| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin 1 . ^^^ In this study , we show that both splice isoforms of VEGF B bind specifically to Neuropilin 1 ( NRP 1 ) , a receptor for collapsins / semaphorins and for the VEGF ( 165 ) isoform . ^^^ The NRP 1 binding of VEGF B could be competed by an excess of VEGF ( 165 ) . ^^^ The binding of VEGF B ( 167 ) was mediated by the heparin binding domain , whereas the binding of VEGF B ( 186 ) to NRP 1 was regulated by exposure of a short COOH terminal proline rich peptide upon its proteolytic processing . ^^^ In immunohistochemistry , NRP 1 distribution was found to be overlapping or adjacent to known sites of VEGF B expression in several tissues , in particular in the developing heart , suggesting the involvement of VEGF B in NRP 1 mediated signaling . . ^^^ |
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| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| Additional VEGF family members such as the heparin binding form of placenta growth factor ( PlGF 2 ) and VEGF B bind to NRP 1 , and it was also shown that both PlGF 2 and VEGF C bind to NRP 2 . ^^^ |
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| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor and Ang 2 expression were increased in SC adipose tissue of ob / ob mice , and thrombospondin 2 was increased in both their SC and GON fat pads . mRNA levels of vascular endothelial growth factor ( VEGF ) A isoforms VEGF B , VEGF C , VEGF receptor 1 , 2 , and 3 , and neuropilin 1 were not markedly modulated by obesity . ^^^ |
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| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| For example , levels of proangiogenic VEGF A , VEGF B , neuropilin 1 , VEGFR 1 , and VEGFR 2 were reduced and the levels of antiangiogenic thrombospondin 1 and retinoblastoma like 2 were increased . ^^^ |
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| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49765 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|