| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.71358255 |
| In addition , TRAIL also binds to 3 `` decoy ' ' receptors , DcR 2 , a receptor with a truncated death domain , DcR 1 , a glycosylphosphatidylinositol anchored receptor , and OPG a secreted protein which is also known to bind to another member of the TNF family , RANKL . 0.71358255^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.52574951 |
| TRAIL R 3 encodes a 299 amino acid protein with 58 and 54 % overall identity to TRAIL R 1 and R 2 , respectively . 0.52574951^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Three closely related receptors bind Apo2L : DR 4 and DR 5 , which contain cytoplasmic death domains and signal apoptosis , and DcR 1 , a decoy receptor that lacks a cytoplasmic tail and inhibits Apo2L function [ 3 5 ] . ^^^ By cross hybridization with DcR 1 , we have identified a fourth Apo2L receptor , which contains a cytoplasmic region with a truncated death domain . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| APO2L ( TRAIL ) is a novel CD95L ( Fas / APO 1 L ) homologous cytotoxic cytokine that interacts with various receptors which transmit ( DR 4 , DR 5 ) or inhibit ( DcR 1 , DcR 2 ) an apoptotic signal . ^^^ APO2L ( TRAIL ) is a novel CD95L ( Fas / APO 1 L ) homologous cytotoxic cytokine that interacts with various receptors which transmit ( DR 4 , DR 5 ) or inhibit ( DcR 1 , DcR 2 ) an apoptotic signal . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| AP 02 ligand ( APO2L ) is a CD 95 ligand ( CD95L ) related cytokine of the tumor necrosis factor family that interacts with agonistic ( DR 4 , DR 5 ) and antagonistic ( DcR 1 , DcR 2 ) receptors . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Transfection experiments indicate that DcR 1 and DcR 2 act as decoys that prevent Apo2L from inducing apoptosis through DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Addition of the APO2L binding decoy receptor 1 ( DcR 1 ) Fc fusion protein inhibited the cytotoxicity by 30 70 % . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In contrast , TRAIL induced apoptosis is prevented by a decoy receptor ( DcR 1 , TRID or TRAIL receptor 3 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The cell surface decoy receptor proteins TRID ( also known as DcR 1 or TRAIL R 3 ) and TRUNDD ( DcR 2 , TRAIL R 4 ) inhibit caspase dependent cell death induced by the cytotoxic ligand TRAIL in part because of their absent or truncated cytoplasmic death domains , respectively . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Two additional TRAIL receptors ( DcR 1 and DcR 2 ) do not transmit an apoptotic signal and have been proposed to confer protection from TRAIL induced apoptosis . ^^^ Resistance to TRAIL did not correlate with DcR 1 or DcR 2 protein expression and was overcome by protein synthesis inhibition in 50 % of the resistant cell lines . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Expression of the decoy receptors DcR 1 and DcR 2 did not correlate with TRAIL sensitivity . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Susceptibility of these acute leukemia cell types , which are known to lack p 53 ( wt ) function , did not appear to correlate with the levels of the apoptosis signaling death receptors ( DRs ) of Apo 2L , ie , DR 4 and DR 5 ; decoy receptors ( DcR 1 and 2 ) ; FLAME 1 ( cFLIP ) ; or proteins in the inhibitors of apoptosis proteins ( IAP ) family . ^^^ Treatment of human leukemic cells with etoposide , Ara C , or doxorubicin increased DR 5 but not DR 4 , Fas , DcR 1 , DcR 2 , Fas ligand , or Apo 2L levels . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Treatment with paclitaxel or taxotere increased DR 4 and / or DR 5 protein levels ( up to 8 fold ) without affecting the protein levels of DcR 1 and DcR 2 , Apo 2L / TRAIL , Fas , or Fas ligand . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor ( DcR 1 and DcR 2 ) expression was limited in the glioma cell lines and did not correlate with TRAIL sensitivity . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Reduced effects of Apo 2L / TRAIL in Bcr Abl positive leukemic cells were not attributable to diminished expression of DR 4 and DR 5 , or higher expressions of the decoy receptors DcR 1 and 2 or c FLIP ( L ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL binds to death receptors ( DRs ) DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ Levels of DcR 1 and DcR 2 or levels of the FLICE inhibitory protein ( FLIP ) did not correlate with TRAIL resistance , and protein synthesis inhibition did not sensitize the TRAIL resistant line to TRAIL . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Apo2L / TRAIL also binds to `` decoy ' ' receptors ( DcR 1 and DcR 2 ) that can antagonize its interaction with DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We found using DNA arrays , reverse transcription polymerase chain reaction , and immunofluorescence that Rel / NF kappaB factors up regulate DcR 1 , a receptor for TNF related apoptosis inducing ligand ( TRAIL ) , a cytokine of the TNF family that induces apoptosis in tumor cells . ^^^ Rel / NF kappaB transcription factors protect against tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) induced apoptosis by up regulating the TRAIL decoy receptor DcR 1 . ^^^ Four related receptors bind TRAIL , two death receptors ( DR 4 and DR 5 ) that signal apoptosis and two decoy receptors ( DcR 1 and DcR 2 ) that act as dominant negative inhibitors of TRAIL mediated apoptosis . ^^^ Our results indicate that overexpression of cRel or activation of endogenous Rel / NF kappaB factors by TNFalpha in HeLa cells up regulates DcR 1 without changing the expression of DcR 2 , DR 4 , and DR 5 and makes cells resistant against TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Although three other TRAIL receptors DR 5 , DcR 1 , and DcR 2 are induced by DNA damage and are regulated by the wild type p 53 tumor suppressor , it was not known whether these factors also affect DR 4 expression . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL ( tumor necrosis factor ( TNF ) related apoptosis inducing ligand ) , a recently identified member of the growing TNF superfamily , binds to its cognate `` death ' ' receptors DR 4 and DR 5 as well as `` decoy ' ' receptors DcR 1 and DcR 2 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL / PSI did not affect the level of mRNA expression for TRAIL receptors ( DR 4 , DR 5 , DcR 1 ) and other apoptosis signal transduction molecules ( TRADD , caspase 8 ) . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| METHODS : Five pancreatic cell lines were investigated for the expression of FasL / Fas , DcR 3 , DR 4 , DR5 / TRAIL , DcR 1 , DcR 2 , and other death pathways related molecules such as Bax , bcl xL , bcl 2 , FADD , and caspase 3 by flow cytometry , immunoblotting , and RT / PCR , both semiquantitative and real time ( TaqMan ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Suppression of TRAIL signaling by expression of the TRAIL decoy receptor , DcR 1 , confers chemoresistance to cancer cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Compared to these primary cells , PrEC were found to contain significantly fewer TRAIL receptors DcR 1 and DcR 2 which are not capable of conducting the apoptotic signal . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We also show the in vivo presence of TRAIL and TRAIL receptors DR 5 and DcR 1 in both normal and inflamed thyroids . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| A glycosylphosphatidylinositol linked TRAIL receptor called DcR 1 behaves as a decoy receptor inhibiting TRAIL mediated cell death in several cellular systems . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL can bind to four different receptors , two pro apoptotic death receptors ( DRs ) , DR 4 and DR 5 , and two antiapoptotic decoy receptors ( DcRs ) , DcR 1 and DcR 2 . ^^^ We studied the tumor specific down regulation of the TRAIL receptors DcR 1 and DcR 2 , as well as DR 4 and DR 5 , in a group of pediatric tumor cell lines [ nine neuroblastoma and three peripheral primitive neuro ectodermal tumors ( PNETs ) ] and three cell lines from adult tumors . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| As B cell lines expressed significant levels of DR 4 and DR 5 , resistance to Trail in SKW 6 . 4 is likely due to the expression of the decoy receptor DcR 1 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The mRNAs of the decoy receptors , DcR 1 and DcR 2 , were present in the rat testis at all ages studied , but the DcR2 / TRAIL R 4 mRNa level was higher from the pubertal period to adulthood . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In the present study , to confirm the inhibitory activity of DcR 1 in granulosa cells , granulosa cells prepared from healthy follicles were treated with phosphatidylinositol specific phospholipase C ( PI PLC ) to cleave glycophospholipid anchor of DcR 1 and to remove DcR 1 from the cell surface , and then incubated with TRAIL . ^^^ The present finding indicated the possibility that TRAIL and its receptors were involved in induction of apoptosis in granulosa cells during atresia , and that DcR 1 plays an inhibitory role in granulosa cell apoptosis . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL binds four different membrane bound receptors : DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) was applied to assay mRNA expression of TRAIl ( the TNF related apoptosis inducing ligand ) receptors ( DR 5 , DcR 1 , and DcR 2 ) in 3 cases of normal ovarian tissues , 6 cases of ovarian benign tumors , and 16 cases of ovarian cancers . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| AIM : To observe the localization of TRAIL / TRAIR ( DR 4 , DR 5 , DcR 1 , DcR 2 ) in the fetal pancreas . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The expression levels of DR 4 and the decoy receptors , DcR 1 and DcR 2 , did not correlate with TRAIL sensitivities . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular mechanisms involved in the enhanced apoptosis , we examined the expression of two TRAIL death receptors ( DR 4 and DR 5 ) and two TRAIL decoy receptors ( DcR 1 and DcR 2 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Differences in the expression of downstream signalling molecules [ Fas associated death domain protein ( FADD ) , caspase 8 ] and inhibitors [ decoy receptor 1 ( DcR 1 ) , cellular FLICE like inhibitory protein ( c FLIP ) ] did not correlate with TRAIL sensitivity . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ Among TRAIL receptors , death receptor 4 ( DR 4 ) and DR 5 containing death domain ( DD ) in their cytoplasmic region mediate apoptosis signaling upon TRAIL binding , while decoy receptor 1 ( DcR 1 ) and DcR 2 with a truncated or non functional DD play `` decoy ' ' role . ^^^ In this study , we raised hybridomas secreting monoclonal antibodies against TRAIL ( FMU1 . 1 , 1 . 2 , 1 . 3 ) , DR 4 ( FMU1 . 4 ) , DR 5 ( FMU1 . 5 , 1 . 6 ) , DcR 1 ( FMU1 . 7 ) and DcR 2 ( FMU1 . 8 , 1 . 9 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Four membrane bound receptors for TRAIL have been identified , two apoptosis mediating receptors , DR 4 and DR 5 , and two apoptosis inhibiting receptors , DcR 1 and DcR 2 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Death receptors DR 4 and DR 5 can induce and decoy receptors DcR 1 and DcR 2 can inhibit TRAIL mediated apoptosis . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Four TRAIL / Apo2L receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) have been identified . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In addition , it may also bind the decoy receptors ( DcRs ) , DcR 1 and DcR 2 , which lack an intracellular signaling domain , thus negatively regulating TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Furthermore , co methylation patterns were observed for the TRAIL receptor pairs DCR 1 and DCR 2 and between DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : Loss of DcR ( especially DcR 1 ) in HCC may contribute to antitumor effects of TRAIL to HCC . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Ad TRAIL infection induced expression of TRAIL in RCJ3 . 1C . 18 cells , increased expression of death receptor 4 ( DR 4 ) , and decreased expression of DR 5 and decoy receptor 1 ( DcR 1 ) . ^^^ Cartilage obtained from rats with experimentally induced OA showed increased expression of TRAIL and DR 4 and decreased expression of DR 5 and DcR 1 compared with control cartilage . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In the present study , expression of TRAIL and its apoptosis inducing death receptors ( DR 4 and DR 5 ) and inhibitory decoy receptor ( DcR 1 ) was studied in normal ovaries and in malignant ovarian tumors before and after chemotherapy to investigate the therapeutic potential of TRAIL . ^^^ METHODS : DR 4 , DR 5 , DcR 1 , and TRAIL were studied immunohistochemically in 5 normal ovaries , 15 stages I / II , and 26 stages III / IV primary ovarian cancers , including 19 paired tumor samples ( pre and post chemotherapy ) . ^^^ RESULTS : Surface epithelium of normal ovaries expressed TRAIL and its receptors ; ovarian stromal cells expressed only DcR 1 . ^^^ Of the ovarian cancers , 73 % expressed DR 4 , 51 % DR 5 , 46 % DcR 1 , and 34 % TRAIL . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL is known to bind to 4 different receptors , 2 proapoptotic ( DR 4 and DR 5 ) , and 2 potentially antiapoptotic receptors lacking death domains ( DcR 1 and DcR 2 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The combined cytotoxicity of TRAIL and EPI was significantly inhibited by the TRAIL neutralizing fusion protein DR 5 : Fc , although EPI did not affect the mRNA expression of DR 4 , DR 5 , DcR 1 or DcR 2 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Recent studies show that death receptors ( DR 4 and DR 5 ) , decoy receptors ( DcR 1 and DcR 2 ) , and death inhibitors ( FLIP , FAP 1 , and IAP ) are responsible for the differential sensitivity to TRAIL of normal and tumor cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We show that both mRNA and protein of TRAIL receptors death receptors ( DR 4 , DR 5 ) and decoy receptors ( DcR 1 , DcR 2 ) are present in GCT stromal tumor cells . ^^^ Taken together , our findings suggest that TG is able to sensitize tumor cells of GCT to TRAIL induced cell death , perhaps in part through up regulating the death receptor DR 5 and down regulating the decoy receptor DcR 1 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We showed that the expression of death receptor DR 5 , but not DR 4 was up regulated and the decoy receptor DcR 1 was down regulated in the cells treated with 8 Cl Ado and the recombinant soluble TRAIL ( rsTRAIL , 95 281 a . a . ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Membrane expression of TRAIL receptors DR 4 ( death receptor 4 ) , DR 5 ( pro apoptotic ) , DcR 1 ( decoy receptor 1 ) , DcR 2 ( anti apoptotic ) was assessed by flow cytometry . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The expression levels of DR 4 , DR 5 , DcR 1 and DcR 2 were measured in TRAIL treated and chemotherapeutic agent treated A 549 cells by Western blotting . ^^^ The expression levels of DR 4 and DR 5 were not significantly different and the expression of DcR 2 was slightly downregulated , but the expression of DcR 1 was not detected in non treated , TRAIL treated and chemotherapeutic agent treated A 549 cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Expression levels of TRAIL death ( DR 4 and DR 5 ) and decoy ( DcR 1 and DcR 2 ) receptors were not different between primary and metastatic OC cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Of four tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors analysed , DR 4 was most commonly methylated ( 41 % ; compared with DcR 2 ( 26 % ) , DcR 1 ( 23 % ) and DR 5 ( 10 % ) ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The selective tumoricidal activity of TRAIL is believed to be modulated by agonistic ( DR 4 and DR 5 ) and antagonistic receptors ( DcR 1 and DcR 2 ) , which appear to compete for ligand binding . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The expression of TRAIL , TRAIL R ( DR 4 , DcR 1 ) and Fas L in patients with ovarian cancer ] . ^^^ OBJECTIVE : To investigate the apoptosis induced by TRAIL , TRAIL R and Fas L in patients METHODS : The expression of TRAIL , TRAIL R ( DR 4 , DcR 1 ) and Fas L in ovarian cancer was detected with immunohistochemistry . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The expression of TRAIL receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) and the expression of death signal transducing proteins were investigated . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Five distinct receptors have been described for TRAIL : TRAIL R 1 ( DR 4 ) , TRAIL R 2 ( DR 5 , TRICK ) , TRAIL R 3 ( TRID , DcR 1 ) , TRAIL R 4 ( TRUNDD , DcR 2 ) , and osteoprotegerin . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Its expression , like the other three TRAIL receptors ( i . e . , DR 4 , DR 5 , and DcR 1 ) , is regulated by p 53 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| No changes were observed in DR 4 , DR 5 , DcR 1 , and TRAIL mRNA and protein levels in prostate after castration . ( 2 ) A specific decrease in DcR 2 expression was observed in the ventral prostate after treatment of rats with the anti androgen flutamide . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Apo2L / TRAIL is a homotrimeric protein that interacts with five receptors : death receptor 4 ( DR 4 ) and DR 5 mediate apoptosis activation , whereas decoy receptor 1 ( DcR 1 ) , DcR 2 , and osteoprotegerin counteract this function . ^^^ Apo2L / TRAIL is a homotrimeric protein that interacts with five receptors : death receptor 4 ( DR 4 ) and DR 5 mediate apoptosis activation , whereas decoy receptor 1 ( DcR 1 ) , DcR 2 , and osteoprotegerin counteract this function . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Two of them , death receptors 4 and 5 ( DR 4 and DR 5 ) , induce apoptosis , whereas decoy receptors 1 and 2 ( DcR 1 and DcR 2 ) are unable to evoke cell death upon TRAIL binding . ^^^ We observed frequent expression of TRAIL DcR 1 and DcR 2 , while expression of DR 4 and DR 5 was less frequent . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TSA induced the transcription of TRAIL death receptor DR 5 without affecting the transcription of DR 4 and the decoy receptors ; DcR 1 and DcR 2 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : As advanced prostate cancers are resistant to currently available chemotherapies , we evaluated the cytotoxic effect of TNF related apoptosis inducing ligand ( TRAIL ) and characterized the involvement of its five receptors DR 4 , DR 5 , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) and of the death inducing signaling complex ( DISC ) forming proteins caspase 8 and c FLIP in prostate cell lines . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In vitro study showed that TRAIL elicited significant cell apoptosis of cell lines 3AO , SKOV 3 , and OVCAR 3 in a dose and time dependent manner ( P < 0 . 05 ) , while normal ovarian epithelial cells were resistant ; this toxicity free effect may be the result of upregulation of TRAIL receptors DcR 1 and DcR 2 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL can also bind to decoy receptors ( DcR 1 , DcR 2 , and osteoprotegerin receptor ) that can not induce apoptosis . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| P gp interacted with the TRAIL receptors DR 4 , DR 5 , and DcR 1 in plasma membranes and enhanced TRAIL binding to DR 5 . ^^^ Interestingly , the decreased level of the decoy TRAIL receptor , DcR 1 , in BC 19 cells further sensitized these cells to TRAIL . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induces apoptosis in melanoma by interaction with death receptors TRAIL R 1 ( DR 4 ) or TRAIL R 2 ( DR 5 ) on melanoma cells or resists apoptosis by interaction with decoy receptors TRAIL R 3 ( DcR 1 ) or TRAIL R 4 ( DcR 2 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL can also bind decoy receptor 1 ( DcR 1 ) ( TRAIL R 3 ) and DcR 2 ( TRAIL R 4 ) that fail to induce apoptosis since they lack and have a truncated cytoplasmic death domain , respectively . ^^^ In addition , DcR 1 and DcR 2 inhibit DR 4 and DR 5 mediated , TRAIL induced apoptosis and we demonstrate here that this occurs through distinct mechanisms . ^^^ While DcR 1 prevents the assembly of the death inducing signaling complex ( DISC ) by titrating TRAIL within lipid rafts , DcR 2 is corecruited with DR 5 within the DISC , where it inhibits initiator caspase activation . ^^^ The specificity of DcR 1 and DcR 2 mediated TRAIL inhibition reveals an additional level of complexity for the regulation of TRAIL signaling . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The ability of interferon gamma when combined with TNF alpha to mediate keratinocyte apoptosis included induction of TRAIL coupled with diminished capacity of keratinocytes with repressed NF kappaB activity to increase the TRAIL decoy receptor 1 , as well as lower levels of several NF kappaB dependent antiapoptotic proteins accompanied by enhanced caspase 8 levels . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Although chemotherapy treatment did not modulate mRNA or cell surface expression of the TRAIL receptors death receptor 4 , death receptor 5 , decoy receptor 1 , or decoy receptor 2 , it was found to down regulate expression of the caspase 8 inhibitor , c FLIP . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Normal kidney epithelial cells , although expressing RASSF1A , did not undergo apoptosis in response to IFN or TRAIL but had > 400 fold higher TRAIL decoy receptor 1 expression than transduced ACHN cells ( real time reverse transcription PCR ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Lymphocyte inhibitor of TRAIL ( TNF related apoptosis inducing ligand ) : a new receptor protecting lymphocytes from the death ligand TRAIL . ^^^ We have cloned LIT ( lymphocyte inhibitor of TRAIL ) , which lacks a death domain . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Two receptors for TRAIL , designated TRAIL R 2 and TRAIL R 3 , have been identified . ^^^ In contrast , TRAIL R 3 does not promote cell death . ^^^ TRAIL R 3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor . ^^^ The extended structure of TRAIL R 3 is due to the presence of multiple threonine , alanine , proline and glutamine rich repeats ( TAPE repeats ) . ^^^ TRAIL R 2 shows a broad tissue distribution , whereas the expression of TRAIL R 3 is restricted to peripheral blood lymphocytes ( PBLs ) and skeletal muscle . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 4 encodes a 386 amino acid protein with an extracellular domain showing 58 % 70 % identity to those of TRAIL R 1 , TRAIL R 2 , and TRAIL R 3 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRID ( also known as TRAIL R 3 ) is an antiapoptotic decoy receptor that lacks the cytoplasmic death domain and competes with KILLER / DR5 and DR 4 for binding to TRAIL . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The specificity of the mAb permitted a precise evaluation of the TRAIL receptors that induce apoptosis ( TRAIL R 1 and R 2 ) compared with the TRAIL receptors that potentially regulate TRAIL mediated apoptosis ( TRAIL R 3 and R 4 ) . ^^^ In contrast , the expression of TRAIL R 3 or TRAIL R 4 did not appear to be a significant factor in determining the resistance or sensitivity of these tumor target cells to the effects of TRAIL . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Constant co expression of TRAIL and of receptors TRAIL R 1 , TRAIL R 2 , and TRAIL R 3 in different tumor entities as well as in normal brain indicates that additional mechanisms might modulate the previously proposed `` decoy ' ' model . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Past studies have shown that apoptosis mediated by TNF related apoptosis inducing ligand ( TRAIL ) is regulated by the expression of two death receptors [ TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 ] and two decoy receptors ( TRAIL R 3 and TRAIL R 4 ) that inhibit apoptosis . ^^^ This was evident for TRAIL R 1 and more so for the TRAIL decoy receptors TRAIL R 3 and R 4 . ^^^ Studies on permeabilized cells revealed that the receptors were located within the cytoplasm and redistribution from the cytoplasm may represent a posttranslational control mechanism . ( c ) Surface expression of TRAIL R 1 and R 2 ( but not TRAIL R 3 and R 4 ) showed an overall correlation with TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The antiapoptotic decoy receptor TRID / TRAIL R 3 is a p 53 regulated DNA damage inducible gene that is overexpressed in primary tumors of the gastrointestinal tract . ^^^ TRID ( also named as TRAIL R 3 ) is an antagonist decoy receptor and lacks the cytoplasmic death domain . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| It has been hypothesized that this difference in TRAIL sensitivity between normal and transformed cells might be due to the expression of the non death inducing TRAIL receptors ( TRAIL R ) TRAIL R 3 and TRAIL R 4 , presumably by competition for limited amounts of TRAIL . ^^^ Yet both cell types exhibited similar TRAIL receptor surface expression , suggesting that expression of TRAIL R 3 and TRAIL R 4 may not be the main regulator of sensitivity to TRAIL . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We show that the death receptors TRAIL R 1 and R 2 are located in the trans Golgi network , whereas the inhibitory receptors TRAIL R 3 and R 4 are located in the nucleus . ^^^ After exposure to TRAIL , TRAIL R 1 and R 2 are internalized into endosomes , whereas TRAIL R 3 and R 4 undergo relocation from the nucleus to the cytoplasm and cell membranes . ^^^ Transfection of TRAIL R 3 and R 4 increased resistance of the melanoma lines to TRAIL induced apoptosis even in melanoma lines that naturally expressed these receptors . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 3 is anchored to the membrane by a glycolipid and acts as a dominant negative inhibitor of TRAIL mediated apoptosis when overexpressed on TRAIL sensitive cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The ( auto ) antigen specific T cells were also resistant to specific TRAIL R1 / TRAIL R 2 directed induction of apoptosis , indicating that coexpression of the truncated TRAIL R 3 and TRAIL R 4 in these T cells is not responsible for the observed resistance . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| It is regulated by 2 death receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 , and 2 decoy receptors , TRAIL R 3 and TRAIL R 4 . ^^^ TRAIL R 1 , R 2 , and R 4 were expressed in 6 HCC cell lines examined , but TRAIL R 3 was expressed in only 2 of the 6 cell lines . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| However , all DC populations expressed CD 95 , TRAIL R 2 , and TRAIL R 3 at comparable levels , suggesting that sensitivity to death ligand induced DC apoptosis is not regulated at the receptor level . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The decoy receptor , TRAIL R 3 , appeared important in protection of endothelial cells , whereas lack of surface death receptor expression and as yet unknown intracellular inhibitor ( s ) of apoptosis downstream of caspase 3 may play a major role in protection of melanocytes and fibroblasts from TRAIL induced apoptosis , respectively . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL sensitivity of the PNET cell lines was correlated with mRNA expression levels of TRAIL , its agonistic ( TRAIL R 1 , TRAIL R 2 ) and antagonistic ( TRAIL R 3 , TRAIL R 4 ) receptors , cellular FLICE like inhibitory protein ( cFLIP ) , caspase 3 and caspase 8 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Semiquantitative RT PCR revealed that TRAIL R 2 and TRAIL R 3 are the main TRAIL receptors used by NB cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| As yet , four TRAIL receptors have been cloned , two of which ( TRAIL R 1 and 2 ) bear a death domain and mediate apoptosis , whereas two others ( TRAIL R 3 and 4 ) lack ( functional ) death domains and are supposed to act as decoy receptors . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NF kappaB activation was mediated by the death receptors , TRAIL R 1 and R 2 , but not by TRAIL R 3 or R 4 and was only observed in HeLa cells in the presence of z VAD . fmk . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We detected the expression of the receptors Fas , TRAMP , TRAIL R 2 and TRAIL R 3 in hLECs . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Variable expression of the two decoy ( TRAIL R 3 and R 4 ) and soluble ( osteoprotegerin ) receptors was seen and this did not correlate with TRAIL resistance . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) , a member of the tumor necrosis factor ( TNF ) family , binds to several cell surface receptors with distinct functions ( agonistic receptors 1 and 2 [ TRAIL R 1 , TRAIL R 2 ] ; decoy receptors 3 and 4 [ TRAIL R 3 , TRAIL R 4 ] ) . ^^^ While normal marrow showed negligible expression of TRAIL and receptors ( except TRAIL R 3 ) , TRAIL and all receptors were constitutively expressed in MDS marrow . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We have found TRAIL R 1 and R 2 death receptor , and TRAIL R 3 and R 4 decoy receptor mRNA expression in most of the 57 B CLL patients studied ( R 1 82 % , R 2 100 % , R 3 96 % and R 4 82 % ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Differential expression of TRAIL R 3 and TRAIL R 4 in human pancreatic cancer . ^^^ TRAIL R 3 and TRAIL R 4 , which belong to the TRAIL receptor family , can inhibit TRAIL induced apoptosis . ^^^ RESULTS : TRAIL R 3 mRNA and protein expression were generally weak in pancreatic cancers and normal pancreatic tissues . ^^^ CONCLUSION : TRAIL R 4 but not TRAIL R 3 levels were significantly different in pancreatic cancer in comparison to the normal pancreas . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 3 and TRAIL R 4 are receptors that do not transmit an apoptotic signal . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| It is regulated by 2 death receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 and 2 decoy receptors , TRAIL R 3 and TRAIL R 4 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : For RPE cells derived directly from the eye , we detected mRNAs of Trail R 2 , Trail R 3 , TRAIL , and APO 3 L , but not Trail R 1 , Trail R 4 , and TRAMP . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Low levels of the death inducing TRAIL receptors , TRAIL R 1 and TRAIL R 2 but not the putative ' decoy ' receptors , TRAIL R 3 and TRAIL R 4 , were expressed on the surface of B CLL cells . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL interacts with four receptors : two signalling receptors ( TRAIL R 1 and TRAIL R 2 ) and two decoy receptors ( TRAIL R 3 and TRAIL R 4 ) . ^^^ Microglial cells had high surface expression of the decoy receptor TRAIL R 3 , suggesting that resistance of these glial cells to TRAIL induced death depends on the presence of the protective effect of TRAIL R 3 . ^^^ Stimulation of microglia with TRAIL increased further expression of TRAIL R 3 , but it had no effect on the expression of TRAIL receptors by ahOL . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Transcription initiation sites and promoter structure of the human TRAIL R 3 gene . ^^^ TRAIL R 3 is a decoy receptor for TRAIL ( tumor necrosis factor related apoptosis inducing ligand ) , a member of the tumor necrosis factor ligand family . ^^^ Here we report the cloning of the promoter region of human TRAIL R 3 and the mapping of the transcriptional start sites . ^^^ Transient transfection assays of luciferase reporter plasmids demonstrate that human TRAIL R 3 promoter can be induced in doxorubicin treated MCF 7 cells in a p 53 independent manner . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL receptor ( TRAIL R ) 1 and TRAIL R 2 , but not TRAIL R 3 and TRAIL R 4 , mediate apoptosis . ^^^ In adenomas , this expression pattern was mostly retained , although some adenomas also neoexpressed TRAIL R 3 . ^^^ TRAIL , TRAIL R 2 , TRAIL R 3 , and TRAIL R 4 expression did not correlate statistically with disease free survival ( multivariate analysis : P = 0 . 54 , P = 0 . 67 , P = 0 . 45 , and P = 0 . 69 , respectively ) , but TRAIL R 1 expression was significantly associated with disease free survival in colon cancer ( multivariate analysis : P = 0 . 003 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| However , treatment with an inhibitor of protein synthesis ( cycloheximide ) or with an enzyme ( PI PLC ) that can remove TRAIL R 3 from the islet cell membrane was able to increase the susceptibility of TRAIL resistant primary islet cells to the TRAIL death pathway . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Neither TRAIL R 3 nor R 4 were observed on ductal epithelium . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| We identified the presence of mRNAs for TRAIL , TRAIL R 2 , and TRAIL R 3 , and cell surface expression of TRAIL R 2 and R 3 in neutrophil populations . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : The role of TRAIL / TRAIL Rs in vascular biology was investigated in primary human umbilical vein endothelial cells ( HUVECs ) and aortic endothelial cells , which showed comparable surface expression of death ( TRAIL R 1 and R 2 ) and decoy ( TRAIL R 3 and R 4 ) TRAIL Rs . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 3 and TRAIL R 4 are receptors that do not transmit an apoptotic signal . ^^^ TRAIL R 1 and TRAIL R 3 were not detected in normal pancreas . ^^^ In chronic pancreatitis , the exocrine epithelium strongly expressed TRAIL R 1 , R 2 , R 4 , and , to a lesser extent , TRAIL R 3 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Consistently , both cytokines also induced the degradation of the NF kappaB inhibitors , IkappaBalpha and IkappaB epsilon , and up regulated the surface expression of TRAIL R 3 , a known NF kappaB target . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 3 and R 4 decoy receptors were detected in term amnion and choriodecidual extracts by immunoblotting and were localized by immunohistochemistry to amnion epithelial cells and chorionic trophoblasts . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The decoy receptors TRAIL R 3 and R 4 were barely detected in both cell lines . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| On the other hand , surface TRAIL R 3 and R 4 were not detected at any culture time . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In contrast , RA SF macrophages expressed TRAIL R 3 , a decoy receptor ( P < 0 . 01 versus isotype control ) , but not TRAIL , or TRAIL R 1 , R 2 , or R 4 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) decoy receptor TRAIL R 3 is up regulated by p 53 in breast tumor cells through a mechanism involving an intronic p 53 binding site . ^^^ Tumor necrosis factor related apoptosis inducing ligand receptor 3 ( TRAIL R 3 ) is a decoy receptor for TRAIL , a member of the tumor necrosis factor family . ^^^ We studied the regulation of TRAIL R 3 gene expression in breast tumor cells treated with the genotoxic drug doxorubicin ( DXR ) . ^^^ The breast tumor cell line MCF 7 ( p 53 wild type ) responded to DXR with a marked elevation of TRAIL R 3 expression at the mRNA , total protein , and cell surface levels . ^^^ In contrast , in EVSA T cells ( p 53 mutant ) DXR did not induce increased expression of TRAIL R 3 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : TRAIL R 1 was constitutively expressed on cultured synovial fibroblasts from RA and OA , however , expression of TRAIL R 2 and TRAIL R 3 was not observed by immunohistochemistry and Western blot . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| On activation , both cell types rapidly expressed TRAIL R 2 and TRAIL R 3 , whose expression peaked at day 10 of culture . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Antisera against human TRAIL R 1 , TRAIL R 3 and TRAIL R 4 failed to reveal any other murine TRAIL receptor analogue . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL is unusual as compared to the other cytokines of this family , as it interacts with a complex system of receptors consisting of two pro apoptotic death receptors ( TRAIL R 1 and TRAIL R 2 ) and three decoy receptors ( TRAIL R 3 , TRAIL R 4 and osteoprotegerin ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In patients infected with cagA+ / vacAs1+ H . pylori strains , expression of TRAIL and the proapoptotic receptors TRAIL R 1 and R 2 was down regulated , whereas expression of the antiapoptotic receptors TRAIL R 3 and R 4 was up regulated . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Increased TRAIL sensitivity during colorectal carcinogenesis has been previously attributed to changes in the balance between TRAIL receptors TRAIL R 1 and R 2 and `` decoy ' ' receptors TRAIL R 3 and R 4 during malignant progression . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In addition , RPA revealed that the ratio of ( TRAIL R 1 plus TRAIL R 2 ) to TRAIL R 3 was also increased after IFN alpha stimulation . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| On the other hand , `` death receptor ' ' TRAIL R 1 , `` decoy receptors ' ' TRAIL R 3 , and TRAIL R 4 were barely detectable or undetectable at any time point examined . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In addition , conventional flow cytometry analysis demonstrated that TRAIL resistant MCF 7 cells exhibited substantial levels of TRAIL R 4 expression but not TRAIL decoy receptor 3 ( TRAIL R 3 ) on surface . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 1 is distinctively expressed on B lymphocytes , TRAIL R 2 on monocytes , TRAIL R 3 on neutrophils and most impressively , CD8+ lymphocytes and NKT lymphocytes but not CD4+ lymphocytes express TRAIL R4 . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The `` decoy receptors ' ' TRAIL R 3 ( TR 3 ) and TRAIL R 4 ( TR 4 ) were believed to negatively regulate TRAIL induced cytotoxicity by competing for ligand binding with TRAIL R 1 ( TR 1 ) and TRAIL R 2 ( TR 2 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| In this report we describe the identification of two additional human TRAIL receptors , TRAIL receptor 2 and TRAIL receptor 3 , that belong to the tumor necrosis factor receptor family . ^^^ Interestingly , TRAIL receptor 2 but not TRAIL receptor 3 contains a cytoplasmic `` death domain ' ' necessary for induction of apoptosis and is hence designated death receptor 5 ( DR 5 ) . ^^^ Because of its lack of a death domain , TRAIL receptor 3 is not capable of inducing apoptosis . ^^^ Thus , TRAIL receptor 3 may function as an antagonistic decoy receptor to attenuate the cytotoxic effect of TRAIL in most tissues that are TRAIL+ , DR4+ , and DR5+ . . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Thus , 4 1BB ligand ( L ) , APRIL , CD27L , CD40L , FasL , LIGHT , TRAIL receptor 4 were upregulated , while TRAIL receptor 3 was downregulated . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| DR 4 , DR 5 , or TRID expression did not correlate with sensitivity to TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL binds to the proapoptotic death receptors DR 4 and the p 53 regulated proapoptotic KILLER / DR5 as well as to the decoy receptors TRID and TRUNDD . ^^^ The expression level of KILLER / DR5 , TRID , TRUNDD or TRID , and TRUNDD did not correlate with TRAIL sensitivity ( P > 0 . 05 ) . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The family of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors , including the pro apoptotic DR 4 and p 53 regulated KILLER / DR5 , as well as the decoys TRID and TRUNDD , are all located on human chromosome 8p21 22 . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL triggers apoptosis by binding to its two proapoptotic receptors DR 4 and DR 5 , a process which is negatively regulated by binding of TRAIL to its two decoy receptors TRID and TRUNDD . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| Abnormalities of various components of these pathways have been identified in human cancer including loss of FAS expression , deletion or loss of TRAIL receptor DR 4 , mutation of TRAIL receptor DR 5 , overexpression of TRAIL decoy TRID or overexpression of Fas decoy , as well as overexpression of the caspase activation inhibitor , FLIP . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| The expression of TRAIL receptor 3 was significantly lower in SLE patients with neutropenia than in patients without neutropenia or in healthy volunteers . ^^^ Treatment with glucocorticoids negated the decrease of TRAIL receptor 3 expression on neutrophils of SLE patients . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| An antagonist decoy receptor ( designated as TRID for TRAIL receptor without an intracellular domain ) that may explain the resistant phenotype of normal tissues was identified . ^^^ TRID is a distinct gene product with an extracellular TRAIL binding domain and a transmembrane domain but no intracellular signaling domain . ^^^ Ectopic expression of TRID protected mammalian cells from TRAIL induced apoptosis , which is consistent with a protective role . ^^^ |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14798 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|