| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGF receptor subtypes KDR and FLT 1 show different sensitivities to heparin and placenta growth factor . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placenta growth factor ( PIGF ) , a growth factor significantly related to VEGF , is coexpressed with flt in placenta and human vascular endothelial cells . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In this study we show that monocytes , in contrast to endothelium , express only the VEGF receptor Flt 1 , and that this receptor specifically binds also the VEGF homolog placenta growth factor ( PlGF ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Mapping the charged residues in the second immunoglobulin like domain of the vascular endothelial growth factor / placenta growth factor receptor Flt 1 required for binding and structural stability . ^^^ Placenta growth factor ( PlGF ) is an additional ligand for Flt 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C gamma and migration of endothelial cells expressing Flt 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| This binding was efficiently competed by placenta growth factor ( PIGF ) , a ligand reportedly specific for the Flt 1 receptor . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In contrast , activation of VEGF receptor 1 ( Flt 1 ) by its specific ligand placenta growth factor ( PlGF ) had no effect on the tyrosine phosphorylation of cadherins and catenins . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We also investigated the expression of vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) and their receptor FLT 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Osteoclasts predominantly expressed VEGF receptor 1 ( VEGFR 1 ) , and activity of recombinant human placenta growth factor 1 on osteoclast recruitment was comparable to that of rhVEGF , showing that the VEGF signal is mediated through VEGFR 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The use of placenta growth factor ( up to 10 ( 8 ) M ) , an Flt 1 specific agonist , induced only a slight increase ( 0 . 6 fold ) of PAF synthesis . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Regulation of placental vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PIGF ) and soluble Flt 1 by oxygen a review . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| To investigate the molecular mechanisms underlying neovascularization in human germ cell tumors ( GCTs ) , we analysed the expression of two angiogenic growth factors , vascular endothelial growth factor ( VEGF ) and placenta growth factor ( P1GF ) , and of their receptors ( FLT 1 ) and Flk 1 / KDR ) in a panel of testicular tumors . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Flt 1 but not KDR / Flk 1 tyrosine kinase is a receptor for placenta growth factor , which is related to vascular endothelial growth factor . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Flt 1 has an alternative ligand , placenta growth factor ( PlGF ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placenta growth factor ( PlGF ) is a growth factor which belongs to the vascular endothelial growth factor ( VEGF ) family and is known to bind to the fms like tyrosine kinase receptor ( flt 1 ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Flt 1 tyrosine kinase , vascular endothelial growth factor ( VEGF ) receptor 1 , binds VEGF and a new VEGF related ligand , placenta growth factor , but KDR / Flk 1 ( VEGF receptor 2 ) binds only VEGF . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Both mutant VEGF , which activates only KDR , and placenta growth factor , which activates only FLT 1 , were able to enhance FLT 1 expression . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The functional role of VEGF release on Mk maturation is indicated by 2 series of observations . ( 1 ) Molecules preventing the VEGF Flt 1 interaction on the precursor membrane ( eg , soluble Flt 1 receptors ) significantly inhibit Mk polyploidization . ( 2 ) Addition of exogenous VEGF or placenta growth factor ( PlGF ) markedly potentiates Mk maturation . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| SU 5416 inhibited cell migration of human vascular endothelial cells expressing both Flt 1 and KDR in response to VEGF and also inhibited the cell migration in response to placenta growth factor ( PIGF ) , a specific ligand for Flt 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| When we focus on the VEGF receptors , recent findings suggest a role of VEGFR 1 as a functional receptor for placenta growth factor ( PlGF ) and vascular endothelial growth factor A ( VEGF ) A in pericytes and vascular smooth muscle cells in vivo rather than in endothelial cells , and strongly suggest involvement of pericytes in early phases of angiogenesis . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Therefore , we used the VEGF homologue placenta growth factor ( PlGF ) , which only binds to VEGFR 1 and VEGF E , which only recognizes VEGFR 2 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Several growth factors and specific receptors , e . g . vascular endothelial growth factor ( VEGF ) , PlGF ( placenta growth factor ) and the soluble VEGF 1 receptor ( VEGFR 1 ) play essential roles in the process . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Both ERK activation and fibronectin secretion appear to be mediated through the VEGF receptor flt 1 , as evidenced by the effects of the flt 1 specific ligand placenta growth factor . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In addition , the Flt 1 ligand placenta growth factor ( PlGF ) , which is unable to bind and activate Flk 1 / KDR , elicits activities in both monocytes and endothelial cells . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Although melanoma cells expressed both , neuropilin 1 and flt 1 , exogenous homodimeric placenta growth factor had no effect on melanoma cell growth . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We found that placenta growth factor , which selectively activates VEGFR 1 , has no effect on the STATs . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Both primary and metastatic melanoma cells were found to express the mRNAs encoding for vascular endothelial growth factor and placenta growth factor receptors ( KDR , Flt 1 , neuropilin 1 , and neuropilin 2 ) , and exposure of melanoma cells to these cytokines resulted in a specific proliferative response , supporting the hypothesis of a role of these angiogenic factors in melanoma growth . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Here we constructed a recombinant bifunctional diabody that is capable of blocking both Flt 1 and KDR from binding to their ligands , including VEGF and placenta growth factor ( PlGF ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Similarly , VEGF and KDR selective mutant induced more potent vasorelaxation than Flt selective mutant or placenta growth factor that binds Flt 1 only ( P < 0 . 01 ) , and the vasorelaxation to KDR selective mutant was not significantly different at low concentrations but less than that to VEGF at high concentrations . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The effect of a VEGFR 1 agonist , placenta growth factor ( PlGF ) , was also studied with or without L NNA . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The amounts of vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) and their antagonist , soluble fms like tyrosine kinase 1 ( sFlt 1 ) released in CT culture media were measured using ELISA . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGF B is closely related to VEGF A and placenta growth factor ( PlGF ) , but unlike VEGF A , which binds to two receptor tyrosine kinases VEGFR 1 ( Flt 1 ) and VEGFR 2 ( Flk 1 / KDR ) , VEGF B and PlGF bind to VEGFR 1 and not VEGFR 2 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Evaluation of placenta growth factor and soluble Fms like tyrosine kinase 1 receptor levels in mild and severe preeclampsia . ^^^ OBJECTIVE : The purpose of this study was to determine if maternal serum concentrations of placenta growth factor ( PlGF ) and soluble Fms like tyrosine kinase 1 receptor ( s Flt 1 ) are more abnormal in patients with severe preeclampsia compared with mild preeclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placenta growth factor binds only to VEGF receptor 1 ( FLT 1 ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| This effect resulted from the activation of VEGFR 2 , and was mimicked by vammin , a VEGFR 2 ligand from snake venom but not placenta growth factor , which binds specifically to VEGFR 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Upregulation of the angiogenic factors PlGF , VEGF and their receptors ( Flt 1 , Flk 1 / KDR ) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil fed rats suggest a TSH dependent paracrine mechanism for goiter hypervascularization . ^^^ Since goiters of the thyroid gland are extremely hypervascular , we investigated the expression of PlGF , VEGF and their receptors , Flt 1 and Flk 1 / KDR , in a small panel of human goiters from patients with Graves ' s disease , in an animal model of thyroid goitrogenesis and in in vitro cultured thyroid cells . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The engineered hbVEGF E was compared with the VEGFR 1 selective and also heparin binding form of placenta growth factor ( PlGF 2 ) in vivo . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Identification of placenta growth factor determinants for binding and activation of Flt 1 receptor . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| To address this , we explored the effect of oxygen tension on the expression of VEGF , placenta growth factor ( PlGF ) , and their antagonist , soluble fms like tyrosine kinase 1 ( sFlt 1 ) using ELISA and real time PCR in a primary CT cell culture . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The cumulative concentration ( 12 to 8 log10M ) relaxation curves were established for VEGF , KDR SM , Flt 1 SM , and placenta growth factor ( PlGF ) in the absence or presence of indomethacin ( INDO , 7 microM ) , N nitro L arginine ( L NNA , 300 microM ) , L NNA + oxyhemoglobin ( HbO , 20 microM ) , or INDO + L NNA + HbO . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Like VEGF , it is a potent angiogenic factor ; however , PlGF homodimers interact with the VEGF receptor Flt 1 ( fms like tyrosine kinase ) , but not with the kinase domain containing region ( KDR ) . ^^^ Since PlGF is made by the human placenta and extravillous trophoblast ( EV T ) cells of the human placenta express Flt 1 in situ , these cells may be responsive to PlGF . ^^^ Therefore , this study examined whether first trimester EVT cells propagated in vitro expressed the mRNA or the protein of Flt 1 and PlGF , and whether exogenous PlGF 1 had any effect on EVT cell proliferation , migration or invasiveness . ^^^ Immunocytochemical and RT PCR analyses revealed that both normal and SV 40 Tag immortalized EVT cells expressed the protein and mRNA for Flt 1 , but not for PlGF 1 or 2 . ^^^ These results raise two possibilities : that exogenous PlGF 1 ( in spite of having a low affinity for heparin ) was sequestered away from its receptor because of binding to heparan sulphate proteoglycans on the EVT cell surface or the ECM , or that HSPGs could modify the interaction between Flt 1 and PlGF . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Likewise , neither VEGF ( 5 10 10 ( 4 ) to 10 ( 15 ) M ) nor PlGF ( 10 ( 6 ) to 10 ( 8 ) M ) , which selectively binds Flt 1 , served to increase FITC Dextran 40 efflux at Day 5 . 0 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Since VEGF E is a specific activator of flk 1 while PlGF specifically activates only flt 1 , SMC migration induced by VEGF ( 165 ) is likely to be mediated primarily through the flk 1 receptor . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) and placental derived growth factor ( PlGF ) stimulate cell proliferation and differentiation by binding to their specific receptors , Flk 1 / KDR and Flt 1 respectively . ^^^ The aim of this study was to directly evaluate the importance of VEGF , PlGF / Flt 1 and Flk 1 / KDR receptor ligand interactions in regulating normal and malignant human haemopoiesis . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| This is further exemplified by the lack of response to placental growth factor ( PlGF ) , an Flt 1 specific ligand . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In addition to its role as a paracrine angiogenic factor within the placenta and endometrium , presence of its receptor , Flt 1 , on trophoblast suggests that PlGF also may have an autocrine role ( s ) in regulating trophoblast function . ^^^ These results provide the first direct evidence of a biochemical and functional role for PlGF / Flt 1 in normal trophoblast and suggest that aberrant PlGF expression during pregnancy may impact upon trophoblast function as well as vascularity within the placental bed . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In a PlGF positive tumour sample , immunoreactive VEGFR 1 and VEGFR 2 were detected in endothelial cells of the blood vessels . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The extracellular portion of the VEGF and PlGF receptor , Flt 1 ( or VEGFR 1 ) , consists of seven immunoglobulin like domains . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression pattern of NP 1 / NP 2 , their co receptors , vascular endothelial growth factor receptor 1 and 2 ( VEGFR 1 , VEGFR 2 ) , and their ligands , class 3 semaphorins , VEGF and PLGF , following experimental cerebral ischemia in mice . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Invasive cytotrophoblasts in early gestation expressed VEGF A , VEGF C , placental growth factor ( PlGF ) , VEGFR 1 , and VEGFR 3 and , at term , VEGF A , PlGF , and VEGFR 1 . ^^^ In severe preeclampsia and hemolysis , elevated liver enzymes , and low platelets syndrome , immunolocalization on tissue sections showed that cytotrophoblast VEGF A and VEGFR 1 staining decreased ; staining for PlGF was unaffected . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Both VEGF and PlGF , acting through the tyrosine kinase receptors VEGFR 1 and VEGFR 2 , have been implicated in playing a role in ovine placental vascular development . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Tumors removed at 1 week intervals up to week 6 were probed by immunohistochemistry ( n = 3 11 samples ) for vascular endothelial growth factor ( VEGF ) , placental growth factor ( PlGF ) , flk 1 and flt 1 , angiopoietin 1 and 2 , and Tie 1 and 2 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor ( PlGF ) , which signals through VEGFR 1 , restored early and late phases of hematopoiesis following BM suppression . ^^^ PlGF enhanced early phases of BM recovery directly through rapid chemotaxis of VEGFR 1 ( + ) BM repopulating and progenitor cells . ^^^ Thus , PlGF promotes recruitment of VEGFR 1 ( + ) HSCs from a quiescent to a proliferative BM microenvironment , favoring differentiation , mobilization and reconstitution of hematopoiesis . . ^^^ Revascularization of ischemic tissues by PlGF treatment , and inhibition of tumor angiogenesis , arthritis and atherosclerosis by anti Flt 1 . ^^^ The therapeutic potential of placental growth factor ( PlGF ) and its receptor Flt 1 in angiogenesis is poorly understood . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Mice expressing a truncated form of the specific receptor for PlGF , the VEGF receptor 1 ( VEGFR 1 ) , show impaired angiogenesis similar to that observed in Plgf ( / ) mice . ^^^ These data suggest a pivotal role for PlGF and VEGFR 1 in regulating VEGF A dependent angiogenesis under pathological conditions . ^^^ This review discusses the possibility of using the PlGF / VEGFR 1 pathway as an alternative target for angiogenic therapy . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| This synergy has been hypothesized to be due to a combination of the following : signaling by PlGF through VEGFR 1 and displacement of VEGF from VEGFR 1 to VEGFR 2 by PlGF , causing increased signaling through VEGFR 2 . ^^^ We show that , whereas a significant change in the formation of endothelial surface growth factor VEGFR 1 complexes is predicted in the presence of PlGF , the increase in the number of VEGFR 2 containing signaling complexes is less significant ; these results were shown to be robust to significant variation in the kinetic parameters of the model . ^^^ Synergistic effects observed in that experiment thus appear unlikely to be due to VEGF displacement but to a shift from VEGF VEGFR 1 to PlGF VEGFR 1 complexes and an increase in total VEGFR 1 complexes . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We have investigated the expression patterns of VEGF , placental growth factor ( PlGF ) , and their receptors fms like tyrosine kinase ( Flt 1 ) and kinase insert domain containing region ( KDR ) in placentas with histopathological changes . ^^^ Positive immunostaining for VEGF , PlGF , and Flt 1 was observed in infiltrated neutrophils and macrophages in the placentas with chorioamnionitis ( CAM ) . ^^^ These findings suggested that in the hypoxic / ischemic regions , VEGF and KDR expression is increased within the villous vessels by paracrine regulation , whereas the expression of PlGF and Flt 1 is enhanced in villous trophoblasts by autocrine regulation . ^^^ Furthermore , the results indicated that VEGF and PlGF stimulate inflammatory cell migration by autocrine regulation via the Flt 1 receptor in the CAM placenta . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor ( PlGF ) and its receptor Flt 1 ( VEGFR 1 ) : novel therapeutic targets for angiogenic disorders . ^^^ Efforts to therapeutically stimulate or inhibit vessel growth have been primarily focused on vascular endothelial growth factor ( VEGF ) and its receptor VEGFR 2 ( Flk 1 ) , while little attention has been devoted to the therapeutic potential for angiogenic disorders of placental growth factor ( PlGF ) , a VEGF family member , and its receptor VEGFR 1 ( Flt 1 ) . ^^^ Thus , PlGF and Flt 1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| To understand the molecular basis of the biological activity of VEGF E , we have functionally mapped residues important for interaction of VEGF E with VEGFR 2 by exchanging the domains between VEGF E ( NZ 7 ) and PlGF , which binds only to VEGFR 1 ( Flt 1 ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Here , we confirm that placental soluble fms like tyrosine kinase 1 ( sFlt 1 ) , an antagonist of VEGF and placental growth factor ( PlGF ) , is upregulated in preeclampsia , leading to increased systemic levels of sFlt 1 that fall after delivery . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| MEK and PI 3 kinase inhibitors and antibody to Flt 1 abrogated PlGF induced chemotaxis of THP 1 monocytes . ^^^ Taken together , these data show that activation of monocytes by PlGF occurs via activation of Flt 1 , which results in activation of PI 3 kinase / AKT and ERK 1 / 2 pathways . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor ( PlGF ) and vascular endothelial growth factor ( VEGF ) are involved in placental angiogenesis through interactions with the VEGFR 1 and VEGFR 2 receptors . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Role of PlGF in the intra and intermolecular cross talk between the VEGF receptors Flt 1 and Flk 1 . ^^^ Here we report that placental growth factor ( PGF , also known as PlGF ) regulates inter and intramolecular cross talk between the VEGF RTKs Flt 1 and Flk 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Plasma elevation of placental growth factor ( PlGF ) , which signals through VEGFR 1 , but not VEGFR 2 , restored hematopoiesis during the early and late phases following BM suppression . ^^^ The mechanism whereby PlGF enhanced early phases of BM recovery was mediated directly through rapid chemotaxis of readily available VEGFR 1 ( + ) BM repopulating and progenitor cells . ^^^ PlGF promotes recruitment of VEGFR 1 ( + ) HSCs from a quiescent to a proliferative microenvironment within the BM , favoring differentiation , mobilization , and reconstitution of hematopoiesis . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Human neovascular membranes consistently expressed VEGF A , B , and C ; PlGF ; and VEGFR 1 and 2 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In contrast to VEGF and its receptor VEGFR 2 , PlGF and its receptor VEGFR 1 have been largely neglected and therefore their potential for therapy has not been previously explored . ^^^ In this review , we describe the molecular properties of PlGF and VEGFR 1 and how this translates into an important role for PlGF in the angiogenic switch in pathological angiogenesis , by interacting with VEGFR 1 and synergizing with VEGF . ^^^ Thus , these preclinical studies show proof of principle that PlGF and VEGFR 1 are promising therapeutic targets to treat angiogenesis and inflammation related disorders . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In contrast , PlGF , another member of this family , binds only to VEGFR 1 , and appears to be crucial exclusively for pathological angiogenesis in the adult . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Preeclampsia was associated with low levels of circulating PlGF and increased levels of total VEGF A and soluble VEGFR 1 . ^^^ The first one is related to an overproduction of competitive soluble VEGFR 1 that may lead to suppression of VEGF A and PlGF effects . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| PlGF exerts its biological activities through binding to VEGFR 1 , a receptor tyrosine kinase that consists of seven immunoglobulin like domains in its extracellular portion . ^^^ Here we report the crystal structure of PlGF bound to the second immunoglobulin like domain of VEGFR 1 at 2 . 5 A resolution and compare the complex to the closely related structure of VEGF bound to the same receptor domain . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Animal models with mutations in the genes coding for placental growth factor ( PlGF ) , a member of vascular endothelial growth factor ( VEGF ) family , or the tyrosine kinase domain of the PlGF receptor ( Flt 1 ) have revealed differences between normal physiological angiogenesis and pathological angiogenesis associated with conditions such as tumor growth , arthritis and atherosclerosis . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The discovery of the vascular endothelial growth factor ( VEGF ) family members VEGF , VEGF B , placental growth factor ( PlGF ) , VEGF C and VEGF D and their receptors VEGFR 1 , 2 and 3 has provided tools for studying the vascular system in development as well as in diseases ranging from ischemic heart disease to cancer . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA expressions of Flt 1 , VEGF and PlGF were determined by RT PCR . ^^^ The increased mRNA expressions for Flt 1 and VEGF and the decreased mRNA expression for PlGF in TCs were consistent with the protein productions under hypoxia condition . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The anti Flt 1 peptide shows specificity toward binding to VEGFR 1 and it inhibits binding of VEGF , placental growth factor ( PlGF ) , and VEGF / PlGF heterodimer to VEGFR 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family that binds specifically to Flt 1 . ^^^ The biological roles of PlGF and Flt 1 have not yet been defined and the signalling mechanisms mediating cellular actions of PlGF remain poorly understood . ^^^ PlGF induced c Fos expression in porcine aortic endothelial cells specifically expressing Flt 1 , and FosB expression in the monocytic RAW 264 . 7 cell line expressing endogenous Flt 1 . ^^^ These findings show for the first time that VEGF and PlGF induce mRNA expression of the transcription factors FosB and c Fos , and suggest that these factors may play a role in the biological responses mediated by PlGF and Flt 1 . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In this prospective nested case control study , we investigated whether first trimester serum levels of placental growth factor ( PlGF ) , a potent angiogenic factor , and its soluble inhibitor , soluble fms like tyrosine kinase 1 ( sFlt 1 ) , distinguished women who developed PE ( n = 40 ) from those who developed gestational hypertension ( n = 40 ) , delivered a small for gestational age ( SGA ) newborn ( n = 40 ) , or completed a full term normal pregnancy ( n = 80 ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Limited data suggest that excess circulating soluble fms like tyrosine kinase 1 ( sFlt 1 ) , which binds placental growth factor ( PlGF ) and vascular endothelial growth factor ( VEGF ) , may have a pathogenic role . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The expression of both VEGF receptor 1 ( VEGFR 1 ) and VEGFR 2 was upregulated both in the satellite cells of the damaged muscles and during myotube formation in vitro ; the VEGF effect was mediated by the VEGFR 2 , since the transfer of PlGF , a VEGF family member interacting with the VEGFR 1 , was ineffective . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We reveal that vascular endothelial growth factor receptor 1 ( FLT 1 ) modulates acute leukemia distribution within the BM , along VEGF and PlGF gradients , regulating leukemia survival and exit into the peripheral circulation . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| PlGF and soluble VEGFR 1 levels did not show any significance in study groups ( P > 0 . 05 ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that high serum levels of soluble fms like tyrosine kinase 1 ( sFlt 1 ) , an antiangiogenic protein , and low levels of placental growth factor ( PlGF ) , a proangiogenic protein , predict subsequent development of preeclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| CONTEXT : An excess of the soluble receptor , fms like tyrosine kinase 1 ( sFlt 1 ) may contribute to maternal vascular dysfunction in women with preeclampsia by binding and thereby reducing concentrations of free vascular endothelial growth factor and placental growth factor ( PlGF ) in the circulation . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Neointimal macrophages were associated with increased expression of the PlGF receptor Flt 1 . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the relationship of neonatal platelet count and preeclampsia to levels of soluble fms like tyrosine kinase 1 ( sFlt 1 ) , placental growth factor ( PlGF ) , and vascular endothelial growth factor ( VEGF ) in the cord blood of preterm infants . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Two factors have been implicated in the genesis of this state : soluble vascular endothelial growth factor receptor 1 ( sVEGFR 1 ) and placental growth factor ( PlGF ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Recent studies have suggested that excess secretion of a naturally occurring anti angiogenic molecule of placental origin referred to as soluble fms like tyrosine kinase 1 ( sFlt 1 , also referred to as sVEGFR 1 ) may contribute to the pathogenesis of preeclampsia . sFlt 1 acts by antagonizing two pro angiogenic molecules vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGF B and placental growth factor ( PlGF ) activate VEGFR 1 selectively , however , mice lacking either ligand display only minor developmental defects . ^^^ We hypothesized that the relative contributions of VEGF B and PlGF to VEGFR 1 signaling may be masked in the presence of VEGF A , which is abundantly expressed during postnatal development . ^^^ To test this hypothesis , neonatal or adult mice were treated with a monoclonal antibody ( G 6 23 IgG ) blocking murine VEGF A or a soluble VEGFR 1 receptor IgG chimeric construct [ mFlt ( 1 3 ) IgG ] , which neutralizes VEGF A , VEGF B , and PlGF . ^^^ In conclusion , our findings suggest that PlGF and VEGF B do not compensate during conditions of VEGF A blockade , suggesting a minor role for compensatory VEGFR 1 signaling during postnatal development and vascular homeostasis in adults . ^^^ The absence of compensatory VEGFR 1 signaling by VEGF B and PlGF may have important implications for the development of anticancer strategies targeting the VEGF ligand / receptor system . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Serum levels of soluble fms like tyrosine kinase 1 ( sFlt 1 ) , vascular endothelial growth factor ( VEGF ) , and placental growth factor ( PlGF ) are altered in women with clinical preeclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Serum levels of vascular endothelial growth factor ( VEGF ) , soluble Flt 1 and Flk 1 receptors , placental growth factor ( PlGF ) , angiopoietin 2 ( Ang 2 ) and soluble Tie 2 receptor were determined by ELISA . ^^^ Interestingly , in CHC patients serum levels of VEGF and Tie 2 correlated with grade of inflammation , PlGF correlated with stage of fibrosis , and Flt 1 and Flk 1 correlated with serum transaminase levels ( p < 0 . 05 in all cases ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| However , the mechanism of PlGF and VEGFR 1 mediated angiogenesis has remained unclear and some in vitro studies suggest that VEGF A / VEGFR 2 signaling may also play a role in PlGF mediated angiogenesis . ^^^ We also investigated the roles of VEGFR 1 and VEGFR 2 in PlGF 2 mediated angiogenesis . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Recent reports of increased serum levels of soluble fms like tyrosine kinase 1 ( sFlt 1 ) and decreased levels of placental growth factor ( PlGF ) suggest the key role of angiogenic factors in development of pre eclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| This response is dependent upon the expression of vascular endothelial growth factor ( VEGF ) receptor 1 ( VEGFR 1 ) , which mediates cell migration in response to VEGF or placental growth factor ( PLGF ) . ^^^ In this study , we found that exposure of cultured mouse bone marrow derived mesenchymal stromal cells ( MSC ) to hypoxia or an adenovirus encoding a constitutively active form of hypoxia inducible factor 1 ( HIF 1 ) induced VEGFR 1 mRNA and protein expression and promoted ex vivo migration in response to VEGF or PLGF . ^^^ MSC in which HIF 1 activity was inhibited by a dominant negative or RNA interference approach expressed markedly reduced levels of VEGFR 1 and failed to migrate or activate AKT in response to VEGF or PLGF . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| As PlGF expression was increased throughout the process of bone repair and all the important cell types involved expressed its receptor VEGFR 1 , the present data suggest that PlGF is required for mediating and coordinating the key aspects of fracture repair . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Adenovirus mediated overexpression of soluble Flt 1 ( sFlt 1 ) in a mouse model of endotoxemia attenuated the rise in VEGF and PlGF levels and blocked the effect of endotoxemia on cardiac function , vascular permeability , and mortality . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| These findings were further supported by our finding that tumor associated placental growth factor ( PlGF ) , a VEGFR 1 specific agonist , increased tumor vasculogenesis in a murine BMT model . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The expression of VEGF , the closely related placental growth factor ( PIGF ) , the newly cloned endothelial high affinity VEGF receptors KDR and FLT 1 , and the endothelial orphan receptors FLT 4 and Tie were analyzed by in situ hybridization in normal human brain tissue and in the following CNS tumors : gliomas , grades 2 , 3 , 4 ; meningiomas , grades 1 and 2 ; and melanoma metastases to the cerebrum . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| We examined the ability of PIGF to bind to soluble VEGF receptors , Flt 1 and Flk 1 / KDR , and characterized the binding of PIGF to endothelial cells . ^^^ While the PIGF proteins bound with high affinity to Flt 1 , they failed to bind to Flk 1 / KDR . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Characterization of the VEGF / PIGF receptors , KDR and flt 1 , revealed the presence of flt 1 mRNA in isolated cytotrophoblast and in vitro differentiated syncytiotrophoblast . ^^^ In addition , presence of function flt 1 on normal trophoblast suggests that VEGF / PIGF functions in an autocrine manner to perform an as yet undefined role in trophoblast invasion , differentiation , and / or metabolic activity during placentation . . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In vitro studies demonstrated that increasing oxygen tension ( hyperoxia ) up regulated PIGF protein in term placental villous explants , whereas hypoxic culture of a term trophoblast choriocarcinoma cell line ( BeWo ) down regulated PIGF mRNA and protein and VEGFR 1 ( Flt 1 ) autophosphorylation . ^^^ VEGF and PIGF exert their biological actions by means of a common receptor VEGFR 1 . ^^^ In the first trimester trophoblast cells , PIGF 1 increased the association of phosphorylated extracellular signal related kinase ( ERK ) with VEGFR 1 immunoprecipitates while both PIGF 1 and PIGF 2 also potentiated endogenous VEGF mediated association of phosphorylated extracellular related kinase ( ERK ) with VEGFR 2 ( KDR ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These results indicated that neither the hyperpermeability in response to simultaneous stimulation of VEGFR 1 and VEGFR 2 nor VEGFR 1 mediated severe inflammation was associated with VEGF E ( NZ 7 ) / PlGF induced angiogenesis . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : This study examined whether atorvastatin increases plasma levels of soluble Fms like tyrosine kinase 1 ( sFlt 1 ) and reciprocally decreases vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) levels in patients with acute myocardial infarction ( AMI ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| METHODS : In a nested case control study of nulliparous pregnancies , we examined levels of placental growth factor ( PlGF ) and soluble fms like tyrosine kinase 1 ( sFlt 1 ) in serum collected prospectively from 31 women who later developed placental abruption and from 31 normal control subjects . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Alterations in circulating soluble fms like tyrosine kinase 1 ( sFlt 1 ) , an antiangiogenic protein , and placental growth factor ( PlGF ) , a proangiogenic protein , appear to be involved in the pathogenesis of preeclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Inhibition of VEGFR 2 blocked activation of extracellular regulated kinase , p 38 , Akt , and endothelial nitric oxide synthetase ( eNOS ) by VEGF , but did not inhibit p 38 activation by the VEGFR 1 specific ligand , placental growth factor ( PIGF ) . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| Recently , the soluble form of VEGFR 1 ( sVEGFR 1 ) , an antagonist to VEGF and PIGF , has been implicated in the pathophysiology of pre eclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| There are nine proteins in the immediate VEGF family : VEGFA , VEGFB , VEGFC , VEGFD , VEGF 3 , placental growth factor ( PGF ) , VEGF receptor ( VEGFR ) 1 , VEGFR 2 , and VEGFR 1 related . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| It has been reported that the concentration of free placental growth factor ( PIGF ) is decreased and that of soluble fms like tyrosine kinase 1 ( sFlt 1 ) is increased before the onset of preeclampsia . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In addition , expression of the PIGF receptor , fms like tyrosine kinase ( flt 1 ) receptor , on trophoblast raises the potential for an autocrine role of PIGF in regulating trophoblast growth and / or function . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| The VEGF family members PIGF and VEGF B with exclusive binding capacities to the VEGFR 1 can influence monocyte activation and differentiation . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| In contrast , gene transfer of placental growth factor ( PGF ) which signals through Flt 1 , but not KDR receptors had negative effects on neurogenesis and inhibited learning , although it similarly increased endothelial cell proliferation . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| To dissect the signals of these two receptors , we generated transgenic mice overexpressing either the VEGFR 2 specific ligand VEGF E ( NZ 7 ) or VEGFR 1 specific ligand PlGF 2 under the control of the Keratin 14 promoter . ^^^ |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49763 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|