| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of three regulatory serines of Tob by Erk 1 and Erk 2 is required for Ras mediated cell proliferation and transformation . tob is a member of an emerging family of genes with antiproliferative function . ^^^ Tob is rapidly phosphorylated at Ser 152 , Ser 154 , and Ser 164 by Erk 1 and Erk 2 upon growth factor stimulation . ^^^ Reintroduction of wild type Tob and mutant Tob with serine to alanine but not to glutamate mutations on the Erk phosphorylation sites in these cells restores the suppression of cyclin D 1 expression . ^^^ Thus , Tob inhibits cell growth by suppressing cyclin D 1 expression , which is canceled by Erk 1 and Erk 2 mediated Tob phosphorylation . ^^^ |
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| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| In this study , our two hybrid screening has identified Tob as an ERK 2 interacting protein . ^^^ Biochemical analyses have then shown that ERK MAPK ( ERK 2 ) and JNK / SAPK ( JNK 2 ) bind to and phosphorylate Tob in vitro . ^^^ When the ERK pathway is activated in cells , phosphorylation of Tob is induced . ^^^ An ERK binding or docking site locates in the N terminal portion of Tob , and phosphorylation sites reside in the C terminal stretch region . ^^^ Mutant forms of Tob , in which serines are replaced by glutamic acids to mimic phosphorylation , show a much reduced ability to inhibit the cell cycle progression to S phase from G ( 0 ) / G ( 1 ) phase , as compared with wild type Tob , indicating that ERK phosphorylation negatively regulates the anti proliferative function of Tob . . ^^^ |
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| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50616 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|