| Interacting proteins: Q15532 and P51532 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15532 and P51532 |
Pubmed |
SVM Score :0.0 |
| In this work , we address how SYT interacts with hBRM and BRG 1 . ^^^ We demonstrate that the conserved N terminal SNH domain of SYT , which is also present in the oncoproteins SYT SSX , binds to both hBRM and BRG 1 . ^^^ |
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| Interacting proteins: Q15532 and P51532 |
Pubmed |
SVM Score :0.0 |
| Transcriptional co activator activity of SYT is negatively regulated by BRM and Brg 1 . ^^^ The N terminal 70 amino acids of SYT bind not only to BRM , but also to Brg 1 , both of which are subunits of SWI / SNF chromatin remodelling complexes . ^^^ Here , we have investigated the functions of BRM and Brg 1 on the repression of SYT activity . ^^^ The negative regulation of SYT transcriptional co activator activity is dependent on the ATP hydrolysis of BRM and Brg 1 in the protein complexes . ^^^ |
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| Interacting proteins: Q15532 and P51532 |
Pubmed |
SVM Score :0.0 |
| SYT has a conserved N terminal domain ( SNH domain ) that interacts with the human paralog of Drosophila Brahma ( hBRM ) and Brahma related gene 1 ( BRG 1 ) chromatin remodeling proteins and a C terminal transactivating sequence rich in glutamine , proline , glycine , and tyrosine ( QPGY domain ) . ^^^ |
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