| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :1.123096 |
| We show that emerin binds directly to barrier to autointegration factor ( BAF ) , a DNA bridging protein , and that this binding to BAF requires conserved residues in the LEM motif of emerin . 1.123096^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.59820808 |
| The function of MAN 1 is unknown , whereas emerin is known to interact with nuclear lamins , barrier to autointegration factor ( BAF ) , nesprin 1 alpha , and a transcription repressor . 0.59820808^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.65763904 |
| Barrier to autointegration factor ( BAF ) , the LEM ( LAP , emerin , MAN ) binding partner of emerin , was required for the association of viral cDNA with emerin and for the ability of emerin to support virus infection . 0.65763904^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.90862175 |
| Importantly , BAF competed with GCL for binding to emerin in vitro , predicting that emerin can form at least two distinct types of complexes in vivo . 0.90862175^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.63291939 |
| Dynamic interaction between BAF and emerin revealed by FRAP , FLIP , and FRET analyses in living HeLa cells . 0.63291939^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.68113007 |
| BAF , however , competes with GCL for binding to emerin in vitro . 0.68113007^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| Barrier to autointegration factor ( BAF ) , a protein that binds nonspecifically to double stranded DNA in vitro , co localized with emerin at the ' core ' region of chromosomes during telophase . ^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| It is believed that emerin is part of a novel nuclear protein complex consisting of the barrier to autointegration factor ( BAF ) , the nuclear lamina , nuclear actin and other associated proteins . ^^^ |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| LAP2alpha contains a LEM ( LAP 2 , emerin , and MAN 1 ) domain in the constant N terminus that binds to chromosomal barrier to autointegration factor , and a C terminal unique region that is essential for chromosome binding . ^^^ |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| Direct binding of nuclear membrane protein MAN 1 to emerin in vitro and two modes of binding to barrier to autointegration factor . ^^^ |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| Dissociation of emerin from barrier to autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell free system . ^^^ It was shown that emerin dissociates from chromatin depending on mitotic phosphorylation of the former , and this plays a critical role in the dissociation of emerin from barrier to autointegration factor ( BAF ) . ^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| Barrier to autointegration factor phosphorylation on Ser 4 regulates emerin binding to lamin A in vitro and emerin localization in vivo . ^^^ |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| BAF binds directly to LEM ( LAP 2 , emerin , MAN 1 ) domain nuclear membrane proteins , including LAP 2 and emerin . ^^^ We used site directed mutagenesis and biochemical analysis to map functionally important residues in human BAF , including those required for direct binding to DNA or emerin . ^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| The C . elegans genome encodes a single lamin protein ( Ce lamin ) , three LEM domain proteins ( Ce emerin , Ce MAN 1 and LEM 3 ) and a single BAF protein ( Ce BAF ) . ^^^ Ce emerin and Ce MAN 1 are both embedded in the inner nuclear membrane , and both bind Ce lamin and Ce BAF ; in addition , both require Ce lamin for their localization . ^^^ These findings suggest that lamin , LEM domain proteins and BAF are part of a lamina network essential for chromatin organization and cell division , and that Ce emerin and Ce MAN 1 share at least one and possibly multiple overlapping functions , which may be relevant to Emery Dreifuss muscular dystrophy . . ^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| BAF forms stable dimers that bind nonspecifically to dsDNA and specifically to LEM domain proteins ( e . g . , LAP2beta , emerin , MAN 1 ) , homeodomain transcription factors , histones , and lamin A . ^^^ BAF L does not bind significantly to DNA , LAP2beta , or emerin but can form ternary complexes in vitro with BAF plus DNA , or BAF plus LAP2beta . ^^^ BAF L mRNA was detectable at low levels in eleven other tissues and undetectable in heart and skeletal muscle which are specifically affected by Emery Dreifuss muscular dystrophy , a disease caused by mutations in either emerin or lamin A . ^^^ |
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| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| Recently , five residues in human emerin were identified as undergoing cell cycle dependent phosphorylation using a Xenopus egg mitotic cytosol model system ( Hirano et al . ( 2005 ) Dissociation of emerin from BAF is regulated through mitotic phosphorylation of emerin in a Xenopus egg cell free system . ^^^ |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75531 and P50402 |
Pubmed |
SVM Score :0.0 |
| NA |
|