| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| Here we report that beta catenin co immunoprecipitates with the endogenous C terminal fragment of presenilin 1 ( PS 1 CTF ) but not with the endogenous CTF of presenilin 2 ( PS 2 CTF ) in H 4 human neuroglioma cells . ^^^ |
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| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| We have used yeast two hybrid and coimmunoprecipitation methods to show that the large cytoplasmic loop domains of PS 1 and PS 2 interact specifically with three members of the armadillo protein family , including beta catenin , p 0071 , and a novel neuronal specific armadillo protein neural plakophilin related armadillo protein ( NPRAP ) . ^^^ |
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| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| Moreover , we found that the expression of the N141I PS 2 FAD gene strongly promoted ( > 2 fold ) glycogen synthase kinase ( GSK ) 3beta activity coincidental with a reduction in the level of beta catenin translocated from the cytoplasmic to the nuclear compartment . ^^^ Most interestingly , we found that inhibition of COX 2 mediated generation of prostaglandin ( PG ) E 2 in H 4 neuronal cells with the preferential COX 2 inhibitor nimesulide protects against N141I PS 2 mediated apoptotic cell death coincidental with an inhibition of GSK 3beta activity and subsequent normalization of beta catenin cellular distribution . ^^^ This study demonstrates for the first time that COX 2 may be a downstream effector of mutant N141I PS 2 mediated apoptotic cell death and that inhibition of COX 2 may neuroprotect in AD through modulation of a GSK 3beta beta catenin mediated response . ^^^ |
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| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|