| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.60640612 |
| However , we suggest that VEGF B , a ligand for VEGFR 1 may contribute to embryonic myocardial vascularization , since we have shown that it plays a key role in this process under normoxic conditions . 0.60640612^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.73173705 |
| The function of VEGFR 1 was evaluated by treating two representative cell lines with VEGF B , a selective ligand for VEGFR 1 , and / or a specific anti VEGFR 1 antibody and assessing the effects on signaling , migration , invasion , and proliferation . 0.73173705^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) is structurally closely related to VEGF and binds one of its receptors , VEGFR 1 . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) is expressed in various tissues , especially strongly in the heart , and binds selectively to one of the VEGF receptors , VEGFR 1 . ^^^ Vascular endothelial growth factor B ( VEGF B ) is expressed in various tissues , especially strongly in the heart , and binds selectively to one of the VEGF receptors , VEGFR 1 . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vegf , Vegf B , Vegf C and their receptors KDR , FLT 1 and FLT 4 during the neoplastic progression of human colonic mucosa . ^^^ Because the crucial role of angiogenesis has been demonstrated in tumor growth and metastasis , the present study was undertaken to characterize the relative expression of vascular endothelial growth factors VEGF ( vascular endothelial growth factor ) , VEGF B , VEGF C , and their receptors KDR ( kinase insert domain containing receptor ) , FLT 1 ( fms like tyrosine kinase ) , and FLT 4 in human colonic cancers , in relation to the Astler Coller pathological classification , and to prognosis . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| The TNX binding site of VEGF B was located in the N terminal 115 amino acid region . mTNX / FNIII13 25 did not prevent the interaction of VEGF B with VEGFR 1 ( VEGF receptor 1 ) , and VEGF B could simultaneously bind to both mTNX / FNIII13 25 and VEGFR 1 . ^^^ A conditioned medium from transfected 293T cells coexpressing full length TNX and VEGF B could promote DNA synthesis in bovine endothelial cells in which VEGFR 1 were expressed . ^^^ VEGFR 1 phosphorylation triggered by VEGF B 186 were increased in cells plated with mTNX / FNIII13 25 or full length mTNX , compared with cells plated with VEGF B 186 alone . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| The VEGF family members PIGF and VEGF B with exclusive binding capacities to the VEGFR 1 can influence monocyte activation and differentiation . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Previously , we demonstrated that TNX binds to vascular endothelial growth factors A and B ( VEGF A and B ) and that VEGF B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR 1 receptor . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the expression of VEGF related factor genes ( VEGF , VEGF B , and VEGF C ) and their receptor genes ( VEGFR 1 and VEGFR 2 ) in renal cell carcinoma ( RCC ) . ^^^ A moderate to high protein expression for VEGF , VEGFR 1 , and VEGFR 2 was observed in both the tumor cells and the endothelial cells , whereas the protein expression was low for VEGF B and VEGF C . ^^^ The present results suggested that VEGF and its receptors VEGFR 1 and VEGFR 2 cooperates to play a crucial role in the angiogenesis of RCC , while VEGF B and VEGFR C may not . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| At protein level , VEGF B and C , Flt 1 , and KDR were not detectable in tissue lysates , whereas VEGF A was increased in stages 3 and 4 . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Arterioles expressed VEGF B , VEGFR 1 , 2 , and 3 moderately and VEGF A variably . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Soluble VEGFR 1 , a receptor for VEGF A and B , inhibited tube formation by 87 % , a finding consistent with that of VEGF B inhibition . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| In contrast , cytokines and mutants which exclusively bind VEGFR 1 ( human VFM 17 and human VEGF B ) had no effect on invasion and tube formation or on the regulation of gene expression . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| The VEGFR 1 ligand VEGF B did not promote either angiogenesis or lymphangiogenesis . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| We measured the gene expression of VEGF ligands ( VEGF A , VEGF B , VEGF C , and VEGF D ) and their receptors ( VEGFR 1 , VEGFR 2 , and VEGFR 3 ) , in normal colorectal tissues ( n = 20 ) , adenomas ( n = 10 ) , and in CRC ( n = 71 ) representing different Duke ' s stages using ribonuclease protection assay , semi quantitative relative reverse transcriptase polymerase chain reaction , together with the pattern of their expression by immunohistochemistry . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Treatment with neutralizing antibody directed against the VEGF B receptor VEGF R 1 ( anti VEGFR 1 , 10 microg ) completely abrogated VEGF B related effects . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION ( S ) : The data confirm that CO 2 pneumoperitoneum is a cofactor in adhesion formation and demonstrate that VEGFR 1 plays a role in pneumoperitoneum enhanced adhesions , which is consistent with a role of placental growth factor , VEGF A , and VEGF B in pneumoperitoneum enhanced adhesions . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Treatment with VEGFR 1 ( placental growth factor and VEGF B ) or VEGFR 2 ( VEGF C ) agonist did not increase PGI ( 2 ) synthesis . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| The discovery of the vascular endothelial growth factor ( VEGF ) family members VEGF , VEGF B , placental growth factor ( PlGF ) , VEGF C and VEGF D and their receptors VEGFR 1 , 2 and 3 has provided tools for studying the vascular system in development as well as in diseases ranging from ischemic heart disease to cancer . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Treatment of the human CRC cell lines HT 29 and SW 480 with VEGF A ( a ligand for both VEGFR 1 and 2 ) or VEGF B ( a ligand specific for VEGFR 1 ) led to activation of Erk 1 / 2 , SAPK / JNK , and translocation of the p 65 subunit of nuclear factor kappaB into the nucleus . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Here we report that the human natural killer cell lines , NK 92 and YT , express the mRNA message and protein product for VEGF B and its receptor , VEGFR 1 / Flt 1 . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGF B and placental growth factor ( PlGF ) activate VEGFR 1 selectively , however , mice lacking either ligand display only minor developmental defects . ^^^ We hypothesized that the relative contributions of VEGF B and PlGF to VEGFR 1 signaling may be masked in the presence of VEGF A , which is abundantly expressed during postnatal development . ^^^ To test this hypothesis , neonatal or adult mice were treated with a monoclonal antibody ( G 6 23 IgG ) blocking murine VEGF A or a soluble VEGFR 1 receptor IgG chimeric construct [ mFlt ( 1 3 ) IgG ] , which neutralizes VEGF A , VEGF B , and PlGF . ^^^ In conclusion , our findings suggest that PlGF and VEGF B do not compensate during conditions of VEGF A blockade , suggesting a minor role for compensatory VEGFR 1 signaling during postnatal development and vascular homeostasis in adults . ^^^ The absence of compensatory VEGFR 1 signaling by VEGF B and PlGF may have important implications for the development of anticancer strategies targeting the VEGF ligand / receptor system . . ^^^ |
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| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Unlike VEGF A , which binds to the two receptor tyrosine kinases VEGFR 1 ( Flt 1 ) and VEGFR 2 ( Flk 1 / KDR ) , VEGF B binds only to VEGFR 1 and the functional significance of VEGFR 1 signalling has remained problematic . ^^^ More recently , however , evidence has emerged suggesting a key role for VEGFR 1 signalling in pathological angiogenesis and this has raised the possibility that , like VEGF A , VEGFR 1 specific ligands such as VEGF B may provide for novel therapeutic strategies and / or represent new therapeutic targets . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Breast cancer cells express VEGF A , VEGF B , VEGF C and their receptors VEGFR 1 ( Flt 1 ) , VEGFR 2 ( Flk 1 / KDR ) and neuropilin ( NP 1 / NP 2 ) . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Our treatment of the human pancreatic cancer cell line L3 . 6pl with the VEGFR 1 ligands VEGF A and VEGF B led to morphologic changes characteristic of EMT , including loss of polarity , increased intercellular separation , and the presence of pseudopodia . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGF B is closely related to VEGF A and placenta growth factor ( PlGF ) , but unlike VEGF A , which binds to two receptor tyrosine kinases VEGFR 1 ( Flt 1 ) and VEGFR 2 ( Flk 1 / KDR ) , VEGF B and PlGF bind to VEGFR 1 and not VEGFR 2 . ^^^ We also present a predicted model for the association of VEGF B with the second domain of its receptor , VEGFR 1 . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| In addition to VEGF A , the cells expressed mRNAs for various members of the VEGF family and for their receptors , including VEGF B , C , D , flt 1 , and KDR . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| Quail embryos were injected with soluble vascular endothelial growth factor ( VEGF ) receptors R 1 ( Flt 1 ) , R 2 ( Flk 1 ) , R 3 ( Flt 4 ) , VEGF Trap ( a chimera of R 1 and R 2 ) , or neutralizing antibodies to VEGF A , VEGF B , or fibroblast growth factor ( FGF ) 2 . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| For example , levels of proangiogenic VEGF A , VEGF B , neuropilin 1 , VEGFR 1 , and VEGFR 2 were reduced and the levels of antiangiogenic thrombospondin 1 and retinoblastoma like 2 were increased . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| There are nine proteins in the immediate VEGF family : VEGFA , VEGFB , VEGFC , VEGFD , VEGF 3 , placental growth factor ( PGF ) , VEGF receptor ( VEGFR ) 1 , VEGFR 2 , and VEGFR 1 related . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^ |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|