| Modifier of cell adhesion protein ( MOCA ; previously called presenilin [ PS ] binding protein ) is a DOCK 180 related molecule , which interacts with PS 1 and PS 2 , is localized to brain areas involved in Alzheimer ' s disease ( AD ) pathology , and is lost from the soluble fraction of sporadic Alzheimer ' s disease ( AD ) brains . ^^^ Modifier of cell adhesion protein ( MOCA ; previously called presenilin [ PS ] binding protein ) is a DOCK 180 related molecule , which interacts with PS 1 and PS 2 , is localized to brain areas involved in Alzheimer ' s disease ( AD ) pathology , and is lost from the soluble fraction of sporadic Alzheimer ' s disease ( AD ) brains . ^^^ |