| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :1.348424 |
| Interaction assays in yeast and in vitro demonstrate that MATH4A interacts efficiently with both MASH 1 and the ubiquitous bHLH protein E 12 . 1.348424^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Moreover , BMP 2 fails to prevent expression of the sensory specific basic helix loop helix ( bHLH ) transcription factors neurogenin 1 , neurogenin 2 and neuroD , although it induces expression of the autonomic specific bHLH factor MASH 1 and the paired homeodomain factor Phox2a in other cells . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Neurogenin 1 ( Ngn 1 ) , Neurogenin 2 ( Ngn 2 ) , and Mash 1 encode bHLH transcription factors with neuronal determination functions . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Our more detailed analysis showed no abnormality in the spatial restriction of expression of Sox 2 , Sox 11 , Mash 1 , neurogenin 1 or neurogenin 2 , although the level of expression of Sox 11 and Mash 1 appeared a little different from the wild type , implying that Sox 4 might indeed have a functional role in CNS development . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| We have addressed the role of the proneural bHLH genes Neurogenin 2 ( Ngn 2 ) and Mash 1 in the selection of neuronal and glial fates by neural stem cells . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| In the vertebrate peripheral nervous system , the proneural genes neurogenin 1 and neurogenin 2 ( Ngn 1 and Ngn 2 ) , and Mash 1 are required for sensory and autonomic neurogenesis , respectively . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| A number of bHLH genes are expressed in the developing cerebral cortex , including MASH 1 , neurogenin 2 and NeuroD implying the existence of a regulatory and possibly redundant network of family members . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors ( Mash 1 , Neurogenin 1 , and Neurogenin 2 ) and a decrease in the activity of Hes and Id factors . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| This approach yielded a group of cells from the small intestine of lactating and adult mice , which ex vivo attach to the culture dish ; actively proliferate ; and express nestin , vimentin , and the pro neural transcription factors neurogenin 2 ( ngn 2 ) , Sox 10 , and Mash 1 . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Neurogenin 2 ( Ngn 2 ) and Mash 1 are expressed in the ventral midline , while Ngn 1 , Ngn 2 and Mash 1 are co localized more laterally in the ventricular zone . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Shortly after cocultivation with rat neurons , nearly all the MOMC expressed early neuroectodermal markers , Mash 1 , Neurogenin 2 and NeuroD , together with nestin , an intermediate filament expressed in neurogenesis . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Such LHRH cells expressed nestin mRNA but not Mash 1 mRNA and were also negative for three other olfactory epithelial developmental transcription factors , Math4A , Math4C / neurogenin1 , and NeuroD mRNA . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| During retinogenesis , Math 5 is expressed significantly before NeuroD , Ngn 2 or Mash 1 . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| To investigate the role ( s ) of basic helix loop helix genes ( bHLH ) genes in the developing murine cerebral cortex , Mash 1 , Math 2 , Math 3 , Neurogenin 1 ( Ngn 1 ) , Ngn 2 , NeuroD , NeuroD 2 and Id 1 were transduced in vivo into the embryonic and postnatal cerebral cortex using retrovirus vectors . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Adult and embryonic progenitors commonly expressed various homeodomain type ( Pax 6 , Pax 7 , Nkx2 . 2 , and Prox 1 ) and basic helix loop helix ( bHLH ) type ( Ngn 2 , Mash 1 , NeuroD 1 , and Olig 2 ) transcriptional regulatory factors in vitro . ^^^ However , neither the expression of the neurogenic bHLH factors including Ngn 2 , Mash 1 , and NeuroD 1 nor subsequent generation of new neurons could be detected in injured tissue . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Divergent functions of the proneural genes Mash 1 and Ngn 2 in the specification of neuronal subtype identity . ^^^ The neural bHLH genes Mash 1 and Ngn 2 are expressed in complementary populations of neural progenitors in the central and peripheral nervous systems . ^^^ Here , we have systematically compared the activities of the two genes during neural development by generating replacement mutations in mice in which the coding sequences of Mash 1 and Ngn 2 were swapped . ^^^ Using this approach , we demonstrate that Mash 1 has the capacity to respecify the identity of neuronal populations normally derived from Ngn 2 expressing progenitors in the dorsal telencephalon and ventral spinal cord . ^^^ In contrast , misexpression of Ngn 2 in Mash 1 expressing progenitors does not result in any overt change in neuronal phenotype . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| It upregulates the expression of proneural genes ( Ngn 2 ) when expressed alone and upregulates the expression of Mash 1 when expressed in combination with Nkx2 . 2 . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| In the retina lacking the bHLH genes Mash 1 , Ngn 2 , and Math 3 , horizontal and other neurons were severely decreased , whereas ganglion cells were increased . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Inactivation of beta catenin in the telencephalon before neurogenesis results in downregulated expression of dorsal markers Emx 1 , Emx 2 and Ngn 2 , and in ectopic up regulation of ventral markers Gsh 2 , Mash 1 and Dlx 2 in the pallium . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Sequential roles for Mash 1 and Ngn 2 in the generation of dorsal spinal cord interneurons . ^^^ The bHLH transcription factors Mash 1 and Ngn 2 have distinct roles in specification of these neurons . ^^^ In the absence of Ngn 2 , there is an increase in the number of dI 3 and dI 5 neurons , in contrast to the effects produced by activity of Mash 1 . ^^^ Mash 1 is epistatic to Ngn 2 , and , unlike the relationship between other neural bHLH factors , cross repression of expression is not detected . ^^^ Thus , bHLH factors , particularly Mash 1 and related family members Math 1 and Ngn 1 , provide a code for generating neuronal diversity in the dorsal spinal cord with Ngn 2 serving to modulate the number of neurons in each population formed . . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| The results obtained from quantitative gene expression analysis of region specific genes ( Emx 1 , Lhx 2 , Ngn 1 , Ngn 2 , Pax 6 , Dlx 2 , Gsh 2 , Mash 1 , and Nkx2 . 1 ) , using real time polymerase chain reaction indicate that FACS of GM 1 expressing cells in the fetal forebrain enriches for the medial pallial neural progenitor cells . . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Although none of the neurogenic factors , such as Pax 6 , Mash 1 , Ngn 2 , was detected in the injured parenchyma , we observed a strong up regulation of the bHLH transcription factor Olig 2 , but not Olig 1 , upon acute and chronic injury . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| These defects are due to a failure of neurogenesis and apoptosis , a defect that can be rescued by ectopic Ngn 2 under the control of the Mash 1 promoter . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| Our data indicate that Otx 2 may prevent GABAergic fate switch by repressing the basic helix loop helix gene Mash 1 ( mammalian achaete schute homolog ) in progenitors expressing Ngn 2 ( neurogenin homolog ) . ^^^ |
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| Interacting proteins: Q9H2A3 and P50553 |
Pubmed |
SVM Score :0.0 |
| We showed previously that the proneural genes Neurogenin 1 ( Ngn 1 ) and Ngn 2 are required to specify the phenotypes of early and not late born neurons in the neocortex , acting in part through repression of Mash 1 , a third cortically expressed proneural gene . ^^^ Here we reveal that Ngn 2 and Mash 1 are expressed in a dynamic fashion , acquiring a cell cycle biased , nonoverlapping distribution , with preferential expression in prospective basal progenitors , during mid corticogenesis . ^^^ Notably , Ngn 2 regulates progenitor maturation at least in part through repression of Mash 1 as misexpression of Mash 1 strongly enhanced progenitor cell exit from the VZ . ^^^ Taken together , these data support a model whereby Ngn 2 and Mash 1 function together to regulate the zonal distribution of progenitors in the developing neocortex . . ^^^ |
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