| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| Thus , RGS 4 regulates Gq class signaling by the combined action of two domains : 1 ) the RGS box accelerates GTP hydrolysis by Galphaq and 2 ) the N terminus conveys high affinity and receptor selective inhibition . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| The Galphaq GAP activity of RGS 4 can also be quantitated by this assay ; it accelerated hydrolysis of bound GTP about 100 fold . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| Quantitative immunoblotting revealed phospholipase C ( PLC ) betaI and Galphaq were unchanged during POH and CHF , as were RGS 2 , RGS 3 , and RGS 4 ( regulators of G protein signaling , which are activators of intrinsic GTPase activity ) . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The paired pre and post left ventricular assist device samples revealed that RGS 2 , a selective inhibitor of G alpha q , was decreased ( P < 0 . 01 ) , while the status of G alpha q , phospholipase C beta 1 , RGS 3 and RGS 4 were unchanged after left ventricular assist device implantation . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| Coexpression of either the dominant negative Galphaq ( 305 359 ) minigene , regulators of G protein signaling ( RGS ) 2 or RGS 4 , inhibited CasR stimulated SRE activity , consistent with CasR activation of Galphaq . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| They were selectively recruited to the plasma membrane by G proteins and correspondingly by receptors that activate those G proteins : GFP RGS 2 when coexpressed with Galphas , beta 2 adrenergic receptor , Galphaq , or AT1A angiotensin 2 receptor , and GFP RGS 4 when coexpressed with Galphai 2 or M 2 muscarinic receptor . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| To determine which G protein ( s ) the CaR couples to in order to activate Rho and PLD , we pretreated the cells with pertussis toxin to inactivate Galphai or coexpressed regulators of G protein signaling ( RGS ) proteins to attenuate G protein signaling ( RGS 4 for Galphai and Galphaq , and a p115RhoGEF construct containing the RGS domain for Galpha12 / 13 ) . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| In contrast , classical RGS proteins ( such as RGS 16 and RGS 4 ) exhibit RGS domain dependent GAP activity on G alpha 1 and G alpha q , but not G alpha 12 or G alpha 13 ( ref 4 ) . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| Both RGS 4 and PLC beta 1 were potent and efficacious GTPase activating proteins for Galphaq and Galpha 11 in P2Y1 R containing vesicles . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| However , these mGluR1a / Galphaq / 11 interactions are not antagonized by the overexpression of either GRK 2 mutants defective in Galphaq / 11 binding or RGS 4 . ^^^ |
|
| Interacting proteins: P49798 and P50148 |
Pubmed |
SVM Score :0.0 |
| In the present study , we transfected PC 3 AR cells with myc tagged Galphai / Galphaq specific RGS proteins RGS 2 , RGS 4 and RGS 10 and examined the effects of melatonin , 8 bromo cGMP and PKC inhibitors on their nuclear cytoplasmic partitioning . ^^^ |
|