| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We have isolated and characterized a novel growth factor for endothelial cells , vascular endothelial growth factor B ( VEGF B ) , with structural similarities to vascular endothelial growth factor ( VEGF ) and placenta growth factor . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) is closely related to VEGF A , an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We found that vascular endothelial growth factor B ( VEGF B ) binds to mTNX / FNIII13 25 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VegfB ) is an angiogenic protein related to VegfA , although it acts on a different set of tyrosine kinase receptors . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Gene transfers of vascular endothelial growth factor A , vascular endothelial growth factor B , vascular endothelial growth factor C , and vascular endothelial growth factor D have no effects on atherosclerosis in hypercholesterolemic low density lipoprotein receptor / apolipoprotein B 48 deficient mice . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The biology of vascular endothelial growth factor B ( VEGF B ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) is a member of the VEGF family of growth factors that regulate blood vessel and lymphatic angiogenesis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Novel human vascular endothelial growth factor genes VEGF B and VEGF C localize to chromosomes 11q13 and 4q34 , respectively . ^^^ The recently isolated VEGF B and VEGF C cDNAs encode novel growth factor genes of the VEGF family . ^^^ METHODS AND RESULTS : Southern blotting and polymerase chain reaction analysis of somatic cell hybrids and fluorescence in situ hybridization ( FISH ) of metaphase chromosomes were used to assess the chromosomal localization of VEGF B and VEGF C genes . ^^^ The VEGF B gene was found on chromosome 11q13 , proximal to the cyclin D 1 gene , which is amplified in a number of human carcinomas . ^^^ However , VEGF B was not amplified in several mammary carcinoma cell lines containing amplified cyclin D 1 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) binds to VEGF receptor 1 and regulates plasminogen activator activity in endothelial cells . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) is structurally closely related to VEGF and binds one of its receptors , VEGFR 1 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor B ( VEGF B ) is expressed in various tissues , especially strongly in the heart , and binds selectively to one of the VEGF receptors , VEGFR 1 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Little is known of the significance and function of the vascular endothelial growth factor ( VEGF ) family , which includes VEGF , VEGF B , and VEGF C , and of placenta growth factor ( PIGF ) in these processes . ^^^ VEGF B and VEGF C mRNAs were strongly expressed in human placenta as evidenced by Northern blot analysis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Comparison of VEGF , VEGF B , VEGF C and Ang 1 mRNA regulation by serum , growth factors , oncoproteins and hypoxia . ^^^ The vascular endothelial growth factor ( VEGF ) family has recently been expanded by the isolation of two additional growth factors , VEGF B and VEGF C . ^^^ Here we compare the regulation of steady state levels of VEGF , VEGF B and VEGF C mRNAs in cultured cells by a variety of stimuli implicated in angiogenesis and endothelial cell physiology . ^^^ Hypoxia , Ras oncoprotein and mutant p 53 tumor suppressor , which are potent inducers of VEGF mRNA did not increase VEGF B or VEGF C mRNA levels . ^^^ Serum and its component growth factors , platelet derived growth factor ( PDGF ) and epidermal growth factor ( EGF ) as well as transforming growth factor beta ( TGF beta ) and the tumor promoter phorbol myristate 12 , 13 acetate ( PMA ) stimulated VEGF C , but not VEGF B mRNA expression . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Differential hormonal regulation of vascular endothelial growth factors VEGF , VEGF B , and VEGF C messenger ribonucleic acid levels in cultured human granulosa luteal cells . ^^^ The complementary DNAs of two other factors structurally related to VEGF , namely VEGF B and VEGF C , were recently cloned , but little is known of their regulation in the ovary . ^^^ Northern blot hybridization analyses indicated that transcripts of 4 . 5 and 3 . 7 kilobases for VEGF , and 1 . 4 and 2 . 4 kilobases for VEGF B and VEGF C , respectively , are expressed in human GL cells . ^^^ The basal VEGF mRNA levels declined steadily , whereas VEGF B mRNA levels were rather invariant over a 10 day culture period of GL cells . ^^^ VEGF B mRNA levels were not regulated by any of the test agents . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have defined the expression of mRNA encoding VEGF B , VEGF C , and placenta growth factor ( PIGF ) , compared with that of VEGF mRNA , in normal ovary and a range of ovarian epithelial tumors . ^^^ Analysis by reverse transcription PCR indicated that mRNA encoding VEGF ( isoforms 121 and 165 ) , VEGF B ( isoforms 167 and 186 ) , and VEGF C , but not PIGF , were present in all ovarian tissues examined . ^^^ The expression pattern of VEGF B mRNA was generally similar to that of VEGF mRNA , in that transcripts were readily detected in the epithelial cells of all histologic types of ovarian carcinoma , but could not be detected in normal or benign tumor epithelium . ^^^ Specific differences in the expression of the two genes were noted in areas of tumor necrosis , in which the expression of VEGF mRNA , but not VEGF B mRNA , was further enhanced , and in a sample in which VEGF B mRNA was strongly expressed in tumor associated macrophages that did not hybridize with the riboprobe to VEGF mRNA . ^^^ These results imply that a second member of the VEGF family , VEGF B , may play a significant role in the angiogenesis , progression , and maintenance of ovarian carcinomas . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Three related endothelial cell growth factors , VEGF B , VEGF C , and VEGF D were recently cloned . ^^^ Interleukin ( IL ) 1beta induced a concentration and a time dependent increase in VEGF C , but not in VEGF B , mRNA steady state levels in human lung fibroblasts . ^^^ Hypoxia , which is an important inducer of VEGF expression , had no effect on VEGF B or VEGF C mRNA levels . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In contrast to VEGF , the isoforms VEGF B and VEGF C are poorly regulated by growth and oncogenic factors . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factors VEGF B and VEGF C are expressed in human tumors . ^^^ We have recently characterized two novel endothelial growth factors with structural homology to VEGF and named them VEGF B and VEGF C . ^^^ To further define the roles of VEGF B and VEGF C , we have studied their expression in a variety of human tumors , both malignant and benign . ^^^ VEGF B mRNA was detected in most of the tumor samples studied , and the mRNA and the protein product were localized to tumor cells . ^^^ Endothelial cells of tumor vessels were also immunoreactive for VEGF B , probably representing the binding sites of the VEGF B polypeptide secreted by adjacent tumor cells . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| A comparative study of the expression patterns for vegf , vegf b / vrf and vegf c in the developing and adult mouse . ^^^ With the goal of better understanding the function and regulation of the different members of the VEGF family this study reports mapping of vegf , vegf b and vegf c mRNA expression in developing and adult mice . ^^^ On embryonic day 14 ( E 14 ) there is a high expression of vegf and vegf b , vegf b being exceptionally high in heart and CNS . ^^^ Prior to birth ( E 17 ) , vegf and vegf b expression is moderately downregulated . ^^^ Overlapping expression is present in intrascapular fat and heart . vegf dominates in thyroid and lung , while vegf b appears to be the only VEGF member expressed at detectable levels in the CNS . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Comparison of expression patterns for placenta growth factor , vascular endothelial growth factor ( VEGF ) , VEGF B and VEGF C in the human placenta throughout gestation . ^^^ In this study we used in situ hybridisation to localise which cells in the placenta expressed mRNA for VEGF , placenta growth factor ( PlGF ) , VEGF B and VEGF C . ^^^ We were unable to find any message for either VEGF B or VEGF C in the placenta , suggesting that only low levels are produced which this method was unable to detect . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| To investigate which other members of the VEGF family are overexpressed in human brain tumours , the mRNA levels of placenta growth factor ( PlGF ) , VEGF A , and VEGF B genes were determined by northern blot analysis in surgically obtained human meningiomas . ^^^ VEGF B mRNA was abundantly expressed in all tumour samples at uniform levels . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) plays a major role and we therefore investigated the other members of the VEGF family : Placental growth factor ( PlGF ) , VEGF B , C , and D , and platelet derived growth factors ( PDGF ) A and B . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Three additional members of the VEGF family , VEGF B , C and D , have recently been discovered . ^^^ Although VEGF A and VEGF B expressions were detected in both node positive and node negative breast tumors , VEGF C expression was detected only in node positive tumors . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the expression of the recently isolated VEGF gene family members ( placenta growth factor ( PlGF ) , VEGF B , and VEGF C ) in human dermal microvascular endothelial cells and bovine retinal pericytes cultured under various oxygen tensions . ^^^ Quantitative reverse transcription polymerase chain reaction analyses demonstrated that the two cell types possess not only VEGF ( VEGF A ) mRNA , but also VEGF B , VEGF C , and PlGF mRNAs . ^^^ Competitive reverse transcription polymerase chain reaction showed that , under normoxic conditions , the rank order of mRNA content in endothelial cells was PlGF > VEGF B > VEGF C > VEGF A and that mRNA coding for PlGF was expressed at > 100 fold higher levels than VEGF A mRNA . ^^^ In pericytes , the rank order was VEGF C > VEGF A > VEGF B > PlGF , and approximately 7 fold higher levels of VEGF C mRNA compared with VEGF A mRNA were noted in this cell type . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined the effect of cold exposure on mRNA expression of other two angiogenic factors , VEGF B and basic fibroblast growth factor ( bFGF ) , in rats . ^^^ Conventional Northern blot analysis revealed abundant mRNA expression of VEGF B as well as VEGF , but not bFGF , in BAT . ^^^ In contrast , the VEGF B mRNA level did not change throughout the course of cold exposure . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We have studied the regulation of VEGF , VEGF B , VEGF C , and VEGF D mRNAs in human MCF 7 and mouse S 115 breast carcinoma cells stimulated by estrogens and androgens , respectively . ^^^ VEGF , VEGF B , and VEGF C were expressed in both cell lines , whereas VEGF D was expressed only in S 115 cells . ^^^ The VEGF B mRNA was not affected , while a decrease occurred in VEGF C mRNA . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to explore whether expressions of VEGF A , VEGF B , VEGF C , and VEGF D are correlated with lymph node status in lung adenocarcinoma . ^^^ The relative mRNA abundance of VEGF A , VEGF B , VEGF C , and VEGF D was measured by real time reverse transcription PCR analysis based on TaqMan fluorescence methodology . ^^^ The only tendency noted was for higher VEGF B and VEGF C and lower VEGF D levels in the node positive group . ^^^ However , two way scatterplot analysis revealed that tumors with lymph node metastasis were associated with a pattern of low VEGF D and high VEGF A , VEGF B , or VEGF C , such that the ratios of VEGF D : VEGF A , VEGF D : VEGF B , or VEGF D : VEGF C were significantly lower in the node positive group . ^^^ Finally , levels of VEGF A , but not VEGF B or VEGF C , were higher in tumors with large nodal metastasis ( > or = 1 cm ) than in those with small ( < 1 cm ) nodal metastasis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Current biology of VEGF B and VEGF C . ^^^ VEGF B and VEGF C provide this gene family with additional functions , for example , VEGF C also regulates lymphangiogenesis . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Vegf , Vegf B , Vegf C and their receptors KDR , FLT 1 and FLT 4 during the neoplastic progression of human colonic mucosa . ^^^ Because the crucial role of angiogenesis has been demonstrated in tumor growth and metastasis , the present study was undertaken to characterize the relative expression of vascular endothelial growth factors VEGF ( vascular endothelial growth factor ) , VEGF B , VEGF C , and their receptors KDR ( kinase insert domain containing receptor ) , FLT 1 ( fms like tyrosine kinase ) , and FLT 4 in human colonic cancers , in relation to the Astler Coller pathological classification , and to prognosis . ^^^ VEGF and VEGF B gene expression was quantified by Northern blot in 72 tumor samples matched with control tissues . ^^^ VEGF B mRNA levels were unchanged during the neoplastic progression of colonic mucosa . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| To determine which angiogenic factors contribute to NB angiogenesis and thereby support tumor progression , we examined the expression of eight angiogenic factors [ vascular endothelial growth factor ( VEGF ) , VEGF B , VEGF C , basic fibroblast growth factor , angiopoietin ( Ang ) 1 , Ang 2 , transforming growth factor alpha , and platelet derived growth factor ( PDGF ) ] by semiquantitative RT PCR in 37 NB primary tumors and in 22 NB cell lines . ^^^ Significantly higher expression levels of VEGF , VEGF B , VEGF C , basic fibroblast growth factor , Ang 2 , transforming growth factor alpha , and PDGF A ( P < 0 . 0001 0 . 026 ) were found in advanced stage tumors ( stages 3 and 4 ) compared with low stage tumors ( stages 1 , 2 , and 4S ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In DCM , except for VEGF C , mRNA transcript levels of VEGF A ( 165 ) , VEGF A ( 189 ) , and VEGF B and the protein level of VEGF A and VEGF R ( 1 ) were downregulated compared with controls ( P : < 0 . 05 ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Over the last few years , several additional members of the VEGF gene family have been identified , including placenta growth factor ( PIGF ) ( Maglione et al . , 1991 , 1993 ) , VEGF B ( Olofsson et al . , 1996 ) , VEGF C ( Joukov et al . , 1996 ; Lee et al . , 1996 ) , and VEGF D ( Orlandini et al . , 1996 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Other ligands that interact differentially with these receptors and that are structurally related to VEGF A include VEGF B , VEGF C , VEGF D , and placenta growth factor ( PLGF ) . ^^^ Compared with VEGF A , relatively little is known about the biological role of the VEGF R 1 specific ligand , VEGF B . ^^^ Recent analysis of mice with a targeted deletion of the VEGF B gene has revealed a defect in heart development and function consistent with an important role in vascularization of the myocardium ( Bellomo D et al . , 2000 , Circ Res 86 : E 29 E35 ) . ^^^ To facilitate further characterization of VEGF B , we have developed a protocol for expression and purification of refolded recombinant protein from Escherichia coli inclusion bodies ( IBs ) . ^^^ The approach developed resolves a number of significant issues associated with VEGF B , including the ability to heterodimerize with endogenous VEGF A when co expressed in mammalian cells , a complex secondary structure incorporating inter and intrachain disulfide bonds and hydrophobic characteristics that preclude the use of standard chromatographic resins . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The diverse functions of VEGF and its homologues ( PIGF , VEGF B , VEGF C , VEGF D , and VEGF E ) can be explained by their differential binding to the three signaling VEGF receptors . ^^^ The VEGF family members PIGF and VEGF B with exclusive binding capacities to the VEGFR 1 can influence monocyte activation and differentiation . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Newly identified members of the VEGF family of angiogenesis factors include placental growth factor , VEGF B , VEGF C , and VEGF D , and show overlapping binding patterns to specific endothelial cell receptors . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Using semi quantitative reverse transcription PCR , we showed that all three c erbB ligands up regulated VEGF A mRNA ( all isoforms ) and VEGF C ( BTC max at 1 10 nM ; TGF alpha and HRG beta 1 max at 10 100 nM ) but had no effect on VEGF B . ^^^ A monoclonal antibody ( mAb ) which blocks EGFR ligand binding ( ICR 62 ) down regulated the basal levels of VEGF A ( all isoforms ) and VEGF C , had no detectable effects on VEGF B and increased VEGF D . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| To determine which angiogenic factors contribute to PNET / MB angiogenesis , we examined the expression of eight angiogenic factors ( vascular endothelial growth factors ( VEGF , VEGF B , VEGF C ) , basic fibroblast growth factor ( bFGF ) , angiopoetins ( Ang 1 , Ang 2 ) , transforming growth factor ( TGF alpha ) , and platelet derived endothelial growth factor ( PDGF A ) ) by semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) in six PNET cell lines and 28 primary PNET / MB . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Secreted vMIP 1A and vMIP 1B were detected in biologically significant concentrations following tetradecanoyl phorbol acetate treatment , which induces productive replication . vIL 6 and vMIP 1A , added exogenously to cultures of four different PEL cell lines , induced the expression of vascular endothelial growth factor type B ( VEGF B ) and VEGF A , respectively . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Previously , we demonstrated that TNX binds to vascular endothelial growth factors A and B ( VEGF A and B ) and that VEGF B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR 1 receptor . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Samples from 30 ( 96 . 8 % ) of 31 patients stained positive for VEGF A , 4 ( 9 . 7 % ) for VEGF B , 17 ( 54 . 5 % ) for VEGF C , and 16 ( 51 . 6 % ) for VEGF D . ^^^ In contrast , there were no significant differences in nidus size and age in patients positive for VEGF A , VEGF B , and Flk 1 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the expression of VEGF related factor genes ( VEGF , VEGF B , and VEGF C ) and their receptor genes ( VEGFR 1 and VEGFR 2 ) in renal cell carcinoma ( RCC ) . ^^^ Expression levels VEGF B and VEGF C genes were not significantly different between RCC and normal renal tissue . ^^^ A moderate to high protein expression for VEGF , VEGFR 1 , and VEGFR 2 was observed in both the tumor cells and the endothelial cells , whereas the protein expression was low for VEGF B and VEGF C . ^^^ The present results suggested that VEGF and its receptors VEGFR 1 and VEGFR 2 cooperates to play a crucial role in the angiogenesis of RCC , while VEGF B and VEGFR C may not . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The expression of vascular endothelial growth factor ( VEGF ) A isoforms ( 121 , 165 , 189 , 206 ) , VEGF B , VEGF C and VEGF D in both experimental and clinical models of head and neck squamous cell carcinoma ( HNSCC ) was determined and correlated with conventional clinicopathologic parameters , with particular reference to cervical nodal metastasis . ^^^ RESULTS : Increased levels of VEGF A ( all four isoforms ) and VEGF C were found in tumor cell lines compared with normal cells , whereas no differences in VEGF B levels were found . ^^^ In contrast , the levels of VEGF D were significantly decreased in tumors , and VEGF B expression appeared similar in both normal and malignant tissues . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Arterioles expressed VEGF B , VEGFR 1 , 2 , and 3 moderately and VEGF A variably . ^^^ VEGF B was expressed in all blood vessels ; however , VEGF B was weakly expressed in capillaries and arterioles and moderately expressed in venules and arterioles . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| If so , the effect of Vegf B appears to be different from that of Vegf A which is reported to protect against , rather than contribute to , hypoxia induced pulmonary vascular remodelling . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Four different factors have recently been identified in the vascular endothelial growth factor ( VEGF ) family , namely , VEGF A , VEGF B , VEGF C , and VEGF D . ^^^ RESULTS : VEGF A and VEGF B mRNA were expressed in all patients , VEGF C mRNA was expressed in 58 ( 95 . 1 % ) , and VEGF D mRNA was expressed in 28 ( 46 . 0 % ) . ^^^ CONCLUSIONS : To our knowledge , this is the first clinical study on VEGF B , VEGF C , and VEGF D mRNA expression in diseased thyroids . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Differential expression of vascular endothelial growth factor A ( VEGF A ) and VEGF B after brain injury . ^^^ In this study , VEGF A expression was compared with that of VEGF B in the rat cortical cold injury model over a period of 6 hours to 6 days post injury . ^^^ VEGF A and VEGF B mRNA were detected by in situ hybridization and their protein was detected by immunohistochemistry . ^^^ The presence of VEGF A and VEGF B proteins in endothelium of lesion vessels was related to BBB breakdown by double labeling for either of these growth factors and fibronectin , which was used as a marker of BBB breakdown . ^^^ Significant induction of both VEGF A and VEGF B mRNA occurred at the lesion site during the period of maximal endothelial proliferation . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| At protein level , VEGF B and C , Flt 1 , and KDR were not detectable in tissue lysates , whereas VEGF A was increased in stages 3 and 4 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| VEGF B mRNA was decreased , but its protein level was unchanged in donors . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The role of VEGF R 1 and the factors that interact exclusively with this receptor ( VEGF B and placenta growth factor ) has remained controversial . 2 . ^^^ To further elucidate the role of VEGF B in blood vessel formation and function , we have expressed , purified and refolded both naturally occurring VEGF B isoforms and a truncated amino acid 10 108 form . ^^^ Robust cell assays for VEGF R 1 ligands , such as VEGF B , have been problematic . ^^^ The cell line expresses luciferase to high levels 24 h after exposure to VEGF A and both refolded VEGF B 167 and the short 10 108 isoform have been demonstrated to be active in this assay . 4 . ^^^ The novel cell based assay , in combination with a variety of immunochemical approaches , has been used to identify and characterize monoclonal antibodies that neutralize VEGF B activity . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| By using the quail heart explant model , we found that neutralizing antibodies to VEGF B or VEGF C inhibited tube formation on the collagen gel more than anti VEGF A . ^^^ Soluble VEGFR 1 , a receptor for VEGF A and B , inhibited tube formation by 87 % , a finding consistent with that of VEGF B inhibition . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Here we report that the human natural killer cell lines , NK 92 and YT , express the mRNA message and protein product for VEGF B and its receptor , VEGFR 1 / Flt 1 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The levels of bFGF and VEGF ( VEGF , VEGF B , and VEGF C ) in corneal epithelial cells were not elevated in matrilysin deficient mice compared with the wild type mice ( experiment 4 ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| To investigate the effect of VEGF B , a factor coexpressed in the lung with VEGF A , we assessed chronic hypoxic pulmonary hypertension in VEGF B knockout mice ( VEGF B / ) and in rats with lung overexpression of VEGF B induced by adenovirus transfer . ^^^ When overexpressed , VEGF B ( 167 ) or VEGF B ( 186 ) had protective effects similar to those of human VEGF A ( 165 ) . ^^^ VEGF A ) overexpression , whereas VEGF B ( 167 ) or VEGF B ( 186 ) had no effect . ^^^ However , when overexpressed in the lung , VEGF B can be as potent as VEGF A in attenuating pulmonary hypertension , although it has no effect on eNOS expression or vascular permeability . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Plasma cells secrete VEGF A ( and VEGF B , VEGF C and VEGF D , albeit marginally ) into their conditioned medium ( CM ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Additional VEGF family members such as the heparin binding form of placenta growth factor ( PlGF 2 ) and VEGF B bind to NRP 1 , and it was also shown that both PlGF 2 and VEGF C bind to NRP 2 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We also studied the expression of VEGF B , C , and D mRNA in human glioblastoma cells and their modulation by HDAC inhibitors . ^^^ The PCR products of VEGF B ( 357bp ) , VEGF C ( 501bp ) , and VEGF D ( 484bp ) were amplified in all glioblastoma cells examined . ^^^ Treatment with SB reduced the expression of VEGF D mRNA in U251MG cells and the expression of VEGF B mRNA in U87MG cells . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In contrast , cytokines and mutants which exclusively bind VEGFR 1 ( human VFM 17 and human VEGF B ) had no effect on invasion and tube formation or on the regulation of gene expression . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We studied the therapeutic potential of human vascular endothelial growth factor ( VEGF ) family members VEGF A , VEGF B , VEGF C , and VEGF D as well as a VEGFR 3 specific mutant ( VEGF C156S ) using adenoviral gene transfer in rabbit hindlimb skeletal muscle . ^^^ The VEGFR 1 ligand VEGF B did not promote either angiogenesis or lymphangiogenesis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The angiogenic switch for vascular endothelial growth factor ( VEGF ) A , VEGF B , VEGF C , and VEGF D in the adenoma carcinoma sequence during colorectal cancer progression . ^^^ We measured the gene expression of VEGF ligands ( VEGF A , VEGF B , VEGF C , and VEGF D ) and their receptors ( VEGFR 1 , VEGFR 2 , and VEGFR 3 ) , in normal colorectal tissues ( n = 20 ) , adenomas ( n = 10 ) , and in CRC ( n = 71 ) representing different Duke ' s stages using ribonuclease protection assay , semi quantitative relative reverse transcriptase polymerase chain reaction , together with the pattern of their expression by immunohistochemistry . ^^^ VEGF A mRNA was the most abundant in colorectal tissue , followed by VEGF B , VEGF C , and VEGF D . ^^^ VEGF A and VEGF B mRNAs were significantly more abundant in adenomas ( p = 0 . 0003 and p = 0 . 04 respectively ) compared with normal tissues , while VEGF A and VEGF C were significantly increased in carcinomas compared with normal tissues ( p = 0 . 0006 and p = 0 . 0009 respectively ) . ^^^ A significantly greater amount of VEGF C mRNA was present in carcinomas compared with adenomas ( p = 0 . 03 ) , whereas there was a significant reduction of VEGF B in carcinomas compared with adenomas ( p = 0 . 0002 ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| They belong to the larger family which also includes VEGF , placenta growth factor ( PlGF ) and VEGF B , VEGF C and VEGF D are ligands for the endothelial cell specific tyrosine kinase receptors VEGFR 2 and VEGFR 3 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We investigated the presence of transcripts for VEGF A , VEGF B , VEGF C , VEGF D , Angiopoietin 1 and Angiopoietin 2 in benign endometrium , atypical complex hyperplasia ( ACH ) and endometrioid endometrial carcinoma using in situ hybridisation . ^^^ We also demonstrate , using quantitative polymerase chain reaction , that levels of VEGF B mRNA are significantly lower in endometrial cancer than benign endometrium . ^^^ We conclude that loss of VEGF B may contribute to the development of endometrial carcinoma by modulating availability of receptors for VEGF A . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| ANIMAL ( S ) : Female wild type mice and transgenic mice ( n = 110 ) , expressing exclusively VEGF A ( 164 ) ( VEGF A ( 164 / 164 ) ) or deficient for VEGF B ( VEGF B ( / ) ) or for PlGF ( PlGF ( / ) ) . ^^^ In comparison with wild type mice , basal adhesions were higher in VEGF A ( 164 / 164 ) mice and similar in VEGF B ( / ) and PlGF ( / ) mice . ^^^ Absence of pneumoperitoneum enhanced adhesions in VEGF A ( 164 / 164 ) , VEGF B ( / ) , and PlGF ( / ) mice indicates up regulation of VEGF A ( 164 ) , VEGF B , and PlGF by CO ( 2 ) pneumoperitoneum as a mechanism for pneumoperitoneum enhanced adhesion formation . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| This study was undertaken to determine whether expressions of the vascular endothelial growth factor ( VEGF ) family ( VEGF A , VEGF B , VEGF C , and VEGF D ) are correlated with clinicopathological parameters , with particular reference to lymph node metastasis in colorectal cancer . ^^^ VEGF B and VEGF C mRNA were significantly higher both in the tumors with lymph node metastasis ( p = 0 . 027 and p = 0 . 024 , respectively ) and in tumors with lymphatic invasion ( p = 0 . 042 and p = 0 . 005 , respectively ) . ^^^ The results of this study demonstrate that high levels of VEGF B , C and low levels of VEGF D mRNA expression are associated with lymph node metastasis and lymphatic involvement . ^^^ These results suggest that a balance among VEGF B , VEGF C , and VEGF D might contribute to the lymphangiogenic process and metastasis in colorectal cancer . . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Plasmids containing human form of VEGF A ( phVEGF A 165 ) or VEGF B ( phVEGF B 167 or phVEGF B 186 ) were administered by in vivo electrotransfer . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| However , we suggest that VEGF B , a ligand for VEGFR 1 may contribute to embryonic myocardial vascularization , since we have shown that it plays a key role in this process under normoxic conditions . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Among the most recently discovered growth factors for endothelial cells are newly isolated members of the platelet derived growth factor / vascular endothelial growth factor ( VEGF ) family , VEGF B , VEGF C , and VEGF D . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| We have then utilized RNase protection and ELISA to measure the relative levels of VEGF B , C , D and flt 1 , KDR , flt 4 and flt 4t ( Delta 773 1081 ) expression in freshly isolated benign prostatic hyperplasia or BPH tissue ( n=21 ) , primary prostate cancers ( n=82 ) and matching sentinel lymph node metastases from stage T2a T2b / T3 tumors ( n=52 ) . ^^^ Comparisons of the primary tumors with BPH showed that there was a significant upregulation of VEGF B ( P=0 . 003 ) , VEGF D ( P=0 . 005 ) , flt 1 ( P=0 . 003 ) , KDR ( P=0 . 002 ) , flt 4 ( P=0 . 007 ) , and flt 4t ( Delta 773 1081 ) ( P=0 . 001 ) , but not VEGF C ( P=0 . 543 ) . ^^^ There was no correlation between VEGF B and its receptor flt 1 ( P=0 . 545 ) , or VEGF C and flt 4 ( P=0 . 16 ) and KDR ( P=0 . 23 ) receptor expression in tumor specimens . ^^^ Statistical analysis further showed that there was no significant correlation between VEGF B , VEGF C , VEGF D , flt 1 , KDR , flt 4 and flt 4t ( Delta 773 1081 ) with patient age ( P > 0 . 10 ) , stage ( P > 0 . 10 ) , PSA value ( P > 0 . 15 ) or tumor size ( P > 0 . 15 ) . ^^^ Likewise , there was no significant correlation between VEGF B , VEGF C , flt 1 , KDR , and flt 4 with Gleason score ( P > 0 . 15 ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Adenoviruses ( 1 10 10 ( 9 ) plaque forming units [ pfu ] ) encoding for VEGF A , VEGF B , VEGF C , VEGF D , VEGF C ( deltaNdeltaC ) and VEGF D ( deltaNdeltaC ) ( deltaNdeltaC are proteolytically cleaved forms ) were transferred locally to the periadventitial space of the rabbit carotid arteries using a collar technique that allows efficient local transfection of the periadventitial tissue . ^^^ VEGF C ( deltaNdeltaC ) also showed angiogenic activity whereas VEGF B was not effective in inducing angiogenesis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The additional members of the VEGF family , VEGF B , C and D have been discovered . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| CBMC expressed mRNA for five isoforms of VEGF A and other members of the VEGF family ( VEGF B , VEGF C , and VEGF D ) with strong expression of the most potent secretory isoforms . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| RESULTS : There were no significant differences between the three lines in IL 6 , TGF beta , VEGF A , VEGF B , VEGF C and FGF 2 mRNAs expression . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| This was accompanied by downregulation of VEGF B and D , and upregulation of angiopoietin 3 as well as angiopoetin receptors in nontumor cells . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION ( S ) : The data confirm that CO 2 pneumoperitoneum is a cofactor in adhesion formation and demonstrate that VEGFR 1 plays a role in pneumoperitoneum enhanced adhesions , which is consistent with a role of placental growth factor , VEGF A , and VEGF B in pneumoperitoneum enhanced adhesions . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Treatment with VEGFR 1 ( placental growth factor and VEGF B ) or VEGFR 2 ( VEGF C ) agonist did not increase PGI ( 2 ) synthesis . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The discovery of the vascular endothelial growth factor ( VEGF ) family members VEGF , VEGF B , placental growth factor ( PlGF ) , VEGF C and VEGF D and their receptors VEGFR 1 , 2 and 3 has provided tools for studying the vascular system in development as well as in diseases ranging from ischemic heart disease to cancer . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Treatment of the human CRC cell lines HT 29 and SW 480 with VEGF A ( a ligand for both VEGFR 1 and 2 ) or VEGF B ( a ligand specific for VEGFR 1 ) led to activation of Erk 1 / 2 , SAPK / JNK , and translocation of the p 65 subunit of nuclear factor kappaB into the nucleus . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The function of VEGFR 1 was evaluated by treating two representative cell lines with VEGF B , a selective ligand for VEGFR 1 , and / or a specific anti VEGFR 1 antibody and assessing the effects on signaling , migration , invasion , and proliferation . ^^^ RESULTS : All 11 pancreatic carcinoma cell lines expressed VEGFR 1 mRNA and protein , as well as the VEGFR 1 ligands VEGF A and VEGF B . ^^^ Two representative cell lines ( L3 . 6 and Panc 1 ) exhibited VEGF B induced mitogen activated protein kinase signaling . ^^^ VEGFR 1 stimulation by VEGF A or VEGF B was found to promote migration in both cell lines . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| From a molecular viewpoint , P 815 cells showed a higher expression of genes promoting tumor growth , such as IGF 1 , IL 8R , FGFR 1 , VEGF A , and VEGF B . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| METHODS : Real time quantitative RT PCR analysis was conducted on selected 11 genes ( total VEGF A , VEGF ( 121 ) , VEGF ( 165 ) , VEGF ( 189 ) , VEGF B , C and D , bFGF , dThdPase , MMP 2 and uPA ) using 11 cervical carcinoma cell lines and 14 normal cervical tissues . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor and Ang 2 expression were increased in SC adipose tissue of ob / ob mice , and thrombospondin 2 was increased in both their SC and GON fat pads . mRNA levels of vascular endothelial growth factor ( VEGF ) A isoforms VEGF B , VEGF C , VEGF receptor 1 , 2 , and 3 , and neuropilin 1 were not markedly modulated by obesity . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Currently , the VEGF family consists of VEGF A , PlGF ( placenta growth factor ) , VEGF B , VEGF C , VEGF D , VEGF E and snake venom VEGF . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| VEGF B , a related factor , binds some of the VEGF A receptors but not to VEGF receptor 2 , which is implicated in the vascular permeability promoting activity of VEGF A . ^^^ Despite little in vitro evidence to date for the ability of Vegf B to directly promote angiogenesis , recent data indicate that it may promote postnatal vascular growth in mice , suggesting that it may have potential therapeutic application . ^^^ We have specifically studied the effects of VEGF B on vascular growth in vivo and on angiogenesis in vitro by analyzing transgenic mice in which individual isoforms ( VEGFB167Tg and VEGFB186Tg ) of VEGF B are overexpressed in endothelial cells . ^^^ In the aortic explant assay , explants from VEGFB167Tg and VEGFB186Tg mice displayed elevated vascular growth , suggesting a direct effect of VEGF B isoforms in potentiating angiogenesis . ^^^ These data support the use of VEGF B as a therapeutic agent to promote vascular growth , in part , by potentiating angiogenesis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Redundant roles of VEGF B and PlGF during selective VEGF A blockade in mice . ^^^ VEGF B and placental growth factor ( PlGF ) activate VEGFR 1 selectively , however , mice lacking either ligand display only minor developmental defects . ^^^ We hypothesized that the relative contributions of VEGF B and PlGF to VEGFR 1 signaling may be masked in the presence of VEGF A , which is abundantly expressed during postnatal development . ^^^ To test this hypothesis , neonatal or adult mice were treated with a monoclonal antibody ( G 6 23 IgG ) blocking murine VEGF A or a soluble VEGFR 1 receptor IgG chimeric construct [ mFlt ( 1 3 ) IgG ] , which neutralizes VEGF A , VEGF B , and PlGF . ^^^ In conclusion , our findings suggest that PlGF and VEGF B do not compensate during conditions of VEGF A blockade , suggesting a minor role for compensatory VEGFR 1 signaling during postnatal development and vascular homeostasis in adults . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Adenoviral vectors encoding VEGF A , VEGF B , VEGF C , VEGF C ( DeltaNDeltaC ) , VEGF D and VEGF D ( DeltaNDeltaC ) were delivered to the adventitia using the collar as a gene delivery device . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Other strategies , such as targeting VEGF receptors directly or using receptor decoys , result in inhibiting not only VEGF A but also VEGF homologues ( e . g . placental growth factor , VEGF B , and VEGF C ) , which may play a role in angiogenesis . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| VEGF A , VEGF B , SDF 1 , and IGF 1 mRNA levels were higher in EPC as compared to HUVEC or HMVEC . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Breast cancer cells express VEGF A , VEGF B , VEGF C and their receptors VEGFR 1 ( Flt 1 ) , VEGFR 2 ( Flk 1 / KDR ) and neuropilin ( NP 1 / NP 2 ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The effect of VEGF was not reproduced by VEGF B or placental growth factor , but was blocked by SU 1498 , consistent with a VEGFR 2 receptor mediated process . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Our treatment of the human pancreatic cancer cell line L3 . 6pl with the VEGFR 1 ligands VEGF A and VEGF B led to morphologic changes characteristic of EMT , including loss of polarity , increased intercellular separation , and the presence of pseudopodia . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Recent work done over the last few years has elucidated the important role of VEGF , which participates in the regulation of normal ( physiological or therapeutic ) and pathological angiogenesis ( VEGF A , VEGF B ) and lymphangiogenesis ( VEGF C , VEGF D ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Low thrombin concentrations were shown to up regulate mRNA levels for VEGF B and VEGF R 1 , suggesting an autocrine / paracrine role for VEGF B . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Furthermore , quantitative reverse transcriptional PCR analysis showed that AdmIFN beta therapy , in C57BL / 6 but not the iNOS null counterparts , reduced levels of the mRNAs for angiopoietin , basic fibroblast growth factor , matrix metalloproteinase 9 , transforming growth factor beta 1 , vascular endothelial growth factor ( VEGF ) A , and VEGF B , as well as the antiapoptotic molecule endothelin 1 . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| In addition to VEGF A , the cells expressed mRNAs for various members of the VEGF family and for their receptors , including VEGF B , C , D , flt 1 , and KDR . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Furthermore , NGF stimulated mRNA expressions of VEGF A and VEGF B and cell proliferation in HMVEC . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Quail embryos were injected with soluble vascular endothelial growth factor ( VEGF ) receptors R 1 ( Flt 1 ) , R 2 ( Flk 1 ) , R 3 ( Flt 4 ) , VEGF Trap ( a chimera of R 1 and R 2 ) , or neutralizing antibodies to VEGF A , VEGF B , or fibroblast growth factor ( FGF ) 2 . ^^^ Antibodies to VEGF B , but not VEGF A , had a strong inhibitory effect on coronary artery development . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Myocardial FGF signaling triggers a wave of HH activation that is essential for vascular endothelial growth factor ( Vegf ) A , Vegf B , Vegf C , and angiopoietin 2 ( Ang 2 ) expression . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| For example , levels of proangiogenic VEGF A , VEGF B , neuropilin 1 , VEGFR 1 , and VEGFR 2 were reduced and the levels of antiangiogenic thrombospondin 1 and retinoblastoma like 2 were increased . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Most uveal melanoma cell lines expressed vascular endothelial growth factor ( VEGF ) A ( isoforms 121 , 165 , 189 ) , VEGF B , VEGF C , VEGF D , and basic fibroblastic growth factor ( b FGF ) to various extents . ^^^ All experimentally induced tumors expressed VEGF A , VEGF B , VEGF C , VEGF D , and basic fibroblastic growth factor ( b FGF ) . ^^^ Similarly , significant amounts of mRNA for VEGF B , VEGF C , VEGF D , and b FGF were detected in uveal melanoma material from patients . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| VEGF A is the prototype member of a gene family that includes also PlGF , VEGF B , VEGF C , VEGF D and the orf virus encoded VEGF E . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Expression of the VEGF related factor gene in pre and postnatal mouse . ^^^ The human VEGF related factor ( VRF ) gene was initially isolated using an 11q13 specific cosmid probe ( D11S750 ) . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| This paper describes the cloning and characterization of a new member of the vascular endothelial growth factor ( VEGF ) gene family , which we have designated VRF for VEGF related factor . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Analysis of the promoter region of the human VEGF related factor gene . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The VEGF related factor , placenta growth factor ( PIGF ) , had little effect on PGI 2 synthesis , arachidonic acid release or cPLA 2 activation . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| The results indicate a coexpression of VEGF mRNA and VEGFB mRNA in human astrocytomas . ^^^ Expression of VEGFB is markedly different from that of VEGF . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| Effects of vascular endothelial growth factor ( VEGF ) A and VEGFB gene transfer on vascular reserve in a conscious rabbit hindlimb ischaemia model . 1 . ^^^ The broad aims of the work briefly summarized here were to compare the effects of VEGFA 165 and VEGFB 167 ( 500 micro g , i . m . , gene transfer ) on calf blood pressure ratio and reactive hyperaemia in a chronic rabbit preparation with unilateral limb ischaemia . 3 . ^^^ There were improvements 14 days after ligation with VEGFA and VEGFB treatments compared with the vehicle control plasmid treatment , but a deficit remained of some 32 % . 4 . ^^^ Gene transfer of either VEGFA or VEGFB allowed significant improvements in these indices compared with vehicle but , at 14 days post ligation , large deficits still remained . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| There are nine proteins in the immediate VEGF family : VEGFA , VEGFB , VEGFC , VEGFD , VEGF 3 , placental growth factor ( PGF ) , VEGF receptor ( VEGFR ) 1 , VEGFR 2 , and VEGFR 1 related . ^^^ |
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| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^ VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^ |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and P15692 |
Pubmed |
SVM Score :0.0 |
| NA |
|