| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.57751211 |
| Despite the fact that TRAIL binds osteoprotegerin and osteoprotegerin transgenic mice are osteopetrotic , TRAIL / Apo2L ( / ) mice show no evidence of altered gross bone density , and no alterations in frequency or in vitro differentiation of bone marrow precursor osteoclasts . 0.57751211^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL . ^^^ We have identified a fifth TRAIL receptor , namely osteoprotegerin ( OPG ) , a secreted tumor necrosis factor receptor homologue that inhibits osteoclastogenesis and increases bone density in vivo . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Indeed , one of the receptors for TRAIL , osteoprotegerin ( OPG ) is a soluble protein whose activities so far have been shown to be inhibition of osteoclastogenesis and increased bone density in vivo . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| This may indicate the presence of inhibitors within the cells , but resistance to apoptosis could not be correlated with expression of the caspase inhibitor FLICE inhibitory protein . mRNA for another TRAIL receptor , osteoprotegerin , was expressed in 22 of the melanoma lines but not on melanocytes . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| In addition , we investigated expression of the ODF receptor on osteoclast precursors , RANK , as well as the ODF inhibitor osteoprotegerin ( OPG ) , and another TNF ligand superfamily member , TRAIL , previously shown to abrogate the inhibitory effects of OPG . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Maintenance of specific prosurvival signals at baseline may be a feature of lung MVEC resistance in TTP as suggested by higher expression than skin EC of the TRAIL antagonist , osteoprotegerin , and the vascular endothelial growth factors , VEGF / VPF and VEGF C , and their receptors , VEGFR 2 ( KDR ) and VEGFR 3 ( Flt 4 ) . . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Variable expression of the two decoy ( TRAIL R 3 and R 4 ) and soluble ( osteoprotegerin ) receptors was seen and this did not correlate with TRAIL resistance . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The expression of TRAIL and its receptors other than osteoprotegerin was found frequently in both PDC and normal tissues . whereas the expression of osteoprotegerin was detected only in PDC . ^^^ CONCLUSION : These findings suggest a relation between osteoprotegerin expression and the biologic aggressiveness of PDC and the involvement of caspase 8 and caspase 3 activation in the TRAIL mediated apoptosis pathway in PDC . . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) is a decoy receptor for tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) that inhibits TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Although , mRNA for the RANKL decoy receptor , osteoprotegerin , was also up regulated by activated T cell conditioned medium , it ' s inhibitory effects may be mitigated by a simultaneous rise in the osteoprotegerin competitor TNF related apoptosis inducing ligand . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL R 2 , R 3 , R 4 and osteoprotegerin ( OPG ) expression did not correlate with TRAIL sensitivity . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| We have studied TNF related apoptosis inducing ligand ( TRAIL ) and its membrane bound ( R 1 R4 ) and soluble receptors [ osteoprotegerin ( OPG ) ] in gestational membranes to assess their significance in preterm parturition and premature rupture of membranes ( PROM ) . ^^^ Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) , TRAIL receptors , and the soluble receptor osteoprotegerin in human gestational membranes and amniotic fluid during pregnancy and labor at term and preterm . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Decoy receptors expressed included a novel soluble form of TNFRSF 25 ( formerly DR 3 or Apo 3 ) , implicated in rheumatoid arthritis linkage studies , as well as osteoprotegerin , a well characterized osteoblast protein that binds TRAIL and RANKL , and DcR 2 , which binds TRAIL . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To observe the regulative effects of 17 beta estradiol ( 17 beta E ( 2 ) ) and ICI 182780 on the expression of osteoprotegerin ( OPG ) , the ligand of osteoprotegerin ( OPGL ) and the related cytokines [ macrophage colony stimulating factor ( M CSF ) , TRAIL and transforming growth factor beta ( TGF beta ) ] in MG 63 cells . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) is a survival factor that exerts its effect by binding to tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) , thus preventing TRAIL from binding to the apoptosis receptors DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) acts as an endogenous decoy receptor in tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) mediated apoptosis of fibroblast like synovial cells . ^^^ We examined the role of osteoprotegerin ( OPG ) on tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) induced apoptosis in rheumatoid fibroblast like synovial cells ( FLS ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| We found up regulated production of RANKL , osteoprotegerin ( OPG ) , and TNF related apoptosis inducing ligand ( TRAIL ) by fresh MM T cells . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) is a molecule involved in bone remodeling , where it acts as an inhibitor of osteoclastogenesis , but it is also a decoy receptor for TRAIL / Apo 2L , a member of the TNF family of pro apoptotic cytokines . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) is a soluble decoy receptor for TRAIL , and circulating OPG has been implicated in the protection of cells from TRAIL mediated apoptosis . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Apo2L / TRAIL is a homotrimeric protein that interacts with five receptors : death receptor 4 ( DR 4 ) and DR 5 mediate apoptosis activation , whereas decoy receptor 1 ( DcR 1 ) , DcR 2 , and osteoprotegerin counteract this function . ^^^ Apo2L / TRAIL is a homotrimeric protein that interacts with five receptors : death receptor 4 ( DR 4 ) and DR 5 mediate apoptosis activation , whereas decoy receptor 1 ( DcR 1 ) , DcR 2 , and osteoprotegerin counteract this function . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) produced by bone marrow stromal cells protects breast cancer cells from TRAIL induced apoptosis . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL is unusual as compared to the other cytokines of this family , as it interacts with a complex system of receptors consisting of two pro apoptotic death receptors ( TRAIL R 1 and TRAIL R 2 ) and three decoy receptors ( TRAIL R 3 , TRAIL R 4 and osteoprotegerin ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) levels in atherosclerosis . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| These cells also expressed osteoprotegerin ( OPG ) , an inhibitor of osteoclastogenesis , and TRAIL , a receptor that binds OPG . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| In addition to its role in bone turnover , osteoprotegerin ( OPG ) has been reported to bind to and inhibit Tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Five distinct receptors have been described for TRAIL : TRAIL R 1 ( DR 4 ) , TRAIL R 2 ( DR 5 , TRICK ) , TRAIL R 3 ( TRID , DcR 1 ) , TRAIL R 4 ( TRUNDD , DcR 2 ) , and osteoprotegerin . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| On the other hand , TRAIL did not significantly modulate the levels of osteoprotegerin ( OPG ) , CXCL8 / IL 8 , CXCL9 / MIG , and CXCL10 / IP10 spontaneously released or induced by inflammatory cytokines . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Recent reports have suggested that osteoprotegerin ( OPG ) is involved in the control of endothelial cell survival through the inhibition of the activity of tumour necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| TNF related apoptosis inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy . ^^^ We assessed expression of TNF related apoptosis inducing ligand ( TRAIL ) and its decoy receptor osteoprotegerin ( OPG ) in men with nonischemic DCM , who underwent coronary angiography and endomyocardial biopsy ( EMB ) after exclusion of coronary artery disease compared to control patients . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Expression of osteoprotegerin ( OPG ) , TNF related apoptosis inducing ligand ( TRAIL ) , and receptor activator of nuclear factor kappaB ligand ( RANKL ) in human breast tumours . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Besides killing of osteoblasts , myeloma cell lines sensitized osteoblasts to cell death mediated by recombinant TRAIL , whereas primary osteoblasts protected myeloma cells from TRAIL mediated apoptosis that was mediated by osteoprotegerin ( OPG ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Expression of receptor activator of nuclear factor kappabeta ligand ( RANKL ) and tumour necrosis factor related , apoptosis inducing ligand ( TRAIL ) in breast cancer , and their relations with osteoprotegerin , oestrogen receptor , and clinicopathological variables . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : As advanced prostate cancers are resistant to currently available chemotherapies , we evaluated the cytotoxic effect of TNF related apoptosis inducing ligand ( TRAIL ) and characterized the involvement of its five receptors DR 4 , DR 5 , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) and of the death inducing signaling complex ( DISC ) forming proteins caspase 8 and c FLIP in prostate cell lines . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL can also bind to decoy receptors ( DcR 1 , DcR 2 , and osteoprotegerin receptor ) that can not induce apoptosis . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| TRAIL is a member of the tumor necrosis factor superfamily that interacts with an unusually complex receptor system , comprising transmembrane ( TRAIL R 1 , R 2 , R 3 and R 4 ) and soluble ( osteoprotegerin ) receptors . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Despite high osteoprotegerin ( OPG ) levels , the persistence of osteoclastogenesis can be related to the formation of the OPG / TRAIL complex . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| TL 2 , TR 1 , TR 2 and TR 3 were recently described by others as TRAIL / Apo 2L , OPG , HVEM and DR3 / WSL 1 / Apo 3 / TRAMP / LARD , respectively . . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| OPG can be neutralized by another TNF family member , the TNF related apoptosis inducing ligand ( TRAIL ) , suggesting that TRANCE is part of a complex cytokine network that regulates a diverse set of functions . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| In addition , TRAIL also binds to 3 `` decoy ' ' receptors , DcR 2 , a receptor with a truncated death domain , DcR 1 , a glycosylphosphatidylinositol anchored receptor , and OPG a secreted protein which is also known to bind to another member of the TNF family , RANKL . ^^^ Although DR 4 , DR 5 , DcR 1 , and OPG show similar affinities for TRAIL at 4 degrees C , their rank ordered affinities are substantially different at 37 degrees C , with DR 5 having the highest affinity ( K ( D ) < / = 2 nm ) and OPG having the weakest ( K ( D ) = 400 nm ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| However , OPG also blocks TRAIL and may not be sufficiently specific in long term therapy , but it is hoped that inhibitors of the interaction of TRANCE and its specific signalling receptor , RANK , can be rationally designed . . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| However , OPG can block tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) mediated apoptosis , suggesting that the clinical use of OPG may prevent apoptosis of tumors mediated by TRAIL . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| OPG , released by osteoblasts and other stromal cells , can act as a decoy receptor for TRAIL , thereby blocking its apoptosis inducing activity . ^^^ MM cells inhibit OPG release by stromal cells , thereby promoting osteoclast activation and lytic bone disease ( by enhancing RANKL availability ) while at the same time exposing themselves to higher levels of ambient TRAIL . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments indicated that OPG formed a complex with tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) in HMECs under these conditions . ^^^ This evidence indicates that OPG blocks endothelial cell apoptosis through binding TRAIL and preventing its interaction with death inducing TRAIL receptors . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Of note , TNF related apoptosis inducing ligand , an inducer of apoptosis that is also blocked by OPG , displayed a similar spatial distribution as OPG . ^^^ In summary , we demonstrate enhanced apoptosis adjacent to vascular calcification , and the concurrent expression of regulators of apoptosis and osteoclastic differentiation , TNF related apoptosis inducing ligand and OPG , suggesting their involvement in the pathogenesis of vascular calcification . . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Also , OPG is a soluble decoy receptor for tumor necrosis factor related apoptosis inducing factor ( TRAIL ) . ^^^ The effect of OPG secretion on TRAIL mediated apoptosis was also investigated . ^^^ When RANKL , which selectively binds OPG , was added to cell cultures along with recombinant TRAIL , apoptosis was shown to increase significantly . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Here we report the generation of monoclonal antibodies against TRAIL and its four membrane bound receptors ( TR 1 4 ) , which have been used to stain a range of normal and malignant cells , as routinely fixed specimens . ^^^ TR 1 and TR 2 expression increases significantly in a number of malignant tissues , but in some common malignancies their expression was low , or patchy , which may limit the therapeutic role of TRAIL . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| The `` decoy receptors ' ' TRAIL R 3 ( TR 3 ) and TRAIL R 4 ( TR 4 ) were believed to negatively regulate TRAIL induced cytotoxicity by competing for ligand binding with TRAIL R 1 ( TR 1 ) and TRAIL R 2 ( TR 2 ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| The discovery that OPG can bind to and inhibit the activity of TRAIL ( TNF related apoptosis inducing ligand ) triggered extensive research into the potential role of OPG in the regulation of tumour cell survival . ^^^ A number of reports from studies using in vitro models have shown that OPG protects tumour cells from the effects of TRAIL , thereby possibly providing tumour cells that produce OPG with a survival advantage . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| Affected receptors include Fas , TRAIL ( TNF related apoptosis inducing ligand ) receptor 1 ( TR 1 ) , TR 2 , and epidermal growth factor receptor ( EGFR ) . ^^^ |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00300 and P50591 |
Pubmed |
SVM Score :0.0 |
| NA |
|