| YT 521 B joins a growing list of candidates for a role in a gene expression model of the pathogenesis of EDMD . . ^^^ Emerin interacts in vitro with the splicing associated factor , YT 521 B . ^^^ Specific binding between emerin and the functional C terminal domain of YT 521 B was confirmed by pull down assays and biomolecular interaction analysis ( BIAcore ) . ^^^ Inhibition by emerin of YT 521 B dependent splice site selection in vivo suggests that the interaction is physiologically significant . ^^^ A ' bipartite ' binding site for YT 521 B in emerin was identified using alanine substitution or disease associated mutations in emerin . ^^^ |