| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.77775288 |
| Here we demonstrate that granuphilin directly binds to syntaxin 1a on the plasma membrane , and this interaction is regulated by Rab27a . 0.77775288^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| The Rab27a / granuphilin complex regulates the exocytosis of insulin containing dense core granules . ^^^ Screening its possible Rab partner by a yeast two hybrid system revealed that an amino terminal zinc finger domain of granuphilin interacts with Rab27a . ^^^ Granuphilin preferentially bound to the GTP form of Rab27a . ^^^ Formation of the Rab27a / granuphilin complex was readily detected in the pancreatic beta cell line MIN 6 . ^^^ Moreover , the tissue distributions of Rab27a and granuphilin are remarkably similar : both had significant and specific expression in pancreatic islets and in pituitary tissue , but no expression was noted in the brain . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| We recently identified a novel set of Rab and its effector , Rab27a / granuphilin , that possibly regulates the exocytosis of insulin containing , dense core granules in pancreatic beta cells . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| Granuphilin , a novel Rab27a effector protein , is involved in the exocytosis of dense core granules ] . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| The vertebrate synaptotagmin like protein granuphilin binds to the vesicle trafficking proteins Rab27a and Munc 18 and can modulate exocytosis of insulin containing secretory granules in pancreatic beta cell lines . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| Rab 27 acts through organelle specific effector proteins , such as granuphilin in pancreatic beta cells and melanophilin in melanocytes . ^^^ The Rab 27 and effector complex then interacts with proteins that are essential for membrane transport and fusion , such as syntaxin 1a and Munc 18 1 for granuphilin and myosin Va for melanophilin . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| Rab 27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a . ^^^ We have shown recently that Rab27a and its effector , granuphilin , are involved in the exocytosis of insulin containing secretory granules through a direct interaction with the plasma membrane syntaxin 1a in pancreatic beta cells . ^^^ The plasma membrane targeting of secretory granules is promoted by wild type granuphilin but not by granuphilin mutants that are defective in binding to either Rab27a or syntaxin 1a . ^^^ These results indicate that granuphilin plays a role in tethering insulin granules to the plasma membrane by an interaction with both Rab27a and syntaxin 1a . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| The Rab27a effector granuphilin is specifically localized on insulin granules and is involved in their exocytosis . ^^^ |
|
| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| Functional analysis of Rab27a effector granuphilin in insulin exocytosis . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| The GTPases Rab3a and Rab27a and their effectors Granuphilin / Slp4 and Noc 2 are essential regulators of neuroendocrine secretion . ^^^ ICER overexpression diminished the level of Granuphilin , Noc 2 , Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta cells in response to secretagogues . ^^^ |
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| Interacting proteins: Q96C24 and P51159 |
Pubmed |
SVM Score :0.0 |
| NA |
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