calcium concentration in the CCR 5 transfectants , but blocked calcium responses elicited by RANTES , MIP 1alpha , or MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Finally , AMD 3100 had no effect on the Ca2+ flux induced by the CC chemokines MIP 1alpha , regulated on activation normal T cell expressed and secreted ( RANTES ; also a ligand for CCR 5 ) , or monocyte chemoattractant protein 3 ( a ligand for CCR 1 and CCR2b ) , nor was it able to induce Ca2+ fluxes by itself . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a receptor for the CC chemokines RANTES , Mip1alpha , and Mip1beta , has been identified as a coreceptor for infections by macrophage tropic isolates of human immunodeficiency virus type 1 ( HIV 1 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a specific RANTES , MIP 1alpha and MIP 1 receptor , is used preferentially by non MT 2 tropic HIV 1 and HIV 2 strains and by simian immunodeficiency virus ( SIV ) , whereas CXCR 4 , a receptor for the C 10 C chemokine SDF 1 , is used by MT 2 tropic HIV 1 and HIV 2 , but not by SIV . ^^^ Viral isolates obtained during the asymptomatic stages generally used only CCR 5 as a co receptor and were inhibited by RANTES , MIP 1alpha and MIP 1beta , but not by SDF 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES ( 3 68 ) showed a reduced activity , relative to that of RANTES ( 1 68 ) , with cells expressing the recombinant CCR 1 chemokine receptor , but retained the ability to stimulate CCR 5 receptors and to inhibit the cytopathic effects of HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Human CC chemokine receptor 5 ( CCR 5 ) , mediates the activation of cells by the chemokines macrophage inflammatory protein 1alpha , macrophage inflammatory protein 1beta , and RANTES , and serves as a fusion cofactor for macrophage tropic strains of human immunodeficiency virus type 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES and MIP 1alpha mediate their effects via shared chemokine receptors ( CCRs ) : CCR 1 , CCR 4 , and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Thus , for CCR 5 , the rank order for down regulation was also RANTES , MIP 1beta , MIP 1alpha . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
It also inhibits binding of the CXC chemokine , SDF 1alpha , to CXCR 4 and subsequent signal transduction , but does not itself cause signaling and has no effect on RANTES signaling via CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Particularly important chemokines for activated / memory T cells are the CXCR 3 ligands IP 10 and Mig and the CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha , and macrophage inflammatory protein 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We showed that the neutralization of 89 . 6 in PBMC was not improved when CCR 5 was blocked by having RANTES , MIP 1alpha , and MIP 1beta in the culture medium , indicating that CCR 5 usage was not responsible for the decreased sensitivity to neutralization in PBMC . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
A major advance in understanding human immunodeficiency virus ( HIV ) biology was the discovery that the beta chemokines MIP 1 alpha ( macrophage inflammatory protein 1 alpha ) , MIP 1 beta ( macrophage inflammatory protein 1 beta ) and RANTES ( regulated on activation , normal T cell expressed and secreted ) inhibit entry of HIV 1 into CD4+ cells by blocking the critical interaction between the CCR 5 coreceptor and the V 3 domain of the viral envelope glycoprotein gp 120 [ 1 , 2 ] . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CC chemokine receptor 5 ( CCR 5 ) functions physiologically as a receptor for the leukocyte chemoattractants macrophage inflammatory protein 1alpha , macrophage inflammatory protein 1beta , and RANTES , and functions pathologically as a key cell entry coreceptor for HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Instead , direct cell cell contact between macrophages and cells engineered to express CD40L ( also known as CD 154 ) resulted in the production of large amounts of macrophage inflammatory protein 1alpha and 1beta , and RANTES ( all ligands for CCR 5 ) , and monocyte chemoattractant protein 1 ( a ligand for CCR 2 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Recombinant human RANTES , MIP 1alpha and MIP 1beta which bind to simian CCR 5 , suppressed SIV replication in a dose dependent manner , with RANTES being more effective than the other two chemokines . ^^^ The results suggest that immunization with SIV grown in human CD 4 ( + ) T cells induces CD 8 suppressor factor , RANTES , MIP 1alpha and MIP 1beta which may block CCR 5 receptors and prevent the virus from binding and fusion to CD 4 ( + ) cells . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Serum from these individuals , in contrast to serum from CCR 5 ( + / + ) individuals , competed with radiolabeled RANTES for binding to the CCR 5 receptor and inhibited infection of peripheral blood mononuclear cells with R 5 , but not X 4 , primary isolates of HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CC chemokines MIP 1alpha , MIP 1beta , and RANTES suppress replication of certain HIV 1 strains in cultured PBMC and T cell lines by blocking interaction of gp 120 with CC chemokine receptor 5 ( CCR 5 ) . ^^^ Here we show that exogenous MIP 1alpha , MIP 1beta , and RANTES markedly suppressed replication of CCR 5 tropic HIV 1 strains in blocks of human lymphoid tissue infected ex vivo . ^^^ Moreover , endogenous MIP 1alpha , MIP 1beta , and RANTES were upregulated in tissues infected ex vivo with CXC chemokine receptor 4 tropic but not CCR 5 tropic HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
At 96 h postinfection , CMV infected cells express mRNA of the CMV encoded CC chemokine receptor US 28 but do not express mRNA of other CC chemokine receptors that bind RANTES ( CCR 1 , CCR 4 , CCR 5 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor CCR 5 , that binds M1P 1 alpha , M1P 1 beta and RANTES , was characterized as the main coreceptors for M tropic strains of HIV 1 , the most important for the transmission of the disease . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normal T cell expressed and secreted ) , which are the natural ligands of the CC chemokine receptor CCR 5 , inhibit replication of MT 2 negative strains of HIV 1 by interfering with the ability of these strains to utilize CCR 5 as a coreceptor for entry in CD 4 ( + ) cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Large Kir 3 . 1 dependent currents generated in response to the corresponding chemokines ( SDF 1alpha for CXCR 4 and MIP 1alpha ; MIP 1beta and RANTES for CCR 5 ) were blocked by pertussis toxin , suggesting involvement of inhibitory guanine nucleotide binding proteins . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULTS : Whereas full length and truncated RANTES derivatives bound to beta chemokine receptor CCR 5 with the same affinity as recombinant RANTES , the truncated forms were not chemotactic and acted as CCR 5 antagonists in this respect , although a partial agonist effect was noted on cell metabolism . ^^^ CONCLUSION : These data indicate that through binding to CCR 5 , truncated RANTES derivatives that are devoid of detectable biological effects may represent candidates as drugs to protect both lymphocytes and macrophages from HIV 1 . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Additional mechanistic studies demonstrated that NSC 651016 inhibited chemokine binding to specific chemokine receptors , induced CXCR 4 and CCR 5 receptor internalization , and inhibited chemokine induced chemotaxis by macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , RANTES , and stromal derived factor 1alpha but not monocyte chemotactic protein 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Immunohistochemistry for MIP 1beta , MIP 1alpha , RANTES , eotaxin , and MCP 3 ( ligands for CCR 5 and / or CCR 3 ) revealed the presence of MIP 1beta predominantly in a subpopulation of reactive astrocytes , which were more widespread in AD than control brains , and MIP 1alpha predominantly in neurons and weakly in some microglia in both AD and controls . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
After cloning CC CKR 5 and establishing reverse transcriptase polymerase chain reaction ( RT PCR ) for its ligands macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation , normal T cell expressed and secreted ( RANTES ) , we studied expression of these four mRNAs in purified microglia and compared it with their expression in rat brain . ^^^ In middle cerebral artery occluded ( MCAO ) animals , RANTES mRNA was unaffected , whereas CKR 5 mRNA showed a sustained rise until 96 hr after surgery . ^^^ MIPs exogenously added to microglial cultures markedly reduced CKR 5 mRNA expression , whereas RANTES did not . ^^^ MIP mRNAs , in contrast to RANTES and CKR 5 mRNAs , were undetectable in normal brain . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The chemokines monocyte chemotactic protein ( MCP ) 3 , MCP 4 , and eotaxin acted like RANTES , whereas macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MCP 1 , and stromal cell derived factor 1 were inactive , suggesting a role for the eotaxin receptor , CCR 3 , and ruling out the involvement of CCR 1 , CCR 2 , CCR 5 , and CXCR 4 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
By contrast , CCR 5 internalisation is induced by the beta chemokine RANTES but not by phorbol esters . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Extracellular accumulation of both constitutively produced monocyte chemoattractant protein ( MCP ) 1 and tumor necrosis factor superinduced RANTES ( regulated on activation , normal T cell expressed and secreted ) was downregulated in HCMV infected fibroblasts in the absence of transcriptional repression or the expression of polyadenylated RNA for the cellular chemokine receptors CCR 1 , CCR 3 , and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
While both nave and memory CD 4 ( + ) subsets downregulated CCR 5 expression in response to CD 28 costimulation , only the memory cells produced high levels of the beta chemokines RANTES , MIP 1alpha , and MIP 1beta upon stimulation . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CCR 5 agonist RANTES stimulated [ 35S ] GTPgammaS binding to the cell membranes and induced inhibition on adenylyl cyclase activity in cells expressing CCR 5 . ^^^ The effects of RANTES were CCR 5 dependent and could be blocked by pertussis toxin . ^^^ Furthermore , overexpression of Gialpha 2 strongly increased both RANTES dependent G protein activation and inhibition on adenylyl cyclase in cells cotransfected with CCR 5 . ^^^ The abilities of CCR 5 to activate G protein and to inhibit cellular cAMP accumulation were significantly diminished after a brief prechallenge with RANTES , showing rapid desensitization of the receptor mediated responsiveness . ^^^ Prolonged exposure of the cells to RANTES caused significant reduction of surface CCR 5 as measured by flow cytometry , indicative of agonist dependent receptor internalization . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The inactivation of CCR 5 was achieved by targeting a modified CC chemokine ( RANTES ) to the lumen of the endoplasmic reticulum ( ER ) to block the transport of the newly synthesized CCR 5 . ^^^ In addition , a functionally defective mutant of RANTES that retains its binding activity to CCR 5 , but loses its signaling ability , was used to generate a mutant RANTES intrakine . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Forty human immunodeficiency virus type 1 ( HIV 1 ) infected women participated in a cross sectional study of possible correlations between chemokine receptor ( CCR 5 and / or CCR2B ) genotype , HIV 1 RNA and DNA load , and beta chemokine levels ( RANTES , MIP 1alpha , MIP 1beta ) in blood and cervix . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We found that MCP 2 could bind to CCR 5 transfectants with high affinity and cross compete effectively with RANTES , MIP 1alpha , and MIP 1beta . ^^^ MCP 2 is a true agonist for CCR 5 , eliciting a robust chemotactic response in CCR 5 transfectants similar to that of the three known CCR 5 ligands and exhibiting cross desensitization with RANTES in the Ca2+ flux response . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Peptide presented to the CD 4 CTLs increased their secretion of RANTES and MIP 1beta , suppressed M tropic HIV 1 replication , downmodulated CCR 5 expression , and preserved CTL recognition . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
However , RANTES can have a similar enhancing effect on macrophagetropic viruses that enter via CC chemokine receptor 5 ( CCR 5 ) , despite binding to the same receptor as the virus . ^^^ The enhancing effects of RANTES are not mediated via CCR 5 or other known chemokine receptors and are not mimicked by MIP 1alpha or MIP 1beta . ^^^ The N terminally modified derivative aminooxypentane RANTES ( AOP RANTES ) efficiently inhibits HIV 1 infection via CCR 5 but otherwise mimics RANTES by enhancing viral infectivity . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This protein was also recognized by antibodies to CCR 5 , the RANTES / MIP 1alpha / MIP 1beta receptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The natural ligands for the chemokine receptors CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta ) and CXCR 4 ( SDF 1 ) can act as potent inhibitors of infection by the human immunodeficiency virus type 1 ( HIV 1 ) at the level of viral entry . ^^^ Inhibition of HIV 1 by RANTES IgG 3 was specific for CCR 5 dependent but not CXCR 4 dependent HIV 1 isolates . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
These data indicate that RANTES inhibits HIV 1 as well as HIV 2 infection of MDM , likely at a post binding step , and support the role of CCR 5 as the major coreceptor for HIV 1 and HIV 2 entry into primary macrophages . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Using CCR 5 transfected HEK 293 cells , we show that both the CCR 5 ligand , RANTES , as well as its derivative , aminooxypentane ( AOP ) RANTES , trigger immediate responses such as Ca2+ influx , receptor dimerization , tyrosine phosphorylation , and Galphai as well as JAK / STAT association to the receptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Mice inoculated with chimeric L 1 CCR5 particles generated autoantibodies that bound to native mouse CCR 5 , inhibited binding of its ligand RANTES , and blocked HIV 1 infection of an indicator cell line expressing a human mouse CCR 5 chimera . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES , IFN gamma , CCR 1 , and CCR 5 mRNA expression in peripheral blood , lymph node , and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques . ^^^ We sought to determine whether there is a temporal relationship linking SIV replication and dissemination and the expression of the chemokine RANTES ( regulated upon activation normal T cell expressed and secreted ) and the SIV / HIV coreceptor CCR 5 in different tissues during acute SIV infection of macaques . ^^^ RT PCR was used to monitor the expression of RANTES and CCR 5 mRNA in fresh isolated mononuclear cells from blood , lymph node , and bronchoalveolar lavages . ^^^ Our results put CCR 5 and RANTES mRNA expression back in the context of inflammatory and immune responses to SIV primary infection . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a RANTES receptor , was detected on lymphocytic cells , macrophages , and microglia in actively demyelinating MS brain lesions . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Recently , it was shown that the natural CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and amino terminal modifications of RANTES ( Met RANTES , AOP RANTES ) significantly differ in their abilities to induce sequestration of CCR 5 from cellular surfaces . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
To assess the influence of defective CCR 5 on production of its ligands we determined the capacity to produce the chemokines macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta and RANTES in comparison with the production of the CXC chemokine IL 8 which does not bind to CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Stimulation of monocyte derived DCs with CD40LT enhanced the production of the CC chemokines macrophage inflammatory protein ( MIP ) 1 alpha , MIP 1 beta , and RANTES and diminished surface expression of CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Highly potent RANTES analogues either prevent CCR 5 using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR 4 using variants . ^^^ The natural ligands for the CCR 5 chemokine receptor , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES ( regulated on T cell activation , normal T cell expressed and secreted ) , are known to inhibit human immunodeficiency virus ( HIV ) entry , and N terminally modified RANTES analogues are more potent than native RANTES in blocking infection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
MAbs PA 9 to PA 12 , whose epitopes include residues in the CCR 5 N terminus , strongly inhibited gp 120 binding but only moderately inhibited HIV 1 fusion and entry and had no effect on RANTES induced calcium mobilization . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES ( regulated on activation normal T cell expressed and secreted ) is one of the natural ligands for the chemokine receptor CCR 5 and potently suppresses in vitro replication of the R 5 strains of HIV 1 , which use CCR 5 as a coreceptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Further comparative analysis between individuals in the exposed but uninfected cohort who demonstrated intermediate levels of in vitro viral replication and CD4+ lymphocytes isolated from uninfected delta 32 heterozygous individuals indicate that reduced levels of in vitro M tropic replication are a CCR 5 related phenomenon : CD4+ lymphocytes from these individuals were more sensitive to the HIV 1 blocking effects of recombinant chemokines , displayed lower CCR 5 cell surface expression levels and a proportionate increase in the production of RANTES when compared to CD4+ lymphocytes from control individuals . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Treatment of CD8+ cell culture supernatant with antibodies to RANTES , MIP 1alpha and MIP 1beta neutralized the CD 8 SF activity , indicating that blocking the CCR 5 by these ligands played an important part in the CD 8 SF activity elicited by TILN immunization . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Exogenous RANTES and macrophage inflammatory protein 1alpha ( natural CCR 5 ligands ) virtually abolished the entry of the R 5 M tropic strain HIV 1 into human LPL . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this study , we found that TAK 779 , a nonpeptide compound with a small molecular weight ( Mr 531 . 13 ) , antagonized the binding of RANTES ( regulated on activation , normal T cell expressed and secreted ) to CCR 5 expressing Chinese hamster ovary cells and blocked CCR 5 mediated Ca2+ signaling at nanomolar concentrations . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 ligands , MIP 1alpha and RANTES , were found in RA SF at high levels . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The effect was dependent on expression of the CCR 5 receptor and was inhibited by the beta chemokine RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , the CCR 5 transmembrane mutants do not respond to RANTES with the classical bell shaped chemotactic response curve , suggesting that they are resistant to RANTES induced desensitization . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
All group O isolates tested were efficiently inhibited by SDF 1 or RANTES , the natural ligands of CXCR 4 and CCR 5 , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a receptor for chemokines MIP 1alpha ( LD78alpha ) , MIP 1beta , RANTES , and MCP 2 , is of particular importance in vivo as polymorphisms in this gene affect HIV infection and rate of progression to AIDS . ^^^ In addition , while RANTES has been described as the most potent inhibitor of CCR 5 mediated HIV entry , MIP 1alphaP was as potent as , if not more potent than , RANTES in HIV 1 suppressive assays . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Tumor derived lymphocytes showed strong chemotactic responses to both CC and CXC chemokines in vitro and expressed high levels of CXCR 3 ( HuMig and IP 10 receptor ) and CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta receptor ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This study investigated the anti HIV 1 activity of a derivative of RANTES , the CCR 5 antagonist aminooxypentane ( AOP ) RANTES , on R 5 HIV 1 isolates in peripheral blood mononuclear cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a receptor for the C C chemokine RANTES , which is expressed in inflammatory kidney diseases and transplant rejection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Pretreatment of neural cells with pertussis toxin abolished responses to stromal derived factor 1alpha , macrophage inflammatory protein 1beta , and RANTES , indicating coupling of CCR 5 and CXCR 4 to a Gialpha protein , as in leukocytes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Subsequent analyses showed that phosphoantigen activated gammadelta T cells produced substantial amounts of beta chemokines ( macrophage inflammatory protein [ MIP ] 1alpha , MIP 1beta , and regulated on activation , normal T cell expressed and secreted beta chemokine [ RANTES ] ) , which represent the natural ligand for the CCR 5 HIV coreceptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Costimulation of normal phorbol 12 myristate 13 acetate treated B cells with the CCR 5 ligand RANTES induced a proliferative response , indicating that RANTES is a mitogen for B cells . ^^^ Taken together , these findings suggest that the CCR 5 gene plays a role in the risk of NHL in HIV infected patients , perhaps through a mechanism involving a decreased response of B cells to the mitogenic activity of RANTES . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Compared with LD78alpha and RANTES , this preferential binding of LD78beta to CCR 5 resulted in a 10 to 50 fold higher potency in inhibiting infection of peripheral blood mononuclear cells by CCR 5 using ( R 5 ) HIV 1 strains . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CC chemokines RANTES , MIP 1alpha , MIP 1beta , and Eotaxin can suppress the replication of CCR 5 and CCR 3 dependent viruses , while SDF 1 alpha / beta suppresses that of CXCR 4 dependent strains . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
T cells treated with B oligomer did not initiate signal transduction in response to macrophage inflammatory protein ( MIP ) 1beta or RANTES ( regulated upon activation , normal T cell expressed and secreted ) ; however , cell surface expression of CCR 5 and binding of MIP 1beta or HIV 1 to such cells were not impaired . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this report , we show that RANTES and its derivative , aminooxypentane ( AOP ) RANTES , a potent RANTES antagonist as well as an inhibitor of HIV 1 infection , both promote CCR 5 desensitization involving G protein coupled receptor kinases 2 and beta arrestin equally well . ^^^ An important difference between the two molecules is that ( AOP ) RANTES is more efficient than RANTES in promoting Ser / Thr phosphorylation of the receptor and association of G protein coupled receptor kinases 2 , beta arrestin , and clathrin to the CCR 5 . ^^^ After stimulation with either ligand , we observe rapid , transient association of dynamin to CCR 5 , implicating this protein in receptor sensitization , but this association is faster and longer lasting following ( AOP ) RANTES stimulation . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Enhanced transmigration of Th 1 type cells was dependent on the chemokine RANTES produced by endothelial cells , as indicated by the findings that Ab neutralizing RANTES , or Ab to its receptor CCR 5 , inhibited transmigration . ^^^ Thus , enhancement of Th 1 type selective migration appeared to be responsible for the diapedesis induced by interaction between CCR 5 on Th 1 type cells and RANTES produced by endothelial cells . ^^^ Further evidence that CCR 5 and RANTES play a modulatory role in Th 1 type selective migration derives from the abrogation of this migration by anti RANTES and anti CCR 5 Abs . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 was first characterized as a receptor for MIP 1alpha , MIP 1beta , and RANTES , and was rapidly shown to be the main coreceptor for M tropic human immunodeficiency virus ( HIV ) 1 strains and simian immunodeficiency virus ( SIV ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
TNF alpha inhibits HIV 1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C C chemokine receptor 5 ( CCR 5 ) expression . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The importance of chemokine expression on HIV infection has been emphasized by the discovery that infection of CD 4 ( + ) T cells by M tropic strains of HIV 1 is antagonized by the chemokines RANTES , MIP 1alpha , and MIP 1beta , which are natural ligands of CCR 5 , a major coreceptor for macrophagetropic ( M tropic ) isolates of HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We found that while all molecules are expressed within the human renal implant at specific time points following infusion of allogeneic human PBMC , peak mRNA expression of IFN gamma , IL 2 , RANTES and CCR 5 is associated with a phase of human mononuclear infiltration and accumulation , prior to graft destruction ( induction phase ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The beta chemokines RANTES , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta suppress infection by macrophage tropic strains of HIV and simian immunodeficiency virus ( SIV ) by binding and down regulating the viral coreceptor , CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Peptide T was also able to suppress monocyte chemotaxis to MIP 1beta , a chemokine with selectivity for CCR 5 chemokine receptors , while chemotaxis of the more promiscuous ligand RANTES was not inhibited , nor was chemotaxis mediated by SDF 1alpha . ^^^ In order to determine if peptide T mediated its gp 120 antagonistic effects via modulation of CCR 5 receptors , RANTES chemotaxis was studied using a CCR 5 receptor transfected HOS cell line . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We have investigated their binding properties as well as their ability to activate the RANTES receptors CCR 1 , CCR 3 , and CCR 5 in cell lines overexpressing these receptors . ^^^ We show that Met RANTES has weak activity in eliciting a calcium response in Chinese hamster ovary cells expressing CCR 1 , CCR 3 , and CCR 5 , whereas AOP RANTES has full agonist activity on CCR 5 but is less effective on CCR 3 and CCR 1 . ^^^ AOP RANTES does not induce calcium mobilization in circulating monocytes but is able to do so as these cells acquire the macrophage phenotype , which coincides with a concomitant up regulation of CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CONCLUSIONS : The amino terminal domain of RANTES was not essential for its antiviral activity or for its binding to the CCR 5 receptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULTS : The percentage of lymphocytes and monocytes expressing CCR 5 was 1 . 6 and 3 . 0 times higher in ETH ( n = 83 ) than in IS ( n = 45 ) , respectively ( P < . 001 ) , whereas RANTES and MIP 1alpha secretion was 0 . 5 and 0 . 7 times lower ( P < . 01 and P < . 05 ) . ^^^ The percentage of CCR 5 expressing cells and RANTES secretion were inversely correlated ( r = 0 . 7 ; P < . 002 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In a parallel manner , binding of labeled MIP 1alpha was first shown to be attenuated by unlabeled RANTES , both of which recognize CCR 1 and CCR 5 , and then separately antagonized by MCP 3 and MIP 1beta , which bind to CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The specific receptor for the beta chemokines ( macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES ) , CCR 5 , also functions as the primary coreceptor for macrophage tropic isolates of HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a functional receptor for MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed ) , MCP 2 , and MCP 4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Conversely , infection of 3T3 CCR 5 cells can be inhibited by RANTES , anti CCR 5 polyclonal antibody , or herbimycin A but not by monoclonal antibodies that block HIV 1 infection or by pertussis toxin . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
During the development of nephrotoxic nephritis ( NTN ) in the mouse , we find that a variety of chemokines and chemokine receptors are induced : CCR 1 ( RANTES , MIP 1alpha ) , CCR 2 ( MCP 1 ) , CCR 5 ( RANTES , MIP 1alpha , MIP 1beta ) , CXCR 2 ( MIP 2 ) , and CXCR 3 ( IP 10 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : This study was designed to evaluate the role of the novel chemokine receptor antagonist amino oxypentane RANTES ( AOP RANTES ) , which blocks the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES to the chemokine receptor 5 ( CCR 5 ) on the infiltration of monocytes in experimental glomerulonephritis . ^^^ CONCLUSION : These data show that the CCR 5 chemokine receptor antagonist AOP RANTES ameliorates M / M infiltration and improves glomerular pathology in experimental glomerulonephritis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We found that human CD 34 ( + ) cells and CD 34 ( + ) KIT ( + ) cells , which are enriched in myeloid progenitor cells , expressed and secreted the CCR 5 ligands RANTES , MIP 1alpha , and MIP 1beta and that IFN gamma stimulated expression of these chemokines . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
To test CCR 5 receptor down modulation from the cell surface , leukocytes were incubated in vitro with a RANTES ( regulated on activation , normal T cell expressed and secreted ) derivative , aminooxypentane ( AOP ) RANTES . ^^^ In vitro , CCR 5 was completely down modulated on synovial fluid leukocytes by AOP RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Concomitant with the induction of chemokine expression was the appearance of cellular receptors for RANTES ( CCR 1 , CCR 5 ) and IP 10 ( CXCR 3 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Recently , several unique HIV 1 entry coreceptors ( e . g . , CCR 5 and CCR 3 ) and a trio of HIV 1 specific suppressor chemokines , namely , RANTES ( regulated upon activation T expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , were identified . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES was found to be involved in the HIV resistance observed , and this was correlated with a down regulation of the CCR 5 HIV entry coreceptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The variants were also resistant to other natural ligands for CCR 5 , namely , MIP 1beta ( > 4 fold ) and RANTES ( regulated upon activation , normal T cell expressed and secreted ) ( 6 fold ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Limited expression of R 5 tropic HIV 1 in CCR 5 positive type 1 polarized T cells explained by their ability to produce RANTES , MIP 1alpha , and MIP 1beta . ^^^ In fact , an inverse correlation was observed between Th 1 polarized naive T cells and Th 1 like memory activated T cells in regards to p 24 Ag production and the release of the following CCR 5 binding chemokines : regulated on activation normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Treatment of immature DCs with TGF beta 1 resulted in increased expressions of CCR 1 , CCR 3 , CCR 5 , CCR 6 , and CXC chemokine receptor 4 ( CXCR 4 ) , which were concomitant with enhanced chemotactic migratory responses to their ligands , RANTES ( for CCR 1 , CCR 3 , and CCR 5 ) , macrophage inflammatory protein 3 alpha ( MIP 3 alpha ) ( for CCR 6 ) , or stromal cell derived growth factor 1 alpha ( for CXCR 4 ) . ^^^ Ligation by TNF alpha resulted in down modulation of cell surface expressions of CCR 1 , CCR 3 , CCR 5 , CCR 6 , and CXCR 4 , and the chemotaxis for RANTES , MIP 3 alpha , and stromal cell derived growth factor 1 alpha , whereas this stimulation up regulated the expression of CCR 7 and the chemotactic ability for MIP 3beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The anti CCR 5 monoclonal antibody ( mAb ) 2D7 inhibits the binding and chemotaxis of the three natural beta chemokine ligands of CCR 5 , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES , to CCR 5 ( + ) cells . ^^^ We show here that ( 1 ) M 23 g3p was specifically recognized with anti CCR 5 mAb ; ( 2 ) M 23 g3p showed inhibitory activity on the infectivity of M tropic but not T tropic HIV 1 strains ; ( 3 ) M 23 g3p bound to MIP 1alpha , MIP 1beta , and RANTES but not MCP 1 . ^^^ These results suggested that the M 23 g3p might mimic the CCR 5 binding domain shared by beta chemokines , MIP 1alpha , MIP 1beta , and RANTES as well as the HIV 1 infection . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Met RANTES has been shown to modulate inflammation in vivo , while AOP RANTES is a potent inhibitor of R 5 human immunodeficiency virus type 1 ( HIV 1 ) strains and has been shown to down modulate CCR 5 and prevent recycling of the receptor . ^^^ AOP RANTES is found to inhibit CCR 3 mediated HIV 1 infection with moderate potency , in contrast to its potent inhibition of CCR 5 mediated HIV 1 infection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In paralyzed control mice , the SC had increased cellular infiltration and strong expression of the chemokines RANTES , IFN inducible 10 kDa protein , and monocyte chemoattractant protein 1 and the cognate chemokine receptors CCR 1 , CCR 2 , and CCR 5 , with lower expression of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and MIP 2 ; whereas brain had less infiltration and a lower expression of a different pattern of chemokines and receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CXCR 3 and CCR 5 receptors were functional , as LPL and IEL migrated to their respective ligands 1 TAC and RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In contrast , the CCR 5 ligands ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , and RANTES ) did not activate calcium flux , MAPK and AKT phosphorylation or chemotaxis of CD 34 ( + ) KIT ( + ) cells or cells isolated from the BFU E colonies . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES , MIP 1alpha and MIP 1beta suppress infection by R 5 HIV 1 particles via induction of CCR 5 internalization , and individuals whose peripheral blood lymphocytes produce high levels of these chemokines are relatively resistant to infection [ 7 ] [ 8 ] [ 9 ] . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this study , Chinese hamster ovary cells were transfected separately with the human chemokine receptors CCR 1 and CCR 5 , and these receptors were shown to induce an intracytoplasmic Ca ( 2+ ) flux and cellular chemotaxis following stimulation with the natural CC chemokine ligands ( MIP 1alpha , RANTES ( regulated on activation normal T cell expressed ) , and MIP 1beta ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CONCLUSIONS : Our data suggest that NSI isolates obtained from AIDS patients remain CCR 5 dependent ( ie , R 5 ) and , in many cases , also remain sensitive to RANTES inhibition . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Variable sensitivity of CCR 5 tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs . ^^^ Aminooxypentane ( AOP ) RANTES efficiently and specifically blocks entry of non syncytium inducing ( NSI ) , CCR 5 tropic ( R 5 ) human immunodeficiency virus type 1 ( HIV 1 ) into host cells . ^^^ Inhibition appears to be mediated by increased intracellular retention of the CCR 5 coreceptor AOP RANTES complex and / or competitive binding of AOP RANTES with NSI R 5 HIV 1 isolates for CCR 5 . ^^^ Exclusive entry via the CCR 5 coreceptor by these NSI R 5 isolates suggests that variable inhibition by AOP RANTES is not due to alternative coreceptor usage but rather differential CCR 5 binding . ^^^ Distribution of AOP RANTES IC ( 50 ) values with these isolates has promoted ongoing screens for new CCR 5 agonists that show broad inhibition of HIV 1 variants . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Immunization induced significant increases in the concentrations of CD 8 cell derived suppressor factor ( CD 8 SF ) , regulated on activation normal T cells expressed and secreted ( RANTES ) , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta , and down modulation of the proportion of cells expressing CCR 5 ( r = 0 . 737 , P < 0 . 05 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS : We have used this experimental model to sequentially analyze transcript levels of interferon gamma and interleukin ( IL ) 2 ( T helper 1 cytokines ) , IL 4 and IL 10 ( T helper 2 cytokines ) , RANTES , MIP1beta ( beta chemokines ) and their receptor CCR 5 , and Fas ligand ( cytolytic effector molecule ) . ^^^ In addition , RANTES ( after an early peak ) , MIP1beta , CCR 5 , and Fas ligand mRNA levels were suppressed in the fetal grafts compared with those in the adult grafts . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Multicolor flow cytometric analysis of whole peripheral blood revealed that , as opposed to CD14++ monocytes , the CD14+CD16+ subset lacked surface expression of monocyte chemotactic protein 1 ( MCP 1 ) receptor CCR 2 , however , it showed significantly higher surface expression of the macrophage inflammatory protein 1alpha ( MIP 1alpha ) / RANTES receptor CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In addition , the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha , MIP1beta , and RANTES , natural ligands of CXCR 4 and CCR 5 , respectively , are potent soluble inhibitors of HIV infection by blocking the binding between the viral envelope glycoprotein gp 120 and the coreceptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The search for new small molecule CCR 5 antagonists by high throughput screening ( HTS ) of the Takeda chemical library using [ ( 125 ) 1 ] RANTES and CHO / CCR5 cells led to the discovery of lead compounds ( A , B ) with a quaternary ammonium or phosphonium moiety , which were synthesized to investigate new MCP 1 receptor antagonists . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES levels correlated with the temporal recruitment of mononuclear cells and the expression of RANTES receptors CCR 1 and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The suppressive effect of beta chemokines , principally RANTES , on certain HIV 1 isolates was established before the discovery of the CCR 5 receptor , and there have since been multiple reports confirming this initial observation . ^^^ It is shown that under a variety of culture and differentiation conditions , RANTES maintains a significant and consistent inhibitory effect on CCR 5 dependent Env mediated fusion , and the role of these findings is discussed in relation to the role of beta chemokines in HIV pathogenesis . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
No difference was observed in TNF alpha , IL 1beta , IL 10 , IL 4 , MIP 1alpha , MIP 1beta , RANTES , CXCR 4 , and CCR 5 mRNA levels in PBMC , but IL 6 levels were higher in the HPS patient . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , we showed that the CXCR 4 and CCR 5 ligands ( stromal derived factor 1 and macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta and RANTES , respectively ) inhibit HIV replication in both maturing Mo and Mk cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Investigations of the mechanism of protection revealed that gammadelta ( + ) T cells can generate antiviral factors , RANTES , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta which can prevent SIV infection by binding to the CCR 5 coreceptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The study demonstrated further that aberrant migration of multiple sclerosis derived T cells toward RANTES and MIP 1 alpha resulted from overexpression of their receptors ( CCR 5 ) and could be blocked by anti CCR 5 antibodies . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Urinary levels of their ligands , for CCR 1 and CCR 5 ; macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta and regulated upon activation in normal T cells expressed and secreted ( RANTES ) were evaluated by enzyme linked immunosorbent assay . ^^^ Glomerular CCR 5 positive cells were well correlated with extracapillary lesions and urinary MIP 1alpha levels , while interstitial CCR 5 positive cells , mainly CD 3 positive T cells , were correlated with interstitial lesions and urinary RANTES levels . ^^^ These results suggest that chemokine receptor signaling may be pivotal for human renal diseases through the recruitment and activation of MPhi and T cells ; CCR 5 positive cells may participate in glomerular lesions including extracapillary lesions via MIP 1alpha and in interstitial lesions via RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta inhibited infection of intestinal lymphocytes by BaL , indicating that R 5 infection of the intestinal lymphocytes was mediated by CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Ligands for CCR 2 and CCR 5 ( chemokines monocyte chemotactic protein 1 [ MCP 1 ] and RANTES ) are implicated in the pathogenesis of sarcoidosis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We show that , like RANTES , the addition of AOP to MIP 1alphaP enhances its interactions with CCR 1 and CCR 5 , allows more effective internalization of CCR 5 , and increases the ligand ' s potency as an inhibitor of HIV entry through CCR 5 . ^^^ Importantly , AOP MIP 1alphaP is about 10 fold more active than AOP RANTES at inhibiting HIV entry , making it the most effective chemokine based inhibitor of HIV entry through CCR 5 described to date . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor CCR 5 , which shares the ligand regulated upon activation , normal T cell expressed and secreted ( RANTES ) with DARC , is expressed by infiltrating T cells in the renal interstitium . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 2 ( / ) mice immunized with MOGp 35 55 failed to develop mononuclear cell inflammatory infiltrates in the CNS and failed to increase CNS levels of the chemokines RANTES ( regulated on activation , normal T cell expressed and secreted ) , MCP 1 , and interferon ( IFN ) inducible protein 10 ( IP 10 ) as well the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We next evaluated the functionality of these chemokine receptors by calcium flux and chemotaxis assays , and by the ability of SDF 1 , MIP 1alpha , MIP 1beta and RANTES to influence the growth of the cells expressing CXCR 4 and / or CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In contrast , M tropic virus infectivity was reduced , possibly because of elevated levels of the CCR 5 ligand cytokines RANTES and MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We report here that treating monocyte derived macrophages ( MDM ) with a trimeric soluble form of CD40L ( CD40LT ) induced them to secrete high levels of the beta chemokines RANTES , MIP 1alpha and MIP 1beta that are ligands for CCR 5 and able to inhibit HIV 1 entry . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The chemokine ligands for CCR 5 , RANTES and MIP 1beta , also potently inhibited HIV 1 infection in microglia , but the third ligand MIP 1alpha failed to show inhibition . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Inhibition of labeled MIP 1alpha binding was achieved with unlabeled MIP 1alpha and RANTES , the latter a beta chemokine that binds to both CCR 1 and CCR 5 , but not by MCP 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
To further evaluate this , we consecutively analyzed the expression of 2 ligands of CCR 5 : RANTES and MIP alpha . ^^^ CCR 5 , RANTES , and MIP 1alpha were analyzed by Northern blot analysis . ^^^ RESULTS : By Northern blot analysis , CCR 5 , RANTES , and MIP 1alpha messenger RNA ( mRNA ) levels were 12 . 9 fold , 13 . 3 fold and 9 . 2 fold higher in CP specimens compared with healthy controls , respectively ( P < . 01 ) . ^^^ CCR 5 is most likely involved in the attraction and activation of these macrophages , since the CCR 5 ligands RANTES and MIP 1alpha are concomitantly upregulated . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We have therefore utilized H 9 cells to test the effects of Product R on expression of mRNAs encoding the chemokine receptors , CD 4 , CXCR 4 and CCR 5 , as well as their ligands , IL 16 , SDF 1 , MIP 1alpha , MIP 1beta , and RANTES , by RT PCR . ^^^ We also assayed the effect of Product R on surface receptor expression by flow cytometry , and on the chemotactic activity of these cells towards the CXCR 4 ligand , SDF 1 , and the CCR 5 ligands , MIP 1alpha and RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
There was significantly increased expression of HIV 1 coreceptors CCR 5 and CXCR 4 , beta chemokine RANTES , and macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta , as well as increased numbers of T cells in lamina propria of HIV 1 infected patients . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES serum levels were measured by commercial ELISA kits in CCR 5 delta 32 heterozygous and CCR 5 homozygous PMR patients at diagnosis before starting corticosteroid therapy and again after 6 months of therapy , as well as in 28 healthy subjects over 50 years of age . ^^^ No significant differences were observed between the patients carrying the CCR 5 delta 32 allele and those homozygous for the normal CCR 5 allele when we compared sex , presence of distal synovitis and systemic signs and / or symptoms , initial and cumulative prednisone dose , duration of therapy , ESR at diagnosis , frequency of relapse / recurrence and RANTES serum levels at diagnosis and after 6 months of corticosteroids . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Enhancement of the HIV 1 inhibitory activity of RANTES by modification of the N terminal region : dissociation from CCR 5 activation . ^^^ C5 RANTES and L RANTES showed a dramatically reduced ability to trigger intracellular calcium mobilization via CCR 3 or CCR 5 , while potently antagonizing the action of the WT chemokine . ^^^ By contrast , two previously described analogues ( RANTES ( 3 68 ) and AOP RANTES ) maintained a WT ability to trigger CCR 5 mediated signaling , while a third one ( RANTES ( 9 68 ) ) showed a dramatic loss of antiviral activity . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Regulation of chemokine receptor CCR 5 and production of RANTES and MIP 1alpha by interferon beta . ^^^ It was demonstrated for the first time that in vitro exposure of T cells to IFN beta 1a selectively inhibited mRNA expression for RANTES and MIP 1alpha and their receptor CCR 5 . ^^^ T cell surface expression of CCR 5 was significantly reduced in MS patients treated with IFN beta , correlating with decreased T cell transmigration toward RANTES and MIP 1alpha . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Of note , CCR 5 expression on both types of MDM was comparable , and it was not downregulated by RANTES on either . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
DESIGN : The CC chemokines RANTES , MIP 1alpha and MIP 1beta are ligands for CCR 5 , which has been identified as the principal co receptor for macrophage tropic strains of HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Cells susceptible to infection by these viruses can be protected by treatment with the CCR 5 ligands regulated on activation , normal T cell expressed and secreted ( RANTES ) , MIP 1alpha , and MIP 1beta . ^^^ AOP RANTES efficiently downmodulates the cell surface expression of CCR 5 and , in contrast with RANTES , appears to prevent recycling of CCR 5 to the cell surface . ^^^ Using CHO cells expressing human CCR 5 , we show that both RANTES and AOP RANTES induce rapid internalization of CCR 5 . ^^^ Addition of RANTES or AOP RANTES has little effect on the rate of CCR 5 turnover . ^^^ Immunofluorescence and immunoelectron microscopy show that most of the CCR 5 internalized after RANTES or AOP RANTES treatment accumulates in small membrane bound vesicles and tubules clustered in the perinuclear region of the cell . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The numbers of macrophages and monocytes in the colonic mucosa increased substantially during the chronic phase , as did expression of two of the receptors ( CCR 1 and CCR 5 ) to which RANTES is known to bind . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
DESIGN : RANTES , a ligand of the major HIV co receptor , CCR 5 , is known to block HIV CCR 5 interactions . ^^^ RESULTS : We found that the two most common RANTES promoter compound genotypes , G 1 ( 403G / G , 28C / C ) found in 67 % of Caucasians , and G 4 ( 403G / A , 28C / C ) found in 23 % of Caucasians , were associated with altered risk of HIV transmission and progression , particularly in individuals who lacked the protective CCR 5 mutation , CCR5delta32 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES ( regulated on activation , normal T cells expressed and secreted ) in interaction with its receptors ( CCR 1 , CCR 3 , CCR 4 and CCR 5 ) may be one of the favorite chemokines involved in the cell trafficking and maintenance . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In quantitative assays of viral infectivity , PRO 140 was compared with RANTES , a natural CCR 5 ligand that can inhibit HIV 1 entry by receptor downregulation as well as receptor blockade . ^^^ Despite their divergent mechanisms of action and binding epitopes on CCR 5 , low nanomolar concentrations of both PRO 140 and RANTES inhibited infection of primary peripheral blood mononuclear cells ( PBMC ) by all CCR 5 using ( R 5 ) viruses tested . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
N terminal modifications of the chemokine RANTES bind to C C chemokine receptor 5 ( CCR 5 ) and block human immunodeficiency virus type 1 ( HIV 1 ) infection with greater efficacy than native RANTES . ^^^ Modified RANTES compounds induce rapid CCR 5 internalization and much slower receptor reexpression than native RANTES , suggesting that receptor sequestration is one mode of anti HIV activity . ^^^ The rates of CCR 5 internalization and reexpression were compared using the potent n nonanoyl ( NNY ) RANTES derivative and CD 4 ( + ) T cells derived from donors with different CCR 5 gene polymorphisms . ^^^ Polymorphisms in the promoter and coding regions of CCR 5 significantly affected the receptor reexpression rate after exposure of cells to NNY RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Peripheral NK cells express the CC chemokine receptor CCR 2 , for MCP 1 and CCR 5 , for MIP 1 alpha and RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Recently we reported that the chemokines MIP 1alpha , MIP 1beta , and RANTES secreted by BM derived CD 34 ( + ) cells may compete with the macrophagotropic HIV ( R 5 HIV ) strain for the CCR 5 coreceptor . ^^^ In this study we extended our previous observations and examined various lympho hematopoietic CD 34 ( + ) cells isolated from thymus ( Th ) , cord blood ( CB ) , mobilized peripheral blood ( mPB ) , and BM for the expression of beta chemokines binding to CCR 5 , i . e . , MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , and MCP 4 , and the alpha chemokine SDF 1 ( binding to CXCR 4 ) as these chemokines may compete with the R 5 and X 4 HIV strains , respectively , for entry into cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The role of the RANTES ( regulated on activation normal T cell expressed and secreted ) receptors CCR 1 and CCR 5 in the selective recruitment of monocytes , T ( H ) 1 like T cell clones , and peripheral T cells enriched for CD45RO ( + ) `` memory ' ' cells were tested in a system in which arrest under flow conditions is triggered by RANTES immobilized to activated endothelium . ^^^ In contrast , CCR 5 mainly contributed to the spreading in shear flow , and both CCR 1 and CCR 5 supported transendothelial chemotaxis toward RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In the present study , the CCR 5 binding chemokine regulated upon activation normal T cell expressed and secreted ( RANTES ) strongly inhibited the replication of two of eight primary R5X4 viruses in mitogen activated primary peripheral blood mononuclear cells ( PBMC ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this study , we found that the amino acid sequences of two chemokines ( SDF 1beta and RANTES ) , whose receptors ( CXCR 4 and CCR 5 ) act as major coreceptors for HIV 1 , HIV 2 or SIV , showed statistically significant similarity to those of the region containing the third variable ( V 3 ) and the third conserved ( C 3 ) domains ( the V 3 C 3 domain ) of the env protein of HIV 1 and HIV 2 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Presence of the beta chemokine RANTES in the culture medium inhibited the phenomenon , suggesting that V 3 plays a costimulatory role that involves the chemokine receptor CCR 5 pathway during the process of antigen presentation to T cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES , the natural ligand of CCR 5 , inhibited infection of monocytes with unopsonized HIV particles and partially that of monocytes infected with HIV particles opsonized with complement derived fragments . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The expression of regulated on activation , normal T cell expressed and secreted ( RANTES ) , monocyte chemotactic protein ( MCP ) 1 , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta was analyzed by in situ hybridization and that of CCR 3 and CCR 5 by immunohistochemistry and flow cytometry . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The Ab MC 21 ( anti CCR 2 ) reduced the activity of murine monocyte chemotactic protein 1 by 95 % , whereas the Ab MC 68 ( anti CCR 5 ) blocked over 99 % of the macrophage inflammatory protein 1alpha and RANTES activity . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This transactivation occurs via a mechanism involving transcriptional upregulation and secretion of RANTES , the natural CCR 5 ligand . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In human monocytes pretreatment with eotaxin decreased responsiveness to MCP 1 , a selective ligand for CCR 2 , as well as to RANTES and MIP 1 beta , which bind to CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The chemokine RANTES ( regulated on activation normal T cell expressed and secreted ) and its cognate receptor CC chemokine receptor 5 ( CCR 5 ) have been implicated in regulating immune cell function . ^^^ Previously we reported that in T cells , RANTES activation of CCR 5 results in Stat 1 and Stat 3 phosphorylation activation , leading to Stat 1 : 1 and Stat 1 : 3 dimers that exhibit DNA binding activity and the transcriptional induction of a Stat inducible gene , c fos . ^^^ Given that RANTES and CCR 5 have been implicated in T cell activation , we have studied RANTES induced signaling events in a CCR 5 expressing T cell line , PM 1 . ^^^ RANTES treatment of PM 1 T cells results in the rapid phosphorylation activation of CCR 5 , Jak 2 , and Jak 3 . ^^^ RANTES inducible Jak phosphorylation is insensitive to pertussis toxin inhibition , indicating that RANTES CCR 5 mediated tyrosine phosphorylation events are not coupled directly to Galpha ( 1 ) protein mediated events . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor activated by the chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha and 1beta , and monocyte chemotactic protein 2 and is the main co receptor for the macrophage tropic human immunodeficiency virus strains . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Expression levels of CCR 5 and CXCR 4 on naive , memory , and total CD4+ T cells tended to be higher in the resistant CSWs , while the production of beta chemokines RANTES , MIP 1alpha , and MIP 1beta by phytohemagglutinin ( PHA ) stimulated peripheral blood mononuclear cells ( PBMCs ) was lower compared with low risk HIV 1 negative controls . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CC chemokines RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are natural ligands for the CC chemokine receptor CCR 5 . ^^^ LD78beta was recently reported to be a much more potent CCR 5 agonist than LD78alpha and RANTES in inducing intracellular Ca2+ signaling and chemotaxis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In summary , in a model of transient IC GN , MCP 1 and RANTES and their receptors CCR 1 , CCR 2 , and CCR 5 are expressed early and are already downregulated at the peak of proteinuria and leukocyte infiltration . ^^^ Therefore , it is concluded that glomerular MCP 1 and RANTES production directs circulating leukocytes that express CCR 1 , CCR 2 , and CCR 5 into the glomerulus . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The beta chemokines , macrophage inflammatory protein ( MIP ) 1 alpha , MIP 1 beta , monocyte chemotactic protein ( MCP ) 1 and regulated on activation normal T cell , expressed and secreted ( RANTES ) are not only chemotactic for mononuclear cells but may be important in suppression of HIV 1 replication through competitive binding to the chemokine receptor , CCR 5 , which is critical to viral entry . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Global survey of genetic variation in CCR 5 , RANTES , and MIP 1alpha : impact on the epidemiology of the HIV 1 pandemic . ^^^ Expression of CC chemokine receptor 5 ( CCR 5 ) , the major coreceptor for HIV 1 cell entry , and its ligands ( e . g . , RANTES and MIP 1alpha ) is widely regarded as central to the pathogenesis of HIV 1 infection . ^^^ By surveying nearly 3 , 000 HIV+ and HIV individuals from worldwide populations for polymorphisms in the genes encoding RANTES , MIP 1alpha , and CCR 5 , we show that the evolutionary histories of human populations have had a significant impact on the distribution of variation in these genes , and that this may be responsible , in part , for the heterogeneous nature of the epidemiology of the HIV 1 pandemic . ^^^ Thus , the varied distribution of RANTES , MIP 1alpha , and CCR 5 haplotype pairs and their population specific phenotypic effects on HIV 1 susceptibility and disease progression results in a complex pattern of biological determinants of HIV 1 epidemiology . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The ability of RANTES ( regulated on activation normal T cell expressed and secreted ) and aminooxypentane RANTES to promote CCR 5 endocytosis was not altered by cysteine replacements . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Intracellular calcium levels in astrocytes were found to increase following application of RANTES , MIP 1beta ( CCR 5 agonist ) , SDF 1alpha ( CXCR 4 agonist ) , but not eotaxin ( CCR 3 agonist ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Glycans are involved in RANTES binding to CCR 5 positive as well as to CCR 5 negative cells . ^^^ We show that cell surface glycans , sialic acid and mannose containing species , are involved beside glycosaminoglycans ( GAGs ) , heparan sulfate and chondroitin sulfate in the binding of full length ( 1 68 ) RANTES not only to CCR 5 positive human primary lymphocytes or macrophages but also to CCR 5 negative monocytic U 937 cells . ^^^ These data demonstrate that full length RANTES , but not its ( 10 68 ) truncated counterpart , interacts with glycans and GAGs , in soluble forms or presented either by affinity matrices or CCR 5 positive as well as CCR 5 negative cells . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Also , the chemokine ligands RANTES , MIP 1 alpha ( both CCR 5 ) , and IP 10 ( CXCR 3 ligand ) were elevated in inflamed periodontal tissues . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This has functional consequences , as the CCR 2 and CCR 5 ligands monocyte chemotactic protein 1 ( MCP 1 ) and RANTES ( regulated upon activation , normal T cell expressed and secreted ) cooperate to trigger calcium responses at concentrations 10 to 100 fold lower than the threshold for either chemokine alone . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES is the natural ligand for the CC chemokine receptor 5 ( CCR 5 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
However , shikonin inhibited neither RANTES nor MIP 1alpha binding to CCR 5 transfected HEK / 293 cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The biological relevance of RANTES GAGs interaction was investigated in CHO K 1 cells expressing CCR 5 , CCR 1 , or CCR 3 and the various GAGs that bind RANTES . ^^^ Our results indicate that the heparin binding site , defined as the 40s loop , is only marginally involved in CCR 5 binding and activation , but largely overlaps the CCR 1 and CCR 3 binding and activation domain in RANTES . ^^^ Thus , cell surface GAGs is not a prerequisite for receptor binding or signaling , but soluble GAGs can inhibit the binding and the functional response of RANTES to CCR 5 expressing cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The mRNA expression of CC chemokines ( predominantly monocyte chemoattractant protein 1 [ MCP 1 ] / CCL2 , RANTES / CCL5 ) and their receptors CCR 1 , CCR 2 , CCR 5 increased progressively from days 2 to 10 . ^^^ By in situ hybridization , a prominent interstitial mRNA expression of MCP 1 and RANTES and their receptors CCR 2 and CCR 5 localized to interstitial mononuclear cell infiltrates . ^^^ These data demonstrate an increased expression of MCP 1 / CCL2 and RANTES / CCL5 at sites of tubulointerstitial damage and progressive fibrosis during unilateral ureteral obstruction that correlates with simultaneous accumulation of interstitial macrophages and T lymphocytes expressing the respective surface receptors CCR 2 and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
However , neither the ligands of CCR 5 , RANTES , and MIP 1alpha , nor a CCR 5 low molecular antagonist , TAK 779 , were able to influence the infection of trHIV 1 ( NL 4 3 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The three C C chemokines , RANTES , macrophage inflammatory protein 1alpha , and macrophage inflammatory protein 1beta , were up regulated by immunization with the CCR 5 derived peptides , and the cell surface expression of CCR 5 was decreased . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Natural anti CCR 5 Abs inhibited the binding of RANTES to macrophages , demonstrating their interaction with the coreceptor of R 5 tropic HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RANTES is a high affinity ligand for CCR 1 and CCR 5 , and it binds CCR 3 with moderate affinity and CCR 4 with low affinity . ^^^ MIP / RANTES has > 100 fold reduction in binding to CCR 1 and does not bind to CCR 3 but retains full , functional binding to CCR 5 . ^^^ It has equivalent affinity for CCR 5 to MIP 1alpha and RANTES , binding with an IC ( 50 ) of 1 . 12 nM , and is able to mobilize calcium and induce endocytosis of CCR 5 in PBMC in a manner equi potent to RANTES . ^^^ Therefore , we conclude that the amino terminus of RANTES is not involved in CCR 5 binding , but it is essential for CCR 1 and CCR3 . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Structural determinants of CCR 5 recognition and HIV 1 blockade in RANTES . ^^^ Here , we identify the structural determinants of CCR 5 recognition and antiviral activity of the CC chemokine RANTES , showing that critical residues form a solvent exposed hydrophobic patch on the surface of the molecule . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
LD78beta ( 3 70 ) competed tenfold more efficiently than LD78beta ( 1 70 ) with [ 125I ] RANTES for binding to the CC chemokine receptors CCR 5 and CCR 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Characterization of cellular infiltrate , detection of chemokine receptor CCR 5 and interleukin 8 and RANTES chemokines in adult periodontitis . ^^^ The purpose of the present study was to investigate the involvement of Interleukin 8 ( IL 8 ) , RANTES , the associated infiltrating cells and expression of CCR 5 chemokine receptors in periodontitis ; furthermore , the effect of periodontal therapy on these parameters was evaluated . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
At 4 and 8 weeks after reconstitution of Rag 2 / mice the mRNA levels of IP 10 , MCP 1 , MDC , MIG , TARC , RANTES , CCR 4 and CCR 5 were significantly increased prior to the appearance of macroscopic lesions . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
DC from mice deficient for CCR 1 , CCR 3 , and CCR 5 respond to RANTES , indicating that none of these receptors are exclusively used to initiate the chemokine cascade . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In addition the beta chemokines RANTES ( regulated on activation T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , and MIP 1beta can block HIV 1 entry into cells by preventing the binding of the macrophage trophic HIV 1 strains to the coreceptor CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The internalization of the receptors CCR 1 and CCR 5 that mediate arrest and transmigration of these cells in response to RANTES was prevented by vMIP 2 , supporting its role as an antagonist of CCR 1 and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Chemokines and their receptors in whiplash injury : elevated RANTES and CCR 5 . ^^^ In a prospective study using flow cytometry , we examined percentages of blood mononuclear cells ( MNC ) expressing the chemokines RANTES , MCP 1 , MIP 1alpha , MIP 1beta , and IL 8 , the chemokine receptor CCR 5 , the T cell activation marker CD 25 , and the T cell chemoattractant IL 16 in patients with WAD and , for reference , in healthy controls . ^^^ In conclusion , WAD is associated with a systemic but transient dysregulation in percentages of RANTES and CCR 5 expressing MNC and T cells . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Aminooxypentane ( AOP ) RANTES is a potent inhibitor of nonsyncytium inducing ( NSI ) , CCR 5 tropic ( R 5 ) human immunodeficiency virus type 1 ( HIV 1 ) isolates . ^^^ Phosphorylation of the mitogen activated protein kinase ( MAPK ) isoforms , extracellular signal regulated kinase 1 ( ERK 1 ) and ERK 2 , was increased in a CD 4 ( + ) CCR 5 ( + ) U 87 cell line treated with AOP RANTES or with an NSI / R5 HIV 1 isolate . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Using the migration chamber method , we assessed the migratory response of human embryonic kidney 293 ( HEK ) transfectant cells expressing the CC chemokine receptor 5 ( CCR 5 ) ( HEK CCR 5 ) to stimulation by chemokines ( macrophage inflamatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation normal T cell expressed and secreted ( RANTES ) ) on ECM substrates ( collagen type 1 and fibronectin ) . ^^^ Our results suggest that the migratory response to CCR 5 stimulation may vary quantitatively with both the CCR 5 ligand ( MIP 1alpha , MIP 1beta , and RANTES ) , as well as the nature and concentration of the ECM substrate involved . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Unlike IL 12 or IL 2 , IL 18 induced high levels of RANTES mRNA expression without modulating CCR 5 expression . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In EAE protected mice , 17 beta estradiol strongly inhibited mRNA expression of the chemokines RANTES , MIP 1 alpha , MIP 2 , IP 10 , and MCP 1 , and of the chemokine receptors CCR 1 , CCR 2 and CCR 5 at both time points . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Several potential mechanisms for expansion of HIV 1 in situ were found , including augmentation in expression of tumor necrosis factor ( TNF ) alpha and the HIV 1 noninhibitory beta chemokine ( MCP 1 ) , low presence of HIV 1 inhibitory beta chemokines ( MIP 1 alpha , MIP 1 beta , and RANTES [ regulated on activation , normal T expressed and secreted ] ) , and upregulation in expression of the HIV 1 coreceptor , CCR 5 , by pleural fluid mononuclear cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Structure activity studies on piperidino piperidine 3 led to the discovery of SCH 351125 ( 1 ) , a selective CCR 5 antagonist with potent activity against RANTES binding ( K ( 1 ) = 2 nM ) , which possesses subnanomolar activity in blocking viral entry and has excellent antiviral potency versus a panel of primary HIV 1 viral isolates . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : The chemokine receptor , CCR 5 , and its three high affinity ligands , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation normal T cell expressed and secreted ( RANTES ) , are expressed by infiltrating mononuclear cells during the rejection of clinical and experimental organ allografts , although the significance of these molecules in the pathogenesis of rejection has not been established . ^^^ First , we studied cardiac transplants in fully MHC mismatched mice that were deficient in CCR 5 or two of its ligands , MIP 1alpha or RANTES . ^^^ RESULTS : Whereas mice deficient in expression of MIP 1alpha or RANTES reject fully MHC mismatched cardiac allografts normally , CCR 5 / mice , or CCR5+ / + mice treated with a neutralizing mAb to mCCR 5 , show enhanced allograft survival . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , we demonstrate that HHV 6 increases the production of the CCR 5 ligand RANTES ( ' regulated upon activation , normal T cell expressed and secreted ' ) , the most potent HIV inhibitory CC chemokine , and that exogenous RANTES mimics the effects of HHV 6 on HIV 1 , providing a mechanism for the selective blockade of CCR 5 tropic HIV 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
These values corresponded well to the IC ( 50 ) for ( 125 ) 1 RANTES ( regulated on activation , T cell expressed , and secreted ) binding to CCR 5 ( 1 . 4 nM ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Infection was inhibited by SDF 1 on cells expressing CD 4 and CXCR 4 for both viruses , whereas RANTES abolished infection of cells expressing CCR 5 in addition to CD 4 in studies of the RV expressing HIV 1 ( 89 . 6 ) Env . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this study , a group of healthy subjects over 90 years old is compared to a group of young subjects , we evaluated the ability of monocytes , T lymphocytes and NK cells : ( 1 ) to produce RANTES and MIP 1alpha , either in basal conditions or after stimulation with , respectively , LPS , anti CD 3 MoAb and IL 2 ; ( 2 ) to express the corresponding chemokine receptors ( CCR 1 , CCR 3 , CCR 5 ) . ^^^ We demonstrate that : ( a ) monocytes , T lymphocytes and NK cells spontaneously produced detectable amounts of chemokines , both in young and old subjects ; ( b ) monocyte dependent RANTES and MIP 1alpha production induced by LPS was up regulated in nonagenarian subjects as anti CD 3 induced secretion from T cells ; ( c ) RANTES and MIP 1alpha production by IL 2 stimulated NK cells was reduced in elderly subjects ; ( d ) CCR 1 , CCR 3 and CCR 5 were widely expressed on monocytes , but less expressed on T lymphocytes and NK cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Using self organizing maps , we identified nine genes ( CD 4 , CCR 3 , CCR 5 , LT beta , MIP 1 alpha , MIP 2 , CD 8 alpha , IP 10 , and RANTES ) , each with a unique profile of transcriptional expression , that reproduce the differentiation of states of rejection in dendrograms . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Finally , amongst RANTES receptors , CCR 1 is found on Caco 2 cells , whereas CCR 3 and CCR 5 are not . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The effect of highly active antiretroviral therapy ( HAART ) on the expression of CCR 5 and CXCR 4 HIV coreceptors and the production of the beta chemokines regulated upon activation , normal T cell expressed and secreted ( RANTES ) , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta has been investigated in 30 HIV 1 infected individuals during 12 36 months of therapy . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
At 26 weeks postirradiation , messages encoding the chemokines BLC ( now known as Scyb 13 ) , C 10 ( now known as Scya 6 ) , IP 10 ( now known as Scyb 10 ) , MCP 1 ( now known as Scya 2 ) , MCP 3 ( now known as Scya 7 ) , MIP 1gamma ( now known as Scya 9 ) , and RANTES ( now known as Scya 5 ) and the chemokine receptors Ccr 1 , Ccr 2 , Ccr 5 and Ccr 6 were elevated in fibrosis sensitive ( C57BL / 6 ) mice . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In contrast , MC 4 did not prevent RANTES binding or subsequent signaling , but inhibited its ability to promote CCR 5 internalization . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This virus was cross resistant to a related inhibitor , SCH C , and partially resistant to RANTES but still sensitive to CCR 5 specific mAbs . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR5+CD8+ T cells effectively migrated in response to RANTES , suggesting that CCR 5 plays a critical role in the migration of Ag specific effector and differentiated memory CD8+ T cells to inflammatory tissues and secondary lymphoid tissues . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We investigated the effects of a number of naturally occurring chemokines ( MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , MCP 4 ) on different processes linked to the chemokine receptor CCR 5 in recombinant CHO cells expressing the receptor at different levels . 2 . ^^^ Internalization of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce internalization ( similar 50 % ) of the receptor . ^^^ Phosphorylation of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce phosphorylation of CCR 5 whereas the other chemokines did not induce CCR 5 phosphorylation . 4 . ^^^ MIP 1alpha , MIP 1beta , RANTES , MCP 2 and MCP 4 were able to stimulate increases in intracellular calcium ions via activation of CCR 5 whereas MCP 3 was without effect . 6 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The possibility that RANTES may act directly on breast tumor cells was supported by detection of the expression of the CCR 5 RANTES receptor in biopsy sections of breast cancer patients and by the ability of RANTES to promote the expression of MMP 9 by MCF 7 cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Fractalkine , SDF 1alpha , RANTES and MDC inhibited the 1 ( Ba ) in CX3CR1 , CXCR 4 , CCR 5 and CCR 4 expressing G1A1 cells , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Fluorescence activated cell sorter analysis revealed that HCC 1 [ 9 74 ] caused up to 75 % down regulation of CCR 5 cell surface expression , whereas RANTES ( regulated on activation , normal T cell expressed and secreted ) achieved a reduction of only about 40 % . ^^^ Studies performed with green fluorescent protein tagged CCR 5 confirmed that both HCC 1 [ 9 74 ] and RANTES , but not full length HCC 1 , mediated specific internalization of the CCR 5 HIV 1 entry cofactor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
It also prevented RANTES mediated influx of calcium in CCR 5 transfected CHO cells while internalization of CCR 5 was only marginally reduced . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CCR 5 agonists macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normally T cell expressed and secreted ) have been shown to block replication of R 5 virus in vitro and have gained attention as potential antiviral factors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Here , we show that expression of CCR 5 , a chemokine receptor for regulated on activation , normal T cell expressed and secreted ( RANTES ) and macrophage inflammatory protein ( MIP ) 1alpha / beta , is elevated on blood myeloid ( CD11c+ ) DC in MS and ON compared to non inflammatory controls . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The PBMC levels of CCR 5 ligands MIP 1 alpha / beta and RANTES , and chemokines MCP 1 , IL 8 , lymphotactin , IP 10 and 1 309 were analysed by ribonuclease protection assay ( RPA ) . ^^^ The CCR 5 ligands RANTES and MIP 1b were expressed constitutively in all patients and controls . ^^^ A correlation was found between the RNA levels of RANTES and CCR 5 in PPMS ( r=0 . 735 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CONCLUSIONS : Here , it was demonstrated that mRNA for the RANTES receptors CCR 1 and CCR 5 are present in human sperm . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Also , increased expression of IFN gamma was associated with a significant increase in expression of RANTES and monocyte chemotactic protein ( MCP ) 1 , chemokines that may inhibit HIV 1 infection by blocking viral attachment to CCR 2 and CCR 5 co receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULTS : SF T cells showed an increase in the population of CCR 5 , CXCR 4 , and CD45RO positive cells and exhibited an increase in chemotactic activity , which was not augmented with RANTES but stromal cell derived factor 1alpha . ^^^ Downmodulation of CCR 5 by RANTES was decreased and recycling of CCR 5 was accelerated in SF T cells when compared with peripheral blood ( PB ) T cells . ^^^ When CD45RO positive PB T cells were cultured with interleukin 2 , blunted responsiveness to RANTES induced chemotaxis was reproduced as well as spontaneous chemotaxis , increased expression of CCR 5 , and aberrant receptor dynamics , after RANTES stimulation as observed in SF T cells . ^^^ CONCLUSION : Synovial fluid T cells highly positive for CCR 5 show aberrant characteristics ; resistant to RANTES in terms of migration , but responsive in terms of dynamics of CCR5 . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The surface expression of CC chemokine receptor ( CCR ) 1 , CCR 4 , and CCR 5 on peripheral blood T lymphocytes and their responsiveness to the chemokines macrophage inflammatory proteins ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normally T cell expressed and secreted ) was analyzed in patients with chronic hepatitis C and hepatitis B infection and compared with healthy subjects . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Astrocytes expressed CCR 1 and CCR 5 ( the redundant RANTES receptors ) . ^^^ Astrocytes derived from mice with targeted mutations of either CCR 1 or CCR 5 respond after RANTES stimulation , suggesting multiple chemokine receptors may separately mediate RANTES responsiveness in astrocytes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Competition experiments , using a stably transfected CHO K 1 cell line overexpressing human CCR 5 , a RANTES receptor , indicated that derivatives biotinylated at positions 1 , 25 , and 67 bound to CCR 5 with the same affinity as native RANTES . ^^^ In addition , B 67 RANTES modulated CCR 5 expression on lymphocytes and elicited chemotaxis of monocytes in the same manner as unmodified RANTES . ^^^ Thus , B 67 RANTES acts as a CCR 5 agonist and may be useful to study the role of RANTES in pathologies such as , for example , human immunodeficiency virus ( HIV ) infection and inflammatory disorders . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Specific and concentration dependent binding of the beta chemokine RANTES to the cell membrane hybrid confirmed that CCR 5 retained ligand binding activity . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Morphine sulfate induces the formation and expression of both forms of CCR 5 whereas RANTES , MIP 1alpha or MIP 1beta inhibits them . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Increased expression of the chemokine receptors CCR 5 and CXCR 3 on T cells and raised amounts of the chemokines RANTES and IP 10 have been noted in the CSF and brain tissue of MS patients , but the contribution of gamma delta T cells to these increases is unknown . ^^^ We therefore compared intracellular RANTES and IP 10 production as well as CCR 5 , CXCR 3 , and CXCR 1 expression by gamma delta T cells derived from the blood and CSF of patients with MS and healthy controls ( HC ) . ^^^ The higher RANTES production by MS gamma delta T cell lines , together with a lower expression of CCR 5 , may reflect an autoregulatory loop , caused by an increased production of its ligands ( RANTES , MIP 1 alpha , and MIP 1 beta ) or due to other pro inflammatory cytokines . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Additive inhibition was most striking for RANTES , CCR 5 , CCR 7 , and Rel B . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
A number of inflammatory CC chemokines , including MIP 1 alpha , MIP 1 beta , RANTES , MCP 2 , and HCC 1 [ 9 74 ] act as CCR 5 agonists , while MCP 3 is a natural antagonist of the receptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We have reported that the principal neutralizing domain of V 3 of the HIV 1 gp 120 induces an antigen specific activation apoptosis of responding effector CD4+ T lymphocytes , a phenomenon inhibited by RANTES , an agonist of CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor responding to four natural agonists , the chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein ( MIP ) 1 alpha , MIP 1 beta , and monocyte chemotactic protein ( MCP ) 2 , and is the main co receptor for the macrophage tropic human immunodeficiency virus strains . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Natural ligands for CCR 5 , MIP 1alpha , MIP 1beta and RANTES , have been shown to inhibit HIV replication in CD4+ T cells . ^^^ In the present study , we examined the CCR 5 genotype by PCR and the plasma levels of RANTES and MIP 1alpha by ELISA among blood donors ( N = 26 ) and among HIV 1 infected individuals ( N = 129 ) . ^^^ RANTES concentrations in plasma samples from HIV+ patients carrying the homozygous CCR 5 allele ( CCR5 / CCR5 ) ( 28 . 23 ng / ml ) were higher than in the control samples ( 16 . 07 ng / ml ; P < 0 . 05 ) ; however , this HIV+ patient group ( mean 26 . 23 pg / ml ) had significantly lower concentrations of MIP 1alpha than those observed in control samples ( mean 31 . 20 pg / ml ; P < 0 . 05 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The presence of chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 , RANTES ) positive cells and chemokine receptor ( CCR 5 , CXCR 3 ) positive cells in inflamed human gingival tissues . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Analysis of gene polymorphisms in the regulatory region of MCP 1 , RANTES , and CCR 5 in liver transplant recipients . ^^^ We investigated whether the functional polymorphisms of the chemokines RANTES , MCP 1 and chemokine receptor CCR 5 are associated with the incidence of acute rejection and long term liver graft survival . ^^^ Two hundred nine liver transplant recipients were genotyped using polymerase chain reaction sequence specific primers for the following polymorphisms : RANTES 28 , MCP 1 2518 , and CCR 5 59029 . ^^^ In addition , no association of RANTES 28 , MCP 1 2518 , or CCR 5 59029 variants with long term liver graft survival was found . ^^^ In conclusion , variants of RANTES 28 , MCP 1 2518 , and CCR 5 59029 neither influenced the incidence of acute rejection nor affected long term allograft survival upon liver transplantation in the context of this analysis . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Most primary HIV strains use CCR 5 as a coreceptor and thereby are sensitive to inhibition by the CCR 5 ligand chemokines , RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a functional receptor for various inflammatory CC chemokines , including macrophage inflammatory protein ( MIP ) 1alpha and RANTES ( regulated on activation normal T cell expressed and secreted ) , and is the main coreceptor of human immunodeficiency viruses . ^^^ Several mutations in CCR 5 extracellular domains ( E172A , R168A , K191A , and D276A ) strongly affected MIP 1alpha binding but had little effect on RANTES binding . ^^^ Several CCR 5 mutants affecting transmembrane helices 2 and 3 ( L104F , L104F / F109H / F112Y , F85L / L104F ) reduced the potency of MIP 1alpha by 10 100 fold with little effect on activation by RANTES . ^^^ Altogether , these results suggest that the core domains of MIP 1alpha and RANTES bind distinct residues in CCR 5 extracellular domains , whereas the N terminus of chemokines mediates receptor activation by interacting with the transmembrane helix bundle . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The antiviral activity of their natural ligands ( stromal cell derived factor 1 [ SDF 1 ] , regulated on activation normal T cell expressed and secreted , ( RANTES ) and macrophage inflammatory proteins 1alpha and 1beta , MIP 1alpha and MIP 1beta ) and the finding that individuals deficient in CCR 5 are relatively resistant to HIV infection led to the concept that chemokine receptor antagonists can play an important role in anti HIV therapy . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Normal cartilage expressed the RANTES receptors CCR 3 and CCR 5 , but not CCR 1 . ^^^ RANTES and CCR 5 were markedly increased in OA and after in vitro treatment of normal chondrocytes with IL 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We have investigated the inhibitory mechanism of three N terminally modified RANTES variants ( AOP , NNY , and PSC RANTES ) with the MT 2 human T cell line stably expressing either native or mutated CCR 5 . ^^^ The RANTES analogues showed the same rank order ( PSC > NNY > AOP ) in their capacity to induce prolonged CCR 5 internalization , inhibit surface reexpression , and prevent HIV 1 infection on MT 2 cells expressing wild type CCR 5 or CCR 5 with four C terminal serine phosphorylation sites mutated to alanine . ^^^ None of the RANTES analogues caused internalization of a C terminal cytoplasmic domain deletion mutant of CCR 5 , and each derivative had equal potency in inhibiting HIV 1 infection of MT 2 cells expressing this mutant . ^^^ We conclude that the C terminal cytoplasmic residues of CCR 5 are necessary for receptor sequestration by RANTES analogues but that the process and the relative activity of each derivative are not dependent upon phosphorylation of the C terminal serine residues . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The expression of interferon ( IFN ) gamma inducible protein ( IP ) 10 , monokine induced by IFN gamma ( Mig ) , interferon inducible T cell alpha chemoattractant ( 1 TAC ) , regulated on activation normal T cell expressed and secreted ( RANTES ) , monocyte chemotactic protein ( MCP ) 1 , interleukin ( IL ) 8 , and the receptors CXCR 3 and CCR 5 were tested using quantitative , real time polymerase chain reaction . ^^^ RESULTS : Expression of IP 10 , Mig , 1 TAC , RANTES , CXCR 3 , and CCR 5 , but not MCP 1 and IL 8 , increased significantly in both grade 2 and grade 3 rejection ( P < / =0 . 0096 ) . ^^^ CONCLUSION : The expression of IP 10 , Mig , 1 TAC , RANTES , CXCR 3 , and CCR 5 in cardiac allografts significantly correlates with the presence and grade of acute rejection . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS : Six chemokine system polymorphisms ( CCR5Delta32 , CCR 5 promoter 59029 G / A , CCR 2 64I , RANTES [ regulated upon activation , normal T cells expressed and secreted ] 403 G / A , and 28 C / G and stromal derived factor 1 3 ' A ) were studied in 417 patients with liver diseases ( 339 with hepatitis C ) and 2380 blood donors . ^^^ Expression of CCR 5 and RANTES may be important in the modulation of hepatic inflammation and response to interferon therapy in chronic hepatitis C . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Matching pairs of receptors / ligands were found to be coordinately expressed , including TGFbetaRII with TGFbeta 3 , FGFRII and cysteine rich fibroblast growth factor receptor ( CRF 1 ) with FGF 7 and FGF 12 , CCR 1 , CCR 3 , CCR 5 with RANTES and calcitronin receptor like gene ( CALCRL ) with adrenomedullin . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In the present study , we examined the expression of chemokine receptors CXCR 1 and CXCR 2 ( receptors for interleukin 8 ) and CCR 5 ( receptor for RANTES [ regulated on activation , normal T cell expressed and secreted ] , macrophage inflammatory protein [ MIP ] 1alpha , and MIP 1beta ) in human endometrium . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the effect of RANTES gene promoter polymorphism and RANTES receptor ( CCR 5 gene ) promoter polymorphism on diabetic nephropathy in Japanese type 2 diabetic subjects . ^^^ Polymorphisms of 28 C / G and 403 G / A in the RANTES gene promoter region , and of 59029 G / A in the CCR 5 gene promoter region were detected by PCR RFLP ( restriction fragment length polymorphism ) . ^^^ The frequency of a RANTES 28G positive genotype ( C / G or G / G ) was higher in the DN 2 group than in the DN 0 and DN 1 groups ( 34 % vs . 25 and 20 % , P = 0 . 0268 , chi ( 2 ) = 4 . 905 ) , and the frequency of a CCR 5 59029 A positive genotype ( G / A or A / A ) was higher in the DN 1 and DN 2 groups than in the DN 0 group ( 84 and 85 % vs . 76 % , P = 0 . 0123 , chi ( 2 ) = 6 . 269 ) . ^^^ Discriminant analysis showed that the RANTES 28G positive genotype and CCR 5 59029A positive genotype were independently associated with nephropathy . ^^^ CONCLUSIONS : The RANTES promoter 28G genotype and CCR 5 promoter 59029A genotype may be independent risk factors for diabetic nephropathy in patients with type 2 diabetes and may have an additive effect on nephropathy . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
All 24 R 5 isolates were inhibited by the CCR 5 specific agents , PRO 140 and RANTES , while the two X 4 viruses and the three R5X4 viruses were sensitive to the CXCR 4 specific inhibitor , AMD 3100 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The beta chemokines RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are the natural ligands of the HIV 1 coreceptor CCR 5 and compete with the virus for receptor binding . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
A SHIV strain termed SHIV JRFL could enter cells via CD 4 with a chemokine receptor CCR 5 , not CXCR 4 , and the viral replication was suppressed by recombinant human RANTES , one of beta chemokines . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Our studies showed that LD infection caused the upregulation of three beta chemokines ( macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta and RANTES ( regulated on activation normal T cell expressed and secreted ) ) , one alpha chemokine ( interleukin 8 ( IL 8 ) ) and the CC chemokine receptor 5 ( CCR 5 ) but not CCR 1 , as evident from reverse transcriptase polymerase chain reaction ( RT PCR ) analysis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands , RANTES and MIP 1 alpha , are expressed in the spinal cords of mice at EAE onset . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
As well as potently inhibiting the entry of CCR 5 using HIV 1 strains , RANTES can enhance HIV 1 infectivity under certain experimental conditions . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Oligomerization of RANTES is required for CCR 1 mediated arrest but not CCR 5 mediated transmigration of leukocytes on inflamed endothelium . ^^^ However , the specific functional relevance of RANTES oligomerization for distinct steps of leukocyte recruitment on inflamed endothelium mediated by the RANTES receptors CC chemokine receptor 1 ( CCR 1 ) and CCR 5 remains undefined . ^^^ Notably , the formation of higher order RANTES oligomers was crucial for CCR 1 mediated arrest but not for CCR 5 mediated spreading / transmigration in flow or transendothelial chemotaxis of leukocytes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
P 2 resembles AOP RANTES in that it is a superagonist of CCR 5 and potently induces receptor sequestration . ^^^ P 1 , while less potent than P 2 , has the advantage of significantly reduced signaling activity via CCR 5 ( 30 % of that of RANTES ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
KA treatment did not affect mRNA levels for the macrophage inflammatory protein 1alpha ( MIP 1alpha ) or the regulated upon activation normal T cells expressed and secreted protein ( RANTES ) in either wild type or CCR 5 KO mice . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This interaction induces a dose dependent release of RANTES and down regulation of CCR 5 surface expression with concomitant intra cellular accumulation of CCR 5 proteins . ^^^ CONCLUSIONS : Our results demonstrate that an interaction of HGV E 2 with CD 81 leads to increased RANTES secretion and decreased CCR 5 surface expression . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Human hepatic stellate cells express CCR 5 and RANTES to induce proliferation and migration . ^^^ In conclusion , RANTES and CCR 5 represent potential mediators of 1 ) HSC migration and proliferation and 2 ) a cross talk between HSCs and leukocytes during fibrogenesis . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS : Expression of inducible protein ( IP ) 10 , monokine induced by IFN gamma ( Mig ) , interferon inducible T cell alpha chemoattractant ( 1 TAC ) , regulated on activation normal T cell expressed and secreted ( RANTES ) , and their receptors CXCR 3 and CCR 5 was tested in 60 endomyocardial biopsies from 24 patients using quantitative ( Taqman ) real time polymerase chain reaction ( PCR ) . ^^^ RESULTS : IP 10 , Mig , RANTES , CXCR 3 , and CCR 5 expression levels were increased in the later versus earlier biopsies ( P < or =0 . 01 ) despite no change in histologic rejection grade status . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The present findings suggest that MCP 1 , RANTES , and IP 10 may participate in the pathogenesis of mercuric chloride induced tubulointerstitial fibrosis with mononuclear cell infiltration , via CCR 2 , CCR 1 or CCR 5 , and CXCR 3 , respectively . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor for RANTES , MIP 1alpha , MIP 1beta , and MCP 2 that functions as the front line coreceptor for human immunodeficiency virus type 1 infection . ^^^ Whereas the amplitude of calcium mobilization induced by RANTES stimulation was lower in the CCR 5 CAM than the wild type ( WT ) receptor , MCP 1 induced a higher signal in the CCR 2 CAM than in CCR 2 WT . ^^^ The chemotactic response of CCR 5 CAM ( T82P ) to RANTES was similar to that of CCR 5 WT , but CCR 5 CAM ( T82K ) was dramatically decreased . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS : Lung biopsies from 4 patients that had classical features of WG were examined for protein expression of CCR 5 , RANTES , MIP 1alpha and MIP 1beta using immunohistochemistry . ^^^ CCR 5 Delta32 and RANTES 28 and 401 polymorphisms were determined by either specific primers or direct sequencing . ^^^ Enhanced protein concentrations of RANTES , MIP 1alpha , and MIP 1beta were present in WG lung lesions , indicating redundancy of ligands for CCR 5 in affected tissue . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
However , the remaining expression of CCR 1 and CCR 5 correlated reciprocally with an ongoing unresponsiveness to the CCR 1 and CCR 5 agonists CCL3 / macrophage inflammatory protein 1alpha ( MIP 1alpha ) , CCL4 / MIP 1beta , and CCL5 / regulated on activation , normal T expressed and secreted ( RANTES ) , all chemokines binding to these two receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Celecoxib also significantly decreased C C family chemokine ( Rantes and MCP 1 ) mRNA expression in irradiated skin tissues , but not in tumor tissues , which was accompanied by a decrease in skin mRNA expression of both C C ( CCR 2 and CCR 5 ) and C 10 C ( CXCR 2 and CXCR 4 ) chemokine receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The beta chemokines MIP 1alpha , MIP 1beta , and RANTES inhibit HIV 1 infection of CD4+ T cells by inhibiting interactions between the virus and CCR 5 receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Using reverse transcriptase analysis of stomachs from normal and gastritic mice we found no difference in expression of CCR 5 and its chemokine ligands MIP 1alpha , MIP 1beta , and RANTES . ^^^ We also found that the CCR 5 antagonist met RANTES failed to prevent the development of EAG induced by neonatal thymectomy . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Two mechanisms induced by IFN tau treatment in macrophages may account for this inhibition : ( 1 ) the synthesis of the cellular antiviral factors such as 2 ' , 5 ' oligoadenylate synthetase / RNase L and MxA protein and ( 2 ) an increased production of MIP 1alpha , MIP 1beta , and RANTES , which are natural ligands of CCR 5 , the principal coreceptor of HIV on macrophages . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Association of genetic variants of the chemokine receptor CCR 5 and its ligands , RANTES and MCP 2 , with outcome of HCV infection . ^^^ The chemokine receptors CCR 5 , CCR 2 , and CCR 3 and their ligands , RANTES , MCP 1 , MCP 2 , and MIP 1alpha , are involved in the immune responses and the selective recruitment of lymphocytes to the liver in HCV infection . ^^^ In conclusion , our study suggests a possible role of the polymorphisms CCR 5 delta32 , RANTES 403 , and MCP 2 Q46K in the outcome of HCV infection . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULTS : SDF 1beta required an essentially complete CXCR 4 , whereas RANTES demanded both the N terminus and the first two extracellular loops of CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
A novel lead compound , N ( 3 [ 4 ( 4 fluorobenzoyl ) piperidin 1 yl ] propyl ) 1 methyl 5 oxo N phenylpyrrolidine 3 carboxamide ( 1 ) , was identified as a CCR 5 antagonist by high throughput screening using [ ( 125 ) 1 ] RANTES and CCR 5 expressing CHO cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Chemokine receptor 5 ( CCR 5 ) binds macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , and members of the monocyte chemotactic protein family and is also a receptor for human immunodeficiency virus ( HIV ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Differential expression of beta chemokines MCP 1 and RANTES and their receptors CCR 1 , CCR 2 , CCR 5 in acute rejection and chronic allograft nephropathy of human renal allografts . ^^^ METHODS : In 24 renal transplant biopsies with AR ( n = 15 ) and CAN ( n = 9 ) , the expression of MCP 1 and RANTES , their receptors CCR 1 , CCR 2 , and CCR 5 and the infiltration with monocytes / macrophages and T cells were studied . ^^^ Biopsies with CAN revealed a lower expression of MCP 1 , RANTES , CCR 1 , CCR 2 and CCR 5 in tubulointerstitial cells , and a significantly lower infiltration with MRP 14 positive monocytes / macrophages than biopsies with AR . ^^^ In AR , MCP 1 and CCR 1 showed a lower expression compared to RANTES , CCR 2 , and CCR 5 . ^^^ CONCLUSIONS : The positive correlation between chemokines and chemokine receptors and infiltrating leukocytes during acute rejection , the lower but detectable expression of MCP 1 , RANTES , CCR 1 , CCR 2 and CCR 5 in CAN , and the differences in the quantity of expression between the different chemokines and chemokine receptors point to a complex regulation of chemokine expression in renal allografts . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Thus we postulated that the genes encoding CCR 5 and CCR 2 , which are the receptors for RANTES and MCP 1 respectively , could be good candidate genes for the disease . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Enzyme linked immunosorbent assay ( ELISA ) and semi quantitative RT PCR were used to examine changes in inflammatory chemokines ( macrophage inflammatory protein 1 ( MIP 1alpha ) , regulated upon activation , normal T cell expressed and secreted ( RANTES ) , and inducible protein 10 ( IP 10 ) ) and chemokine receptor ( C C chemokine receptor 5 ( CCR 5 ) and C 10 C chemokine receptor 3 ( CXCR 3 ) ) production , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The present experiments were carried out to test the central role of CCR 5 , a functional receptor for MIP 1beta and RANTES , in the febrile responses induced by these chemokines when injected directly into the POA . ^^^ However , pretreatment with the same dose of anti CCR 5 suppressed the febrile response induced by RANTES given at the same site . ^^^ The present experiments show that hypothalamic CCR 5 are functionally involved in the febrile response induced by RANTES , but not by MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The cerebral malaria associated expression of RANTES , CCR 3 and CCR 5 in post mortem tissue samples . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta are described to inhibit viral entry . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , cell migration evoked by regulated on activation , normal T expressed and secreted ( RANTES ) / CCL5 and MIP 1beta / CCL4 , the selective agonist of CCR 5 , was inhibited in transfected cells and monocytes , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Here , we explore the influence of genetic polymorphisms of chemokine and chemokine receptors such as regulated upon activation and T cell secreted ( RANTES ) , CC chemokine receptor 5 ( CCR 5 ) and CCR 2 on the outcome of interferon ( IFN ) monotherapy . ^^^ METHODS : In a cohort of 105 patients with chronic hepatitis C as well as in 50 sustained responders and 55 nonresponders the presence of polymorphisms such as CCR 5 Delta32 , CCR 5 59029G / A , CCR 2 V64I and RANTES 403G / C was determined . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Longer survival in HIV positive individuals is associated with high serum concentrations of ligands for CCR 5 ( RANTES [ regulated on activation , normal T cell expressed and secreted ] and macrophage inflammatory proteins [ MIP ] 1alpha and 1beta ) and CXCR 4 ( stromal derived factor [ SDF 1 ] ) , and with decreased expression of CCR 5 on lymphocytes . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
During the 7 d after transplantation , the chemokines MCP 1 , MCP 2 , RANTES , MIG , IP 10 , 1 TAC , and two CC chemokine receptors CCR 2 and CCR 5 were highly expressed in allografts when compared with isografts . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
PSC RANTES blocks R 5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR 5 diplotypes . ^^^ Competition experiments between primary R 5 and X 4 HIV isolates showed blocking of R 5 HIV by PSC RANTES and no evidence of increased propagation of X 4 HIV , data that are consistent with the specificity of PSC RANTES for CCR 5 and the CCR 5 ( + ) CXCR 4 ( ) phenotype of immature LC . ^^^ Finally , when CCR 5 genetic polymorphism data were integrated with results from the in vitro LC infection studies , PSC RANTES was found to be equally effective in inhibiting R 5 HIV in LC isolated from individuals with CCR 5 diplotypes known to be associated with low , intermediate , and high cell surface levels of CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
AK 602 , despite its much greater anti HIV 1 activity than other previously published CCR 5 inhibitors , including TAK 779 and SCH C , preserved RANTES ( regulated on activation normal T cell expressed and secreted ) and MIP 1beta binding to CCR 5 ( + ) cells and their functions , including CC chemokine induced chemotaxis and CCR 5 internalization , while TAK 779 and SCH C fully blocked the CC chemokine / CCR5 interactions . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The RANTES chemokine acts on target cells by binding to the CCR 5 receptor , which is present on the surface of various cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Analysis of genetic polymorphisms in CCR 5 , CCR 2 , stromal cell derived factor 1 , RANTES , and dendritic cell specific intercellular adhesion molecule 3 grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV 1 . ^^^ However , the CCR 5 59029A , CCR 2 64I , stromal cell derived factor ( SDF ) 1 3 ' A , RANTES ( regulated on activation , normally T cell expressed and secreted ) 403A , and RANTES 28G polymorphisms were not associated with resistance to HIV 1 infection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
AIMS : Polymorphisms in the RANTES ( G 403A ) , monocyte chemoattractant protein 1 ( MCP 1 ; A 2518G ) , stromal cell derived factor 1beta ( SDF 1beta ; G801A ) , and C C chemokine receptor 5 ( CCR 5 ; Delta 32 ) genes have been associated with functional effects . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : Ligands of chemokine receptor CCR 5 , including MIP 1 alpha , MIP 1 beta , and RANTES , have been implicated in rheumatoid arthritis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We report that during the early phase of infection in C3H / HeJ mice infected with 100 blood trypomastigotes of T cruzi , most of the inflammatory cells invading the heart tissue were CD8+ cells and expressed CCR 5 , a CCL5 / RANTES , and CCL3 / MIP1 alpha receptor . ^^^ These findings led us to use Met RANTES , a selective CCR 1 and CCR 5 antagonist , to modulate the acute T cruzi elicited myocarditis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Our main findings were , with similar qualitative patterns in both healthy controls and HIV infected patients : ( 1 ) TLR 2 stimulation induced up regulation of several chemokines at the mRNA level as well as increased protein levels of macrophage inflammatory protein ( MIP ) 1alpha , interleukin ( IL ) 8 and regulated on activation , normal T cell expressed and secreted ( RANTES ) ; ( 2 ) TLR 2 stimulation induced enhanced protein expression of CCR 5 ( a receptor for MIP 1alpha and RANTES ) on monocytes ; ( 3 ) In vitro stimulation with RANTES induced release of MIP 1alpha , MCP 1 , IL 8 and interferon gamma from PBMC . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 ligands RANTES , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta are potent and specific inhibitors of strains of human immunodeficiency virus ( HIV ) that use CCR 5 as a receptor , which are the strains most involved in primary infection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Coevolution of RANTES sensitivity and mode of CCR 5 receptor use by human immunodeficiency virus type 1 of the R 5 phenotype . ^^^ Our results indicate a close relationship between HIV 1 phenotypic changes and the pathogenic process , since the mode and efficiency of CCR 5 use as well as the decrease in the RANTES sensitivities of isolated viruses are significantly correlated with CD 4 ( + ) T cell decline in a patient . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Using a chimeric simian / human immunodeficiency virus ( SHIV SF 162 ) , which is tropic for the chemokine receptor CCR 5 , we report that topical application of high doses of PSC RANTES , an amino terminus modified analog of the chemokine RANTES , provided potent protection against vaginal challenge in rhesus macaques . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Chemokines ( RANTES and MCP 1 ) and chemokine receptors ( CCR 2 and CCR 5 ) gene polymorphisms in Alzheimer ' s and Parkinson ' s disease . ^^^ We examined whether DNA polymorphisms at the genes encoding chemokines MCP 1 ( 2518 A / G ) and RANTES ( 403 A / G ) , and chemokine receptors 5 ( CCR 5 , Delta 32 ) and 2 ( CCR 2 , V64I ) , were associated with the risk and / or the clinical outcome of LOAD and PD . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Exposure of PBMC to HCV E 2 induced a dose dependent release of regulated on activation normal T cell expressed and secreted ( RANTES ) , down regulation of CCR 5 expression and intracellular accumulation of CCR 5 . ^^^ Our results suggest that interaction of HCV E 2 with CD 81 leads to increased RANTES secretion by CD8+ lymphocytes which induces down regulation of CCR 5 surface via receptor internalization resulting in altered lymphocyte migration . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The remarkable potency of our RANTES analogs probably involves the unusual mechanism of intracellular sequestration of CC chemokine receptor 5 ( CCR 5 ) , and it has been suggested that this arises from enhanced affinity for the receptor . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Pulmonary mRNA and protein levels of RANTES were significantly elevated in allo SCT recipients compared to syngeneic controls and were associated with enhanced mRNA expression of CCR 5 and CCR 1 and with inflammatory cell infiltration into the lung . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Likewise the intrarenal RNA expression of the CXCR 3 ligands IP 10 ( 5 . 2 fold ) and 1 TAC ( 7 . 2 fold ) and the CCR 5 ligand RANTES ( 5 . 7 fold ) , was significantly up regulated in rejecting organs . ^^^ CONCLUSIONS : These data from a prospective , biopsy controlled study indicate that the local expression of IP 10 and RANTES leads to the directional movement of activated CXCR 3 and CCR 5 bearing T cells into the renal allograft and mediates acute rejection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In this study , to investigate the role of chemokines in pathogenic mechanism of neurodegeneration in prion diseases , we determined the cerebral expression of RANTES , a major chemoattractant of monocytes and activated lymphocytes , and its receptors CCR 1 , CCR 3 and CCR 5 in ME 7 scrapie infected mice . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS : Using the surgically obtained tissue of patients ( n = 36 ) with BPH or prostate carcinoma ( PCA ) , we studied among others the expression of chemokines ( Rantes , IL 8 ) , chemotaxin receptors ( CXCR 3 and 4 , CCR 3 , CCR 5 ) , of matrixmetalloproteinases ( MMP 2 and 9 ) , of Toll like ( TL ) receptors 1 , 2 , 3 , 4 , 5 , 7 , and 9 and of the inducible cyclooxygenase 2 ( cox 2 ) by RT PCR . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Substantial levels of CCR 5 ligands , MIP 1alpha and RANTES mRNA were found in the inflamed intestinal mucosa in CD . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
As the ligands of CCR 5 , MIP1alpha and MIP1beta were detected , whereas RANTES was not . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the serum RANTES ( Regulated upon Activation of Normal T cell Expressed and Secreted ) levels and the expression of CCR 5 , as well as the percentage of apoptotic cells , in peripheral T lymphocytes from renal transplanted patients with acute rejection ( AR ) , chronic rejection ( CR ) or stable evolution ( SE ) . ^^^ RANTES serum levels were determined by enzyme linked immunoadsorbent assay and CCR 5 expression , as well as the percentage of apoptotic lymphocytes , on a FACScan flow cytometer . ^^^ The RANTES serum levels and the percentage of peripheral CCR 5 T lymphocytes would not indicate the renal allograft state . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Conversely , MPA modestly decreased the secretion of the CCR 5 ligand RANTES in resting lymphocytes , but had no effect after activation . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The recruitment of major histocompatibility complex ( MHC ) class 2 ( + ) LC was significantly suppressed in CCR 5 ( / ) mice and blockade of RANTES and MIP 1beta , but not in CCR 1 ( / ) , CCR 2 ( / ) / MIP 1alpha ( / ) , or MIP 1alpha ( / ) mice . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
PDTC effectively inhibited NF kappaB activation in the iris and ciliary body , and markedly inhibited the expression of chemokine genes , including monocyte chemoattractant protein ( MCP ) 1 , regulated on activation normal T cell expressed and secreted ( RANTES ) , and interleukin ( IL ) 8 and chemokine receptors genes including CCR 2 , CCR 5 , and CXCR 3 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Genetic variants were identified in the chemokine receptors ( CCR 2 , CCR 5 , and CCR 5 promoter ) and the chemokine RANTES using TaqMan and restriction fragment length polymorphism assays . ^^^ Because RANTES is a critical chemokine and competitively inhibits HIV 1 by binding to its receptor CCR 5 , treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Immunohistochemical analysis of endometrial cryosections showed that the RANTES receptor , CCR 5 , was expressed by trophoblasts on anchoring villi and by cells within the trophoblastic shell . ^^^ Isolated trophoblasts migrated towards RANTES when cultured in migration chambers and migration was reduced in the presence of anti CCR 5 antibody . ^^^ These data suggest a role for RANTES and CCR 5 in the regulation of trophoblast migration within the endometrium and within the uterine vasculature . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The natural ligands of CCR 5 , the beta chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES , interfere with HIV 1 binding to CCR 5 receptors and decrease the amount of virions entering cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
RESULTS : The result of cDNA array showed that one chemotactic related gene was up regulated more than two fold ( RANTES ) and seven chemotactic related genes were down regulated more than two fold ( CCR 1 , CCR 5 , ccl 16 , GRObeta , GROgamma , IL 8 and granulocyte chemotactic protein 2 ) in MCP 1 treated U 937 cells at mRNA level . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : We hypothesized that the chemokine receptor 5 ( CCR 5 ) ligands , MIP 1alpha , MIP 1beta and RANTES , are virulence correlates in M . tuberculosis infection and are indispensable to granuloma formation . ^^^ CONCLUSIONS : The production of the CCR 5 ligands , MIP 1alpha , MIP 1beta , and RANTES , does not clearly correlate with virulence of M . tuberculosis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
As a result , RANTES mediated chemoattraction of CCR 5 ( + ) target cells was also severely impaired . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The aim of this study was to assess the involvement of inherited variations in CCR 2 , CCR 5 , and the ligand RANTES in determining disease outcome in hepatitis C virus ( HCV ) infected individuals . ^^^ METHODS : A total of 283 women , all exposed to HCV genotype 1b from a single donor , and including those who had spontaneously cleared the virus and those chronically infected , were genotyped for CCR 2 , CCR 5 , and RANTES polymorphisms . ^^^ RESULTS : CCR 5 , CCR 2 , and RANTES genotypes were compared with HCV polymerase chain reaction ( PCR ) status , alanine aminotransferase levels , and liver histology . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In a previous study , we showed that during disease progression in the presence of R 5 variants only , HIV 1 variants emerge with a decreased sensitivity to inhibition by RANTES , a natural ligand of CCR 5 that inhibits cellular entry of R 5 variants . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Infiltrating T cells , confined to the adventitia and intima , expressed CXCR 3 and CCR 5 , but were not recruited into the media despite production by vascular smooth muscle cells of IP 10 , Mig , 1 TAC , RANTES and MIP 1beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Upregulation of RANTES and MIP 1alpha transcripts in the absence of a significant CCR 5 increase suggests a possible involvement of other chemokine receptors . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We examined the expression of chemokine receptors CCR 5 and CXCR 4 on CD4+ T cells and plasma chemokine levels of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , regulated on activation normal T expressed and secreted ( RANTES ) , and stromal cell derived factor ( SDF ) 1alpha among TB patients with HIV coinfection during the first 2 months of anti TB treatment . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
It was insensitive to the CCR 5 entry inhibitors RANTES and PRO 140 , but was partially inhibited by vMIP 1 , a chemokine that binds CCR 3 , CCR 8 , GPR 15 and CXCR 6 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Furthermore , the prevalent expression of the receptors CCR 3 , CCR 5 , CXCR 1 , and CXCR 3 and of the chemokines RANTES , IP 10 , and MCP 1 in cysts may point to a role in the progression of granulomas to cysts . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a seven transmembrane G protein coupled receptor that binds the CC chemokines including RANTES , eotaxin , MIP 1alpha and beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
A flow cytometric analysis showed that the expressed RANTES down modulated CC chemokine receptor 5 ( CCR 5 ) on PM 1 cells , which was restored by adding anti RANTES antibody . ^^^ UV irradiated culture supernatants from the SHIV RANTES infected cells suppressed replication of CCR 5 tropic HIV 1 BaL in PM 1 cells . ^^^ Differentiating real time RT PCR showed that pre infection of SHIV RANTES in C 8166 cells expressing CCR 5 suppressed the replication of HIV 1 BaL . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene ( CCR 5 ) : a sex specific effect . ^^^ To determine whether the risk of diabetic nephropathy is influenced by two functional polymorphisms in the regulated upon activation normal T cell expressed and secreted ( RANTES ) receptor gene ( CCR 5 ) , we recruited patients with type 1 diabetes , including 496 case subjects with overt proteinuria or end stage renal disease and 298 control subjects with normoalbuminuria . ^^^ In conclusion , two functional polymorphisms in CCR 5 that decrease expression of the RANTES receptor on immunocompetent cells are associated with increased risk of diabetic nephropathy in type 1 diabetes , but only in men . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
TAK 652 inhibited the binding of RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta to CCR 5 expressing cells at nanomolar concentrations . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We have designed bifunctional fusion proteins , consisting of RANTES / CCL5 and a single chain Fv Ab fragment against CD 4 to simultaneously block CD 4 and CCR 5 . ^^^ The fusion proteins bind to both receptors , compete with RANTES / CCL5 binding , and induce down modulation of CCR 5 approximately 10 times more efficiently on CD4+ compared with CD8+ T cells . ^^^ Moreover , after short incubation and subsequent washout , a significant down modulation of CCR 5 was only seen with the fusion proteins and only on CD4+ cells , but not with unmodified RANTES or on CD 4 cells , indicating a preferential targeting of CCR 5 on CD4+ T cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CCR 5 , RANTES and CX3CR1 polymorphisms : possible genetic links with acute heart rejection . ^^^ METHODS : In a retrospective analysis of a cohort of heart transplanted patients ( n=158 ) , we examined eight polymorphisms in four genes implicated in this inflammatory process : RANTES , CCR 5 , CCR 2 and CX3CR1 . ^^^ In contrast subjects carrying both the CCR 5 E haplotype and the RANTES 403A allele were significantly at higher risk to develop LAR ( OR=8 . 1 [ 95 % CI=2 . 3 28 . 7 ] , P=0 . 002 ) . ^^^ CONCLUSIONS : This exploratory study in heart transplantation suggests that the outcomes of EAR and LAR episodes may be influenced by genetic variant interactions such as `` CX3CR1 249I * CCR5 No E ' ' and `` CCR 5 E * RANTES 403A . ' ' . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
METHODS : We conducted a nested case control study of African Americans ( 266 HIV 1 seroconverter cases and 532 seronegative controls from the AIDS Link to Intravenous Experience cohort ) , to examine the association between 50 single nucleotide polymorphisms ( SNPs ) in 9 candidate genes ( CCR 5 , CCR 2 , RANTES , MIP1A , MCP 2 , IL 10 , IFNG , MCSF , and IL 2 ) and susceptibility to HIV 1 infection . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
The aim of the study was to compare the immunoexpression of monocyte chemoattractant protein 1 ( MCP 1 ) , monocyte inflammatory protein 1alpha ( MIP 1alpha ) , Regulated upon Activation Normal T cell Expressed and Secreted ( RANTES ) and CC chemokine receptors : CCR 1 and CCR 5 in renal biopsy specimens in IgA nephropathy ( IgAN ) and in non IgA mesangial proliferative glomerulonephritis ( MesProGN ) , and to find any relationships between the immunoexpression of chemokines and chemokine receptors and renal interstitial lesions . ^^^ In conclusion , these observations suggest that in the renal tissue in IgAN patients MCP 1 , RANTES and CCR 5 are up regulated as compared with renal biopsy specimens from patients with MesProGN . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
High RANTES and IL 6 were induced in patients ' lymphocytes by pathogenic LCM , along with their receptors CCR 5 and CD 126 as compared to NP LCM . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Plasmodium yoelii 17XL infection up regulates RANTES , CCR 1 , CCR 3 and CCR 5 expression , and induces ultrastructural changes in the cerebellum . ^^^ The hypothesis of this study is that RANTES and its corresponding receptors ( CCR 1 , CCR 3 and CCR 5 ) modulate malaria immunopathogenesis . ^^^ RESULTS : RANTES ( p < 0 . 002 ) , CCR 1 ( p < 0 . 036 ) , CCR 3 ( p < 0 . 033 ) , and CCR 5 ( p < 0 . 026 ) mRNA were significantly upregulated at peak parasitaemia and remained high thereafter in the experimental mouse model . ^^^ CONCLUSION : The upregulation of RANTES , CCR 1 , CCR 3 , and CCR 5 mRNA , and RANTES protein mediate inflammation and cellular degradation in the cerebellum during P . yoelii 17XL malaria . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
CD3+ T cells , infiltrating the retina , also expressed the chemokine receptor CCR 5 , and CCR 5 ligands , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated on activation , normal T expressed and secreted ( RANTES ) , were strongly expressed in the retina at peak EAU . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Induction of RANTES and CCR 5 through NF kappaB activation via MAPK pathway in aged rat gingival tissues . ^^^ In the 24 month old ( Old ) rat gingival tissues , RANTES and CCR 5 mRNA and protein levels were 2 4 fold increased over those of the 6 month old ( Young ) rats . ^^^ These results suggest that age related increases in RANTES and CCR 5 expression are associated with increased IkappaBalpha , nuclear NF kappaB , and MAPK activity in gingival tissues . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
To better understand the interaction of the host with HIV 1 during active tuberculosis , we investigated in vivo expression of the HIV 1 coreceptors , CCR 5 and CXCR 4 , and circulating levels of the inhibitory beta chemokines , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , macrophage inflammatory protein 1 beta ( MIP 1beta ) , and regulated upon activation T cell expressed and secreted ( RANTES ) , in HIV positive individuals with and without active pulmonary tuberculosis . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We determined the pattern of expression of CD11c , CD 14 , CD 40 , CCR 5 , and CXCR 4 and quantified IL 1beta , IL 6 , IL 8 , TNF alpha , and RANTES in tuberculosis patients and HIV patients . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Increased expression of RANTES , CCR 3 and CCR 5 in the lesional skin of patients with atopic eczema . ^^^ Regulated on activation normal T cell expressed and secreted ( RANTES / CCL5 ) is a chemokine that induces eosinophil migration , and CCR 3 and CCR 5 are the receptors of RANTES . ^^^ OBJECTIVE : In order to further clarify the pathomechanisms of eosinophil infiltration in ongoing chronic inflammation in the skin of patients with AE and its relation to disease severity , we examined the expression of RANTES and its receptors CCR 3 and CCR 5 in challenged and unchallenged lesional skin of AE . ^^^ The cellular source of RANTES , CCR 3 and CCR 5 was analyzed by double immunohistochemistry using specific antibodies to RANTES , CCR 3 or CCR 5 , and antibodies to ECP ( EG 2 ) or CD 3 . ^^^ CONCLUSION : Taken together , these results suggest that RANTES as well as its receptors CCR 3 and CCR 5 may play important roles in the orchestration of eosinophil infiltration in ongoing chronic inflammation in AE , and also reflect the severity of disease . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We analyzed the differential role of the RANTES receptors CCR 1 and CCR 5 by genetic deletion in apolipoprotein E deficient mice . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Although polymorphisms of chemokine genes ( SDF 1 , stromal cell derived factor 1 and RANTES , regulated on activation , normal T cell expressed and secreted ) and chemokine receptor genes ( CCR 5 , CCR 2 , CX ( 3 ) CR 1 ) were shown to be associated with sensitivity to HIV infection and untreated HIV disease progression , their association with the response to highly active antiretroviral therapy ( HAART ) remains unclear . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We previously demonstrated that macaque trophoblasts express the chemokine receptor CCR 5 and that this receptor mediates trophoblast migration toward RANTES ( regulated upon activation normal T cell expressed and secreted ) . ^^^ These results support the idea that cigarette smoke constituents inhibit directional trophoblast migration by causing increased desensitization of trophoblast CCR 5 and inhibiting the secretion of RANTES by endothelial cells . . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Whole cell RNA was isolated and chemokine ( IL 8 , CCL2 / MCP 1 , CXCL10 / IP 10 and CCL5 / RANTES ) and chemokine receptor ( CCR 2 and CCR 5 ) expression was tested by quantitative PCR . ^^^ RANTES , CCR 2 , and CCR 5 expression did not change in ischemic vs . reperfusion biopsies . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
There were no significant increases in the expression of IL 1beta , IL 8 , IP 10 , SDF 1 , RANTES , Fractalkine , CX3CR 1 , CCR 2 , CCR 5 , CCR 11 , TNF alpha , GM CSF and TGF beta using RT PCR . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Following the cross linking of CCR 5 , monocytes synthesized high levels of M CSF , RANTES , MIP 1 alpha , and MIP 1 beta associated with a readily detectable down modulation of CD 14 , CD 4 , CCR 5 , and CXCR 4 expression . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Preclinical evaluation of synthetic 2 RANTES as a candidate vaginal microbicide to target CCR 5 . ^^^ Certain CC chemokines , including RANTES , MIP 1alpha , and MIP 1beta , might facilitate the development of such microbicides since they potently suppress HIV 1 infection by binding to CCR 5 , the viral coreceptor used by most sexually transmitted strains of HIV 1 to enter host cells . ^^^ In this study , we evaluated whether a CCR 5 specific fragment of RANTES that lacks two N terminal residues ( 2 RANTES ) and possesses especially potent HIV 1 suppressive activity has toxicity profiles conducive to the advancement of testing in candidate microbicide formulations . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This study further elucidates the roles of selected chemokines ( IP 10 , MIG , and RANTES ) and their receptors ( CCR 3 , CCR 5 , and CXCR 3 ) in asthma . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Inflammation , genetic polymorphisms in proinflammatory genes TNF A , RANTES , and CCR 5 , and risk of pancreatic adenocarcinoma . ^^^ There was no overall association between pancreatic cancer risk and tumor necrosis factor alpha ( TNF A 308G / A ) , regulated upon activation , normally T cell expressed , and presumably secreted ( RANTES 403G / A ) , and CC chemokine receptor 5 ( CCR 5 Delta32 ) polymorphisms . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
This structure of V 3 ( MN ) was found to have conformation and sequence similarities to beta hairpins in CD 8 and CCR 5 ligands MIP 1alpha , MIP 1beta , and RANTES and differed from the beta hairpin of a V 3 ( IIIB ) peptide bound to the strain specific murine anti gp 120 ( IIIB ) antibody 0 . 5beta . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Using intravital microscopy within the rat mesenteric microcirculation 4 h after exposure to 1 nM Ang 2 , arteriolar mononuclear cell adhesion was 80 90 % inhibited by pretreatment with Met RANTES , a CCR 1 and CCR 5 antagonist , or an anti MCP 1 antiserum , without affecting the increased endothelial expression of P selectin and VCAM 1 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Our solubilization conditions maintained high affinity binding of chemokines SDF 1alpha and RANTES to CXCR 4 and CCR 5 , respectively . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Several N terminus modified CCL5 / RANTES derivatives , such as N Terminal truncated CCL5 / RANTES , Met RANTES , and amino oxypentane ( AOP ) RANTES exhibited antagonist or partial agonist functions when investigated on the properties of their receptors CCR 1 , CCR 3 , and CCR 5 . ^^^ S24F binds CCR 1 , CCR 3 , and CCR 5 and triggers receptor down modulation comparable to CCL5 / RANTES . ^^^ Moreover , in CCR 5 positive cells , S24F elicits cellular calcium mobilization equivalent to that obtained with CCL5 / RANTES . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In functional calcium signalling assays , the CCR 5 endogenous ligands MIP 1alpha , MIP 1beta and RANTES evoked a robust response in the dog recombinant CCR 5 cells . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
On the other hand , non MHC encoded genes are CCR 5 , CCR 2 , RANTES , CXCL 12 , CXCR 6 , CCL3L1 , Interleukin 10 ( IL 10 ) , and interferon gamma . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
In vitro studies indicated that HCV E 2 induced secretion of RANTES efficiently attracts CCR 5 ( + ) immature DC . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
Tissue slides were stained for a variety of cell markers ( CD 3 , CD 4 , CD 8 , CD 20 , CD 68 , CD79a ) , chemokines ( monokine induced by interferon [ MIG ] , interferon inducible protein 10 [ IP 10 ] , interferon inducible T cell alpha chemoattractant [ ITAC ] , RANTES [ regulated on activation normal T cell expressed and secreted ] , and fractalkine ) , and chemokine receptors ( CXCR 3 , CCR 5 , and CX3CR1 ) . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
We report that A / J mice immunized with mc TnI developed severe inflammation of the myocardium with increased expression of inflammatory chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , monocyte chemoattractant protein 1 , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MIP 2 , T cell activation gene 3 , and eotaxin and chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13501 and P51681	Pubmed	SVM Score :0.0
NA