| Interacting proteins: Q9Y2W7 and P49810 |
Pubmed |
SVM Score :0.55740056 |
| Calsenilin , a calcium binding protein that has been shown to interact with the C termini of both presenilin 1 ( PS 1 ) and presenilin 2 ( PS 2 ) , appears to play a role in transcriptional regulation and apoptosis and to bind to A type voltage gated potassium channels . 0.55740056^^^ |
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| Interacting proteins: Q9Y2W7 and P49810 |
Pubmed |
SVM Score :0.0 |
| Using this PS 2 domain in the yeast two hybrid system , we have identified a neuronal protein that binds calcium and presenilin , which we call calsenilin . ^^^ Calsenilin interacts with both PS 1 and PS 2 in cultured cells , and can regulate the levels of a proteolytic product of PS 2 . ^^^ |
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| Interacting proteins: Q9Y2W7 and P49810 |
Pubmed |
SVM Score :0.0 |
| Although the molecular mechanisms underlying these changes are not known , one candidate molecular mediator is calsenilin , a recently identified calcium binding protein that associates with the C terminus of both PS 1 and PS 2 . ^^^ |
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| Interacting proteins: Q9Y2W7 and P49810 |
Pubmed |
SVM Score :0.0 |
| Calsenilin is a substrate for caspase 3 that preferentially interacts with the familial Alzheimer ' s disease associated C terminal fragment of presenilin 2 . ^^^ Calsenilin is a member of the recoverin family of neuronal calcium binding proteins that we have previously shown to interact with presenilin 1 ( PS 1 ) and presenilin 2 ( PS 2 ) holoproteins . ^^^ The expression of calsenilin can regulate the levels of a proteolytic product of PS 2 ( Buxbaum , J . ^^^ Here , we have used cultured mammalian cells that transiently or stably express calsenilin to extend the characterization of calsenilin and of the calsenilin PS 2 interaction . ^^^ We have found that calsenilin has the ability to interact with endogenous 25 kDa C terminal fragment ( CTF ) that is a product of regulated endoproteolytic cleavage of PS 2 and that the presence of the N141I PS 2 mutation does not significantly alter the interaction of calsenilin with PS 2 . ^^^ |
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