| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.70083712 |
| Here , we report that VASP also directly binds to vinculin , another component of adherens junctions . 0.70083712^^^ The same motif is present in zyxin but the interactions of VASP with vinculin and zyxin differ in detail . 0.69055693^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.50980672 |
| VASP binds to the focal adhesion proteins vinculin and zyxin and this probably directs the phosphoprotein to focal adhesions and the leading edge of stimulated cells . 0.50980672^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| The focal adhesion vasodilator stimulated phosphoprotein ( VASP ) binds to the proline rich domain in vinculin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Reports on the role of vasodilator stimulated phosphoprotein ( VASP ) and proline rich sequences in actin based motility of Listeria and potentially of Shigella flexneri have led to the suggestion that vinculin might be an essential docking protein on the surface O 2 motile Shigella . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| A chimera comprising the full length vinculin clone recruited a substantial amount of the cellular F actin , the vasodilator stimulated phosphoprotein ( VASP ) and paxillin , but little alpha actinin and talin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Recently , the vasodilator stimulated phosphoprotein ( VASP ) , a substrate of cyclic AMP dependent or cyclic GMP dependent kinases and a component of focal adhesion sites , was shown to bind to vinculin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| To date , several actin cytoskeleton associated proteins have been implicated in the motility of Listeria or Shigella : vasodilator stimulated phosphoprotein ( VASP ) , vinculin and the actin related protein complex of Arp 2 and Arp 3 [ 4 ] [ 5 ] [ 6 ] [ 7 ] . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| The actin based motilities of L . monocytogenes and S . flexneri are known to require the bacterial proteins ActA and IcsA , respectively , and several mammalian cytoskeleton proteins including the Arp2 / 3 complex and VASP ( vasodilator stimulated phosphoprotein ) for L . monocytogenes and vinculin and N WASP ( the neural Wiskott Aldrich syndrome protein ) for S . flexneri . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| By indirect immunofluorescence , both R . rickettsii and Listeria monocytogenes actin tails were shown to contain the cytoskeletal proteins vasodilator stimulated phosphoprotein profilin , vinculin , and filamin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Zyxin is not colocalized with vasodilator stimulated phosphoprotein ( VASP ) at lamellipodial tips and exhibits different dynamics to vinculin , paxillin , and VASP in focal adhesions . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| WASP WA and Scar WA ( which incorporate the actin and Arp2 / 3 binding regions of WASP and Scar 1 ) , to compete with endogenous WASP family members ; ( 2 ) . proline rich motifs ( PRM ) from the ActA protein of L . monocytogenes or from vinculin , which bind vasodilator stimulated phosphoprotein ( VASP ) , a regulator of cytoskeleton assembly . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| By using green fluorescent protein ( GFP ) fusion constructs , the recruitment of the Arp2 / 3 complex , vasodilator stimulated phosphoprotein ( VASP ) , Neural Wiskott Aldrich syndrome protein ( N WASP ) , zyxin , vinculin , paxillin and alpha actinin to the surface of B . pseudomallei and into corresponding actin tails was studied . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Vinculin did not colocalize with VASP on motile virions and remained in focal adhesion contacts ; however , another ABM 1 containing host protein , zyxin , was concentrated at the rear of motile virions . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| In addition , vinculin contains a binding site for VASP ( vasodilator stimulated phospho protein ) , a protein which may serve to recruit a profilin / G actin complex to talin , which has actin nucleating activity . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| VASP , which is expressed in most cell types and in particularly high levels in human platelets , binds to profilin , zyxin , vinculin , F actin , and the Listeria monocytogenes surface protein ActA . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Opposing cell surfaces are clamped by desmosomes , while vinculin , zyxin , VASP , and Mena are recruited to adhesion zippers by a mechanism that requires alpha catenin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Like V12rac , expression of the E1A hypertransforming mutant resulted in the upregulation of vinculin and VASP , concomitant with the altered organization of the actin cytoskeleton in these cells . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| In contrast , phosphorylation had no significant effect on VASP oligomerization or its interaction with its known ligands profilin , vinculin , and zyxin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| We propose that this epitope , which is absent in the sequences of the native EVH 1 interaction partners zyxin and vinculin , may provide the pathogen with an advantage when competing for the recruitment of the host VASP and Mena proteins in the infected cell . . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| We quantitatively determined the amounts of laminin , fibronectin , vitronectin , and thrombospondin secreted by these glioma cell lines in vitro , as well as the amount of each of the eight beta integrin subunits and the adhesion complex related molecules , including talin , vinculin , profilin , zyxin , alpha actinin , paxillin , and VASP . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| During leukocyte adhesion in static or under flow conditions , VCAM 1 , ICAM 1 , and activated moesin and ezrin clustered in an endothelial actin rich docking structure that anchored and partially embraced the leukocyte containing other cytoskeletal components such as alpha actinin , vinculin , and VASP . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| However , using RNAi ablation , we demonstrate that zyxin is required to recruit Tes , as well as Mena and VASP , but not vinculin or paxillin , to focal adhesions . . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Ena VASP proteins share an identical domain organization with an NH 2 terminal Ena VASP homology ( EVH 1 ) domain , which mediates the binding of these proteins to FPPPP motif containing partners such as zyxin and vinculin . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| V12rac1 alters the expression and localization of the actin regulating proteins vinculin and VASP , which results in the loss of stable F actin structures and actin based differentiation characteristics . ^^^ In the presence of N17rac1 , VASP was downregulated and vinculin and F actin colocalization restored . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| VASP binds both profilin , an actin monomer binding protein , and vinculin , a component of intercellular contacts that also binds the Shigella actin assembly protein IcsA . ^^^ It has been postulated that VASP might serve as a linker between vinculin and profilin on intracellular Shigella , thereby delivering profilin to the Shigella actin assembly machinery . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| Vinculin , VASP , and profilin are coordinately regulated during actin remodeling in epithelial cells , which requires de novo protein synthesis and protein kinase signal transduction pathways . ^^^ To identify the underlying mechanism of formation of the adhesion dependent , circumferential actin network , the expression and localization of the actin binding and regulating proteins ( ABPs ) , vinculin , VASP , and profilin were evaluated . ^^^ Experimental depolarization of epithelial cells results in the loss of normal F actin structures and the transient upregulation of vinculin , VASP , and profilin . ^^^ Constitutive expression of VASP results in altered cell morphology and adhesion and F actin and vinculin structures . ^^^ Thus , vinculin , VASP , and profilin are coordinately regulated by signal transduction pathways that effect a translational response . ^^^ |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P50552 and P18206 |
Pubmed |
SVM Score :0.0 |
| NA |
|