| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| Generation of anti apoptotic presenilin 2 polypeptides by alternative transcription , proteolysis , and caspase 3 cleavage . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| In contrast to the recent finding that the Volga German mutation on presenilin 2 ( PS 2 ) affects the increasing caspase 3 PS 2 fragment , the PS 1 mutation did not cause a significant change in PS 1 fragmentation . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| We show first that overexpression of the presenilinase derived maturation product of presenilin 2 ( CTF PS 2 ) increases Abeta recovery , the production of which is almost abolished by a caspase 3 inhibitor and increased by staurosporine . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| In cells undergoing apoptosis , a 22 amino acid presenilin 2 loop peptide ( PS 2 LP , amino acids 308 329 in presenilin 2 ) is generated through cleavage of the carboxyl terminal fragment of presenilin 2 by caspase 3 . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| During apoptosis , PS 1 and PS 2 were shown to be cleaved at sites distal to their normal cleavage sites by a caspase 3 family protease . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| The PS 2 derived peptide substrate was also cleaved by recombinant human caspase 3 . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of PS 2 inhibits its cleavage by caspase 3 . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| The authors performed linkage analysis to APP , PS 1 , PS 2 , FTDP 17 , BRI , PI 12 , FND , HD like , SCA 4 , SCA 5 , SCA 10 , SCA 11 , SCA 13 , PARK 1 , PARK 2 , PARK 3 loci ; direct mutation analysis of HD , DRPLA , SCA 1 , SCA 2 , SCA 3 , SCA 6 , SCA 7 , SCA 8 , SCA 12 , and PRNP genes ; and sequencing of the PRNP open reading frame . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| Alterations in behavior , amyloid beta 42 , caspase 3 , and Cox 2 in mutant PS 2 transgenic mouse model of Alzheimer ' s disease . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| PS 2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase 3 by enhancing of ryanodine receptor mediated calcium release . ^^^ |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|