| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| Finally , although the absence of APH 1 destabilizes the presenilins , in contrast to nicastrin and PEN 2 , APH 1 itself is only modestly destabilized in cells lacking functional expression of presenilin 1 or presenilin 2 . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| Presenilin 1 or presenilin 2 , nicastrin , APH 1 , and PEN 2 form high molecular weight complexes that play a pivotal role in the cleavage of various Type 1 transmembrane proteins , including the beta amyloid precursor protein . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| We found that knock down of APH 1a , but not APH 1b , resulted in impaired maturation of nicastrin and reduced expression of presenilin 1 , presenilin 2 , and PEN 2 proteins . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| The native gamma secretase is a heterogeneous population of large membrane protein complexes containing presenilin 1 ( PS 1 ) or presenilin 2 ( PS 2 ) , aph 1a or aph 1b , nicastrin , and pen 2 . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| Macromolecular complexes containing presenilins ( PS 1 and PS 2 ) , nicastrin , anterior pharynx defective phenotype 1 ( APH 1 ) , and PS enhancer 2 ( PEN 2 ) mediate the intramembranous , gamma secretase cleavage of beta amyloid precursor protein ( APP ) , Notch , and a variety of type 1 membrane proteins . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| PS ( presenilin ) dependent gamma secretase occurs as a high molecular mass complex composed of either PS 1 or PS 2 associated with Nct ( nicastrin ) , PEN 2 ( presenilin enhancer 2 homologue ) and APH 1 ( anterior pharynx defective 1 homologue ) . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| The presenilin proteins ( PS 1 and PS 2 ) and their interacting partners nicastrin , aph 1 ( refs 4 , 5 ) and pen 2 ( ref . 5 ) form a series of high molecular mass , membrane bound protein complexes that are necessary for gamma secretase and epsilon secretase cleavage of selected type 1 transmembrane proteins , including the amyloid precursor protein , Notch and cadherins . ^^^ |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NZ42 and P49810 |
Pubmed |
SVM Score :0.0 |
| NA |
|