| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| To ascertain whether expression of human CD 4 and CCR 5 is sufficient to make murine T lymphocytes susceptible to HIV infection , the lck promoter was used to direct the T cell specific expression of human CD 4 and CCR 5 in transgenic mice . ^^^ |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| Using murine T cell hybridomas transfected to express native or mutated forms of CD 4 , it was determined that IL 16 / CD4 induces a p56lck dependent signal that results in desensitization of CCR 5 . ^^^ Of interest , while p56lck enzymatic activity is not required for IL 16 induced migration , it was required for desensitization of CCR 5 . ^^^ |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of T cells with gp 120 results in modulation of both CCR 5 and CXCR 4 responsiveness , which is dependent upon p 56 ( lck ) enzymatic activity . ^^^ |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| UV inactivated myxoma virus induces the rapid phosphorylation of CCR 5 on tyrosine residues , the association of CCR 5 with Jaks and p 56 ( lck ) , and their phosphorylation activation within minutes of virus adsorption . ^^^ |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| The results showed that in four patient / donor pairs with B ALL , 5 up regulated ( RIZ , STK 1 , T cell leukemia / lymphoma 1A , Cbp / p300 , Op 18 ) and 1 down regulated genes ( hematopoietic proteoglycan core protein ) were identified ; In five patient / donor pairs with AML M ( 4 ) and AML M ( 5 ) , 6 up regulated ( STAT5B , ligand p 62 for the Lck SH 2 , CST 3 , LTC4S , myeloid leukemia factor 2 and epb 72 ) and 1 down regulated genes ( CCR 5 ) were identified . ^^^ |
|
| Interacting proteins: P51681 and P06239 |
Pubmed |
SVM Score :0.0 |
| This effect does require p 56 ( lck ) enzymatic activity and the presence of CCR 5 , because desensitization is not transmitted in the absence of CCR 5 . ^^^ |
|