| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Data suggest that caspase 8 may be sufficient to deliver the TRAIL induced apoptotic signal in the absence of both caspase 10 and c FLIP ( Rh 18 ) but not in the presence of c FLIP ( Rh 41 ) . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| The evidence that Fas L ( + ) / TRAIL ( + ) malignant plasma cells prime erythroblast apoptosis by direct cytotoxicity was also supported by the increase of FLICE in fresh immature GpA ( +dim ) erythroid cells , whereas ICE and caspase 10 increased in subsequent maturative forms . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and caspase 10 were recruited to the DISC , where they were proteolytically activated to initiate apoptosis in TRAIL sensitive glioma cells . ^^^ Caspase 8 and caspase 10 were also recruited to the DISC in TRAIL resistant cells , but their further activation was inhibited by two antiapoptotic proteins termed cellular Fas associated death domain like interleukin 1beta converting enzyme inhibitory protein ( c FLIP ) and phosphoprotein enriched in diabetes / phosphoprotein enriched in astrocytes 15kDa ( PED / PEA 15 ) . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| TRAIL , but not CD95L , induced activation of caspase 10 . bcl 2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented CD95L mediated loss of MMP and cytochrome c release . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Caspase 10 is recruited to and activated at the native TRAIL and CD 95 death inducing signalling complexes in a FADD dependent manner but can not functionally substitute caspase 8 . ^^^ Here we show that caspase 10 is recruited not only to the native TRAIL DISC but also to the native CD 95 DISC , and that FADD is necessary for its recruitment to and activation at these two protein complexes . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Gene array demonstrated that leptin inhibits apoptosis via potent down regulation of caspase 10 and TNF related apoptosis inducing ligand . ^^^ Our data thus demonstrate , for the first time , that leptin stimulates , in a time and dose dependent manner , neuroblastoma cell proliferation and that the underlying mechanisms involve suppression of apoptosis via the Janus kinase STAT , phosphatidylinositol 3 kinase , and MAPK pathways that culminate altogether in the down regulation of the apoptotic factors caspase 10 and TNF related apoptosis inducing ligand . . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| By contrast , recombinant TRAIL induced apoptosis in 10 of 12 thyroid carcinoma cell lines tested , by activating caspase 10 at the receptor level and triggering a caspase mediated apoptotic cascade . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| To examine molecular mechanisms in cell resistance , we analyzed TRAIL induced DISC in TRAIL sensitive melanoma cells and showed that apoptosis initiating caspase 8 and caspase 10 were recruited to the DISC where they became activated through autocatalytical cleavage , leading to apoptosis through cleavage of downstream substrates such as caspase 3 and DFF 45 . ^^^ In TRAIL resistant melanoma cells , however , c FLIP proteins were recruited to the DISC , resulting in the inhibition of caspase 8 and caspase 10 cleavage in the DISC . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| We detected rapid cleavage of caspases 8 , 9 , 3 , and 6 , as well as the caspase substrates poly ( ADP ribose ) polymerase ( PARP ) and DNA fragmentation factor 45 ( DFF 45 ) , but not caspase 10 , upon TRAIL treatment in sensitive MM cells , pointing to caspase 8 as the apical caspase of TRAIL signaling in MM cells . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| However , both caspase 8 and caspase 10 recruitment and processing within the TRAIL death inducing signaling complex ( DISC ) were greater in GCDCA treated cells whereas recruitment of cFLIP long and short was reduced . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : Our data show that a combined therapy with TRAIL and irradiation will only be effective in cells expressing at least one agonistic TRAIL receptor , FADD and caspase 8 or caspase 10 . . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| The recently observed deregulation of caspase 10 in these cells prompted us to investigate the particular contribution of caspase 8 silencing in the resistance to TRAIL in N type cells . ^^^ In conclusion , restoration of active caspase 8 expression in caspase 8 and caspase 10 deficient IGR N 91 cell line is necessary and sufficient to fully restore TRAIL mediated cell death . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Caspase 10 activation and IRS 1 cleavage are regulated by a MKK 1 signaling pathway but not by a phosphatidylinositol 3 kinase pathway nor by the extracellular proapoptotic ligands FasL , tumor necrosis factor alpha related apoptosis inducing ligand ( TRAIL ) , or transforming growth factor beta 3 . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| HIV 1 Tat protein concomitantly down regulates apical caspase 10 and up regulates c FLIP in lymphoid T cells : a potential molecular mechanism to escape TRAIL cytotoxicity . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Caspase 10 sensitizes breast carcinoma cells to TRAIL induced but not tumor necrosis factor induced apoptosis in a caspase 3 dependent manner . ^^^ Here we show that expression of caspase 10 sensitizes MCF 7 breast carcinoma cells to TRAIL but not tumor necrosis factor ( TNF ) induced apoptosis . ^^^ Caspase 10 mediated sensitization for TRAIL induced apoptosis appears to be dependent on caspase 3 , as expression of caspase 10 in MCF 7 / casp 3 cells but not in caspase 3 deficient MCF 7 cells overcomes TRAIL resistance . ^^^ Interestingly , neutralization of TRAIL receptor 2 ( TRAIL R 2 ) , but not TRAIL R 1 , impaired apoptosis in a caspase 10 dependent manner , indicating that caspase 10 enhances TRAIL R 2 induced cell death . ^^^ Furthermore , whereas processing of caspase 10 was delayed in TNF treated cells , TRAIL triggered a very rapid activation of caspase 10 and 3 . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Additional intracellular factors leading to TRAIL resistance affect the caspase 8 / c FLIP ratio , such as loss of caspase 8 and caspase 10 due to mutations or gene methylation , CARP dependent degradation of active caspase 8 and changes in caspase 8 or c FLIP expression levels . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| Cotreatment with 15d PGJ ( 2 ) and TRAIL enhanced the sequential activation of caspase 8 , caspase 10 , caspase 9 , caspase 3 , and Bid . ^^^ |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50591 and Q92851 |
Pubmed |
SVM Score :0.0 |
| NA |
|