| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.76092187 |
| RANTES is a high affinity ligand for CCR 1 and CCR 5 , and it binds CCR 3 with moderate affinity and CCR 4 with low affinity . 0.76092187^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| CD 40 ligation and poly 1 : C elicited increased production of inflammatory cytokines interleukin ( IL ) 6 and tumor necrosis factor alpha , of IL 10 and the CCL 5 chemokine , but profiles differed as to higher IL 10 , IL 12 and CCL 22 ( a CCR 4 ligand important for T cell recruitment ) levels for the former , and of CCL 4 and CCL 5 for the latter . ^^^ |
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| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| RESULT : The chemokines of CCL 11 ( eotaxin 1 ) , CCL 24 ( eotaxin 2 ) , CCL 7 ( MCP 3 ) , CCL 13 ( MCP 4 ) , RANTES ( CCL 5 ) and receptors of CCR 2 , CCR 3 , CCR 4 , CCR 5 were differential expressed on four samples , and most of the chemokines and their receptors has tendency regulation on T help 2 ( Th 2 ) lymphocytes and involved in the prodeeds such as inducement of allergic reaction , accumulation of inflammacytes and degranulation of sensitized cells . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The natural ligands for CCR 4 , CCL17 / TARC and CCL22 / MDC could both compete for binding with radiolabelled CCL 5 . ^^^ Further , both CCL 17 and CCL 22 act as CCR 4 antagonists by inhibiting CCL 5 induced migration . ^^^ CONCLUSIONS : These results suggest that CCL 5 induced migration of MCs via CCR 4 can be regulated by the natural agonists CCL 17 and CCL 22 , which are up regulated at sites of allergic inflammation . . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| Through analysis of mononuclear cell infiltration in WT and IL 6 deficient mice during peritoneal inflammation , we now report that IL 6 selectively governs T cell infiltration by regulating chemokine secretion ( CXCL 10 , CCL 4 , CCL 5 , CCL 11 , and CCL 17 ) and chemokine receptor ( CCR 3 , CCR 4 , CCR 5 , and CXCR 3 ) expression on the CD3+ infiltrate . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| Serum ELISAs were performed to detect the CCR 5 ligands CCL 5 , CCL 3 ; the CXCR 3 ligands CXCL 10 , CXCL 9 ; and the CCR 4 ligand , CCL 17 before and after administration of the TNFalpha blocking agent infliximab . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| In equilibrium competition binding assays performed in undifferentiated HL 60 cells transfected with human and murine CC CKR 4 cDNA , the IC 50 values for the binding of [ 125I ] macrophage inflammatory protein 1 alpha to human and murine CC CKR 4 were 14 . 5 + / 9 . 0 nM and 10 . 1 + / 3 . 0 nM , respectively , and the IC 50 values for the binding of [ 125I ] RANTES to human and murine CC CKR 4 were 9 . 3 + / 3 . 0 nM and 5 . 7 + / 2 . 6 nM , respectively . ^^^ |
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| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| Only TARC and not five other CC chemokines ( MCP 1 ( monocyte chemoattractant protein 1 ) , RANTES ( regulated upon activation , normal T cells expressed and secreted ) , MIP 1alpha ( macrophage inflammatory protein 1alpha ) , MIP 1beta , and LARC ( liver and activation regulated chemokine ) ) competed with TARC SEAP for binding to CCR 4 . ^^^ TARC but not RANTES or MIP 1alpha induced migration and calcium mobilization in 293 / EBNA 1 cells stably expressing CCR 4 . ^^^ |
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| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| RANTES and MIP 1alpha mediate their effects via shared chemokine receptors ( CCRs ) : CCR 1 , CCR 4 , and CCR 5 . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| MDC and TARC competed for binding to CCR 4 , while no binding competition was observed for six other chemokines ( MCP 1 , MCP 3 , MCP 4 , RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha , macrophage inflammatory protein 1 beta ) . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| At 96 h postinfection , CMV infected cells express mRNA of the CMV encoded CC chemokine receptor US 28 but do not express mRNA of other CC chemokine receptors that bind RANTES ( CCR 1 , CCR 4 , CCR 5 ) . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| RANTES ( regulated on activation , normal T cells expressed and secreted ) in interaction with its receptors ( CCR 1 , CCR 3 , CCR 4 and CCR 5 ) may be one of the favorite chemokines involved in the cell trafficking and maintenance . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| First , mRNA levels encoding the chemokines MIG , RANTES , lymphotactin , MIP 3alpha , TCA 3 , TARC , MIP 3beta , LIX , MCP 1 and MIP 1beta and the receptors CCR 4 , CCR 6 and CCR 2 were significantly increased in chronically inflamed colons of IL 10 / mice when compared with wildtype mice . ^^^ Interestingly , reversal of colitis in IL 10 / mice by anti IL 12 mAb was accompanied by the inhibition in the expression of LIX , lymphotactin , MCP 1 , MIG , MIP 3alpha , MIP 3beta , TCA 3 , CCR 2 and CCR 4 , whereas the increased mRNA levels of MIP 1beta , RANTES , TARC and CCR 6 were unaffected . ^^^ At 4 and 8 weeks after reconstitution of Rag 2 / mice the mRNA levels of IP 10 , MCP 1 , MDC , MIG , TARC , RANTES , CCR 4 and CCR 5 were significantly increased prior to the appearance of macroscopic lesions . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| Soluble RANKL activated NF kappaB and induced messenger RNA expression of interferon gamma , interleukin 8 ( IL 8 ) , IL 13 , IL 9 , IL 15 , and RANTES , in addition to the receptors for IL 9 , IL 13 , IL 15 , and CCR 4 . ^^^ |
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| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| The surface expression of CC chemokine receptor ( CCR ) 1 , CCR 4 , and CCR 5 on peripheral blood T lymphocytes and their responsiveness to the chemokines macrophage inflammatory proteins ( MIP ) 1alpha , MIP 1beta , and RANTES ( regulated on activation , normally T cell expressed and secreted ) was analyzed in patients with chronic hepatitis C and hepatitis B infection and compared with healthy subjects . ^^^ |
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| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| We investigated tissue samples and tumor cell suspensions of patients with CD 30 ( + ) CTCL ( n = 8 ) and CD 30 ( ) CTCL ( mycosis fungoides , n = 6 ; Szary syndrome , n = 6 ) for expression of the chemokine receptors CCR 3 , CCR 4 , and CCR 8 and the CCR 3 ligands eotaxin / CCL11 , monocyte chemoattractant protein 3 ( MCP 3 ) / CCL7 , and RANTES ( regulated on activation , normal T expressed and secreted ) / CCL5 . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| Induction of chemokines and chemokine receptors CCR2b and CCR 4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP 1 and RANTES . ^^^ Unexpectedly , treatment with MCP 1 in the absence of RANKL resulted in 458 fold induction of CCR 4 ( P = 1 . 0 10 10 ( 10 ) ) , while RANTES treatment resulted in twofold repression ( P = 1 . 0 10 10 ( 4 ) ) . ^^^ |
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| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To investigate tissue samples from patients with CD30+ CLPD for the expression of the chemokine receptors CXCR 3 , CCR 4 and CCR 3 and their ligands MIG , TARC and RANTES . ^^^ |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13501 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|