| Interacting proteins: P37198 and P49790 |
Pubmed |
SVM Score :0.0 |
| In vitro binding studies demonstrate that eIF 5A is required for efficient interaction of Rev NES with CRM1 / exportin1 and that eIF 5A interacts with the nucleoporins CAN / nup214 , nup 153 , nup 98 , and nup 62 . ^^^ |
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| Interacting proteins: P37198 and P49790 |
Pubmed |
SVM Score :0.0 |
| To this end , we have used quantitative solid phase binding analysis to determine the affinity of an importin beta cargo complex for Nup 358 , the Nup 62 complex , and Nup 153 , which are in the cytoplasmic , central , and nucleoplasmic regions of the NPC , respectively . ^^^ Our results indicate that the importin beta transport complex binds to nucleoporins with progressively increasing affinity as the complex moves from Nup 358 to the Nup 62 complex and to Nup 153 . ^^^ Antibody inhibition studies support the possibility that importin beta moves from Nup 358 to Nup 153 via the Nup 62 complex during import . ^^^ |
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| Interacting proteins: P37198 and P49790 |
Pubmed |
SVM Score :0.0 |
| We found that the karyopherin beta related export receptor CRM 1 competes with the Tap transport domain for binding to Nup 214 but not for binding to Nup 62 or Nup 153 , suggesting that the Tap and CRM 1 nuclear export pathways converge at the cytoplasmic periphery of the nuclear pore complex . ^^^ |
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| Interacting proteins: P37198 and P49790 |
Pubmed |
SVM Score :0.0 |
| PU . 1 interacted directly with two nucleoporins , Nup 62 and Nup 153 . ^^^ The binding of PU . 1 to Nup 153 , but not to Nup 62 , increased dramatically in the presence of RanGMPPNP , indicating the formation of a PU . 1 . ^^^ Because Nup 62 is located close to the midplane of the nuclear pore complex whereas Nup 153 is at its nuclear side , these findings suggest a model whereby RanGTP propels PU . 1 toward the nuclear side of the nuclear pore complex by increasing its affinity for Nup 153 . ^^^ |
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| Interacting proteins: P37198 and P49790 |
Pubmed |
SVM Score :0.0 |
| VSV Matrix ( M ) protein inhibits mRNA export by forming a complex with the mRNA export factor Rae 1 whereas poliovirus inhibits nuclear import of proteins by probably degrading Nup 62 and Nup 153 . ^^^ |
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| Interacting proteins: P37198 and P49790 |
Pubmed |
SVM Score :0.0 |
| NA |
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