Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P10147 and P51681	Pubmed	SVM Score :1.2582352
We demonstrate that the key region of CCR 5 involved in its specific interaction with MIP 1alpha , MIP 1beta , and RANTES , and its subsequent activation , lies within the second extracellular loop ( and possibly the adjacent transmembrane segments ) . 1.2582352^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.53781674
CCR 5 was first characterized as a receptor for MIP 1alpha , MIP 1beta , and RANTES , and was rapidly shown to be the main coreceptor for M tropic human immunodeficiency virus ( HIV ) 1 strains and simian immunodeficiency virus ( SIV ) . 0.53781674^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.66660869
Inhibition of labeled MIP 1alpha binding was achieved with unlabeled MIP 1alpha and RANTES , the latter a beta chemokine that binds to both CCR 1 and CCR 5 , but not by MCP 1 . 0.66660869^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Since chemokine receptors CXCR 3 and CCR 5 are preferentially expressed on Th 1 cells , we tested the expression and regulation of several chemokines , including those that signal through CXCR 3 ( interferon gamma inducible protein of 10 kDa , IP 10 , CXCL 10 ; and monokine induced by interferon gamma , Mig , CXCL 9 ) and CCR 5 ( macrophage inflammatory protein ( Mip ) 1 alpha , CCL 3 ; and Mip 1 beta , CCL 4 ) in RA synovial fluids , synovial tissues , and blood . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The most active chemokines for resting Th ( IL 10 ) , in terms of calcium mobilization and in vitro migration , were in order of potency : CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , CCL 17 ( thymus and activation regulated chemokine , CCR 4 ligand ) , CCL 1 ( 1 309 , CCR 8 ligand ) , CXCL 12 ( stromal derived factor 1 , CXCR 4 ) , and CCL 11 ( eotaxin , CCR 3 ligand ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Survival of CCR 5 ( / ) mice was equivalent to that of controls , indicating that the enhanced susceptibility of CCL 3 ( / ) mice to K . pneumoniae is mediated via another CCL 3 receptor , presumably CCR 1 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
It was shown that residues in the N ter are necessary for binding of the physiologic ligands , RANTES ( CCL 5 ) and MIP 1 alpha ( CCL 3 ) . vMIP 2 , encoded by the Kaposi ' s sarcoma associated herpesvirus , is a high affinity CCR 5 antagonist , but lacks efficacy as a coreceptor inhibitor . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CC chemokine receptor 5 ( CCR 5 ) binds the chemokine ligands RANTES ( CCL 5 ) and MIP 1alpha ( CCL 3 ) , which have been implicated in the development of alveolitis in sarcoidosis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
An abortive ligand induced activation of CCR 1 mediated downstream signaling event and a deficiency of CCR 5 expression are associated with the hyporesponsiveness of human naive CD4+ T cells to CCL 3 and CCL 5 . ^^^ Thus , a failure of the ligand induced activation of CCR 1 mediated downstream signaling event as well as a deficiency of CCR 5 expression may be involved in the hyporesponsiveness of naive CD 4 ( + ) T cells to CCL 3 and CCL5 . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We also determined that CCR 5 binding chemokines MIP 1alpha ( CCL 3 ) , CCL 4 , and RANTES ( CCL 5 ) , specifically by signaling through CCR 5 , could affect all progenitor B cell populations through a novel mechanism involving heterologous desensitization of CXCR 4 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We and others have shown that the human beta chemokine CCL 3 L1 , unlike its related non allelic isoform CCL 3 , has high affinity for the chemokine receptors D 6 , CCR 3 and CCR 5 . ^^^ Moreover , CCL 3 L1 , but not CCL 3 , is susceptible to cleavage by CD 26 , creating a truncated 2 form with enhanced affinity for CCR 1 and CCR 5 . ^^^ Strong interaction with CCR 5 means that CCL 3 L1 , and particularly its 2 variant , are by far the most potent natural HIV entry inhibitors described to date . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
High levels of CCL 3 and CCL 4 were produced within 8 h after infection , which is likely to account for the observed CCR 5 down modulation on Mtb infected DC . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Blocking Gi protein coupled receptor signaling by pertussis toxin as well as deficiencies in G alpha 12 , chemokine receptor 2 ( CCR 2 ) , CCR 5 , chemokine ligand 2 ( CCL 2 , also known as monocyte chemoattractant protein 1 , or MCP 1 ) , CCL 3 ( macrophage inflammatory protein 1 alpha , or MIP 1 alpha ) and CCL 5 ( RANTES ) have all been found to have effects on the magnitude and cytokine polarity of the T cell response . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The effect is not unique to CCL 5 , as other CCR 5 ligands such as CCL 3 ( MIP 1alpha ) and CCL 4 ( MIP 1beta ) also trigger TIL cell death , nor is it limited to melanoma cells , as it also operates in activated primary T lymphocytes . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In parallel , CCR 1 and CCR 5 expression is down regulated and CXCL 8 , CCL 2 , CCL 3 and CCL 5 production is up regulated . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In contrast , CCL 3 , a ligand of CCR 1 and CCR 5 , induced rapid uptake of FITC dextran by immature DCs but not mature DCs . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Although virus specific CD 8 ( + ) T cells from CCL 3 ( / ) mice were CD 44 ( high ) , they remained CD62L ( high ) and CD 25 ( low ) , retained CCR 7 expression , and contained limited transcripts of the proinflammatory chemokine receptors CCR 5 and CXCR 3 compared with virus specific CD 8 ( + ) T cells from CCL 3 ( + / + ) mice . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In contrast , the loss of the CCR 5 ligand , CCL 3 , led to an early delay in tumor growth that did not persist , while the absence of the CCR 5 ligand , CCL 5 , had no effect . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
After 2 to 4 weeks , L . amazonensis infected mice had significantly delayed and depressed expression of inflammatory cytokines ( interleukin 12 [ IL 12 ] , gamma interferon , IL 1 alpha , IL 1 beta ) , CC chemokines ( CC chemokine ligand 3 [ CCL 3 ] / macrophage inflammatory protein 1 alpha [ MIP 1 alpha ] , CCL4 / MIP 1 beta , CCL5 / RANTES , MIP 2 ) , and chemokine receptors ( CCR 1 , CCR 2 , CCR 5 ) in foot tissues and draining lymph nodes compared to the expression in L . major infected controls . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In addition , the relative roles of the chemokines that bind CXCR 3 ( CXCL 9 , CXCL 10 , CXCL 11 ) and CCR 5 ( CCL 3 , CCL 4 , CCL 5 ) in this process are unknown . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In situ hybridization histochemistry revealed local production of the CCR 1 ligands CCL 3 ( MIP 1 alpha ) and CCL 5 ( RANTES ) , as well as large numbers of CCR 1 and CCR 5 expressing cells within inflammatory brain lesions . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 2 and CCR 5 interact primarily with the human CC family ligands CCL 2 ( formerly called monocyte chemoattractant protein ; MCP 1 ) , CCL 3 and CCL 4 ( macrophage inflammatory protein 1 alpha and 1 beta ; MIP 1 alpha / beta ) , and their main function is to recruit leukocytes from circulation into the tissues , thus playing an important role in human inflammatory disorders . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The chemokine receptor , CCR 5 , is a G protein coupled receptor responsible for some of the effects of the chemokines CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The focus of TGFbeta inhibition is observed to be directed in genes involved in chemotaxis ( IL 15 , CXCL 1 , CXCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 9 ) , chemokine receptors ( CCR 5 , CCR 9 ) , LIF receptor , and FPR 2 , and on genes mediating cell migration ( MMP 9 , MMP 13 , MacMARCKS , endothelin receptor B , Ena / VASP , Gas 7 ) , apoptosis ( FAS , TNF , TNF receptor , caspase 1 and 11 ) , and host response to infection ( toll like receptor 6 , Mx 1 , and MARCO ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
One anti CXCR 4 factor is macrophage derived chemokine ( chemokine ligand 22 , CCL 22 ) , and anti CCR 5 factors include macrophage inflammatory protein 1 alpha ( CCL 3 ) , macrophage inflammatory protein 1 beta ( CCL 4 ) , and RANTES ( regulated upon activation of normal T cells expressed and secreted ) ( CCL 5 ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In addition , chemotaxis toward the CCR 1 and CCR 5 ligands CCL 3 and CCL 5 was also increased . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the production of dynamic alpha and beta chemokines represented by interleukin 8 ( IL 8 ) as alpha chemokine and CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , ( CCL 5 , regulated upon activation , normal T cell expressed and secreted ( RANTES , CCR 5 ligand ) as beta chemokines by the human intestinal cell line INT 407 stimulated with factors produced by living Campylobacter jejuni ( C . jejuni ) and those present within sonicated and filtrated bacteria . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Three CC chemokines MIP 1alpha ( CCL 3 ) , MIP 1beta ( CCL 4 ) , and RANTES ( CCL 5 ) are natural ligands for the human immunodeficiency virus 1 ( HIV 1 ) coreceptor CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In particular , the interaction between chemokines CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) and CCL 5 ( RANTES ) and their receptor , CC chemokine receptor 5 ( CCR 5 ) , may be critical in regulating T cell functions by mediating recruitment , polarization , activation and differentiation of antiviral type 1 cytokine secreting T helper and cytotoxic T cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
This was associated with reduced renal expression of CC chemokines CCL 2 , CCL 3 , CCL 4 , and CCL 5 and the chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In this study , we show that 1 TAC , in addition to these effects , acts as an antagonist for CCR 5 . 1 TAC inhibited the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) / CC chemokine ligand 3 ( CCL 3 ) to cells transfected with CCR 5 and to monocytes . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
M . tuberculosis infection causes an increase in the expression of beta chemokines CCL 3 , CCL 4 , and CCL 5 , and their receptor CCR 5 , in the lungs . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
To assess the role of the chemokine receptors CCR 1 and CCR 5 , and a ligand for these receptors CCL3 / macrophage inflammatory protein 1alpha , in this pathogenic process , the reverse passive cutaneous Arthus reaction was induced in mice lacking CCR 1 , CCR 5 , or CCL 3 . ^^^ Edema was significantly attenuated in CCR 1 deficient ( CCR 1 ( / ) ) and CCL 3 ( / ) mice but not CCR 5 ( / ) mice , compared with wild type mice . ^^^ Remarkably , the intradermal mRNA expression of CCL5 / RANTES , another ligand for CCR 1 and CCR 5 , was increased in CCR 5 ( / ) and CCL 3 ( / ) mice , compared with wild type mice , while the cutaneous CCL 3 mRNA expression was augmented in CCR 1 ( / ) and CCR 5 ( / ) mice . ^^^ These results indicate that CCR 1 , CCR 5 , and CCL 3 cooperatively contribute to the cutaneous Arthus reaction , and also suggest that enhanced expression of CCL 3 and CCL 5 compensates for the loss of CCR 1 , CCR 5 , and CCL 3 in the reaction . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
AMD 3451 dose dependently inhibited the intracellular Ca ( 2+ ) signaling induced by the CXCR 4 ligand CXCL 12 in T lymphocytic cells and in CXCR 4 transfected cells , as well as the Ca ( 2+ ) flux induced by the CCR 5 ligands CCL 5 , CCL 3 , and CCL 4 in CCR 5 transfected cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCL 3 ( MIP 1alpha ) induces in vitro migration of GM CSF primed human neutrophils via CCR 5 dependent activation of ERK 1 / 2 . ^^^ CCL 3 and CCL 4 triggered migration of GM CSF primed neutrophils was inhibited by the CCR 5 antagonist TAK 779 . ^^^ This suggests that by activating ERK 1 , GM CSF renders neutrophils rapidly responsive to CCL 3 stimulation throughout CCR 5 which is constitutively expressed on the cell surface . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
To do this , they have characterised haplotypes comprising alleles at 11 biallelic loci in four chemokine receptor genes ( CCR 3 , CCR 2 , CCR 5 and CCRL 2 ) , which span 150 kb on chromosome 3p21 , and haplotyes of nine biallelic loci in six chemokine genes [ MCP 1 ( CCL 2 ) , Eotaxin ( CCL 11 ) , RANTES ( CCL 5 ) , MPIF 1 ( CCL 23 ) , PARC ( CCL 18 ) and MIP 1alpha ( CCL 3 ) ] on chromosome 17q11 12 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
SNP haplotypes , estimated from unphased genotypes using the Expectation Maximization algorithm , are described in a cluster of four CC chemokine receptor genes ( CCR 3 , CCR 2 , CCR 5 and CCRL 2 ) on chromosome 3p21 , and a cluster of three CC chemokine genes [ MPIF 1 ( CCL 23 ) , PARC ( CCL 18 ) and MIP 1alpha ( CCL 3 ) ] on chromosome 17q11 12 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The expression of CCL 3 ( MIP 1alpha ) , CCL 4 ( MIP 1beta ) , CCL 5 ( RANTES ) and their main receptors ( CCR 1 and CCR 5 ) was studied by semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry in a series of 16 IIM and five controls ( four normal muscles and one tonsil ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We investigated the role played by chemokine receptor 5 ( CCR 5 ) in the influx of T cells to the cardiac tissue of T . cruzi infected mice . mRNA and protein for the CCR 5 ligands CCL 3 , CCL 4 , and CCL 5 were detected in the hearts of infected mice in association with CD4+ and CD8+ T cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Expression of the chemokine receptors CCR 2 and CCR 5 by DC and their responsiveness to the respective ligands , CCL 2 and CCL 3 , were downregulated , while the level of CCR 7 and the DC response to its ligand CCL 21 were enhanced . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
MIP 1alpha [ CCL 3 ] used CCR 1 to promote neutrophil recruitment , as OVA or MIP 1alpha [ CCL 3 ] failed to induce neutrophil migration in CCR 1 ( / ) mice , in contrast to CCR 5 ( / ) mice . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
From each blood sample PBMCs were separated and gene expression levels for chemokines CCL 3 , CCL 4 , CCL 5 , CXCL 10 , and their receptors CCR 1 , CCR 5 , and CXCR 3 , were determined using real time quantitative PCR . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Similar kinetics of expression were found for the chemokines CCL 5 , CCL 4 , CCL 3 and CXCL 10 and for the receptors CCR 5 and CXCR 3 , all of them linked to the Th 1 type pattern . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCL 3 binds to the chemokine receptors CCR 1 and CCR 5 , which are expressed by inflammatory leukocytes such as macrophages and T cells present in the affected joints of RA patients . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Met RANTES , an amino terminal modified methionylated form of RANTES ( CCL 5 ) , antagonizes the binding of the chemokines RANTES and macrophage inflammatory protein 1alpha ( MIP 1alpha ; CCL 3 ) to their receptors CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Variants of CCR 5 , which are permissive for HIV 1 infection , show distinct functional responses to CCL 3 , CCL 4 and CCL 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
To test the hypothesis that chemokines exhibit previously undiscovered pleiotropic effects important for the behavioral actions of ethanol , we studied mutant mice with deletion of the Ccr 2 , Ccr 5 , Ccl 2 or Ccl 3 genes . ^^^ Ccr 2 and Ccr 5 null mutant mice did not differ from wild type mice in ethanol induced loss of righting reflex ( LORR ) , but mice lacking Ccl 2 or Ccl 3 showed longer LORR than wild type mice . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Serum ELISAs were performed to detect the CCR 5 ligands CCL 5 , CCL 3 ; the CXCR 3 ligands CXCL 10 , CXCL 9 ; and the CCR 4 ligand , CCL 17 before and after administration of the TNFalpha blocking agent infliximab . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
U83A Npep acted only as antagonist , efficiently blocking binding of CCL 3 to CCR 1 or CCR 5 on differentiated monocytic / macrophage leukemic cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Ocular herpes simplex virus type 1 ( HSV 1 ) infection elicits a strong inflammatory response that is associated with production of the beta chemokines CCL 3 and CCL 5 , which share a common receptor , CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
To determine whether the chemokine receptor CCR 5 is a relevant target for CCL 3 in the brain , we used RT PCR and immunocytochemistry to assess changes in CCR 5 expression and localization in developing normal and injured rat forebrain . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Because the chemokine receptor CCR 5 and its ligands ( CCL 3 , CCL 4 , and CCL 5 ) regulate leukocyte chemotaxis and activation , we investigated the role of CCR 5 during Con A induced liver injury . ^^^ CCR 5 / mice also exhibited increased production of interleukin 4 , tumor necrosis factor alpha , CCL 3 , CCL 4 , and CCL 5 , and a prominent liver mononuclear cell infiltrate , among which many cells were CCR1+ . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Here we demonstrate that after immunization but before antigen recognition , naive CD8+ T cells in immunogen draining lymph nodes upregulate the chemokine receptor CCR 5 , permitting these cells to be attracted to sites of antigen specific dendritic cell CD4+ T cell interaction where the cognate chemokines CCL 3 and CCL 4 ( also known as MIP 1alpha and MIP 1beta ) are produced . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Expression microarrays and real time reverse transcription PCR revealed that gonadally intact females exhibited higher expression of interleukin 10 ( IL 10 ) , IL 15Ralpha , IL 12Rbeta , Gadd45gamma , gamma interferon ( IFN gamma ) , CCL 3 , CXCL 10 , CCR 5 , and several IFN inducible genes in white blood cells and produced more IFN gamma than did intact males and gdx females , with these differences being most pronounced during peak parasitemia . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCL 3 and CCL 4 are natural ligands for the primary human immunodeficiency virus type 1 ( HIV 1 ) coreceptor CCR 5 and are also known to activate and enhance the cytotoxicity of natural killer cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Genetic deletion of one of the MIP1alpha and RANTES receptors , CCR 5 , is associated with protection from infection with HIV 1 in humans , while deletion of the ligand MIP1alpha protects against Coxsackie virus associated myocarditis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a receptor for the CC chemokines RANTES , Mip1alpha , and Mip1beta , has been identified as a coreceptor for infections by macrophage tropic isolates of human immunodeficiency virus type 1 ( HIV 1 ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Recently , a common deletion mutation in the gene for the major receptor for MIP 1 alpha , chemokine receptor 5 ( CCR 5 ) has been described . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
A major advance in understanding human immunodeficiency virus ( HIV ) biology was the discovery that the beta chemokines MIP 1 alpha ( macrophage inflammatory protein 1 alpha ) , MIP 1 beta ( macrophage inflammatory protein 1 beta ) and RANTES ( regulated on activation , normal T cell expressed and secreted ) inhibit entry of HIV 1 into CD4+ cells by blocking the critical interaction between the CCR 5 coreceptor and the V 3 domain of the viral envelope glycoprotein gp 120 [ 1 , 2 ] . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Directed selection of MIP 1 alpha neutralizing CCR 5 antibodies from a phage display human antibody library . ^^^ We describe the use of MIP 1 alpha in a biotin tyramine mediated proximity selection to guide the selection of CCR 5 specific phage antibodies from a large phage display human library . ^^^ Proximity based selections resulted in a population of antibodies recognizing CCR 5 on primary CD4+ lymphocytes , none of which blocked MIP 1 alpha binding to cells . ^^^ This generated a panel of CCR 5 binding antibodies , of which around 20 % inhibited MIP 1 alpha binding to CD4+ . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Sulfated tyrosines contribute to the binding of CCR 5 to MIP 1 alpha , MIP 1 beta , and HIV 1 gp120 / CD4 complexes and to the ability of HIV 1 to enter cells expressing CCR 5 and CD 4 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We investigated the immune responses in mice lacking CCR 2 , CCR 5 , or macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , a ligand for CCR 5 , in two situations : following T cell stimulation or after challenge with Leishmania donovani , an intracellular microbe whose control is dependent on a Th 1 immune response . ^^^ Mice deficient in CCR 5 , MIP 1 alpha , or CCR 2 had reduced IFN gamma responses following ligation of the TCR . ^^^ To the contrary , during the late phase of infection , an exaggerated Ag specific IFN gamma response was evident in CCR 5 / and MIP 1 alpha / mice , and this correlated with an enhanced control of parasite replication . ^^^ Collectively , these findings indicate an important role for CCR 5 , MIP 1 alpha , and CCR 2 in granulomatous inflammation , and that CCR 5 and MIP 1 alpha , possibly acting through CCR 5 , might play a deleterious role in the outcome of chronic L . donovani infection . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically ablated for CCR 2 , CCR 5 and the CCR 5 receptor ligand , MIP 1 alpha . ^^^ Peripheral NK cells express the CC chemokine receptor CCR 2 , for MCP 1 and CCR 5 , for MIP 1 alpha and RANTES . ^^^ To assess the roles of CCR 2 , CCR 5 and MIP 1 alpha in NK cell migration to the uterus and localization within implantation sites , histological analysis was conducted on implantation sites from mice genetically ablated for CCR 2 , CCR 5 , MIP 1 alpha or CCR 2 and MIP 1 alpha . ^^^ Thus , migration , distribution and activation of NK cells within the pregnant uterus are independent of CCR 2 , CCR 5 and MIP 1 alpha . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
For examples , Langerhans cells migrate selectively to MIP 3 alpha ( via CCR 6 ) , blood CD11c+ DC to MCP chemokines ( via CCR 2 ) , monocytes derived DC respond to MIP 1 alpha / beta ( via CCR 1 and CCR 5 ) , while blood CD11c DC precursors do not respond to any of these chemokines . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Stimulation of these CCR 5 positive T cells with the relevant chemokine MIP 1 alpha elicited Ca ( 2+ ) influx , showing that IL 12 induced CCR 5 is functional . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In EAE protected mice , 17 beta estradiol strongly inhibited mRNA expression of the chemokines RANTES , MIP 1 alpha , MIP 2 , IP 10 , and MCP 1 , and of the chemokine receptors CCR 1 , CCR 2 and CCR 5 at both time points . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Several potential mechanisms for expansion of HIV 1 in situ were found , including augmentation in expression of tumor necrosis factor ( TNF ) alpha and the HIV 1 noninhibitory beta chemokine ( MCP 1 ) , low presence of HIV 1 inhibitory beta chemokines ( MIP 1 alpha , MIP 1 beta , and RANTES [ regulated on activation , normal T expressed and secreted ] ) , and upregulation in expression of the HIV 1 coreceptor , CCR 5 , by pleural fluid mononuclear cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Using self organizing maps , we identified nine genes ( CD 4 , CCR 3 , CCR 5 , LT beta , MIP 1 alpha , MIP 2 , CD 8 alpha , IP 10 , and RANTES ) , each with a unique profile of transcriptional expression , that reproduce the differentiation of states of rejection in dendrograms . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The PBMC levels of CCR 5 ligands MIP 1 alpha / beta and RANTES , and chemokines MCP 1 , IL 8 , lymphotactin , IP 10 and 1 309 were analysed by ribonuclease protection assay ( RPA ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In addition , the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha , MIP1beta , and RANTES , natural ligands of CXCR 4 and CCR 5 , respectively , are potent soluble inhibitors of HIV infection by blocking the binding between the viral envelope glycoprotein gp 120 and the coreceptors . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The study demonstrated further that aberrant migration of multiple sclerosis derived T cells toward RANTES and MIP 1 alpha resulted from overexpression of their receptors ( CCR 5 ) and could be blocked by anti CCR 5 antibodies . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Furthermore , urinary levels of MIP 1 alpha , the cognate ligand for CCR 5 , were determined by enzyme linked immunosorbent assay . ^^^ CONCLUSIONS : We conclude that the phosphorylation of p 38 MAPK associated with the activation of NF kappa B may be involved in the upregulation of intrarenal MIP 1 alpha and the utilization of CCR 5 signalling , which may result in human crescentic glomerulonephritis . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The higher RANTES production by MS gamma delta T cell lines , together with a lower expression of CCR 5 , may reflect an autoregulatory loop , caused by an increased production of its ligands ( RANTES , MIP 1 alpha , and MIP 1 beta ) or due to other pro inflammatory cytokines . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
A number of inflammatory CC chemokines , including MIP 1 alpha , MIP 1 beta , RANTES , MCP 2 , and HCC 1 [ 9 74 ] act as CCR 5 agonists , while MCP 3 is a natural antagonist of the receptor . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The MIP 1 alpha isoform LD 78 beta , that was purified form natural sources , inhibited HIV infection completely in CCR 5 transfected cells , mononuclear leukocytes and purified monocytes at low ( ng / ml ) concentrations . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands , RANTES and MIP 1 alpha , are expressed in the spinal cords of mice at EAE onset . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : Ligands of chemokine receptor CCR 5 , including MIP 1 alpha , MIP 1 beta , and RANTES , have been implicated in rheumatoid arthritis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Consistent with reports from in vitro and human studies , mice undergoing Th 1 polarized inflammation showed preferential expression of the transcription factor t bet , the chemokines IFN gamma inducible protein ( IP ) 10 and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , and the chemokine receptor CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
As the ligands of CCR 5 , MIP1alpha and MIP1beta were detected , whereas RANTES was not . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Following the cross linking of CCR 5 , monocytes synthesized high levels of M CSF , RANTES , MIP 1 alpha , and MIP 1 beta associated with a readily detectable down modulation of CD 14 , CD 4 , CCR 5 , and CXCR 4 expression . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In addition the beta chemokines RANTES ( regulated on activation T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , and MIP 1beta can block HIV 1 entry into cells by preventing the binding of the macrophage trophic HIV 1 strains to the coreceptor CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The expression of the chemokines macrophage inflammatory protein 1 alpha ( MIP 1alpha ) and interferon gamma inducible protein 10 ( IP 10 ) and of their respective receptors , CCR 5 and CXCR 3 , were more prevalent and higher in aggressive periodontitis , and associated with higher interferon gamma ( IFN gamma ) expression and lower interleukin 10 ( IL 10 ) expression . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Our studies showed that LD infection caused the upregulation of three beta chemokines ( macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , MIP 1beta and RANTES ( regulated on activation normal T cell expressed and secreted ) ) , one alpha chemokine ( interleukin 8 ( IL 8 ) ) and the CC chemokine receptor 5 ( CCR 5 ) but not CCR 1 , as evident from reverse transcriptase polymerase chain reaction ( RT PCR ) analysis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
To better understand the interaction of the host with HIV 1 during active tuberculosis , we investigated in vivo expression of the HIV 1 coreceptors , CCR 5 and CXCR 4 , and circulating levels of the inhibitory beta chemokines , macrophage inflammatory protein 1 alpha ( MIP 1alpha ) , macrophage inflammatory protein 1 beta ( MIP 1beta ) , and regulated upon activation T cell expressed and secreted ( RANTES ) , in HIV positive individuals with and without active pulmonary tuberculosis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
LLDT 8 decreased CC chemokine receptor 5 ( CCR 5 ) and their ligands macrophage inflammatory protein 1 alpha ( MIP 1alpha ) and beta ( MIP 1beta ) mRNA expressions in allografts . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a receptor for chemokines MIP 1alpha ( LD78alpha ) , MIP 1beta , RANTES , and MCP 2 , is of particular importance in vivo as polymorphisms in this gene affect HIV infection and rate of progression to AIDS . ^^^ Here we show that a non allelic isoform of human MIP 1alpha ( LD78alpha ) , termed LD78beta or MIP 1alphaP , has enhanced receptor binding affinities to CCR 5 ( approximately 6 fold ) and the promiscuous beta chemokine receptor , D 6 ( approximately 15 20 fold ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Using CC chemokine receptor transfected cells , both molecular forms of LD78beta proved to be much more potent than LD78alpha in inducing an intracellular calcium rise through CCR 5 . ^^^ Compared with LD78alpha and RANTES , this preferential binding of LD78beta to CCR 5 resulted in a 10 to 50 fold higher potency in inhibiting infection of peripheral blood mononuclear cells by CCR 5 using ( R 5 ) HIV 1 strains . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
LD78beta was recently reported to be a much more potent CCR 5 agonist than LD78alpha and RANTES in inducing intracellular Ca2+ signaling and chemotaxis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Since both human MIP 1alpha subtypes ( LD78alpha and LD78beta ) and MIP 1beta signal through CCR 5 , the major co receptor for M tropic HIV 1 strains , these chemokines are capable of inhibiting HIV 1 infection in susceptible cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage tropic strains of HIV 1 is CC CKR 5 , a receptor for the beta chemokines RANTES , MIP 1alpha and MIP 1beta . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^ CC CKR 5 : a RANTES , MIP 1alpha , MIP 1beta receptor as a fusion cofactor for macrophage tropic HIV 1 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Molecular cloning and functional characterization of a novel human CC chemokine receptor ( CCR 5 ) for RANTES , MIP 1beta , and MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES were all potent agonists for CC CKR 5 ( EC 50 = 3 30 nM ) when calcium flux was measured in transfected HEK 293 cells , yet the apparent binding affinities of the corresponding iodinated chemokines to intact cells expressing the receptor were low ( IC 50 approximately 100 nM ) . ^^^ These data suggest that CC CKR 5 is a G ( 1 ) coupled receptor that may mediate monocyte responses to MIP 1alpha , MIP 1beta , and RANTES . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Macrophage tropic HIV 1 isolates are generally specific for CCR 5 , a receptor for the CC chemokines RANTES , MIP 1alpha , and MIP 1beta , while T cell line tropic viruses tend to use CXCR 4 ( also known as fusin , LESTR , or HUMSTR ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Chinese hamster ovary cells expressing CCR 1 , 3 , 5 , and D 6 bound 125I murine MIP 1alpha : the order of affinity was D 6 > CCR 5 > CCR 1 > CCR 3 . ^^^ Thus , we have characterized four murine beta chemokine receptors that are likely involved in mediating the pro inflammatory functions of MIP 1alpha and other chemokines , and we present D 6 , CCR 3 , and CCR 5 as candidate receptors in MIP 1alpha induced HSC inhibition . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Ligation of CCR 5 by the CC chemokines RANTES , MIP 1alpha or MIP 1beta , and of CXCR 4 by the CXC chemokine SDF 1alpha , profoundly inhibits the replication of HIV strains that use these coreceptors for entry into CD 4 ( + ) T lymphocytes . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Although reverse transcription polymerase chain reaction ( RT PCR ) showed the presence of CCR 1 , CCR 4 , and CCR 5 transcripts in CD34+ cells in BM , anti CCR 1 antibodies significantly abrogated the inhibitory effects of MIP 1alpha on BFU E formation both in a methylcellulose culture and in a single cell proliferation assay of purified CD34+ cells . ^^^ Although the contribution of CCR 4 or CCR 5 can not be completely excluded , these results suggest that MIP 1alpha mediated suppression of the proliferation of immature , but not mature erythroid progenitor cells , is largely mediated by CCR 1 expressed on these progenitor cells . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are HIV 1 suppressive factors secreted by CD8+ cells that inhibit NSI viruses . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Physiological ligands of CCR 5 , namely the beta chemokines MIP 1alpha , MIP 1beta , and RANTES , were found to competitively inhibit the V 3 loop CCR 5 interaction . ^^^ We therefore hypothesized that the V 3 loop of gp 120 of macrophage tropic HIV 1 may share a binding site on CCR 5 with MIP 1alpha , MIP 1beta , and RANTES and that the V 3 loop therefore might have some homology with these beta chemokines . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
This mAb was a genuine antagonist of CCR 5 , since it failed to stimulate an increase in intracellular calcium concentration in the CCR 5 transfectants , but blocked calcium responses elicited by RANTES , MIP 1alpha , or MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 , a specific RANTES , MIP 1alpha and MIP 1 receptor , is used preferentially by non MT 2 tropic HIV 1 and HIV 2 strains and by simian immunodeficiency virus ( SIV ) , whereas CXCR 4 , a receptor for the C 10 C chemokine SDF 1 , is used by MT 2 tropic HIV 1 and HIV 2 , but not by SIV . ^^^ Viral isolates obtained during the asymptomatic stages generally used only CCR 5 as a co receptor and were inhibited by RANTES , MIP 1alpha and MIP 1beta , but not by SDF 1 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
RANTES and MIP 1alpha mediate their effects via shared chemokine receptors ( CCRs ) : CCR 1 , CCR 4 , and CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Thus , for CCR 5 , the rank order for down regulation was also RANTES , MIP 1beta , MIP 1alpha . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We showed that the neutralization of 89 . 6 in PBMC was not improved when CCR 5 was blocked by having RANTES , MIP 1alpha , and MIP 1beta in the culture medium , indicating that CCR 5 usage was not responsible for the decreased sensitivity to neutralization in PBMC . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Recombinant human RANTES , MIP 1alpha and MIP 1beta which bind to simian CCR 5 , suppressed SIV replication in a dose dependent manner , with RANTES being more effective than the other two chemokines . ^^^ The results suggest that immunization with SIV grown in human CD 4 ( + ) T cells induces CD 8 suppressor factor , RANTES , MIP 1alpha and MIP 1beta which may block CCR 5 receptors and prevent the virus from binding and fusion to CD 4 ( + ) cells . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CC chemokines MIP 1alpha , MIP 1beta , and RANTES suppress replication of certain HIV 1 strains in cultured PBMC and T cell lines by blocking interaction of gp 120 with CC chemokine receptor 5 ( CCR 5 ) . ^^^ Here we show that exogenous MIP 1alpha , MIP 1beta , and RANTES markedly suppressed replication of CCR 5 tropic HIV 1 strains in blocks of human lymphoid tissue infected ex vivo . ^^^ Moreover , endogenous MIP 1alpha , MIP 1beta , and RANTES were upregulated in tissues infected ex vivo with CXC chemokine receptor 4 tropic but not CCR 5 tropic HIV 1 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Large Kir 3 . 1 dependent currents generated in response to the corresponding chemokines ( SDF 1alpha for CXCR 4 and MIP 1alpha ; MIP 1beta and RANTES for CCR 5 ) were blocked by pertussis toxin , suggesting involvement of inhibitory guanine nucleotide binding proteins . ^^^ However , adsorption of the gp 120 from a T cell tropic virus resulted in CD 4 dependent antagonism of CXCR 4 response to SDF 1alpha , whereas gp 120 from macrophage tropic viruses caused CD 4 dependent antagonism of CCR 5 response to MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Finally , AMD 3100 had no effect on the Ca2+ flux induced by the CC chemokines MIP 1alpha , regulated on activation normal T cell expressed and secreted ( RANTES ; also a ligand for CCR 5 ) , or monocyte chemoattractant protein 3 ( a ligand for CCR 1 and CCR2b ) , nor was it able to induce Ca2+ fluxes by itself . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
However , when Northern blot analysis was used , mRNA for two different MIP 1alpha receptors CCR 1 and CCR 5 could be detected in bone marrow , but only CCR 1 mRNA was seen in cord blood CD34+ samples . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Forty human immunodeficiency virus type 1 ( HIV 1 ) infected women participated in a cross sectional study of possible correlations between chemokine receptor ( CCR 5 and / or CCR2B ) genotype , HIV 1 RNA and DNA load , and beta chemokine levels ( RANTES , MIP 1alpha , MIP 1beta ) in blood and cervix . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The expression of the MIP 1alpha receptor subtypes on LP CD 34 ( + ) cells was studied by indirect immunofluorescence using specific antibodies for the detection of CCR 1 , CCR 4 , and CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We found that MCP 2 could bind to CCR 5 transfectants with high affinity and cross compete effectively with RANTES , MIP 1alpha , and MIP 1beta . ^^^ More importantly , we found that MCP 2 could bind and elicit chemotaxis in CD 3 activated and IL 2 maintained T cells , and most of these functions could be specifically inhibited by the anti CCR 5 mAb 2D7 , whereas the responses mediated by MIP 1alpha or MCP 4 were only partially inhibited by 2D7 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The enhancing effects of RANTES are not mediated via CCR 5 or other known chemokine receptors and are not mimicked by MIP 1alpha or MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
This protein was also recognized by antibodies to CCR 5 , the RANTES / MIP 1alpha / MIP 1beta receptor . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The natural ligands for the chemokine receptors CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta ) and CXCR 4 ( SDF 1 ) can act as potent inhibitors of infection by the human immunodeficiency virus type 1 ( HIV 1 ) at the level of viral entry . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Immunohistochemistry for MIP 1beta , MIP 1alpha , RANTES , eotaxin , and MCP 3 ( ligands for CCR 5 and / or CCR 3 ) revealed the presence of MIP 1beta predominantly in a subpopulation of reactive astrocytes , which were more widespread in AD than control brains , and MIP 1alpha predominantly in neurons and weakly in some microglia in both AD and controls . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
While both nave and memory CD 4 ( + ) subsets downregulated CCR 5 expression in response to CD 28 costimulation , only the memory cells produced high levels of the beta chemokines RANTES , MIP 1alpha , and MIP 1beta upon stimulation . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Monocytes treated with IFN gamma showed increased chemotaxis to the CCR 5 ligands macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , confirming the functional relevance of IFN gamma induced CCR 5 expression . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Here we report that superantigen stimulation of human peripheral blood monocytes results in a rapid , dose dependent , and specific down regulation of chemokine ( macrophage inflammatory protein 1alpha ( MIP 1alpha ) , monocyte chemotactic protein 1 and MIP 1beta ) binding sites ( e . g . , CCR 1 , CCR 2 , and CCR 5 ) , which correlates with a concomitant hyporesponsiveness of human monocytes to these CC chemokine ligands . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
When preincubated with the CD4+ve MM 6 macrophage cell line , which expresses mRNA for the CCR 3 and CCR 5 chemokine receptors , both 3 . 7 and gp 120 inhibit binding of the chemokine MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Recently , it was shown that the natural CCR 5 ligands RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and amino terminal modifications of RANTES ( Met RANTES , AOP RANTES ) significantly differ in their abilities to induce sequestration of CCR 5 from cellular surfaces . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
C . neoformans infection of MIP 1alpha and CCR 5 knockout mice has highlighted the complex role that some chemokines may play in different organs . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The natural ligands for the CCR 5 chemokine receptor , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES ( regulated on T cell activation , normal T cell expressed and secreted ) , are known to inhibit human immunodeficiency virus ( HIV ) entry , and N terminally modified RANTES analogues are more potent than native RANTES in blocking infection . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Treatment of CD8+ cell culture supernatant with antibodies to RANTES , MIP 1alpha and MIP 1beta neutralized the CD 8 SF activity , indicating that blocking the CCR 5 by these ligands played an important part in the CD 8 SF activity elicited by TILN immunization . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Specific Ab to the MIP 1alpha receptor implicated in HIV infection , CCR 5 , revealed that very few CD34+ cells expressed these receptors and that expression was confined to the CD34+ Thy progenitor population . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 ligands , MIP 1alpha and RANTES , were found in RA SF at high levels . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 ( + ) and CXCR 3 ( + ) T cells are increased in multiple sclerosis and their ligands MIP 1alpha and IP 10 are expressed in demyelinating brain lesions . ^^^ In the brain , the CCR 5 ligand , MIP 1alpha , was strongly associated with microglia / macrophages , and the CXCR 3 ligand , IP 10 , was expressed by astrocytes in MS lesions but not unaffected white matter of control or MS subjects . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Tumor derived lymphocytes showed strong chemotactic responses to both CC and CXC chemokines in vitro and expressed high levels of CXCR 3 ( HuMig and IP 10 receptor ) and CCR 5 ( RANTES , MIP 1alpha , and MIP 1beta receptor ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Moreover , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , one of the ligands for CCR 5 , was selectively expressed on intralobular bile duct epithelial cells , endothelial cells , and infiltrating macrophages and lymphocytes . ^^^ These results suggest that MIP 1alpha induced migration of CCR 5 expressing CD 8 ( + ) T cells into the portal areas of the liver plays a significant role in causing liver injury in GVHD ; thus , CCR 5 and its ligand may be the novel target molecules of therapeutic intervention of hepatic GVHD . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CC chemokines RANTES , MIP 1alpha , MIP 1beta , and Eotaxin can suppress the replication of CCR 5 and CCR 3 dependent viruses , while SDF 1 alpha / beta suppresses that of CXCR 4 dependent strains . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The presence of MIP 1alpha , MCP 1 , and the cognate chemokine receptor for MIP 1alpha , CCR 5 , in the diseased kidneys was evaluated by immunohistochemical and in situ hybridization analyses . ^^^ Urinary MIP 1alpha levels in the patients with crescentic glomerulonephritis were well correlated with the percentage of cellular crescents and the number of CD 68 positive infiltrating cells and CCR 5 positive cells in the glomeruli . ^^^ CONCLUSIONS : These observations suggest that locally produced MIP 1alpha may be involved in the development of cellular crescents in the acute phase via CCR 5 and that MCP 1 may be involved mainly in the development of interstitial lesions in the chronic phase when fibrocellular / fibrous crescents are present , possibly through Mphi recruitment and activation . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The importance of chemokine expression on HIV infection has been emphasized by the discovery that infection of CD 4 ( + ) T cells by M tropic strains of HIV 1 is antagonized by the chemokines RANTES , MIP 1alpha , and MIP 1beta , which are natural ligands of CCR 5 , a major coreceptor for macrophagetropic ( M tropic ) isolates of HIV 1 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
RESULTS : The percentage of lymphocytes and monocytes expressing CCR 5 was 1 . 6 and 3 . 0 times higher in ETH ( n = 83 ) than in IS ( n = 45 ) , respectively ( P < . 001 ) , whereas RANTES and MIP 1alpha secretion was 0 . 5 and 0 . 7 times lower ( P < . 01 and P < . 05 ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In a parallel manner , binding of labeled MIP 1alpha was first shown to be attenuated by unlabeled RANTES , both of which recognize CCR 1 and CCR 5 , and then separately antagonized by MCP 3 and MIP 1beta , which bind to CCR 1 and CCR 5 , respectively . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a functional receptor for MIP 1alpha , MIP 1beta , RANTES ( regulated on activation normal T cell expressed ) , MCP 2 , and MCP 4 and constitutes the main coreceptor for macrophage tropic human and simian immunodeficiency viruses . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
During the development of nephrotoxic nephritis ( NTN ) in the mouse , we find that a variety of chemokines and chemokine receptors are induced : CCR 1 ( RANTES , MIP 1alpha ) , CCR 2 ( MCP 1 ) , CCR 5 ( RANTES , MIP 1alpha , MIP 1beta ) , CXCR 2 ( MIP 2 ) , and CXCR 3 ( IP 10 ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
BACKGROUND : This study was designed to evaluate the role of the novel chemokine receptor antagonist amino oxypentane RANTES ( AOP RANTES ) , which blocks the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES to the chemokine receptor 5 ( CCR 5 ) on the infiltration of monocytes in experimental glomerulonephritis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Based on the observation of CC chemokine induction in monocytes by Tat , we also examined the cellular localization of the CC chemokine Macrophage Inflammatory Protein 1alpha ( MIP 1alpha ) and its cognate receptor CCR 5 in these samples . ^^^ In both HIVE and PML , prominent expression of MIP 1alpha and CCR 5 was found within areas containing histopathological lesions . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Flow cytometric analysis of the MIP 1alpha receptor subtype CCR 5 revealed comparable CCR 5 expression levels on normal and CML CD34+ cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We found that human CD 34 ( + ) cells and CD 34 ( + ) KIT ( + ) cells , which are enriched in myeloid progenitor cells , expressed and secreted the CCR 5 ligands RANTES , MIP 1alpha , and MIP 1beta and that IFN gamma stimulated expression of these chemokines . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Recently , several unique HIV 1 entry coreceptors ( e . g . , CCR 5 and CCR 3 ) and a trio of HIV 1 specific suppressor chemokines , namely , RANTES ( regulated upon activation T expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta , were identified . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The selected variants displayed reduced sensitivities to MIP 1alpha ( fourfold ) through CCR 5 expressing CD 4 HeLa / long terminal repeat beta galactosidase ( MAGI / CCR5 ) cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Limited expression of R 5 tropic HIV 1 in CCR 5 positive type 1 polarized T cells explained by their ability to produce RANTES , MIP 1alpha , and MIP 1beta . ^^^ In fact , an inverse correlation was observed between Th 1 polarized naive T cells and Th 1 like memory activated T cells in regards to p 24 Ag production and the release of the following CCR 5 binding chemokines : regulated on activation normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In particular , immature DC express CC chemokine receptor 5 ( CCR 5 ) and migrate in response to macrophage inflammatory protein 1alpha ( MIP 1alpha ) , whereas mature DC switch expression to CCR 7 and respond exclusively to MIP 3beta and 6Ckine . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We show here that ( 1 ) M 23 g3p was specifically recognized with anti CCR 5 mAb ; ( 2 ) M 23 g3p showed inhibitory activity on the infectivity of M tropic but not T tropic HIV 1 strains ; ( 3 ) M 23 g3p bound to MIP 1alpha , MIP 1beta , and RANTES but not MCP 1 . ^^^ These results suggested that the M 23 g3p might mimic the CCR 5 binding domain shared by beta chemokines , MIP 1alpha , MIP 1beta , and RANTES as well as the HIV 1 infection . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In contrast , the CCR 5 ligands ( macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta , and RANTES ) did not activate calcium flux , MAPK and AKT phosphorylation or chemotaxis of CD 34 ( + ) KIT ( + ) cells or cells isolated from the BFU E colonies . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CCR 5 ligands RANTES , MIP 1alpha and MIP 1beta suppress infection by R 5 HIV 1 particles via induction of CCR 5 internalization , and individuals whose peripheral blood lymphocytes produce high levels of these chemokines are relatively resistant to infection [ 7 ] [ 8 ] [ 9 ] . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In this study , Chinese hamster ovary cells were transfected separately with the human chemokine receptors CCR 1 and CCR 5 , and these receptors were shown to induce an intracytoplasmic Ca ( 2+ ) flux and cellular chemotaxis following stimulation with the natural CC chemokine ligands ( MIP 1alpha , RANTES ( regulated on activation normal T cell expressed ) , and MIP 1beta ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Multicolor flow cytometric analysis of whole peripheral blood revealed that , as opposed to CD14++ monocytes , the CD14+CD16+ subset lacked surface expression of monocyte chemotactic protein 1 ( MCP 1 ) receptor CCR 2 , however , it showed significantly higher surface expression of the macrophage inflammatory protein 1alpha ( MIP 1alpha ) / RANTES receptor CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The CTL clones expressed the CCR 5 receptor and localized among HIV infected cells expressing the ligands MIP 1alpha and MIP 1beta , CC chemokines produced at sites of virus replication . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We examined the role of MIP 1alpha and its CCR 5 receptor in the induction of EAE by immunizing C57BL / 6 mice deficient in either MIP 1alpha or CCR 5 with myelin oligodendrocyte glycoprotein ( MOG ) . ^^^ The dispensability of MIP 1alpha and CCR 5 for MOG induced EAE in C57BL / 6 mice supports the idea that differential chemokine expression patterns represent differences in disease mechanism that underlie various models of EAE , and possibly distinct patterns of pathology seen in MS . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
IL 4 treatment , which prevents diabetes in NOD mice by polarizing intraislet Th 2 responses , decreased CCR 5 expression in islets and potentiated a high ratio of MIP 1beta and monocyte chemotactic protein 1 ( MCP 1 ) : MIP 1alpha in the pancreas . ^^^ These studies illustrate that the temporal expression of certain CC chemokines , particularly MIP 1alpha , and the CCR 5 chemokine receptor in the pancreas is associated with the development of insulitis and spontaneous type 1 diabetes . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Two of seven elevated genes were identical to HIV 1 sequences and the other five were MIP 1alpha , ACTE 3 , CD11c , arginase 1 , and CCR 5 . ^^^ We also revealed that the amount of MIP 1alpha in culture supernatant of HIV 1 infected cells was increased by more than 15 fold relative to control cells , and the expression of its receptor CCR 5 was cooperatively upregulated on the surface of these cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We found that deficiency of CCR 2 but not CCR 5 or MIP 1alpha led to distinct defects in DC biology . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
No difference was observed in TNF alpha , IL 1beta , IL 10 , IL 4 , MIP 1alpha , MIP 1beta , RANTES , CXCR 4 , and CCR 5 mRNA levels in PBMC , but IL 6 levels were higher in the HPS patient . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The sulfated peptide also inhibited the association of CCR 5 expressing cells with gp 120 soluble CD 4 complexes and , less efficiently , with MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Furthermore , we showed that the CXCR 4 and CCR 5 ligands ( stromal derived factor 1 and macrophage inflammatory protein 1alpha [ MIP 1alpha ] , MIP 1beta and RANTES , respectively ) inhibit HIV replication in both maturing Mo and Mk cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
RANTES , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta inhibited infection of intestinal lymphocytes by BaL , indicating that R 5 infection of the intestinal lymphocytes was mediated by CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We next evaluated the functionality of these chemokine receptors by calcium flux and chemotaxis assays , and by the ability of SDF 1 , MIP 1alpha , MIP 1beta and RANTES to influence the growth of the cells expressing CXCR 4 and / or CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We report here that treating monocyte derived macrophages ( MDM ) with a trimeric soluble form of CD40L ( CD40LT ) induced them to secrete high levels of the beta chemokines RANTES , MIP 1alpha and MIP 1beta that are ligands for CCR 5 and able to inhibit HIV 1 entry . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The chemokine ligands for CCR 5 , RANTES and MIP 1beta , also potently inhibited HIV 1 infection in microglia , but the third ligand MIP 1alpha failed to show inhibition . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 , RANTES , and MIP 1alpha were analyzed by Northern blot analysis . ^^^ RESULTS : By Northern blot analysis , CCR 5 , RANTES , and MIP 1alpha messenger RNA ( mRNA ) levels were 12 . 9 fold , 13 . 3 fold and 9 . 2 fold higher in CP specimens compared with healthy controls , respectively ( P < . 01 ) . ^^^ CCR 5 is most likely involved in the attraction and activation of these macrophages , since the CCR 5 ligands RANTES and MIP 1alpha are concomitantly upregulated . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We have therefore utilized H 9 cells to test the effects of Product R on expression of mRNAs encoding the chemokine receptors , CD 4 , CXCR 4 and CCR 5 , as well as their ligands , IL 16 , SDF 1 , MIP 1alpha , MIP 1beta , and RANTES , by RT PCR . ^^^ We also assayed the effect of Product R on surface receptor expression by flow cytometry , and on the chemotactic activity of these cells towards the CXCR 4 ligand , SDF 1 , and the CCR 5 ligands , MIP 1alpha and RANTES . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Regulation of chemokine receptor CCR 5 and production of RANTES and MIP 1alpha by interferon beta . ^^^ It was demonstrated for the first time that in vitro exposure of T cells to IFN beta 1a selectively inhibited mRNA expression for RANTES and MIP 1alpha and their receptor CCR 5 . ^^^ T cell surface expression of CCR 5 was significantly reduced in MS patients treated with IFN beta , correlating with decreased T cell transmigration toward RANTES and MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Glomerular CCR 5 positive cells were well correlated with extracapillary lesions and urinary MIP 1alpha levels , while interstitial CCR 5 positive cells , mainly CD 3 positive T cells , were correlated with interstitial lesions and urinary RANTES levels . ^^^ These results suggest that chemokine receptor signaling may be pivotal for human renal diseases through the recruitment and activation of MPhi and T cells ; CCR 5 positive cells may participate in glomerular lesions including extracapillary lesions via MIP 1alpha and in interstitial lesions via RANTES . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
One such compound E 913 ( M ( r ) 484 ) specifically blocked the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) to CCR 5 ( IC ( 50 ) 0 . 002 microm ) and MIP 1alpha elicited cellular Ca ( 2+ ) mobilization ( IC ( 50 ) approximately 0 . 02 microm ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Our data showed that phagocytosis of apoptotic / necrotic tumor cells resulted in maturation of DCs with up regulated expression of proinflammatory cytokines [ interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha , interferon gamma and granulocyte macrophage colony stimulating factor ] , chemokines ( MIP 1alpha , MIP 1beta and MIP 2 ) , the CC chemokine receptor CCR 7 and the cell surface molecules ( MHC class 2 , CD11b , CD 40 and CD 86 ) , and down regulated expression of the CC chemokine receptors CCR 2 and CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Expression of macrophage inflammatory protein ( MIP ) 1alpha , another CC chemokine expressed in atherosclerotic lesions , was also reduced after irbesartan treatment , without effect on CCR 3 and CCR 5 , the receptors of MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In a prospective study using flow cytometry , we examined percentages of blood mononuclear cells ( MNC ) expressing the chemokines RANTES , MCP 1 , MIP 1alpha , MIP 1beta , and IL 8 , the chemokine receptor CCR 5 , the T cell activation marker CD 25 , and the T cell chemoattractant IL 16 in patients with WAD and , for reference , in healthy controls . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Our results suggest that the migratory response to CCR 5 stimulation may vary quantitatively with both the CCR 5 ligand ( MIP 1alpha , MIP 1beta , and RANTES ) , as well as the nature and concentration of the ECM substrate involved . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
DESIGN : The CC chemokines RANTES , MIP 1alpha and MIP 1beta are ligands for CCR 5 , which has been identified as the principal co receptor for macrophage tropic strains of HIV 1 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Cells susceptible to infection by these viruses can be protected by treatment with the CCR 5 ligands regulated on activation , normal T cell expressed and secreted ( RANTES ) , MIP 1alpha , and MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Recently we reported that the chemokines MIP 1alpha , MIP 1beta , and RANTES secreted by BM derived CD 34 ( + ) cells may compete with the macrophagotropic HIV ( R 5 HIV ) strain for the CCR 5 coreceptor . ^^^ In this study we extended our previous observations and examined various lympho hematopoietic CD 34 ( + ) cells isolated from thymus ( Th ) , cord blood ( CB ) , mobilized peripheral blood ( mPB ) , and BM for the expression of beta chemokines binding to CCR 5 , i . e . , MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , and MCP 4 , and the alpha chemokine SDF 1 ( binding to CXCR 4 ) as these chemokines may compete with the R 5 and X 4 HIV strains , respectively , for entry into cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The SPC 3 induced chloride conductance in oocytes is alpha / beta chemokine receptor dependent because : ( 1 ) SPC 3 alters the sensitivity of this channel to external applications of human recombinant MIP 1alpha , a natural ligand of human CCR 5 receptor , and ( 2 ) the amplitude of the inward current could be increased by the expression of exogenous human CXCR 4 chemokine receptor . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We then examined HIV infection , HIV receptor ( CD 4 , CCR 5 ) expression , and beta chemokine [ macrophage inflammatory protein 1alpha and 1beta ( MIP 1alpha , MIP 1beta ) ] production by placental cord monocyte derived dendritic cells ( MDDC ) as compared to that of autologous cord monocyte derived macrophages ( MDM ) . ^^^ This limited susceptibility of cord MDDC to M tropic HIV infection may be due to lower expression of CD 4 and CCR 5 on the cell membrane and higher production of MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The presence of chemokine receptor ( CCR 5 , CXCR 3 , CCR 3 ) positive cells and chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 ) positive cells in human periapical granulomas . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In this study , a group of healthy subjects over 90 years old is compared to a group of young subjects , we evaluated the ability of monocytes , T lymphocytes and NK cells : ( 1 ) to produce RANTES and MIP 1alpha , either in basal conditions or after stimulation with , respectively , LPS , anti CD 3 MoAb and IL 2 ; ( 2 ) to express the corresponding chemokine receptors ( CCR 1 , CCR 3 , CCR 5 ) . ^^^ We demonstrate that : ( a ) monocytes , T lymphocytes and NK cells spontaneously produced detectable amounts of chemokines , both in young and old subjects ; ( b ) monocyte dependent RANTES and MIP 1alpha production induced by LPS was up regulated in nonagenarian subjects as anti CD 3 induced secretion from T cells ; ( c ) RANTES and MIP 1alpha production by IL 2 stimulated NK cells was reduced in elderly subjects ; ( d ) CCR 1 , CCR 3 and CCR 5 were widely expressed on monocytes , but less expressed on T lymphocytes and NK cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We investigated the effects of a number of naturally occurring chemokines ( MIP 1alpha , MIP 1beta , RANTES , MCP 2 , MCP 3 , MCP 4 ) on different processes linked to the chemokine receptor CCR 5 in recombinant CHO cells expressing the receptor at different levels . 2 . ^^^ Internalization of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce internalization ( similar 50 % ) of the receptor . ^^^ Phosphorylation of CCR 5 following chemokine treatment was studied and MIP 1alpha , MIP 1beta and RANTES ( 50 nM ) were able to induce phosphorylation of CCR 5 whereas the other chemokines did not induce CCR 5 phosphorylation . 4 . ^^^ MIP 1alpha , MIP 1beta , RANTES , MCP 2 and MCP 4 were able to stimulate increases in intracellular calcium ions via activation of CCR 5 whereas MCP 3 was without effect . 6 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
First , we studied cardiac transplants in fully MHC mismatched mice that were deficient in CCR 5 or two of its ligands , MIP 1alpha or RANTES . ^^^ RESULTS : Whereas mice deficient in expression of MIP 1alpha or RANTES reject fully MHC mismatched cardiac allografts normally , CCR 5 / mice , or CCR5+ / + mice treated with a neutralizing mAb to mCCR 5 , show enhanced allograft survival . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Viral entry can be inhibited by the natural ligands for CXCR 4 , the CXC chemokine SDF 1 and CCR 5 , the CC chemokines RANTES , MIP 1alpha and MIP 1beta , respectively . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Natural ligands for CCR 5 , MIP 1alpha , MIP 1beta and RANTES , have been shown to inhibit HIV replication in CD4+ T cells . ^^^ In the present study , we examined the CCR 5 genotype by PCR and the plasma levels of RANTES and MIP 1alpha by ELISA among blood donors ( N = 26 ) and among HIV 1 infected individuals ( N = 129 ) . ^^^ RANTES concentrations in plasma samples from HIV+ patients carrying the homozygous CCR 5 allele ( CCR5 / CCR5 ) ( 28 . 23 ng / ml ) were higher than in the control samples ( 16 . 07 ng / ml ; P < 0 . 05 ) ; however , this HIV+ patient group ( mean 26 . 23 pg / ml ) had significantly lower concentrations of MIP 1alpha than those observed in control samples ( mean 31 . 20 pg / ml ; P < 0 . 05 ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The presence of chemokine ( MCP 1 , MIP 1alpha , MIP 1beta , IP 10 , RANTES ) positive cells and chemokine receptor ( CCR 5 , CXCR 3 ) positive cells in inflamed human gingival tissues . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Immunocytochemistry assays were also used to detect 2 MIP 1alpha receptors , CCR 1 and CCR 5 . ^^^ In P 7 to P 12 brain , many cells expressed MIP 1alpha receptors ; both CCR 1 and CCR 5 immunoreactivity were localized to endothelium and ependyma ; CCR 1 immunoreactive astrocytes and neurons and CCR 5 immunoreactive microglia were also identified . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In contrast , the expression of CCR 5 in spleens and MIP 1alpha / MIP 1beta in tumor masses was marginally induced before and even after IL 12 treatment in the Meth A model in which T cell migration is not observed . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Morphine sulfate induces the formation and expression of both forms of CCR 5 whereas RANTES , MIP 1alpha or MIP 1beta inhibits them . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory peptide 1alpha ( MIP 1alpha ) / CC chemokine receptor ligand 3 is an 8 kDa peptide that induces chemotaxis of various lymphocytes to sites of inflammation through interaction with the G protein coupled chemokine receptors CCR 1 and CCR 5 . ^^^ Benzophenone MIP 1alpha is a full agonist that specifically and covalently labels CCR 1 and CCR 5 receptors upon irradiation . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Importantly , these effects were mostly reversed by neutralizing antibodies against MIP 1alpha and MIP 1beta , or their cognate receptor , CCR 5 , suggesting critical roles of these chemokines . ^^^ We also demonstrated that stromal cells express CCR 5 and that recombinant MIP 1alpha and MIP 1beta induce expression of receptor activator of nuclear factor kappaB ( RANK ) ligand by stromal cells , thereby stimulating osteoclast differentiation of preosteoclastic cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Macrophage inflammatory protein 1alpha ( MIP 1alpha ) and MIP 1beta are distinct but highly homologous CC chemokines produced by a variety of host cells in response to various external stimuli and share affinity for CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
KA treatment did not affect mRNA levels for the macrophage inflammatory protein 1alpha ( MIP 1alpha ) or the regulated upon activation normal T cells expressed and secreted protein ( RANTES ) in either wild type or CCR 5 KO mice . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a G protein coupled receptor for RANTES , MIP 1alpha , MIP 1beta , and MCP 2 that functions as the front line coreceptor for human immunodeficiency virus type 1 infection . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
METHODS : Lung biopsies from 4 patients that had classical features of WG were examined for protein expression of CCR 5 , RANTES , MIP 1alpha and MIP 1beta using immunohistochemistry . ^^^ Enhanced protein concentrations of RANTES , MIP 1alpha , and MIP 1beta were present in WG lung lesions , indicating redundancy of ligands for CCR 5 in affected tissue . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Most primary HIV strains use CCR 5 as a coreceptor and thereby are sensitive to inhibition by the CCR 5 ligand chemokines , RANTES , MIP 1alpha and MIP 1beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Several mutations in CCR 5 extracellular domains ( E172A , R168A , K191A , and D276A ) strongly affected MIP 1alpha binding but had little effect on RANTES binding . ^^^ Several CCR 5 mutants affecting transmembrane helices 2 and 3 ( L104F , L104F / F109H / F112Y , F85L / L104F ) reduced the potency of MIP 1alpha by 10 100 fold with little effect on activation by RANTES . ^^^ Altogether , these results suggest that the core domains of MIP 1alpha and RANTES bind distinct residues in CCR 5 extracellular domains , whereas the N terminus of chemokines mediates receptor activation by interacting with the transmembrane helix bundle . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The antiviral activity of their natural ligands ( stromal cell derived factor 1 [ SDF 1 ] , regulated on activation normal T cell expressed and secreted , ( RANTES ) and macrophage inflammatory proteins 1alpha and 1beta , MIP 1alpha and MIP 1beta ) and the finding that individuals deficient in CCR 5 are relatively resistant to HIV infection led to the concept that chemokine receptor antagonists can play an important role in anti HIV therapy . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In LAG 3 matured DC , surface expression of CCR 5 ( a receptor for MIP 1alpha / CCL3 ) was down regulated and CCR 7 ( a receptor for MIP 3beta and SLC ) was up regulated . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The beta chemokines RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta are the natural ligands of the HIV 1 coreceptor CCR 5 and compete with the virus for receptor binding . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Regulation of CCR 5 expression and MIP 1alpha production in CD4+ T cells from patients with rheumatoid arthritis . ^^^ Production of CCR 5 expression and MIP 1alpha , a ligand of CCR 5 , by CD4+ T cells from patients with rheumatoid arthritis ( RA ) were studied . ^^^ Taken together , these data suggest CCR5+CD4+ T cells infiltrate the inflamed synovium and IL 15 up regulates CCR 5 and CD40L expression further and enhance MIP 1alpha production in synovial CD4+ T cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The chemokine receptors CCR 5 , CCR 2 , and CCR 3 and their ligands , RANTES , MCP 1 , MCP 2 , and MIP 1alpha , are involved in the immune responses and the selective recruitment of lymphocytes to the liver in HCV infection . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Chemokine receptor 5 ( CCR 5 ) binds macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , RANTES , and members of the monocyte chemotactic protein family and is also a receptor for human immunodeficiency virus ( HIV ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We previously reported that F4 / 80 ( ) B 220 ( ) CD11c ( + ) DC precursors expressing the CC chemokine receptors CCR 1 and CCR 5 are mobilized rapidly into the circulation in mice injected with Propionibacterium acnes and are recruited into inflammatory tissue by macrophage inflammatory protein 1alpha ( MIP 1alpha ) , which binds to CCR 1 and CCR 5 . ^^^ METHODS : Numbers of DC precursors in peripheral blood were determined in P . acnes treated mice ( groups of 10 C57BL / B6 [ B 6 ] wild type mice , CCR 1 ( / ) mice , CCR 5 ( / ) mice , and B 6 mice treated with antibody to MIP 1alpha or control antibody ) and in B 6 mice injected with recombinant MIP 1alpha . ^^^ RESULTS : The recruitment of DC precursors into the circulation by P . acnes administration was higher in B 6 mice ( 12 . 6 % , 95 % confidence interval [ CI ] = 9 . 1 % to 16 . 1 % ) than in CCR 1 ( / ) ( 9 . 0 % , 95 % CI = 7 . 5 % to 10 . 5 % ) , CCR 5 ( / ) ( 6 . 3 % , 95 % CI = 5 . 2 % to 7 . 3 % ) , or anti MIP 1alpha antibody treated ( 6 . 6 % , 95 % CI = 5 . 7 % to 7 . 5 % ) mice . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
However , the remaining expression of CCR 1 and CCR 5 correlated reciprocally with an ongoing unresponsiveness to the CCR 1 and CCR 5 agonists CCL3 / macrophage inflammatory protein 1alpha ( MIP 1alpha ) , CCL4 / MIP 1beta , and CCL5 / regulated on activation , normal T expressed and secreted ( RANTES ) , all chemokines binding to these two receptors . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The beta chemokines MIP 1alpha , MIP 1beta , and RANTES inhibit HIV 1 infection of CD4+ T cells by inhibiting interactions between the virus and CCR 5 receptors . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In both strains , we detected similarly increased expression of chemokines RANTES / CCL5 , macrophage inflammatory protein 1alpha ( MIP 1alpha ) / CCL3 , MIP 1beta / CCL4 , and MIP 2 , as well as chemokine receptors CCR 1 , CCR 2 , and CCR 5 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Using reverse transcriptase analysis of stomachs from normal and gastritic mice we found no difference in expression of CCR 5 and its chemokine ligands MIP 1alpha , MIP 1beta , and RANTES . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Two mechanisms induced by IFN tau treatment in macrophages may account for this inhibition : ( 1 ) the synthesis of the cellular antiviral factors such as 2 ' , 5 ' oligoadenylate synthetase / RNase L and MxA protein and ( 2 ) an increased production of MIP 1alpha , MIP 1beta , and RANTES , which are natural ligands of CCR 5 , the principal coreceptor of HIV on macrophages . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In this study , we have investigated the effects of IFNgamma on PA induced MIPs expression and secretion by mouse Mphi as well as the regulation of MIP 1alpha / beta receptor , CCR 5 , by both stimuli alone or in combination . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
We identified a novel spirodiketopiperazine ( SDP ) derivative , AK602 / ONO4128 / GW873140 , which specifically blocked the binding of macrophage inflammatory protein 1alpha ( MIP 1alpha ) to CCR 5 with a high affinity ( K ( d ) of approximately 3 nM ) , potently blocked human immunodeficiency virus type 1 ( HIV 1 ) gp120 / CCR5 binding and exerted potent activity against a wide spectrum of laboratory and primary R 5 HIV 1 isolates , including multidrug resistant HIV 1 ( HIV 1 ( MDR ) ) ( 50 % inhibitory concentration values of 0 . 1 to 0 . 6 nM ) in vitro . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
With the goal of reducing CCR 5 and protecting CCR5+ cells from R 5 tropic HIV , we used Tag deleted SV 40 derived vectors to deliver several anti CCR 5 transgenes : 2C7 , a single chain Fv ( SFv ) antibody ; VCKA 1 , a hammerhead ribozyme ; and two natural CCR 5 ligands , MIP 1alpha and MIP 1beta , modified to direct these chemokines , and hence their receptor to the endoplasmic reticulum . ^^^ All transgenes except MIP 1alpha decreased CCR 5 , as assayed by immunostaining , Northern blotting , and cytofluorimetry ( FACS ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Our main findings were , with similar qualitative patterns in both healthy controls and HIV infected patients : ( 1 ) TLR 2 stimulation induced up regulation of several chemokines at the mRNA level as well as increased protein levels of macrophage inflammatory protein ( MIP ) 1alpha , interleukin ( IL ) 8 and regulated on activation , normal T cell expressed and secreted ( RANTES ) ; ( 2 ) TLR 2 stimulation induced enhanced protein expression of CCR 5 ( a receptor for MIP 1alpha and RANTES ) on monocytes ; ( 3 ) In vitro stimulation with RANTES induced release of MIP 1alpha , MCP 1 , IL 8 and interferon gamma from PBMC . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Both WT B 6 and IRF 1 / profiles showed 13 genes upregulated ( IFN gamma , MCP 2 , MIP 1alpha , MIP 1beta , CCR 5 , MIG , IP 10 and others ) and one gene downregulated ( SDF 2 ) among the 76 genes detectable on the array . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Taken together , these observations suggest that CCR 5 ligands , and in particular MIP 1alpha and MIP 1beta , released in the course of memory responses may play a role in protecting CD 4 ( + ) memory T cells from infection . . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Substantial levels of CCR 5 ligands , MIP 1alpha and RANTES mRNA were found in the inflamed intestinal mucosa in CD . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Increased expression of mRNA specific for various chemokines ( eotaxin , MIP 1alpha , MIP 2 ) and chemokine receptors ( CCR 1 , CCR 2 and CCR 5 ) was observed in the lungs of nonsensitized mice challenged with the spores . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
MIP 1alpha utilizes both CCR 1 and CCR 5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells . ^^^ Several chemokine receptors ( CCR 1 , CCR 5 , and CCR 9 ) mediate the effects of MIP 1alpha . ^^^ METHODS : We employed RT PCR analysis , neutralizing antibodies to CCR 1 and CCR 5 as well as a CCR 1 specific antagonist and OCL formation assays to identify the MIP 1alpha receptors involved in MIP 1alpha ' s effects on myeloma cells and OCL formation . ^^^ Neutralizing antibodies to CCR 1 or CCR 5 inhibited MIP 1alpha induced OCL formation . ^^^ Furthermore , monocyte chemotactic protein 3 ( MCP 3 ) , which binds CCR 1 but not CCR 5 and the CCR 1 specific antagonist , BX 471 , markedly inhibited OCL formation stimulated with MIP 1alpha . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The recruitment of major histocompatibility complex ( MHC ) class 2 ( + ) LC was significantly suppressed in CCR 5 ( / ) mice and blockade of RANTES and MIP 1beta , but not in CCR 1 ( / ) , CCR 2 ( / ) / MIP 1alpha ( / ) , or MIP 1alpha ( / ) mice . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The natural ligands of CCR 5 , the beta chemokines macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and RANTES , interfere with HIV 1 binding to CCR 5 receptors and decrease the amount of virions entering cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
OBJECTIVE : We hypothesized that the chemokine receptor 5 ( CCR 5 ) ligands , MIP 1alpha , MIP 1beta and RANTES , are virulence correlates in M . tuberculosis infection and are indispensable to granuloma formation . ^^^ CONCLUSIONS : The production of the CCR 5 ligands , MIP 1alpha , MIP 1beta , and RANTES , does not clearly correlate with virulence of M . tuberculosis . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Upregulation of RANTES and MIP 1alpha transcripts in the absence of a significant CCR 5 increase suggests a possible involvement of other chemokine receptors . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 is a seven transmembrane G protein coupled receptor that binds the CC chemokines including RANTES , eotaxin , MIP 1alpha and beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CXCR3+ and CCR5+ expressing Th 1 cells were decreased ( CXCR 3 44 . 6 + / 3 . 2 to 33 . 3 + / 4 . 6 and CCR 5 24 . 8 + / 2 . 3 to 12 + / 1 . 4 ) , whereas plasma levels of their chemokine ligands IFN gamma inducible protein 10 and MIP 1alpha were increased ( 61 . 4 + / 13 . 9 to 1103 . 7 + / 274 . 5 and 22 . 8 + / 6 . 2 to 55 . 7 + / 9 . 5 , respectively ) . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
TAK 652 inhibited the binding of RANTES ( regulated on activation , normal T cell expressed and secreted ) , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and MIP 1beta to CCR 5 expressing cells at nanomolar concentrations . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CONCLUSIONS : Overall , these findings suggest that the chemokines MCP 1 and MIP 1alpha , acting through their receptors CCR 2 and CCR 5 , are important in the induction of EAM and that inhibition of MCP 1 with 7ND gene transfection significantly reduced disease severity . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CCR 5 , binding MIP 1alpha / CCL3 and RANTES / CCL5 , was up regulated on ST macrophages during the course of AIA , correlating with macrophage expression of CCR 2 , a receptor for monocyte chemoattractant protein 1 / CCL2 . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
METHODS : We conducted a nested case control study of African Americans ( 266 HIV 1 seroconverter cases and 532 seronegative controls from the AIDS Link to Intravenous Experience cohort ) , to examine the association between 50 single nucleotide polymorphisms ( SNPs ) in 9 candidate genes ( CCR 5 , CCR 2 , RANTES , MIP1A , MCP 2 , IL 10 , IFNG , MCSF , and IL 2 ) and susceptibility to HIV 1 infection . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
The aim of the study was to compare the immunoexpression of monocyte chemoattractant protein 1 ( MCP 1 ) , monocyte inflammatory protein 1alpha ( MIP 1alpha ) , Regulated upon Activation Normal T cell Expressed and Secreted ( RANTES ) and CC chemokine receptors : CCR 1 and CCR 5 in renal biopsy specimens in IgA nephropathy ( IgAN ) and in non IgA mesangial proliferative glomerulonephritis ( MesProGN ) , and to find any relationships between the immunoexpression of chemokines and chemokine receptors and renal interstitial lesions . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
CD3+ T cells , infiltrating the retina , also expressed the chemokine receptor CCR 5 , and CCR 5 ligands , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , MIP 1beta , and regulated on activation , normal T expressed and secreted ( RANTES ) , were strongly expressed in the retina at peak EAU . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
Certain CC chemokines , including RANTES , MIP 1alpha , and MIP 1beta , might facilitate the development of such microbicides since they potently suppress HIV 1 infection by binding to CCR 5 , the viral coreceptor used by most sexually transmitted strains of HIV 1 to enter host cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
This structure of V 3 ( MN ) was found to have conformation and sequence similarities to beta hairpins in CD 8 and CCR 5 ligands MIP 1alpha , MIP 1beta , and RANTES and differed from the beta hairpin of a V 3 ( IIIB ) peptide bound to the strain specific murine anti gp 120 ( IIIB ) antibody 0 . 5beta . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
In functional calcium signalling assays , the CCR 5 endogenous ligands MIP 1alpha , MIP 1beta and RANTES evoked a robust response in the dog recombinant CCR 5 cells . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
By measuring the inhibitory activity of each compound in the initial library against the intracellular calcium mobilization stimulated by MIP 1alpha , several compounds were found to show modest but selective CCR 5 antagonistic activity . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
RESULTS : Expression of Sstr 2 and CCR 5 in gustatory neurons allow C . elegans to specifically detect and respond to somatostatin and MIP 1alpha respectively in a robust avoidance assay . ^^^
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
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Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA
Interacting proteins: P10147 and P51681	Pubmed	SVM Score :0.0
NA