| Interacting proteins: P50548 and P29323 |
Pubmed |
SVM Score :0.0 |
| Treatment with the Erk kinase inhibitor PD 98058 further enhanced the erythroid phenotype in ERF expressing cells and cells expressing a non phosphorylatable ERF mutant exhibited an even more enhanced phenotype . ^^^ |
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| Interacting proteins: P50548 and P29323 |
Pubmed |
SVM Score :0.0 |
| ERF nuclear shuttling , a continuous monitor of Erk activity that links it to cell cycle progression . ^^^ The ets domain transcriptional repressor ERF is an effector of the receptor tyrosine kinase / Ras / Erk pathway , which , it has been suggested , is regulated by subcellular localization as a result of Erk dependent phosphorylation and is capable of suppressing cell proliferation and ras induced tumorigenicity . ^^^ Here , we analyze the effect of ERF phosphorylation on nuclear import and export , the timing of its phosphorylation and dephosphorylation in relation to its subcellular location , Erk activity , and the requirements for ERF induced cell cycle arrest . ^^^ ERF phosphorylation and export correlate with the levels of nuclear Erk activity . ^^^ These data suggest that ERF may be a very sensitive and constant sensor of Erk activity that can affect cell cycle progression through G ( 1 ) , providing another link between the Ras / Erk pathway and cellular proliferation . . ^^^ |
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| Interacting proteins: P50548 and P29323 |
Pubmed |
SVM Score :0.0 |
| Here , we show that active and inactive Erk 2 proteins bind ERF with high affinity through a hydrophobic pocket formed by the alphaF and alphaG helices and the activation loop of Erk 2 . ^^^ Expression of ERF regions harboring these motifs could inhibit Erk activity in cells . ^^^ |
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| Interacting proteins: P50548 and P29323 |
Pubmed |
SVM Score :0.0 |
| NA |
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