Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.93619904
We demonstrate that the key region of CCR 5 involved in its specific interaction with MIP 1alpha , MIP 1beta , and RANTES , and its subsequent activation , lies within the second extracellular loop ( and possibly the adjacent transmembrane segments ) . 0.93619904^^^ The chemokine receptor CCR 5 binds macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation , normal T cell expressed and secreted ( RANTES ) , and constitutes the major co receptor allowing infection of CD 4 ( + ) T lymphocytes , macrophages , and microglial cells by macrophage tropic strains of human and simian immunodeficiency virus . 0.70948253^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.65489022
In addition , we identified Phe 13 , the residue immediately following the conserved CC motif in MIP 1 beta , as a key determinant for binding to CCR 5 . 0.65489022^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.70867087
Although membrane expression of the CCR 5 mutant was diminished , the molecules reaching the membrane were still able to interact efficiently with the chemokine ligand MIP 1 beta and remained able to function as HIV co receptors . 0.70867087^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.87780113
The single most important MIP 1beta residue known to contribute to its interaction with the receptor is Phe 13 , which when mutated reduces the ability of MIP 1beta to bind to CCR 5 by more than 1000 fold . 0.87780113^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.51247414
We have now investigated further the relative contribution of other MIP 1beta residues in the interaction of the chemokine with CCR 5 , by studying the functional consequences of point mutations within the N loop and the 3 ( 10 ) turn of MIP 1beta , affecting the charge , size , and H bonding properties of the side chains . 0.51247414^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :1.1180384
Thus , we suggest that various conformational states of CD 4 exist , which differ markedly with regard to inhibiting the interaction of CCR 5 with its ligand MIP 1beta . 1.1180384^^^ In contrast , the two domain amino terminal fragment of soluble CD 4 was able to completely inhibit the interaction of CCR 5 with MIP 1beta . 0.60899432^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.52707718
To do this we cloned and expressed CCR 5 from rhesus macaque and compared the binding properties of [ 125I ] MIP 1beta and [ 3H ] maraviroc with human recombinant CCR 5 . [ 125I ] MIP 1beta bound with similar high affinity to CCR 5 from macaque ( K ( d ) = 0 . 24 + / 0 . 05 nM ) and human ( K ( d ) = 0 . 23 + / 0 . 05 nM ) and with similar kinetic properties . 0.52707718^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The chemokine macrophage inflammatory protein 1beta / CCL4 , ligand of the major HIV co receptor CCR 5 , is encoded by two genes , Act 2 and Lag 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Since chemokine receptors CXCR 3 and CCR 5 are preferentially expressed on Th 1 cells , we tested the expression and regulation of several chemokines , including those that signal through CXCR 3 ( interferon gamma inducible protein of 10 kDa , IP 10 , CXCL 10 ; and monokine induced by interferon gamma , Mig , CXCL 9 ) and CCR 5 ( macrophage inflammatory protein ( Mip ) 1 alpha , CCL 3 ; and Mip 1 beta , CCL 4 ) in RA synovial fluids , synovial tissues , and blood . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The most active chemokines for resting Th ( IL 10 ) , in terms of calcium mobilization and in vitro migration , were in order of potency : CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , CCL 17 ( thymus and activation regulated chemokine , CCR 4 ligand ) , CCL 1 ( 1 309 , CCR 8 ligand ) , CXCL 12 ( stromal derived factor 1 , CXCR 4 ) , and CCL 11 ( eotaxin , CCR 3 ligand ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The effect is not unique to CCL 5 , as other CCR 5 ligands such as CCL 3 ( MIP 1alpha ) and CCL 4 ( MIP 1beta ) also trigger TIL cell death , nor is it limited to melanoma cells , as it also operates in activated primary T lymphocytes . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Increased responsiveness of murine eosinophils to MIP 1beta ( CCL 4 ) and TCA 3 ( CCL 1 ) is mediated by their specific receptors , CCR 5 and CCR 8 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We examined the responses of human peripheral blood T cells , present in an ECM like context , to combinatorial signaling transduced by SDF 1alpha ( CXCL 12 ) , and two CCR 5 ligands , RANTES ( CCL 5 ) and MIP 1beta ( CCL 4 ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
High levels of CCL 3 and CCL 4 were produced within 8 h after infection , which is likely to account for the observed CCR 5 down modulation on Mtb infected DC . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In addition , the relative roles of the chemokines that bind CXCR 3 ( CXCL 9 , CXCL 10 , CXCL 11 ) and CCR 5 ( CCL 3 , CCL 4 , CCL 5 ) in this process are unknown . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 2 and CCR 5 interact primarily with the human CC family ligands CCL 2 ( formerly called monocyte chemoattractant protein ; MCP 1 ) , CCL 3 and CCL 4 ( macrophage inflammatory protein 1 alpha and 1 beta ; MIP 1 alpha / beta ) , and their main function is to recruit leukocytes from circulation into the tissues , thus playing an important role in human inflammatory disorders . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor , CCR 5 , is a G protein coupled receptor responsible for some of the effects of the chemokines CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Here , we demonstrate that CO treatment ( 0 . 25 2 . 0 U / ml ) of human T cells inhibits CXCL 12 ( SDF 1alpha ) and CCL 4 ( MIP 1beta ) binding to cell surface CXCR 4 and CCR 5 , respectively , resulting in the inhibition of chemokine mediated intracellular calcium mobilization and chemotaxis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The focus of TGFbeta inhibition is observed to be directed in genes involved in chemotaxis ( IL 15 , CXCL 1 , CXCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 9 ) , chemokine receptors ( CCR 5 , CCR 9 ) , LIF receptor , and FPR 2 , and on genes mediating cell migration ( MMP 9 , MMP 13 , MacMARCKS , endothelin receptor B , Ena / VASP , Gas 7 ) , apoptosis ( FAS , TNF , TNF receptor , caspase 1 and 11 ) , and host response to infection ( toll like receptor 6 , Mx 1 , and MARCO ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
One anti CXCR 4 factor is macrophage derived chemokine ( chemokine ligand 22 , CCL 22 ) , and anti CCR 5 factors include macrophage inflammatory protein 1 alpha ( CCL 3 ) , macrophage inflammatory protein 1 beta ( CCL 4 ) , and RANTES ( regulated upon activation of normal T cells expressed and secreted ) ( CCL 5 ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Stimulation of bone marrow B cells with the CCR 5 binding chemokine macrophage inflammatory protein 1beta ( MIP 1beta ; CCL 4 ) did not cause chemotaxis , but CCL 4 was able to trigger potent calcium mobilization responses and activation of the mitogen activated protein kinase ( MAPK ) pathway in developing B cells . ^^^ We also determined that CCR 5 binding chemokines MIP 1alpha ( CCL 3 ) , CCL 4 , and RANTES ( CCL 5 ) , specifically by signaling through CCR 5 , could affect all progenitor B cell populations through a novel mechanism involving heterologous desensitization of CXCR 4 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Activated T cells from GRK2+ / mice , which have a 50 % reduction in GRK 2 protein levels , showed a significant 40 % increase in chemotaxis toward the CCR 5 ligand CCL 4 . ^^^ Binding of CCL 4 to activated T cells from GRK2+ / and wild type ( WT ) mice was similar , but agonist induced CCR 5 phosphorylation was attenuated in GRK2+ / cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the production of dynamic alpha and beta chemokines represented by interleukin 8 ( IL 8 ) as alpha chemokine and CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , ( CCL 5 , regulated upon activation , normal T cell expressed and secreted ( RANTES , CCR 5 ligand ) as beta chemokines by the human intestinal cell line INT 407 stimulated with factors produced by living Campylobacter jejuni ( C . jejuni ) and those present within sonicated and filtrated bacteria . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Three CC chemokines MIP 1alpha ( CCL 3 ) , MIP 1beta ( CCL 4 ) , and RANTES ( CCL 5 ) are natural ligands for the human immunodeficiency virus 1 ( HIV 1 ) coreceptor CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In particular , the interaction between chemokines CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) and CCL 5 ( RANTES ) and their receptor , CC chemokine receptor 5 ( CCR 5 ) , may be critical in regulating T cell functions by mediating recruitment , polarization , activation and differentiation of antiviral type 1 cytokine secreting T helper and cytotoxic T cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
This was associated with reduced renal expression of CC chemokines CCL 2 , CCL 3 , CCL 4 , and CCL 5 and the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 bound RANTES ( CCL 5 ) and MIP 1beta ( CCL 4 ) only exhibit pH dependent dissociation at pH < 4 . 0 , below the values normally found in endocytic organelles . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In the present study , we report that two CCR 5 ligands , CCL 4 and CCL 5 , are expressed in gut tissues after Ag feeding . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
M . tuberculosis infection causes an increase in the expression of beta chemokines CCL 3 , CCL 4 , and CCL 5 , and their receptor CCR 5 , in the lungs . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Their migration to the CCR 5 ligand MIP 1beta ( CCL 4 ) and homing to kidneys of Flt3L treated recipients were inhibited by CCR 5 antagonism . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
AMD 3451 dose dependently inhibited the intracellular Ca ( 2+ ) signaling induced by the CXCR 4 ligand CXCL 12 in T lymphocytic cells and in CXCR 4 transfected cells , as well as the Ca ( 2+ ) flux induced by the CCR 5 ligands CCL 5 , CCL 3 , and CCL 4 in CCR 5 transfected cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
GM CSF treated neutrophils migrate also to the selective CCR 5 agonist CCL 4 ( MIP 1beta ) . ^^^ CCL 3 and CCL 4 triggered migration of GM CSF primed neutrophils was inhibited by the CCR 5 antagonist TAK 779 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Despite these changes in the IFN DC migratory behavior , the expression of CCR 5 and CCR 7 and the calcium fluxes triggered by CCL 4 and CCL 19 were not affected . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The expression of CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , CCL 5 ( RANTES ) and their main receptors ( CCR 1 and CCR 5 ) was studied by semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry in a series of 16 IIM and five controls ( four normal muscles and one tonsil ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We investigated the role played by chemokine receptor 5 ( CCR 5 ) in the influx of T cells to the cardiac tissue of T . cruzi infected mice . mRNA and protein for the CCR 5 ligands CCL 3 , CCL 4 , and CCL 5 were detected in the hearts of infected mice in association with CD4+ and CD8+ T cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
From each blood sample PBMCs were separated and gene expression levels for chemokines CCL 3 , CCL 4 , CCL 5 , CXCL 10 , and their receptors CCR 1 , CCR 5 , and CXCR 3 , were determined using real time quantitative PCR . ^^^ RESULTS : Different gene expression patterns were seen between the rejector and nonrejector groups with decreases in CCL 4 and CCR 5 expression on days 6 to 8 and increases in CCR 1 expression on days 9 and 10 posttransplant . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Similar kinetics of expression were found for the chemokines CCL 5 , CCL 4 , CCL 3 and CXCL 10 and for the receptors CCR 5 and CXCR 3 , all of them linked to the Th 1 type pattern . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Through analysis of mononuclear cell infiltration in WT and IL 6 deficient mice during peritoneal inflammation , we now report that IL 6 selectively governs T cell infiltration by regulating chemokine secretion ( CXCL 10 , CCL 4 , CCL 5 , CCL 11 , and CCL 17 ) and chemokine receptor ( CCR 3 , CCR 4 , CCR 5 , and CXCR 3 ) expression on the CD3+ infiltrate . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Variants of CCR 5 , which are permissive for HIV 1 infection , show distinct functional responses to CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The selective CCR 5 ligand CC chemokine ligand 4 ( CCL 4 ) / macrophage inflammatory protein ( MIP ) 1beta induced the chemotaxis of thymocytes that had been derived from the transgenic mice , but not from littermate mice , suggesting that the human CCR 5 expressed in the transgenic mice were functional . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Finally , we show that G protein coupling is required for high affinity binding of macrophage inflammatory protein 1beta ( CCL 4 ) to CCR 5 and that the dissociation from G proteins , after incubation with Gpp ( NH ) p , promotes the release of prebound radiolabeled chemokines with kinetics similar to those measured after the addition of an excess of unlabeled chemokines . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Because the chemokine receptor CCR 5 and its ligands ( CCL 3 , CCL 4 , and CCL 5 ) regulate leukocyte chemotaxis and activation , we investigated the role of CCR 5 during Con A induced liver injury . ^^^ CCR 5 / mice also exhibited increased production of interleukin 4 , tumor necrosis factor alpha , CCL 3 , CCL 4 , and CCL 5 , and a prominent liver mononuclear cell infiltrate , among which many cells were CCR1+ . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Here we demonstrate that after immunization but before antigen recognition , naive CD8+ T cells in immunogen draining lymph nodes upregulate the chemokine receptor CCR 5 , permitting these cells to be attracted to sites of antigen specific dendritic cell CD4+ T cell interaction where the cognate chemokines CCL 3 and CCL 4 ( also known as MIP 1alpha and MIP 1beta ) are produced . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Here , we analyzed the expression and role of selected chemokines ( CXCL 12 and CCL 4 ) and their receptors ( CXCR 4 and CCR 5 ) in regulating thymocyte migration in conjunction with extracellular matrix during acute T . cruzi infection . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCL 3 and CCL 4 are natural ligands for the primary human immunodeficiency virus type 1 ( HIV 1 ) coreceptor CCR 5 and are also known to activate and enhance the cytotoxicity of natural killer cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage tropic strains of HIV 1 is CC CKR 5 , a receptor for the beta chemokines RANTES , MIP 1alpha and MIP 1beta . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^ CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Molecular cloning and functional characterization of a novel human CC chemokine receptor ( CCR 5 ) for RANTES , MIP 1beta , and MIP 1alpha . ^^^ CCR 5 is expressed in lymphoid organs such as thymus and spleen , as well as in peripheral blood leukocytes , including macrophages and T cells , and is the first example of a human chemokine receptor that signals in response to MIP 1beta . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES were all potent agonists for CC CKR 5 ( EC 50 = 3 30 nM ) when calcium flux was measured in transfected HEK 293 cells , yet the apparent binding affinities of the corresponding iodinated chemokines to intact cells expressing the receptor were low ( IC 50 approximately 100 nM ) . ^^^ These data suggest that CC CKR 5 is a G ( 1 ) coupled receptor that may mediate monocyte responses to MIP 1alpha , MIP 1beta , and RANTES . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Here we show that a complex of gp 120 , the exterior envelope glycoprotein , of macrophage tropic primary HIV 1 and soluble CD 4 interacts specifically with CCR 5 and inhibits the binding of the natural CCR 5 ligands , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta ( refs 7 , 8 ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CCR 3 ligand , eotaxin , and an anti CCR 3 antibody inhibited HIV 1 infection of microglia , as did MIP 1beta , which is a CCR 5 ligand . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Macrophage tropic HIV 1 isolates are generally specific for CCR 5 , a receptor for the CC chemokines RANTES , MIP 1alpha , and MIP 1beta , while T cell line tropic viruses tend to use CXCR 4 ( also known as fusin , LESTR , or HUMSTR ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Ligation of CCR 5 by the CC chemokines RANTES , MIP 1alpha or MIP 1beta , and of CXCR 4 by the CXC chemokine SDF 1alpha , profoundly inhibits the replication of HIV strains that use these coreceptors for entry into CD 4 ( + ) T lymphocytes . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are HIV 1 suppressive factors secreted by CD8+ cells that inhibit NSI viruses . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Physiological ligands of CCR 5 , namely the beta chemokines MIP 1alpha , MIP 1beta , and RANTES , were found to competitively inhibit the V 3 loop CCR 5 interaction . ^^^ We therefore hypothesized that the V 3 loop of gp 120 of macrophage tropic HIV 1 may share a binding site on CCR 5 with MIP 1alpha , MIP 1beta , and RANTES and that the V 3 loop therefore might have some homology with these beta chemokines . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
One mAb termed 2D7 completely blocked the binding and chemotaxis of the three natural chemokine ligands of CCR 5 , RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta , to CCR 5 transfectants . ^^^ This mAb was a genuine antagonist of CCR 5 , since it failed to stimulate an increase in intracellular calcium concentration in the CCR 5 transfectants , but blocked calcium responses elicited by RANTES , MIP 1alpha , or MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
It did not inhibit the binding of the biotinylated CC chemokine macrophage inflammatory protein ( MIP ) 1alpha or MIP 1beta , ligands for the chemokine receptor CCR 5 ( the main coreceptor for M tropic viruses ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Viral isolates obtained during the asymptomatic stages generally used only CCR 5 as a co receptor and were inhibited by RANTES , MIP 1alpha and MIP 1beta , but not by SDF 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Thus , for CCR 5 , the rank order for down regulation was also RANTES , MIP 1beta , MIP 1alpha . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1 beta ( MIP 1 beta ) binding to its cognate receptor CCR 5 resulted in activation of the related adhesion focal tyrosine kinase ( RAFTK ) , with subsequent activation of the cytoskeletal protein paxillin and the down stream transcriptional activators , c Jun N terminal kinase ( JNK ) / stress activated protein kinase ( SAPK ) and p 38 mitogen activated protein ( MAP ) kinase . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In an effort to further characterize the binding properties of MCP 2 on leukocytes , we observed that MCP 2 , but not MCP 1 , effectively competed with MIP 1beta for binding to monocytes , suggesting that MCP 2 may interact with CCR 5 . ^^^ As predicted , MCP 2 competitively inhibited MIP 1beta binding to HEK 293 cells stably transfected with CCR 5 ( CCR5 / 293 cells ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We showed that the neutralization of 89 . 6 in PBMC was not improved when CCR 5 was blocked by having RANTES , MIP 1alpha , and MIP 1beta in the culture medium , indicating that CCR 5 usage was not responsible for the decreased sensitivity to neutralization in PBMC . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
A major advance in understanding human immunodeficiency virus ( HIV ) biology was the discovery that the beta chemokines MIP 1 alpha ( macrophage inflammatory protein 1 alpha ) , MIP 1 beta ( macrophage inflammatory protein 1 beta ) and RANTES ( regulated on activation , normal T cell expressed and secreted ) inhibit entry of HIV 1 into CD4+ cells by blocking the critical interaction between the CCR 5 coreceptor and the V 3 domain of the viral envelope glycoprotein gp 120 [ 1 , 2 ] . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Radioligand binding analyses showed specific and displaceable binding of MIP 1beta to thymocytes with a Kd of approximately 1 nmol / L , a profile that was comparable with MIP 1beta binding to CCR 5 transfected NIH 3T3 cells . ^^^ In addition , CCR 5 mRNA was detected in total thymocyte populations indicating that activation of thymocytes by MIP 1beta may occur through binding to CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Recombinant human RANTES , MIP 1alpha and MIP 1beta which bind to simian CCR 5 , suppressed SIV replication in a dose dependent manner , with RANTES being more effective than the other two chemokines . ^^^ The results suggest that immunization with SIV grown in human CD 4 ( + ) T cells induces CD 8 suppressor factor , RANTES , MIP 1alpha and MIP 1beta which may block CCR 5 receptors and prevent the virus from binding and fusion to CD 4 ( + ) cells . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CC chemokines MIP 1alpha , MIP 1beta , and RANTES suppress replication of certain HIV 1 strains in cultured PBMC and T cell lines by blocking interaction of gp 120 with CC chemokine receptor 5 ( CCR 5 ) . ^^^ Here we show that exogenous MIP 1alpha , MIP 1beta , and RANTES markedly suppressed replication of CCR 5 tropic HIV 1 strains in blocks of human lymphoid tissue infected ex vivo . ^^^ Moreover , endogenous MIP 1alpha , MIP 1beta , and RANTES were upregulated in tissues infected ex vivo with CXC chemokine receptor 4 tropic but not CCR 5 tropic HIV 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Chemotaxis and intracellular Ca2+ mobilization in monocytes pretreated with prostaglandin E 2 or dibutyryl cAMP for 24 hours were significantly reduced in response to the CCR 5 ligand , MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normal T cell expressed and secreted ) , which are the natural ligands of the CC chemokine receptor CCR 5 , inhibit replication of MT 2 negative strains of HIV 1 by interfering with the ability of these strains to utilize CCR 5 as a coreceptor for entry in CD 4 ( + ) cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Large Kir 3 . 1 dependent currents generated in response to the corresponding chemokines ( SDF 1alpha for CXCR 4 and MIP 1alpha ; MIP 1beta and RANTES for CCR 5 ) were blocked by pertussis toxin , suggesting involvement of inhibitory guanine nucleotide binding proteins . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Additional mechanistic studies demonstrated that NSC 651016 inhibited chemokine binding to specific chemokine receptors , induced CXCR 4 and CCR 5 receptor internalization , and inhibited chemokine induced chemotaxis by macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , RANTES , and stromal derived factor 1alpha but not monocyte chemotactic protein 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Immunohistochemistry for MIP 1beta , MIP 1alpha , RANTES , eotaxin , and MCP 3 ( ligands for CCR 5 and / or CCR 3 ) revealed the presence of MIP 1beta predominantly in a subpopulation of reactive astrocytes , which were more widespread in AD than control brains , and MIP 1alpha predominantly in neurons and weakly in some microglia in both AD and controls . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
After cloning CC CKR 5 and establishing reverse transcriptase polymerase chain reaction ( RT PCR ) for its ligands macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation , normal T cell expressed and secreted ( RANTES ) , we studied expression of these four mRNAs in purified microglia and compared it with their expression in rat brain . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The chemokines monocyte chemotactic protein ( MCP ) 3 , MCP 4 , and eotaxin acted like RANTES , whereas macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MCP 1 , and stromal cell derived factor 1 were inactive , suggesting a role for the eotaxin receptor , CCR 3 , and ruling out the involvement of CCR 1 , CCR 2 , CCR 5 , and CXCR 4 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
While both nave and memory CD 4 ( + ) subsets downregulated CCR 5 expression in response to CD 28 costimulation , only the memory cells produced high levels of the beta chemokines RANTES , MIP 1alpha , and MIP 1beta upon stimulation . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Forty human immunodeficiency virus type 1 ( HIV 1 ) infected women participated in a cross sectional study of possible correlations between chemokine receptor ( CCR 5 and / or CCR2B ) genotype , HIV 1 RNA and DNA load , and beta chemokine levels ( RANTES , MIP 1alpha , MIP 1beta ) in blood and cervix . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We found that MCP 2 could bind to CCR 5 transfectants with high affinity and cross compete effectively with RANTES , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Peptide presented to the CD 4 CTLs increased their secretion of RANTES and MIP 1beta , suppressed M tropic HIV 1 replication , downmodulated CCR 5 expression , and preserved CTL recognition . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Of these three chemokine receptors , only CCR 5 and CXCR 4 were able to transduce a signal in microglia in response to their respective ligands , MIP 1beta and SDF 1alpha , as recorded by single cell calcium flux experiments . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The enhancing effects of RANTES are not mediated via CCR 5 or other known chemokine receptors and are not mimicked by MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
This protein was also recognized by antibodies to CCR 5 , the RANTES / MIP 1alpha / MIP 1beta receptor . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The natural ligands for the chemokine receptors CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta ) and CXCR 4 ( SDF 1 ) can act as potent inhibitors of infection by the human immunodeficiency virus type 1 ( HIV 1 ) at the level of viral entry . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Monocytes treated with IFN gamma showed increased chemotaxis to the CCR 5 ligands macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , confirming the functional relevance of IFN gamma induced CCR 5 expression . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Here we report that superantigen stimulation of human peripheral blood monocytes results in a rapid , dose dependent , and specific down regulation of chemokine ( macrophage inflammatory protein 1alpha ( MIP 1alpha ) , monocyte chemotactic protein 1 and MIP 1beta ) binding sites ( e . g . , CCR 1 , CCR 2 , and CCR 5 ) , which correlates with a concomitant hyporesponsiveness of human monocytes to these CC chemokine ligands . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Recently , it was shown that the natural CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and amino terminal modifications of RANTES ( Met RANTES , AOP RANTES ) significantly differ in their abilities to induce sequestration of CCR 5 from cellular surfaces . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
To assess the influence of defective CCR 5 on production of its ligands we determined the capacity to produce the chemokines macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta and RANTES in comparison with the production of the CXC chemokine IL 8 which does not bind to CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Sulfated tyrosines contribute to the binding of CCR 5 to MIP 1 alpha , MIP 1 beta , and HIV 1 gp120 / CD4 complexes and to the ability of HIV 1 to enter cells expressing CCR 5 and CD 4 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Stimulation of monocyte derived DCs with CD40LT enhanced the production of the CC chemokines macrophage inflammatory protein ( MIP ) 1 alpha , MIP 1 beta , and RANTES and diminished surface expression of CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
So far , immunoreactivity for a number of chemokines ( including IL 8 , IP 10 , MIP 1beta , MIPalpha and MCP 1 ) and chemokine receptors ( including CXCR 2 , CXCR 3 , CXCR 4 , CCR 3 , CCR 5 and Duffy antigen ) have been demonstrated in resident cells of the CNS , and upregulation of some of the chemokines and receptors are found associated with AD pathological changes . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The natural ligands for the CCR 5 chemokine receptor , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES ( regulated on T cell activation , normal T cell expressed and secreted ) , are known to inhibit human immunodeficiency virus ( HIV ) entry , and N terminally modified RANTES analogues are more potent than native RANTES in blocking infection . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Treatment of CD8+ cell culture supernatant with antibodies to RANTES , MIP 1alpha and MIP 1beta neutralized the CD 8 SF activity , indicating that blocking the CCR 5 by these ligands played an important part in the CD 8 SF activity elicited by TILN immunization . ^^^ Indeed , blocking CCR 5 with monoclonal antibodies inhibited SIV replications and MIP 1beta mediated chemotaxis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a receptor for chemokines MIP 1alpha ( LD78alpha ) , MIP 1beta , RANTES , and MCP 2 , is of particular importance in vivo as polymorphisms in this gene affect HIV infection and rate of progression to AIDS . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
All cysteine mutants were unable to bind detectable levels of MIP 1beta , and did not respond functionally to CCR 5 agonists . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Tumor derived lymphocytes showed strong chemotactic responses to both CC and CXC chemokines in vitro and expressed high levels of CXCR 3 ( HuMig and IP 10 receptor ) and CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta receptor ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Moreover , IL 10 treated monocytes responded with augmented intracellular Ca++ mobilization and enhanced ( 3 4 fold ) chemotaxis in response to the CCR 5 ligand MIP 1beta ( 25 ng / ml ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Human colon epithelial cells stimulated with stromal cell derived factor 1alpha and macrophage inflammatory protein ( MIP ) 1alpha or MIP 1beta , which are the chemokine ligands for CXCR 4 or CCR 5 , up regulated production of the CXC chemokines IL 8 and GROalpha . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Subsequent analyses showed that phosphoantigen activated gammadelta T cells produced substantial amounts of beta chemokines ( macrophage inflammatory protein [ MIP ] 1alpha , MIP 1beta , and regulated on activation , normal T cell expressed and secreted beta chemokine [ RANTES ] ) , which represent the natural ligand for the CCR 5 HIV coreceptor . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
A synthetic peptide domain , designated F peptide , corresponding to amino acid residues 414 434 in the V 4 C4 region of gp 120 of the HIV 1 Bru strain , potently reduced monocyte binding and chemotaxis response to macrophage inflammatory protein 1beta ( MIP 1beta ) and stromal cell derived factor 1alpha ( SDF 1alpha ) , chemokines that use the receptors CCR 5 and CXCR 4 , respectively . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CC chemokines RANTES , MIP 1alpha , MIP 1beta , and Eotaxin can suppress the replication of CCR 5 and CCR 3 dependent viruses , while SDF 1 alpha / beta suppresses that of CXCR 4 dependent strains . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
T cells treated with B oligomer did not initiate signal transduction in response to macrophage inflammatory protein ( MIP ) 1beta or RANTES ( regulated upon activation , normal T cell expressed and secreted ) ; however , cell surface expression of CCR 5 and binding of MIP 1beta or HIV 1 to such cells were not impaired . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Desensitization of CCR 5 by IL 16 required at least 10 min of pretreatment ; no modulation of CCR 5 expression was observed , nor was MIP 1 beta binding to CCR 5 altered . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 was first characterized as a receptor for MIP 1alpha , MIP 1beta , and RANTES , and was rapidly shown to be the main coreceptor for M tropic human immunodeficiency virus ( HIV ) 1 strains and simian immunodeficiency virus ( SIV ) . ^^^ All CC chemokines currently available were tested for their ability to compete with [ ( 125 ) 1 ] MIP 1beta binding on a stable cell line expressing recombinant CCR 5 , and / or to induce a functional response in these cells . ^^^ Among these ligands , MCP 3 had the remarkable property of binding CCR 5 with high affinity without eliciting a functional response , MCP 3 could also inhibit the activation of CCR 5 by MIP 1beta and may therefore be considered as a natural antagonist for CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The importance of chemokine expression on HIV infection has been emphasized by the discovery that infection of CD 4 ( + ) T cells by M tropic strains of HIV 1 is antagonized by the chemokines RANTES , MIP 1alpha , and MIP 1beta , which are natural ligands of CCR 5 , a major coreceptor for macrophagetropic ( M tropic ) isolates of HIV 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The beta chemokines RANTES , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta suppress infection by macrophage tropic strains of HIV and simian immunodeficiency virus ( SIV ) by binding and down regulating the viral coreceptor , CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Peptide T was also able to suppress monocyte chemotaxis to MIP 1beta , a chemokine with selectivity for CCR 5 chemokine receptors , while chemotaxis of the more promiscuous ligand RANTES was not inhibited , nor was chemotaxis mediated by SDF 1alpha . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In a parallel manner , binding of labeled MIP 1alpha was first shown to be attenuated by unlabeled RANTES , both of which recognize CCR 1 and CCR 5 , and then separately antagonized by MCP 3 and MIP 1beta , which bind to CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The specific receptor for the beta chemokines ( macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES ) , CCR 5 , also functions as the primary coreceptor for macrophage tropic isolates of HIV 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a functional receptor for MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed ) , MCP 2 , and MCP 4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
During the development of nephrotoxic nephritis ( NTN ) in the mouse , we find that a variety of chemokines and chemokine receptors are induced : CCR 1 ( RANTES , MIP 1alpha ) , CCR 2 ( MCP 1 ) , CCR 5 ( RANTES , MIP 1alpha , MIP 1beta ) , CXCR 2 ( MIP 2 ) , and CXCR 3 ( IP 10 ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : This study was designed to evaluate the role of the novel chemokine receptor antagonist amino oxypentane RANTES ( AOP RANTES ) , which blocks the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES to the chemokine receptor 5 ( CCR 5 ) on the infiltration of monocytes in experimental glomerulonephritis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We found that human CD 34 ( + ) cells and CD 34 ( + ) KIT ( + ) cells , which are enriched in myeloid progenitor cells , expressed and secreted the CCR 5 ligands RANTES , MIP 1alpha , and MIP 1beta and that IFN gamma stimulated expression of these chemokines . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Recently , several unique HIV 1 entry coreceptors ( e . g . , CCR 5 and CCR 3 ) and a trio of HIV 1 specific suppressor chemokines , namely , RANTES ( regulated upon activation T expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , were identified . ^^^ Further , cocaine significantly downregulates endogenous MIP 1beta gene expression , while it upregulates HIV 1 entry coreceptor CCR 5 by normal PBMC . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The variants were also resistant to other natural ligands for CCR 5 , namely , MIP 1beta ( > 4 fold ) and RANTES ( regulated upon activation , normal T cell expressed and secreted ) ( 6 fold ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Limited expression of R 5 tropic HIV 1 in CCR 5 positive type 1 polarized T cells explained by their ability to produce RANTES , MIP 1alpha , and MIP 1beta . ^^^ In fact , an inverse correlation was observed between Th 1 polarized naive T cells and Th 1 like memory activated T cells in regards to p 24 Ag production and the release of the following CCR 5 binding chemokines : regulated on activation normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
By immunohistochemistry , CCR 5 and the CCR 5 ligand , macrophage inflammatory protein 1beta ( MIP 1beta ) , were detected in smooth muscle cells and macrophages of the atherosclerotic plaque . ^^^ In smooth muscle cell culture , MIP 1beta induced a significant increase in intracellular calcium concentrations , which was blocked by an antibody to CCR 5 . ^^^ These data suggest that human arterial smooth muscle cells express functional CCR 5 receptors and MIP 1beta is an agonist for these cells . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The anti CCR 5 monoclonal antibody ( mAb ) 2D7 inhibits the binding and chemotaxis of the three natural beta chemokine ligands of CCR 5 , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES , to CCR 5 ( + ) cells . ^^^ We show here that ( 1 ) M 23 g3p was specifically recognized with anti CCR 5 mAb ; ( 2 ) M 23 g3p showed inhibitory activity on the infectivity of M tropic but not T tropic HIV 1 strains ; ( 3 ) M 23 g3p bound to MIP 1alpha , MIP 1beta , and RANTES but not MCP 1 . ^^^ These results suggested that the M 23 g3p might mimic the CCR 5 binding domain shared by beta chemokines , MIP 1alpha , MIP 1beta , and RANTES as well as the HIV 1 infection . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We analyzed sera from ESN , their HIV infected sexual partners ( HIV+ ) , and healthy controls ( USN ) searching for CCR 5 specific Abs , studying whether incubation of PBMC with sera could prevent macrophage inflammatory protein 1 beta ( Mip 1 beta ) ( natural ligand of CCR 5 ) binding to CCR 5 . ^^^ Results showed that Mip 1 beta binding to CCR 5 was not modified by sera of either 40 HIV+ or 45 USN but was greatly reduced by sera of 6 / 48 ESN . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In paralyzed control mice , the SC had increased cellular infiltration and strong expression of the chemokines RANTES , IFN inducible 10 kDa protein , and monocyte chemoattractant protein 1 and the cognate chemokine receptors CCR 1 , CCR 2 , and CCR 5 , with lower expression of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and MIP 2 ; whereas brain had less infiltration and a lower expression of a different pattern of chemokines and receptors . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In contrast , the CCR 5 ligands ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , and RANTES ) did not activate calcium flux , MAPK and AKT phosphorylation or chemotaxis of CD 34 ( + ) KIT ( + ) cells or cells isolated from the BFU E colonies . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CTL clones expressed the CCR 5 receptor and localized among HIV infected cells expressing the ligands MIP 1alpha and MIP 1beta , CC chemokines produced at sites of virus replication . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Functional loss of CCR 5 is reflected in a decreased capability of the treated cells to migrate and signal calcium after MIP 1beta stimulation . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
IL 4 treatment , which prevents diabetes in NOD mice by polarizing intraislet Th 2 responses , decreased CCR 5 expression in islets and potentiated a high ratio of MIP 1beta and monocyte chemotactic protein 1 ( MCP 1 ) : MIP 1alpha in the pancreas . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
No difference was observed in TNF alpha , IL 1beta , IL 10 , IL 4 , MIP 1alpha , MIP 1beta , RANTES , CXCR 4 , and CCR 5 mRNA levels in PBMC , but IL 6 levels were higher in the HPS patient . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Furthermore , we showed that the CXCR 4 and CCR 5 ligands ( stromal derived factor 1 and macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta and RANTES , respectively ) inhibit HIV replication in both maturing Mo and Mk cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Investigations of the mechanism of protection revealed that gammadelta ( + ) T cells can generate antiviral factors , RANTES , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta which can prevent SIV infection by binding to the CCR 5 coreceptors . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Urinary levels of their ligands , for CCR 1 and CCR 5 ; macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta and regulated upon activation in normal T cells expressed and secreted ( RANTES ) were evaluated by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES , MIP 1alpha and MIP 1beta suppress infection by R 5 HIV 1 particles via induction of CCR 5 internalization , and individuals whose peripheral blood lymphocytes produce high levels of these chemokines are relatively resistant to infection [ 7 ] [ 8 ] [ 9 ] . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
MIP 1beta and SDF 1alpha , chemokine ligands for CCR 5 and CXCR 4 , respectively , also activated K ( Ca ) and Cl ( ) currents in macrophages , but nonselective cation channel activation was unique to gp 120 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In this study , Chinese hamster ovary cells were transfected separately with the human chemokine receptors CCR 1 and CCR 5 , and these receptors were shown to induce an intracytoplasmic Ca ( 2+ ) flux and cellular chemotaxis following stimulation with the natural CC chemokine ligands ( MIP 1alpha , RANTES ( regulated on activation normal T cell expressed ) , and MIP 1beta ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Immunization induced significant increases in the concentrations of CD 8 cell derived suppressor factor ( CD 8 SF ) , regulated on activation normal T cells expressed and secreted ( RANTES ) , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta , and down modulation of the proportion of cells expressing CCR 5 ( r = 0 . 737 , P < 0 . 05 ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta inhibited infection of intestinal lymphocytes by BaL , indicating that R 5 infection of the intestinal lymphocytes was mediated by CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We next evaluated the functionality of these chemokine receptors by calcium flux and chemotaxis assays , and by the ability of SDF 1 , MIP 1alpha , MIP 1beta and RANTES to influence the growth of the cells expressing CXCR 4 and / or CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In contrast , M tropic virus infectivity was reduced , possibly because of elevated levels of the CCR 5 ligand cytokines RANTES and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We report here that treating monocyte derived macrophages ( MDM ) with a trimeric soluble form of CD40L ( CD40LT ) induced them to secrete high levels of the beta chemokines RANTES , MIP 1alpha and MIP 1beta that are ligands for CCR 5 and able to inhibit HIV 1 entry . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The chemokine ligands for CCR 5 , RANTES and MIP 1beta , also potently inhibited HIV 1 infection in microglia , but the third ligand MIP 1alpha failed to show inhibition . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Labeled MIP 1alpha binding was also antagonized by unlabeled MCP 3 , which is also recognized by CCR 1 , and MIP 1beta , which is a ligand for CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We have therefore utilized H 9 cells to test the effects of Product R on expression of mRNAs encoding the chemokine receptors , CD 4 , CXCR 4 and CCR 5 , as well as their ligands , IL 16 , SDF 1 , MIP 1alpha , MIP 1beta , and RANTES , by RT PCR . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
There was significantly increased expression of HIV 1 coreceptors CCR 5 and CXCR 4 , beta chemokine RANTES , and macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta , as well as increased numbers of T cells in lamina propria of HIV 1 infected patients . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
DESIGN : The CC chemokines RANTES , MIP 1alpha and MIP 1beta are ligands for CCR 5 , which has been identified as the principal co receptor for macrophage tropic strains of HIV 1 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Cells susceptible to infection by these viruses can be protected by treatment with the CCR 5 ligands regulated on activation , normal T cell expressed and secreted ( RANTES ) , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Recently we reported that the chemokines MIP 1alpha , MIP 1beta , and RANTES secreted by BM derived CD 34 ( + ) cells may compete with the macrophagotropic HIV ( R 5 HIV ) strain for the CCR 5 coreceptor . ^^^ In this study we extended our previous observations and examined various lympho hematopoietic CD 34 ( + ) cells isolated from thymus ( Th ) , cord blood ( CB ) , mobilized peripheral blood ( mPB ) , and BM for the expression of beta chemokines binding to CCR 5 , i . e . , MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , and MCP 4 , and the alpha chemokine SDF 1 ( binding to CXCR 4 ) as these chemokines may compete with the R 5 and X 4 HIV strains , respectively , for entry into cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1beta ( MIP 1beta ) binding to CCR 5 was potently and specifically inhibited by guanine nucleotides . ^^^ HIV 1 envelope glycoprotein decreased the affinity of CCR 5 for MIP 1beta but also altered the kinetics of MIP 1beta binding to CCR 5 , proving that it interacts with a distinct , but allosterically coupled binding site . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In addition the beta chemokines RANTES ( regulated on activation T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , and MIP 1beta can block HIV 1 entry into cells by preventing the binding of the macrophage trophic HIV 1 strains to the coreceptor CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In a prospective study using flow cytometry , we examined percentages of blood mononuclear cells ( MNC ) expressing the chemokines RANTES , MCP 1 , MIP 1alpha , MIP 1beta , and IL 8 , the chemokine receptor CCR 5 , the T cell activation marker CD 25 , and the T cell chemoattractant IL 16 in patients with WAD and , for reference , in healthy controls . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In contrast , MIP 1beta , whose receptor is CCR 5 , did not induce significant chemotaxis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Using the migration chamber method , we assessed the migratory response of human embryonic kidney 293 ( HEK ) transfectant cells expressing the CC chemokine receptor 5 ( CCR 5 ) ( HEK CCR 5 ) to stimulation by chemokines ( macrophage inflamatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation normal T cell expressed and secreted ( RANTES ) ) on ECM substrates ( collagen type 1 and fibronectin ) . ^^^ Our results suggest that the migratory response to CCR 5 stimulation may vary quantitatively with both the CCR 5 ligand ( MIP 1alpha , MIP 1beta , and RANTES ) , as well as the nature and concentration of the ECM substrate involved . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We found that A ) SDF 1 , after binding to CXCR 4 , activates multiple signaling pathways and that in comparison with the MIP 1beta CCR 5 axis , plays a privileged role in hematopoiesis ; B ) SDF 1 activation of the MAPK p42 / 44 pathway and the PI 3K AKT axis does not affect proliferation and apoptosis but modulates integrin mediated adhesion to fibronectin , and C ) SDF 1 induces secretion of VEGF , but not of MMPs or TIMPs . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Furthermore , expression of CC chemokine receptor 5 ( CCR 5 ) mRNA in these cells suggests an autocrine role for MIP 1beta in HTLV 1 infected T cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Our data showed that phagocytosis of apoptotic / necrotic tumor cells resulted in maturation of DCs with up regulated expression of proinflammatory cytokines [ interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha , interferon gamma and granulocyte macrophage colony stimulating factor ] , chemokines ( MIP 1alpha , MIP 1beta and MIP 2 ) , the CC chemokine receptor CCR 7 and the cell surface molecules ( MHC class 2 , CD11b , CD 40 and CD 86 ) , and down regulated expression of the CC chemokine receptors CCR 2 and CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : The chemokine receptor , CCR 5 , and its three high affinity ligands , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and regulated on activation normal T cell expressed and secreted ( RANTES ) , are expressed by infiltrating mononuclear cells during the rejection of clinical and experimental organ allografts , although the significance of these molecules in the pathogenesis of rejection has not been established . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We then examined HIV infection , HIV receptor ( CD 4 , CCR 5 ) expression , and beta chemokine [ macrophage inflammatory protein 1alpha and 1beta ( MIP 1alpha , MIP 1beta ) ] production by placental cord monocyte derived dendritic cells ( MDDC ) as compared to that of autologous cord monocyte derived macrophages ( MDM ) . ^^^ This limited susceptibility of cord MDDC to M tropic HIV infection may be due to lower expression of CD 4 and CCR 5 on the cell membrane and higher production of MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The presence of chemokine receptor ( CCR 5 , CXCR 3 , CCR 3 ) positive cells and chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 ) positive cells in human periapical granulomas . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Pyk 2 phosphorylation was also induced by macrophage inflammatory protein 1beta ( MIP 1beta ) and stromal cell derived factor 1alpha , chemokine ligands for CCR 5 and CXCR 4 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The effect of highly active antiretroviral therapy ( HAART ) on the expression of CCR 5 and CXCR 4 HIV coreceptors and the production of the beta chemokines regulated upon activation , normal T cell expressed and secreted ( RANTES ) , macrophage inflammatory protein ( MIP ) 1alpha , and MIP 1beta has been investigated in 30 HIV 1 infected individuals during 12 36 months of therapy . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Several potential mechanisms for expansion of HIV 1 in situ were found , including augmentation in expression of tumor necrosis factor ( TNF ) alpha and the HIV 1 noninhibitory beta chemokine ( MCP 1 ) , low presence of HIV 1 inhibitory beta chemokines ( MIP 1 alpha , MIP 1 beta , and RANTES [ regulated on activation , normal T expressed and secreted ] ) , and upregulation in expression of the HIV 1 coreceptor , CCR 5 , by pleural fluid mononuclear cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CCR 5 agonists macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normally T cell expressed and secreted ) have been shown to block replication of R 5 virus in vitro and have gained attention as potential antiviral factors . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We found that cholesterol extraction by hydroxypropyl beta cyclodextrin ( BCD ) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta ( MIP 1 beta ) using CCR 5 expressing CEM NKR T cells . ^^^ Moreover , cells stained with fluorescently labeled MIP 1 beta extensively colocalized with the GM 1 lipid raft marker while using anti CCR 5 antibodies ; most of CCR 5 on these cells only partially colocalized with GM 1 , suggesting that active ligand binding facilitates receptor association with lipid rafts or that raft association promotes a higher affinity conformation of CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Functional studies of the purified protein revealed that MIP 1 beta ( 3 69 ) retains the abilities to induce down modulation of surface expression of the chemokine receptor CCR 5 and to inhibit the CCR 5 mediated entry of HIV 1 in T cells . ^^^ Characterization of the chemokine receptor specificity of MIP 1 beta ( 3 69 ) showed that the truncated protein not only shares the ability of intact MIP 1 beta to induce Ca ( 2+ ) signaling through CCR 5 , but unlike the full length protein , it also triggers a Ca ( 2+ ) response via CCR 1 and CCR2b . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The surface expression of CC chemokine receptor ( CCR ) 1 , CCR 4 , and CCR 5 on peripheral blood T lymphocytes and their responsiveness to the chemokines macrophage inflammatory proteins ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normally T cell expressed and secreted ) was analyzed in patients with chronic hepatitis C and hepatitis B infection and compared with healthy subjects . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We investigated the effects of a number of naturally occurring chemokines ( MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , MCP 4 ) on different processes linked to the chemokine receptor CCR 5 in recombinant CHO cells expressing the receptor at different levels . 2 . ^^^ Internalization of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce internalization ( similar 50 % ) of the receptor . ^^^ Phosphorylation of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce phosphorylation of CCR 5 whereas the other chemokines did not induce CCR 5 phosphorylation . 4 . ^^^ MIP 1alpha , MIP 1beta , RANTES , MCP 2 and MCP 4 were able to stimulate increases in intracellular calcium ions via activation of CCR 5 whereas MCP 3 was without effect . 6 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta are distinct but highly homologous CC chemokines produced by a variety of host cells in response to various external stimuli and share affinity for CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Since both human MIP 1alpha subtypes ( LD78alpha and LD78beta ) and MIP 1beta signal through CCR 5 , the major co receptor for M tropic HIV 1 strains , these chemokines are capable of inhibiting HIV 1 infection in susceptible cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
A number of inflammatory CC chemokines , including MIP 1 alpha , MIP 1 beta , RANTES , MCP 2 , and HCC 1 [ 9 74 ] act as CCR 5 agonists , while MCP 3 is a natural antagonist of the receptor . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor responding to four natural agonists , the chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein ( MIP ) 1 alpha , MIP 1 beta , and monocyte chemotactic protein ( MCP ) 2 , and is the main co receptor for the macrophage tropic human immunodeficiency virus strains . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In the two IL 12 responsive tumor models ( CSA1M and OV HM ) , IL 12 treatment up regulated the mRNA expression of CCR 5 in splenic T cells as well as ligands for CCR 5 , such as macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta in tumor masses . ^^^ In contrast , the expression of CCR 5 in spleens and MIP 1alpha / MIP 1beta in tumor masses was marginally induced before and even after IL 12 treatment in the Meth A model in which T cell migration is not observed . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 / lymphocytes showed decreased chemotactic responses to the chemokine MIP 1beta but not to RA SF . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Morphine sulfate induces the formation and expression of both forms of CCR 5 whereas RANTES , MIP 1alpha or MIP 1beta inhibits them . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The higher RANTES production by MS gamma delta T cell lines , together with a lower expression of CCR 5 , may reflect an autoregulatory loop , caused by an increased production of its ligands ( RANTES , MIP 1 alpha , and MIP 1 beta ) or due to other pro inflammatory cytokines . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In addition , MIP 1beta , the most specific CCR 5 ligand , displaces AFP binding to MDM ( IC ( 50 ) =4 . 3nM ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Importantly , these effects were mostly reversed by neutralizing antibodies against MIP 1alpha and MIP 1beta , or their cognate receptor , CCR 5 , suggesting critical roles of these chemokines . ^^^ We also demonstrated that stromal cells express CCR 5 and that recombinant MIP 1alpha and MIP 1beta induce expression of receptor activator of nuclear factor kappaB ( RANK ) ligand by stromal cells , thereby stimulating osteoclast differentiation of preosteoclastic cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Functional studies revealed that a combination treatment of cells with morphine , an agonist for mu , and MIP 1beta , a ligand for CCR 5 , suppresses the inhibitory effect of MIP 1beta and increases the stimulatory effect of morphine on CCR 5 expression . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta , respectively . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Natural ligands for CCR 5 , MIP 1alpha , MIP 1beta and RANTES , have been shown to inhibit HIV replication in CD4+ T cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The presence of chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 , RANTES ) positive cells and chemokine receptor ( CCR 5 , CXCR 3 ) positive cells in inflamed human gingival tissues . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Most primary HIV strains use CCR 5 as a coreceptor and thereby are sensitive to inhibition by the CCR 5 ligand chemokines , RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The antiviral activity of their natural ligands ( stromal cell derived factor 1 [ SDF 1 ] , regulated on activation normal T cell expressed and secreted , ( RANTES ) and macrophage inflammatory proteins 1alpha and 1beta , MIP 1alpha and MIP 1beta ) and the finding that individuals deficient in CCR 5 are relatively resistant to HIV infection led to the concept that chemokine receptor antagonists can play an important role in anti HIV therapy . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We further demonstrate that the physical association of CCR 5 and CD 4 in membrane vesicles results in the formation of a receptor complex that exhibits macrophage inflammatory protein 1beta ( MIP 1beta ) binding properties that are distinct from CCR 5 . ^^^ The affinity of the CD 4 CCR5 complex for MIP 1beta was 3 . 5 fold lower than for CCR 5 , but the interaction of CD 4 and CCR 5 resulted in a receptor complex that exhibited enhanced G protein signaling as compared with CCR 5 alone . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In the present study , we examined the expression of chemokine receptors CXCR 1 and CXCR 2 ( receptors for interleukin 8 ) and CCR 5 ( receptor for RANTES [ regulated on activation , normal T cell expressed and secreted ] , macrophage inflammatory protein [ MIP ] 1alpha , and MIP 1beta ) in human endometrium . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The beta chemokines RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are the natural ligands of the HIV 1 coreceptor CCR 5 and compete with the virus for receptor binding . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Our studies showed that LD infection caused the upregulation of three beta chemokines ( macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta and RANTES ( regulated on activation normal T cell expressed and secreted ) ) , one alpha chemokine ( interleukin 8 ( IL 8 ) ) and the CC chemokine receptor 5 ( CCR 5 ) but not CCR 1 , as evident from reverse transcriptase polymerase chain reaction ( RT PCR ) analysis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
This was accompanied by enhanced responsiveness of H ( 2 ) O ( 2 ) pretreated monocytes to the CCR 5 ligand MIP 1beta in terms of chemotaxis and c fos gene activation . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor for RANTES , MIP 1alpha , MIP 1beta , and MCP 2 that functions as the front line coreceptor for human immunodeficiency virus type 1 infection . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
C 18 bound directly to human CCR 5 , and this interaction was partially competed by the beta chemokine macrophage inflammatory protein 1 beta ( MIP 1 beta ) and by HIV 1 R 5 gp120 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
METHODS : Lung biopsies from 4 patients that had classical features of WG were examined for protein expression of CCR 5 , RANTES , MIP 1alpha and MIP 1beta using immunohistochemistry . ^^^ Enhanced protein concentrations of RANTES , MIP 1alpha , and MIP 1beta were present in WG lung lesions , indicating redundancy of ligands for CCR 5 in affected tissue . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Reduced expression of CCR 5 on PBMCs cultured in the presence of RAPA was associated with increased extracellular levels of macrophage inflammatory protein ( MIP ) 1 alpha and MIP 1 beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The beta chemokines MIP 1alpha , MIP 1beta , and RANTES inhibit HIV 1 infection of CD4+ T cells by inhibiting interactions between the virus and CCR 5 receptors . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Using reverse transcriptase analysis of stomachs from normal and gastritic mice we found no difference in expression of CCR 5 and its chemokine ligands MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Two mechanisms induced by IFN tau treatment in macrophages may account for this inhibition : ( 1 ) the synthesis of the cellular antiviral factors such as 2 ' , 5 ' oligoadenylate synthetase / RNase L and MxA protein and ( 2 ) an increased production of MIP 1alpha , MIP 1beta , and RANTES , which are natural ligands of CCR 5 , the principal coreceptor of HIV on macrophages . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Chemokine receptor 5 ( CCR 5 ) binds macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , and members of the monocyte chemotactic protein family and is also a receptor for human immunodeficiency virus ( HIV ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
AK 602 , despite its much greater anti HIV 1 activity than other previously published CCR 5 inhibitors , including TAK 779 and SCH C , preserved RANTES ( regulated on activation normal T cell expressed and secreted ) and MIP 1beta binding to CCR 5 ( + ) cells and their functions , including CC chemokine induced chemotaxis and CCR 5 internalization , while TAK 779 and SCH C fully blocked the CC chemokine / CCR5 interactions . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
With the goal of reducing CCR 5 and protecting CCR5+ cells from R 5 tropic HIV , we used Tag deleted SV 40 derived vectors to deliver several anti CCR 5 transgenes : 2C7 , a single chain Fv ( SFv ) antibody ; VCKA 1 , a hammerhead ribozyme ; and two natural CCR 5 ligands , MIP 1alpha and MIP 1beta , modified to direct these chemokines , and hence their receptor to the endoplasmic reticulum . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : Ligands of chemokine receptor CCR 5 , including MIP 1 alpha , MIP 1 beta , and RANTES , have been implicated in rheumatoid arthritis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Both WT B 6 and IRF 1 / profiles showed 13 genes upregulated ( IFN gamma , MCP 2 , MIP 1alpha , MIP 1beta , CCR 5 , MIG , IP 10 and others ) and one gene downregulated ( SDF 2 ) among the 76 genes detectable on the array . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CCR 5 ligands RANTES , macrophage inflammatory protein ( MIP ) 1alpha and MIP 1beta are potent and specific inhibitors of strains of human immunodeficiency virus ( HIV ) that use CCR 5 as a receptor , which are the strains most involved in primary infection . ^^^ Taken together , these observations suggest that CCR 5 ligands , and in particular MIP 1alpha and MIP 1beta , released in the course of memory responses may play a role in protecting CD 4 ( + ) memory T cells from infection . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Plasma concentrations of MIP 1beta , the CCR 5 agonist , were twice as high in sCCR 5 positives ( 140 . 8+ / 25 . 8 pg / ml ) as in the sCCR 5 negatives ( 77 . 6+ / 11 . 0 pg / ml , P=0 . 0157 ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The recruitment of major histocompatibility complex ( MHC ) class 2 ( + ) LC was significantly suppressed in CCR 5 ( / ) mice and blockade of RANTES and MIP 1beta , but not in CCR 1 ( / ) , CCR 2 ( / ) / MIP 1alpha ( / ) , or MIP 1alpha ( / ) mice . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The natural ligands of CCR 5 , the beta chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES , interfere with HIV 1 binding to CCR 5 receptors and decrease the amount of virions entering cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : We hypothesized that the chemokine receptor 5 ( CCR 5 ) ligands , MIP 1alpha , MIP 1beta and RANTES , are virulence correlates in M . tuberculosis infection and are indispensable to granuloma formation . ^^^ CONCLUSIONS : The production of the CCR 5 ligands , MIP 1alpha , MIP 1beta , and RANTES , does not clearly correlate with virulence of M . tuberculosis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Infiltrating T cells , confined to the adventitia and intima , expressed CXCR 3 and CCR 5 , but were not recruited into the media despite production by vascular smooth muscle cells of IP 10 , Mig , 1 TAC , RANTES and MIP 1beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In vitro studies have shown that murine IgG and IgA ( 1 ) specifically bind human and mouse CD4+ lymphocytes and the CCR 5 transfected U 87 cell line , ( 2 ) down regulate CCR 5 expression of CD4+ cells from both humans and untreated mice , ( 3 ) inhibit Mip 1beta chemotaxis of CD4+ CCR5+ lymphocytes , and ( 4 ) neutralize HIV R 5 strains . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines , MCP 1 , and MIP 1 beta , while reciprocally upregulating the expression of their specific receptors , CCR2b , CCR 3 , and CCR 5 as detected by real time quantitative PCR . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Overproduction of MIP 1beta in CCR 5 deficient mice after CII immunization may contribute partially to the occurrence of arthritis . . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We examined the expression of chemokine receptors CCR 5 and CXCR 4 on CD4+ T cells and plasma chemokine levels of macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , regulated on activation normal T expressed and secreted ( RANTES ) , and stromal cell derived factor ( SDF ) 1alpha among TB patients with HIV coinfection during the first 2 months of anti TB treatment . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Herein we describe the effects of morphine and / or gp 120 on the expression of the genes for the beta chemokine MIP 1beta and its receptors CCR 3 and CCR 5 by the U 373 cells which are a human brain derived astrocytoma / glioblastoma cell line . ^^^ Our results indicate that treatment of U 373 cells with morphine significantly downregulated the gene expression of the beta chemokine , MIP 1 beta , while reciprocally upregulating the expression of its specific receptors , CCR 3 and CCR 5 suggesting that the capacity of mu opioids to increase HIV 1 co receptor expression may promote viral binding , trafficking of HIV 1 infected cells , and enhanced disease progression . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
TAK 652 inhibited the binding of RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta to CCR 5 expressing cells at nanomolar concentrations . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CD3+ T cells , infiltrating the retina , also expressed the chemokine receptor CCR 5 , and CCR 5 ligands , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated on activation , normal T expressed and secreted ( RANTES ) , were strongly expressed in the retina at peak EAU . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
To better understand the interaction of the host with HIV 1 during active tuberculosis , we investigated in vivo expression of the HIV 1 coreceptors , CCR 5 and CXCR 4 , and circulating levels of the inhibitory beta chemokines , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , macrophage inflammatory protein 1 beta ( MIP 1beta ) , and regulated upon activation T cell expressed and secreted ( RANTES ) , in HIV positive individuals with and without active pulmonary tuberculosis . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Following the cross linking of CCR 5 , monocytes synthesized high levels of M CSF , RANTES , MIP 1 alpha , and MIP 1 beta associated with a readily detectable down modulation of CD 14 , CD 4 , CCR 5 , and CXCR 4 expression . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
Certain CC chemokines , including RANTES , MIP 1alpha , and MIP 1beta , might facilitate the development of such microbicides since they potently suppress HIV 1 infection by binding to CCR 5 , the viral coreceptor used by most sexually transmitted strains of HIV 1 to enter host cells . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
LLDT 8 decreased CC chemokine receptor 5 ( CCR 5 ) and their ligands macrophage inflammatory protein 1 alpha ( MIP 1alpha ) and beta ( MIP 1beta ) mRNA expressions in allografts . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
This structure of V 3 ( MN ) was found to have conformation and sequence similarities to beta hairpins in CD 8 and CCR 5 ligands MIP 1alpha , MIP 1beta , and RANTES and differed from the beta hairpin of a V 3 ( IIIB ) peptide bound to the strain specific murine anti gp 120 ( IIIB ) antibody 0 . 5beta . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The Src kinase Lyn is required for CCR 5 signaling in response to MIP 1beta and R 5 HIV 1 gp 120 in human macrophages . ^^^ Stimulation of human monocyte derived macrophages with either HIV 1 gp 120 or MIP 1beta results in the CCR 5 mediated activation of Lyn and the concomitant Lyn dependent activation of the mitogen activated protein ( MAP ) kinase ERK 1 / 2 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
We report that A / J mice immunized with mc TnI developed severe inflammation of the myocardium with increased expression of inflammatory chemokines RANTES ( regulated on activation normal T cell expressed and secreted ) , monocyte chemoattractant protein 1 , macrophage inflammatory protein ( MIP ) 1alpha , MIP 1beta , MIP 2 , T cell activation gene 3 , and eotaxin and chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
CXCR 4 , CCR 5 and amphiregulin were up regulated by cAMP agonist , whereas other cytokine related genes including macrophage inflammatory protein 1 beta , tumour necrosis factor alpha and lymphotoxin beta were markedly down regulated by cAMP agonist in T cells from both HIV infected patients and controls . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES and MIP 1b were expressed constitutively in all patients and controls . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
At 26 weeks postirradiation , messages encoding the chemokines BLC ( now known as Scyb 13 ) , C 10 ( now known as Scya 6 ) , IP 10 ( now known as Scyb 10 ) , MCP 1 ( now known as Scya 2 ) , MCP 3 ( now known as Scya 7 ) , MIP 1gamma ( now known as Scya 9 ) , and RANTES ( now known as Scya 5 ) and the chemokine receptors Ccr 1 , Ccr 2 , Ccr 5 and Ccr 6 were elevated in fibrosis sensitive ( C57BL / 6 ) mice . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
In functional calcium signalling assays , the CCR 5 endogenous ligands MIP 1alpha , MIP 1beta and RANTES evoked a robust response in the dog recombinant CCR 5 cells . ^^^ In a CRE Luc ( cAMP response element luciferase ) reporter gene assay , MIP 1beta ( 0 . 01 30nM ) produced concentration dependent inhibition of forskolin induced elevation in cAMP levels , and was equipotent in dog , human and macaque recombinant CCR 5 cells ( EC ( 50 ) 0 . 4 , 0 . 21 and 0 . 47nM , respectively ) . ^^^
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13236 and P51681	Pubmed	SVM Score :0.0
NA