| Mi 2 beta associates with BRG 1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities . ^^^ Here we show that the amino terminal and carboxyl terminal regions of Mi 2 beta have distinct transcriptional activities and bind to BRG 1 , a component of the SWI / SNF complex , and the RET finger protein ( RFP ) , respectively . ^^^ On the other hand , we demonstrated that Mi 2 and BRG 1 were associated with each other and that the bromodomain region of BRG 1 strongly suppressed transactivation by the amino terminal region of Mi 2 beta . ^^^ The findings that Mi 2 beta interacts with both transactivating and repressing proteins and directly associates with another chromatin remodeling protein , BRG 1 , provide new insight into the formation of multiprotein supercomplex involved in transcriptional regulation . . ^^^ |