| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| The most active chemokines for resting Th ( IL 10 ) , in terms of calcium mobilization and in vitro migration , were in order of potency : CCL 2 ( monocyte chemoattractant protein 1 , CCR 2 ligand ) , CCL 4 ( macrophage inflammatory protein 1beta , CCR 5 ligand ) , CCL 3 ( macrophage inflammatory protein 1alpha , CCR1 / 5 ligand ) , CCL 17 ( thymus and activation regulated chemokine , CCR 4 ligand ) , CCL 1 ( 1 309 , CCR 8 ligand ) , CXCL 12 ( stromal derived factor 1 , CXCR 4 ) , and CCL 11 ( eotaxin , CCR 3 ligand ) . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| Serum ELISAs were performed to detect the CCR 5 ligands CCL 5 , CCL 3 ; the CXCR 3 ligands CXCL 10 , CXCL 9 ; and the CCR 4 ligand , CCL 17 before and after administration of the TNFalpha blocking agent infliximab . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| In equilibrium competition binding assays performed in undifferentiated HL 60 cells transfected with human and murine CC CKR 4 cDNA , the IC 50 values for the binding of [ 125I ] macrophage inflammatory protein 1 alpha to human and murine CC CKR 4 were 14 . 5 + / 9 . 0 nM and 10 . 1 + / 3 . 0 nM , respectively , and the IC 50 values for the binding of [ 125I ] RANTES to human and murine CC CKR 4 were 9 . 3 + / 3 . 0 nM and 5 . 7 + / 2 . 6 nM , respectively . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| Only TARC and not five other CC chemokines ( MCP 1 ( monocyte chemoattractant protein 1 ) , RANTES ( regulated upon activation , normal T cells expressed and secreted ) , MIP 1alpha ( macrophage inflammatory protein 1alpha ) , MIP 1beta , and LARC ( liver and activation regulated chemokine ) ) competed with TARC SEAP for binding to CCR 4 . ^^^ TARC but not RANTES or MIP 1alpha induced migration and calcium mobilization in 293 / EBNA 1 cells stably expressing CCR 4 . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| Although reverse transcription polymerase chain reaction ( RT PCR ) showed the presence of CCR 1 , CCR 4 , and CCR 5 transcripts in CD34+ cells in BM , anti CCR 1 antibodies significantly abrogated the inhibitory effects of MIP 1alpha on BFU E formation both in a methylcellulose culture and in a single cell proliferation assay of purified CD34+ cells . ^^^ Although the contribution of CCR 4 or CCR 5 can not be completely excluded , these results suggest that MIP 1alpha mediated suppression of the proliferation of immature , but not mature erythroid progenitor cells , is largely mediated by CCR 1 expressed on these progenitor cells . . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| RANTES and MIP 1alpha mediate their effects via shared chemokine receptors ( CCRs ) : CCR 1 , CCR 4 , and CCR 5 . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| The expression of the MIP 1alpha receptor subtypes on LP CD 34 ( + ) cells was studied by indirect immunofluorescence using specific antibodies for the detection of CCR 1 , CCR 4 , and CCR 5 . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| After high dose LPS treatment , serum levels of tumor necrosis factor alpha , interleukin 1beta , and MIP 1alpha were reduced in CCR 4 ( / ) mice , and decreased expression of MDC and MIP 2 mRNA was detected in peritoneal exudate cells . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| MDC and TARC competed for binding to CCR 4 , while no binding competition was observed for six other chemokines ( MCP 1 , MCP 3 , MCP 4 , RANTES ( regulated on activation normal T cell expressed and secreted ) , macrophage inflammatory protein 1 alpha , macrophage inflammatory protein 1 beta ) . ^^^ |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10147 and P51679 |
Pubmed |
SVM Score :0.0 |
| NA |
|